Epigenomic and clinical analyses of striatal DAT binding in healthy individuals reveal well-known loci of Parkinson's disease by Arash Yaghoobi, Homa Seyedmirzaei, Marzie Jamaat, Moein Ala

“…Background: Striatal dopamine transporter (DAT) binding is a sensitive and specific endophenotype for detecting dopaminergic deficits across Parkinson's disease (PD) spectrum. …”
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Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics by Xi Chen, Elizabeth A. Grimm, Yong Qin

“…Treatment with selective iNOS inhibitors significantly reduced nitrite accumulation, confirming the functional activity of iNOS and the model’s applicability for pharmacologic evaluation of NO-modulatory compounds.DiscussionOur findings establish the DLD-1 cell line as a reproducible and well-controlled in vitro system for studying inducible iNOS expression and downstream NO/RNS signaling in human epithelial cancer cells. …”
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MR Defecography Improves Diagnosis of Postoperative Pelvic Floor Dysfunction After Gynecological Surgery by Rosa Alba Pugliesi, Marika Triscari Barberi, Giovanni Roccella, Giuseppe Gullo, Valentina Billone, Elena Chitoran, Gaspare Cucinella, Federica Vernuccio, Roberto Cannella, Giuseppe Lo Re

“…Pelvic floor dysfunction (PFD) is one of the most significant postoperative consequences in gynecological surgery, leading to impaired bowel function, structural alteration, and reduced quality of life. …”
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Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction by Marius Witt, Leticia Oliveira-Ferrer, Friedrich Koch-Nolte, Stephan Menzel, Louisa Hell, Tabea Sturmheit, Elisa Seubert, Pauline Weimer, Yi Ding, Minyue Qi, Barbara Schmalfeldt, Carsten Bokemeyer, Walter Fiedler, Jasmin Wellbrock, Franziska Brauneck

“…In addition, these OVCA-characteristic CD8+ T cells showed reduced expression of the transcription factor TCF-1, which may also indicate reduced effector function and memory formation. …”
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An Observational Study on Pre-natal Diagnosis of Congenital Talipes Equinovarus by Gaurav Vatsa, Saurabh Suman, Siddharth Kumar Singh

“…Discussion: Despite its effectiveness, US remains operator-dependent, necessitating standardized protocols to reduce misdiagnosis. Early detection benefits psychological preparedness and treatment planning. …”
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Prioritizing Research for Enhancing the Technology Readiness Level of Wind Turbine Blade Leading-Edge Erosion Solutions by Sara C. Pryor, Rebecca J. Barthelmie, Jacob J. Coburn, Xin Zhou, Marianne Rodgers, Heather Norton, M. Sergio Campobasso, Beatriz Méndez López, Charlotte Bay Hasager, Leon Mishnaevsky

“…An enhanced understanding of the mechanisms responsible for wind turbine blade leading-edge erosion (LEE) and advancing technology readiness level (TRL) solutions for monitoring its environmental drivers, reducing LEE, detecting LEE evolution, and mitigating its impact on power production are a high priority for all wind farm owners/operators and wind turbine manufacturers. …”
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Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…Immunohistochemistry techniques were also applied to detect and localize specific protein markers relevant to endometrial receptivity and function. …”
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Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives by Zitong Zhang, Jiahua Meng, Jiaqi Tian, Ning Li, Zhen Chen, Xiang Yun, Dandan Song, Fei Li, Shuyin Duan, Lin Zhang

“…We show a potential relationship between MNP exposure and increased prevalence of infertility and adverse pregnancy outcomes based on the fact that MNPs exert detrimental effects on reproductive parameters, including sperm quality, ovarian function, and steroidogenesis. In male reproductive systems, MNPs disrupt testicular tissue structure, impair reproductive endocrinology, and reduce sperm quality. …”
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Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-Mediated deacetylation of P53 by Zhili Xiong, Zhili Xiong, Zhili Xiong, Zhili Xiong, Xinyu Hu, Rui Wang, Rui Wang, Rui Wang, Chengyin Li, Chengyin Li, Chengyin Li, Huanbo Cheng, Wei Zhao, Yinfeng Shen, Linqun Wang, Weinan Li, Weinan Li, Weinan Li, Xiaoyun Zhu, Yuanming Ba, Yuanming Ba, Yuanming Ba

“…The levels of reactive oxygen species (ROS) were detected.ResultsJT significantly reduced collagen deposition in the kidneys. …”
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An openEHR based infection control system to support monitoring of nosocomial bacterial clusters and contacts by Pascal Biermann, Claas Baier, Ann Christin Vietor, Benedikt Zacher, Tom Baumgartl, Tatiana von Landesberger, Michael Behnke, Michael Storck, Markus Petzold, Martin Kaase, HiGHmed lnfection Control Study Group, Dirk Schlüter, Michael Marschollek, Simone Scheithauer, Antje Wulff

“…Abstract Early outbreak detection, allowing rapid intervention, is essential to reduce the burden of healthcare-associated pathogen transmission, including multidrug-resistant bacteria. …”
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Sodium-Dependent Glucose Transporter-2 Inhibitor Enhances the Hypotensive Effect of Renal Denervation by Inhibiting Sympathetic Activity and Inflammatory Reaction by Hao Zhang, Zhuqing Li, Wei Cai, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Qi Li, Ning Yang, Chengzhi Lu, Yuming Li

