PET Imaging of CD206 Macrophages in Bleomycin-Induced Lung Injury Mouse Model by Volkan Tekin, Yujun Zhang, Clayton Yates, Jesse Jaynes, Henry Lopez, Charles Garvin, Benjamin M. Larimer, Suzanne E. Lapi

“…In contrast, the healthy mice exhibited no detectable CD206 staining, lower PET signals, and reduced radiopharmaceutical accumulation in lung tissues at the same timepoint. …”
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Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma by Yuhang Chen, Fenglin Zhang, Suoyi Dai, Jiangang Zhao, Wenxun Cai, Ke Zhang, Xinghe Liao, Lianyu Chen

“…In vitro experiments were executed to examine the function of MCU in PDAC cells. In vitro experiments were conducted to detect the malignant potential of MCU in PDAC cells and its effect on lactic acid metabolism. …”
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Effect of conditioned medium from miRNA-34a transfected gastric cancer-associated fibroblast on peripheral blood mononuclear cells by Mozhgan Esmaili, Narjes Jafari, Fatemeh Ahmadzadeh, Seyed Mohammad Valizadeh Toosi, Saeid Abediankenari

“…Therefore, this study aimed to evaluate the function of miRNA34a in CAF cells in gastric carcinoma. …”
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Metabolomics-Based Pharmacodynamic Analysis of Zhuang Yao Shuang Lu Tong Nao Granules in a Rat Model of Ischemic Cerebral Infarction by Yang Zhai, Yangling Chen, Yihui Luo, Xiaoping Mei, Lin Wu, Xueni Mo, Min Zou, Mingzhao Zhou, Yangling Wu, Guangshan Zheng, Peng Yang, Qingyu He, Rui Chen

“…The neurological deficit scores were significantly higher in the MCAO_R group than in the NC group, indicating that the mice had significantly impaired motor functions. The YHT group had significantly lower scores than the MCAO_R group, suggesting that YHT significantly improved motor function in rats. …”
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Projection neurons are necessary for the maintenance of the mouse olfactory circuit by Luis Sánchez-Guardado, Peyman Razavi, Bo Wang, Antuca Callejas-Marín, Carlos Lois

“…The assembly and maintenance of neural circuits is crucial for proper brain function. Although the assembly of brain circuits has been extensively studied, much less is understood about the mechanisms controlling their maintenance as animals mature. …”
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Luteolin Treatment Protects against Renal Ischemia-Reperfusion Injury in Rats by Xin Hong, Xiaojing Zhao, Gang Wang, Zhengliang Zhang, Honghong Pei, Zhong Liu

“…In conclusion, luteolin improved renal function in I/R rats by reducing oxidative stress, neutrophil infiltration, inflammation, renal cell apoptosis, and expression of HMGB1 and NF-κB, and ER stress.…”
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EGb761 suppressed vascular dementia via modulating Wnt/β-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells by Nan Yin, Zhipeng Tang, Yanyan Yang, Xiuqin Li, Ruisheng Duan, Guodong Xu, Peiyuan Lv

“…Results EGb761 significantly improved the cognitive function of vascular dementia rats (P < 0.01) and reduced the apoptosis of hippocampal neurons.Furthermore, EGb761 suppressed ROS, thereby promoting the expression of proteins related to the Wnt/β-catenin signaling pathway and inhibiting the expression of C-Jun N-terminal Kinase (p-JNK), c-Jun N-terminal kinase (p-c-JUN), Protein 53 (P53), immunity-related GTPase M (IRGM), Transcription Factor EB (TFEB), microtubule-associated proteins light chain 3 (LC3), Lysosomal Associated Membrane Protein 1 (LAMP1), and Sequestosome 1 (SQSTM1). …”
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Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway by Jinbo Zhang, Wenxin Zhang, Zhiyong Yang, Bingbing Fan, Chunhe Wang, Zhengkun Tian

“…CA significantly alleviated lung damage and reduced α-SMA and Col I expression. TLR4/NF-kB/HIF-1a activation with RS09TFA inhibited CA’s effects. …”
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PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT by Zejin Zhang, Zejin Zhang, Zhenzhen Yan, Zhenzhen Yan, Tao Yuan, Tao Yuan, Xiaona Zhao, Xiaona Zhao, Minghui Wang, Minghui Wang, Guoqing Liu, Guoqing Liu, Lijun Gan, Wei Qin, Wei Qin, Wei Qin

