Studies Related to the Involvement of EsA in Improving Intestinal Inflammation in Acute Pancreatitis via the NF-κB Pathway by CuiPing Pan, ChunXiang Zhang, YiJie Li, Jie Cao, ShiWei Liang, HaiCheng Fang, Ying Liu

“…Intestinal damage can occur early in the course of AP and is manifested by impaired intestinal mucosal barrier function, and inflammatory reactions of the intestinal mucosa, among other factors. …”
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ZIP7 contributes to the pathogenesis of diabetic cardiomyopathy by suppressing mitophagy in mouse hearts by Ningzhi Yang, Rui Zhang, Hualu Zhang, Yonghao Yu, Zhelong Xu

“…The cardiac-specific ZIP7 conditional knockout (ZIP7 cKO) mice were generated by adopting CRISPR/Cas9 system. Cardiac function was evaluated with echocardiography. Mitophagy was assessed by detecting mito-LC3II, mitoKeima, and mitoQC. …”
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Wearable Sensors-Based Intelligent Sensing and Application of Animal Behaviors: A Comprehensive Review by Luyu Ding, Chongxian Zhang, Yuxiao Yue, Chunxia Yao, Zhuo Li, Yating Hu, Baozhu Yang, Weihong Ma, Ligen Yu, Ronghua Gao, Qifeng Li

“…In addition, algorithm development for functional applications post behavior recognition may represent a critical future research direction.…”
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Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids by Hui Shen, Chaoxu Zhang, Qian Zhang, Qing Lv, Hao Liu, Huiya Yuan, Changliang Wang, Fanyue Meng, Yufu Guo, Jiaxin Pei, Chenyang Yu, Jinming Tie, Xiaohuan Chen, Hao Yu, Guohua Zhang, Xiaolong Wang

“…Conclusion SCFAs not only mitigate damage to intestinal structure and function but also alleviate various lesions in the central nervous system, such as neuroinflammation, and reduce anxiety and depression-like behaviors, which were triggered by transplantation with fecal microbiota that had been affected by chronic ethanol exposure, adding more support that SCFAs serve as a bridge between the gut and the brain.…”
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Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC by Xufan Cai, Weihui Guo, Fang Wu, Weilang Xu, Tao Ding, Yizhe Diao, Lei Wang, Zhenyuan Qian, Guangyuan Song

“…Abstract Objective hnRNPA3 is highly expressed in numerous malignancies, including hepatocellular carcinoma (HCC), but its function and mechanism has not been elucidated. In this study, we performed a comprehensive bioinformatics analysis of hnRNPA3 in the TCGA-LIHC dataset and several experiments in vitro to investigate the function and potential mechanisms of hnRNPA3 in HCC. …”
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In vitro biological activities of silver nanoparticles using methanolic leaf extract of Plumeria rubra by Abhinash Marukurti, Alavala Matta Reddy, Pangi Vijaya Nirmala, Dasari Kalyani, K. Ramaneswari, I. J. N. Padmavathi, L. Pradeepthi Pemmaraju, Gotham Samuel Silvanus, Buddha Sai Keerthana, Shaik Farhana, D. Ramachandran, B. Mallikarjuna, Phanindra Babu Kasi

“…The successful synthesis of AgNPs was achieved by reducing Ag⁺ ions using PR extract. The phytochemistry of PR extract was observed using qualitative screening, Fourier transform infrared spectroscopy (FTIR), and gas chromatography with flame ionisation detection (GC-FID). …”
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Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke by Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Shensen Zhang, Chao Han, Chengcheng Tan, Yubing Huang, Zhaokai Sun, Liang Wang, Jing Liu

“…We demonstrate that hNSC-Exos activate mitophagy via the PINK1/Parkin pathway, improving mitochondrial function and reducing neuronal apoptosis. Conclusions These findings suggest that hNSC-Exos alleviate OS-induced neuronal damage by regulating the PINK1/Parkin pathway. …”
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Lysinibacillus sphaericus exposure impedes Anopheles dirus’s oviposition via downregulating vitellogenin by Shasha Yu, Zhilong Liu, Jing Wang, Hong Zheng, Shiqian Han, Feifei Zheng, Dan Zheng, Caizhi Zhao, Xin Li, Tingting Liu, Xuesen Yang, Ying Wang

“…Notably, L. sphaericus inhibit lysosomal function and lipid metabolism, which are critical for mosquito physiology. …”
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Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes by Mohammed Usama, Mohammed Usama, Ying Deng, Ying Deng, Yiran Chen, Théa Milland, Théa Milland, Mohan Malleshaiah, Mohan Malleshaiah, Mohan Malleshaiah, Yasaman Aghazadeh, Yasaman Aghazadeh, Yasaman Aghazadeh

“…Recent efforts can be broadly categorized into: (1) improving the cell product as surrogates of native beta cells, (2) promoting engraftment post-transplant to support cell survival, integration into the host, and endocrine function, and (3) developing immunomodulation strategies to reduce or circumvent immunosuppression regimen. …”
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Enteromorpha prolifera soluble dietary fiber alleviates ulcerative colitis through restoration of mucosal barrier and gut microbiota homeostasis by Yuan-Yuan Ding, Yuan-Yuan Ding, Xin-Yi Tang, Yu Tian, Feng-Long Zhang, Xiang Ding, Meng-Chun Qi, Wei Dong, Chen-Guang Liu