“…Additionally, the proportions of inflammatory mononuclear cell subsets and the levels of inflammatory factors improved. Although DAPA reduced inflammation and sympathetic nerve overexcitation alone, it could not completely reverse blood pressure (BP) or cardiac function. …”
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Human umbilical cord mesenchymal stem cells improve disease characterization of Sjogren's syndrome in NOD mice through regulation of gut microbiota and Treg/Th17 cellular immunity by Yao Zou, Wei Xiao, Dongzhou Liu, Xianyao Li, Lihua Li, Lijuan Peng, Ying Xiong, Haina Gan, Xiang Ren

“…UC‐MSCs and UC‐MSCs‐exo partially restored salivary secretion function, reduced Ro/SSA antibody and α‐Fodrin immunoglobulin A levels, reduced inflammatory cell infiltration in the intestine and submandibular gland, raised proportion of Treg cells, decreased IFN‐γ, IL‐6, IL‐2, IL‐17, lipopolysaccharide, and tumor necrosis factor‐alpha levels, and raised IL‐10, Foxp3, and TGF‐β1 levels by affecting co‐cultured T cells. …”
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Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling by Xuechen Yin, Wenwen Chen, Xudong Ao, Luxia Xu, Jiujiu Cao, Tinghui Huang, Junqing Liang, Jianhua Hu, Jiaqi Liu, Xinping Wang, Wenying Li, Muya Zhou, Lingfeng He, Zhigang Guo

“…To further validate our observation, we also treated anti-mesothelin (MSLN) CAR-T cells with sodium citrate and detected the phenotypes and anti-tumor function of CAR-T cells.ResultsWe found that sodium citrate-pretreated anti-CD70 CAR-T cells exhibited reduced exhaustion, increased memory T cell proportions, and enhanced anti-tumor efficacy both in vitro and in vivo. …”
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Fucoxanthin inhibits the proliferation of MOLM13 cells by targeting AKT to disrupt glucose metabolism by Tingting Niu, Tingting Niu, Ying Chen, Mengmeng Sun, Cong Shi, Duobing Zou, Wei Wu, Yuzhan Chen, Juanjuan Chen, Haimin Chen, Guifang Ouyang, Qitian Mu

“…Here, we combined molecular docking, dynamics simulations, and functional assays (CCK-8, flow cytometry, glucose/ATP detection) to decipher the mechanism of Fucoxanthin on FLT3-ITD AML cells. …”
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Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention by Nawal Alsubaie, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Tarek Khamis, Mohamed M. M. Metwally, Mohamed M. M. Metwally, Nawal Helmi, Afnan M. Alnajeebi, Badriyah S. Alotaibi, Amirah Albaqami, Wedad Mawkili, Mai A. Samak, Mai A. Samak, Samar A. Eissa

“…Moreover, their splenic tissues displayed a substantial increase in the ROS, MDA, IL-6, and IL-1β content, altered splenic histology, and reduced GPX, GSH, and GSH/GSSG. Furthermore, a substantial upregulation of mRNA expression of splenic CD20, CD56, CD8, CD4, CD3, IL-6, and TNF-α, but downregulation of CD8 was detected in FTN-exposed rats. …”
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Low Levels of MicroRNA-10a in Cardiovascular Endothelium and Blood Serum Are Related to Human Atherosclerotic Disease by Jong-Tar Kuo, Hsiao-En Tsai, Ching-Ting Lin, Chih-I Lee, Pei-Ling Lee, Yu-Rong Ruan, Jeng-Jiann Chiu, Ding-Yu Lee

“…In addition, sera from CAD patients and healthy subjects were collected to detect the level of circulating miR-10a. Results. …”
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Quantitative evaluation of radiation-induced heart disease in beagle dogs by speckle tracking echocardiography by Zi-Ying Wang, Long Huang, Li-Qun Li, Chun-Quan Zhang, Liang-Yun Guo, Yan-Na Liu, Ling-Min Liao

“…Abstract Objective This study aimed to detect early changes in left ventricular systolic function in Beagle dogs after radiotherapy using two-dimensional speckle tracking echocardiography and to explore its potential value in evaluating radiation-induced heart disease. …”
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New domestic intraocular lenses. Resistance to biodegradation processes in comparison with foreign analogues by K.G. Khliyan, I.R. Omarieva, S.Yu. Kopaev

“…Results. Glistening was not detected in Aquamarine IOL and Rumex rAqua-4. The 2nd and higher degree of glistening was not detected in any model of hydrophobic IOLs. …”
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Frequency and risk factors of sarcopenia in the elderly people by Yu. A. Safonova, N.  V. Toroptsova

“…The results of multivariate analysis showed that the probability of SP increased with a BMI of less than 25 kg / m2 (OR 5,459; 95 % CI: 1,939–15,369; p = 0.0013), severe comorbidity calculated by the Charlson index (OR 5,178; 95 % CI: 1,597–14,128; p = 0.0030) and the presence of such laboratory indicators like level 25 (OH) D less than 20 ng / ml (OR 4,989; 95 % CI: 1,321–12,626; p = 0.0420), total protein less than 64 g / l (OR 8,567; 95 % CI: 2,658–27,617; p = 0.00032), CRP more than 5 mg / l (OR 14,279; 95 % CI: 3,511–58,071; p = 0.00020) and moderately reduced renal function (GFR <60 ml / min / 1.73 m (OR 12,108; 95 % CI: 3,944–37,170; p = 0.00001).Conclusions. …”
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GATOR1 gene variants in focal epilepsy by Kovačević Maša, Vojvodić Nikola, Novaković Ivana

“…Variants in GATOR1 genes have been detected in multiplex families with rare familial focal epilepsy syndromes where they demonstrate an autosomal dominant inheritance pattern with reduced penetrance. …”
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