Joint ancestry and association testing in admixed individuals. by Daniel Shriner, Adebowale Adeyemo, Charles N Rotimi

“…We then describe a joint test that uses the posterior probabilities from admixture mapping as prior probabilities for association mapping, capitalizing on the reduced testing burden of admixture mapping relative to association mapping. …”
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The Microcirculatiory Changes of the Optic Nerve Disc in Patients with Normal Tension Glaucoma in Comparison High Tension Glaucoma by A. Sh. Zagidullina, A. I. Arslanova, V. U. Galimova, A. A. Aleksandrov

“…In the advanced stage NTG the vessel density of the peripapillary region was reduced in all sectors of the ONH and correlated with the thickness of the RNFL in the upper sector (r = 0.404, p < 0.05). …”
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Right-ventricular mechanics assessed by cardiovascular magnetic resonance feature tracking in children with hypertrophic cardiomyopathy. by Joanna Petryka-Mazurkiewicz, Lidia Ziolkowska, Łukasz Mazurkiewicz, Monika Kowalczyk-Domagała, Agnieszka Boruc, Mateusz Śpiewak, Magdalena Marczak, Grażyna Brzezinska-Rajszys

“…<h4>Conclusions</h4>Children with HCM, especially with LVOTO, have significantly reduced indices of RV mechanics despite normal RV systolic function. …”
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Ugd Is Involved in the Synthesis of Glycans of Glycoprotein and LPS and Is Important for Cellulose Degradation in <em>Cytophaga hutchinsonii</em> by Wenxia Song, Shaoqi Geng, Qingsheng Qi, Xuemei Lu

“…The contents of mannose, glucose, galactose, and xylose were detected to be reduced in the glycoproteins of the ∆<i>ugd</i> mutant compared to that of wild-type. …”
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Circular RNAs related to skeletal muscle atrophy in diabetic mouse model by YANG Lei, WANG Yun, DENG Fang, XU Te, GOU Deming, ZHOU Wei, HU Zhangli, ZOU Xianghui

“…The profiles of circRNA in gastrocnemius muscle of streptozotocin-induced diabetic mice were detected. Results showed that, compared with the same tissue of normal isogenic background mice, the gastrocnemius muscle of diabetic mice showed: (a) the areas of muscle fiber were significantly reduced, and the grasping power and motor function were decreased; (b) there were 1 403 differentially expressed circRNAs in skeletal muscles of diabetes model, of which 690 were up-regulated and 713 were down-regulated; and (c) these disease related candidate circRNAs matched parent genes were revealed by the functional enrichment analyses of gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG). …”
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Low-Dose ACTH Stimulation Test in Obesity: A Randomized Dose Assessment by Leonardo G. Mancillas-Adame, Adriana Sánchez-García, Rene Rodriguez-Gutierrez, Camilo Gonzalez-Velazquez, Fernando Javier Lavalle-Gonzalez, Jorge A. Zuñiga-Hernandez, Adriana Gabriela Rios-Ortega, José Gerardo González-González

“…Lower cosyntropin doses may have greater sensitivity vs. the standard dose in detecting adrenal dysfunction. Obesity and overweight are increasing, impacting the clinical presentation of some diseases. …”
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MicroRNA-221 protects myocardial contractility in myocardial ischemia/reperfusion injury through phospholamban. by Hongyu Li, Jimiao Qiu, Chang Liu, Guobing Yu, Danyu Wu, Yichun Chu, Kai Wang

“…Changes in myocardium calcium concentration were detected with reagent kits and the targeting interaction between miRNA 221 and PLB was evaluated using a luciferase reporter assay.…”
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Alleviation of Rheumatoid Arthritis by Inducing IDO Expression with Trichinella spiralis Recombinant Protein 43 by Xiao Ma, Dongming Liu, Wenhao Yu, Caixia Han

“…It is difficult to treat and can lead to joint deformation and function loss. At present, Trichinella spiralis (T. spiralis) antigen has attracted much attention because it plays a role in host immune regulatory mechanisms. …”
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A systematic review and meta-analysis of unilateral versus bilateral pedicle screw fixation in transforaminal lumbar interbody fusion. by Xu-Qi Hu, Xin-Lei Wu, Cong Xu, Xu-Hao Zheng, Yong-Long Jin, Li-Jun Wu, Xiang-Yang Wang, Hua-Zi Xu, Nai-Feng Tian

“…Our meta-analysis showed that no significant difference was detected between the two groups in terms of postoperative clinical function, fusion status, reoperation rate, complication rate, and hospital stay (p>0.05). …”
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Ghrelin improves small intestinal barrier damage in sepsis by promoting miR-143/ATG2B-mediated autophagy. by Jingquan Liu, Kai Shi, Hanhui Cai, Zihao Zheng, Bin Fan, Xianghong Yang, Ziqiang Shao

“…Ghrelin (GHS) can restore intestinal barrier function. However, the mechanisms of GHS on intestinal barrier damage in sepsis remain unclear. …”
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Vitamin C in Allergy Mechanisms and for Managing Allergic Diseases: A Narrative Review by Chiara Trincianti, Matteo Naso, Maria Angela Tosca, Giorgio Ciprandi