“…The severity of UC was evaluated through daily disease activity index (DAI) scoring; quantification of pro-inflammatory cytokines (TNF-α, IL-1β) via ELISA; histopathological analysis of colon sections with H&E staining; immunofluorescence detection of tight junction proteins (ZO-1, occludin); and 16S rRNA sequencing for gut microbiota.ResultsEDFM treatment significantly reduced the expression of pro-inflammatory cytokines (TNF-α and IL-1β), enhanced the expression of tight junction proteins (ZO-1 and occludin), and stimulated mucin (MUC2) production. …”
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Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection by Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang

“…The expression of CD161 on HBV‐specific CD8+T cells was also detected by analyzing CD161+CD8+T cell functions during infection. …”
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Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage by Xue Li, Yao Zhuang, Ya Ru Zhang, Ke Ke Fan, Xin Xin Chen, Xin Xing Chen, Xuan Yi Liu, Jing Sun, Li Liu

“…Future studies are needed to explore targeted antioxidant therapies and receptor-selective modulation strategies to reduce the side effects.…”
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Multi-omics insights into Palmitoylation-mediated brain network remodeling and glioblastoma risk by Shasha Tan, Jinliang You, Huijun Wang, Long Zhao, Shun Li, Xiaoping Tang, Hongjun Liu

“…Neuroimaging mediation analysis revealed that 15–23% of this protection operates through structural and functional brain remodeling, including reduced parahippocampal volume (mediated 15.96% for ZDHHC13), diminished default mode network connectivity ICA100 edge 295, and ICVF Body of corpus callosum(15.29% mediation for ZDHHC6). …”
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LncRNA-TUG1: Implications in the Myocardial and Endothelial Cell Oxidative Stress Injury Caused by Hemorrhagic Shock and Fluid Resuscitation by Wei Li, Huaiyu Chen, Xueli Zhu, Mingrui Lin

“…In vivo, we silenced TUG1 and quantified its expression along with inflammatory factors through quantitative reverse transcription polymerase chain reaction (qRT-PCR), mean arterial pressure (MAP) detection and blood gas analysis. Myocardial functional impairment was assessed via Triphenyl-2H-Tetrazolium Chloride (TTC), Hematoxylin and eosin, and Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) stainings. …”
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Unveiling Ventilator-Associated Pneumonia: S100A8 as a Promising Biomarker Through Integrated RNA-Seq Analysis by Wang Q, Dong J, Jing X, Long Y, Jia H, Li Y, Wang J

“…This phenomenon was caused by the cellular level differential expression of B cells. In contrast, the reduced FN1 and HLA-DRB5 expressions in the VAP group may be influenced by the expression of T cells, macrophages, and ciliated cells. …”
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TREATMENT OPTIONS FOR COVID-19 WITH VITAMIN D SUPPLEMENTS by Tetiana V. Fartushok, Nadiia V. Fartushok, Serhii Z. Baran

“…Confirmation that vitamin D affects the functioning of the immune system was the detection of calcitriol receptors in cells of the immune system, as well as the ability of mononuclear phagocytes to produce 1,25(OH)2D3. …”
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The de Winter's sign as an ECG equivalent to STEMI by Vukićević Verica, Ilić Andrijana, Mirković Olja, Janković Tamara

“…The precordial leads showed a reduced R-wave in V2-V4, an upslopping ST depression in V3-V5 with high, symmetrical T-waves in V2-V5. …”
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Avicularin Treatment Ameliorates Ischemic Stroke Damage by Regulating Microglia Polarization and its Exosomes via the NLRP3 Pathway by Yan Shi, Yufeng Yang, Juntong Liu, Jinling Zheng

“…Modified neurological severity score, Triphenyltetrazolium chloride (TTC) staining, brain-water-content detection, TdT-mediated dUTP nick-end labeling (TUNEL) assay, flow cytometry, immunofluorescence assay, Enzyme linked immunosorbent assay (ELISA), and Western-blot analysis were used to investigate the functions and mechanism of the effect of AL treatment on IS. …”
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Identification of PECAM1 as a Prognostic Biomarker for Lung Adenocarcinoma by Shih-Sen Lin, Pei-Sung Hsu, Ying-Chu Lin, Jie-Yu You, Yung-Leun Shih, Hung-Chih Lai

“…Functional enrichment was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses to interpret the biological relevance of these genes. …”
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Development of hyaluronate tethered magnetic nanoparticlesfor targeted anti-cancer drug delivery by Dipsikha Bhattacharya

“…For this, these MNPs should be modified with some highly biocompatible polymers (specially polysaccharides) exhibiting the cancer targeting properties that can strongly interact with receptors expressed on the target cancer to facilitate accurate detection of the specific cancer and enhanced delivery to the target site while reducing unintended tside effects. …”
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