“…Recent evidence suggests a protective role for vitamin C in asthma, with several studies reporting reduced oxidative stress markers, improved lung function, and decreased airway inflammation following regular intake or supplementation. …”
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Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats by Xiaoyu Sun, Na Ge, Qingqing Liang, Qian Wang, Hui Yu, Min Jin

“…Furthermore, the total flavonoids of D. moldavica have been demonstrated to enhance the intestinal mucosal barrier function, reduce LPS translocation, and inhibit the activation of hepatic TLR4/MyD88/NF-κB pathway. …”
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BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization by Yanbin Zhang, Jing Bai, Bin Xiao, Chunyan Li

“…Abstract Osteoporosis is characterized by reduced bone mass due to imbalanced bone metabolism. …”
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The impact of early age-related hearing loss on working memory capacity and speech recognition in noise in middle-aged and older adults by Chen-Wei Chang, Yu-chun Chen

“…Speech-in-noise testing proved more sensitive than pure-tone audiometry or word recognition in detecting auditory and cognitive decline. To comprehensively evaluate the impact of ARHL on communication in middle-aged and older adults, it is recommended to incorporate assessments of EHF hearing sensitivity, cognitive function (e.g., WMC), and speech-in-noise perception.…”
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Characterization of cardiac sarcoidosis in Iranian patients using cardiac magnetic resonance and positron emission tomography imaging techniques by Simin Almasi, Amir Azimi, Kiyan Heshmat-Ghahdarijani, Amir Ghaffari Jolfayi, Mahsa Ghorbani, Shahla Meshgi, Maedeh Dastmardi, Ghazaleh SalehAbadi, Ali Mohammadzadeh

“…All patients underwent CMR to evaluate myocardial function, edema, scarring, and strain. 28 patients also underwent FDG-PET/CT to assess active myocardial inflammation. …”
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Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode. by Roz Laing, Stephen R Doyle, Jennifer McIntyre, Kirsty Maitland, Alison Morrison, David J Bartley, Ray Kaplan, Umer Chaudhry, Neil Sargison, Andy Tait, James A Cotton, Collette Britton, Eileen Devaney

“…After ivermectin selection, we identified differential expression of genes with roles in neuronal function and chloride homeostasis, which is consistent with an adaptive response to ivermectin-induced hyperpolarisation of neuromuscular cells. …”
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Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Postoperative Cognitive Dysfunction in Elderly Mice Based on BDNF/TrkB Signaling Pathway by LI Min, YANG Xiao, REN Lulu, WU Tingmei, ZHANG Hong

“…On the third day after operation，the locomotor activity of mice was evaluated by open field test （percentage of stay time in the central area，total distance and average speed of movement）; On the fourth day after operation，the cognitive function of mice was evaluated by Y-maze test （the percentage of times to enter the new arm，the percentage of time to stay in the new arm，and the total distance to move the new arm）; After the Y-maze test，the protein expression levels of brain-derived neurotrophic factor （BDNF），tropomyosin related kinase B （TrkB） and nerve growth factor （NGF） in mice hippocampus were detected by immunoblotting.Results（1） Exercise capacity：there was no significant difference in the percentage of time spent in the central area of the open field，total distance and average speed among the three groups （<italic>P</italic>&gt;0. 05）. （2） Cognitive function：there was no significant difference among the three groups in the percentage of times of exploring new forearm （<italic>P</italic>&gt;0. 05）; Compared with the control group，the percentage of stay time in the new arm and the total distance of new arm movement in the operation group were significantly reduced，and the differences were statistically significant （<italic>P</italic>&lt;0. 05）. …”
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Beneficial effects of liraglutide on peripheral blood vessels by Zhang Xueyang, Wang Yongbo, Yang Simengge, Zong Junwei, Wang Xuejiao, Bai Ran

“…Blood urea nitrogen (BUN) and so on were detected. Homeostasis model assessment of insulin resistance (HOMA-IR) and islet β cell function (HOMA-β) were computed. …”
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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…We verified its expression level and function by protein blotting, immunohistochemistry, and cell scratch and cell viability assays. …”
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ZnO nanoparticles induce acute arrhythmia and heart failure in mice by disturbing cardiac ion channels by Xuexue Liu, Xuexue Liu, Hongmei Deng, Zijuan Zhao, Shan Wen, Shan Wen, Kailong Ma, Xinyu Wang, Yanfei Du, Chang Li, Jun Li, Guangqin Zhang, Xiaobo Zhou, Tuck Wah Soong, Ziqi Yuan, Jian Feng, Guang Li

“…Meanwhile, acute exposure to ZnO NPs did not induce endocytosis, impair membrane integrity, or promote ROS production in the mitochondria of cardiomyocytes.ConclusionAcute ZnO NPs exposure causes heart failure and arrhythmia in mice by directly impacting ion channel function.…”
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