“…Western blot, qRT-PCR, and immunofluorescence staining were used to detect the expression of TCF12, TGF-β1, and endothelial-to-mesenchymal transition (EndMT) markers. …”
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Deficiency of lysophosphatidic acid receptor 3 decreases erythropoietin production in hypoxic mouse kidneys by Nan Yin, Xuyuan Li, Di Zhang, Mengxia Qu, Shengqiang Pei, Xi Chen, Xiaotian Zhang, Junjie Zhang

“…Abstract Background Lysophosphatidic acid (LPA) is a lipid mediator with diverse biological functions through its receptors on the cell membrane. …”
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Effects of human umbilical cord-derived mesenchymal stem cell therapy for cavernous nerve injury-induced erectile dysfunction in the rat model by Wei Wang, Ying Liu, Zi-Hao Zhou, Kun Pang, Jing-Kai Wang, Peng-Fei Huan, Jing-Ru Lu, Tao Zhu, Zuo-Bin Zhu, Cong-Hui Han

“…Significant changes were detected in the microstructures of various types of cells. …”
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Improving Fall Classification Accuracy of Multi-Input Models Using Three-Axis Accelerometer and Heart Rate Variability Data by Seunghui Kim, Jae Eun Ko, Seungbin Baek, Daechang Kim, Sungmin Kim

“…Reduced body movement and weakened musculoskeletal function as a result of aging increase the risk of falls and serious physical injuries requiring medical attention. …”
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Single-cell and multi-omics analysis reveals the role of stem cells in prognosis and immunotherapy of lung adenocarcinoma patients by Jianan Zheng, Haoran Lin, Wei Ye, Mingjun Du, Chenjun Huang, Jun Fan

“…Key marker genes were identified using the FindAllMarkers function, and these genes were subsequently analyzed for mutations, copy number variations, and prognostic significance in LUAD patients. …”
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Correlating NAD(P)H lifetime shifts to tamoxifen resistance in breast cancer cells: A metabolic screening study with time-resolved flow cytometry by Samantha Valentino, Karla Ortega-Sandoval, Kevin D. Houston, Jessica P. Houston

“…Differences in fluorescence lifetime are attributed to the binding states of the autofluorescent metabolite NAD(P)H. The function of NAD(P)H is well described and in general involves cycling from a reduced to oxidized state to facilitate electron transport for the conversion of pyruvate to lactate. …”
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Therapeutic drug monitoring vs. pharmacogenetic testing in the context of elevated olanzapine concentrations and prior clozapine intolerability: a case study by Farah Khorassani, Ricardo Azevedo, Reza Farokhpay

“…Conclusion This case highlights the utility of TDM over pharmacogenetic testing for patients on these medications with a suspected alteration in CYP1A2 metabolism. therapeutic drug monitoring emerges as a more practical approach with stronger evidence for its use, particularly in cases of suspected reduced CYP1A2 activity, where suballeles resulting in decreased enzyme function are not readily detectable on standard commercial pharmacogenomic panels.…”
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Altered Memory T-Cell Responses to Bacillus Calmette-Guerin and Tetanus Toxoid Vaccination and Altered Cytokine Responses to Polyclonal Stimulation in HIV-Exposed Uninfected Kenyan... by Miguel A Garcia-Knight, Eunice Nduati, Amin S Hassan, Faith Gambo, Dennis Odera, Timothy J Etyang, Nassim J Hajj, James Alexander Berkley, Britta C Urban, Sarah L Rowland-Jones

“…The present study assessed T-cell phenotype and function in HEU infants with a focus on memory Th1 responses to vaccination. …”
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Inhibitory effects of Caveolin-1-m ediated atorvastatin on vasoconstriction of interlobar renal artery in SHR rats by XIE Xiao-ping, ZHANG Hai-jun, GUO Yi-bin, ZHANG Xi, CHANG Yao-ming, BAO Jun-xiang

“…Isometric force recording system was used to detect the vascular function. Western blotting was conducted toexamine the protein abundance of caveolin-1 or angiotensin Ⅱ type 1 receptor（ AT₁）. …”
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miR-135a Regulates Atrial Fibrillation by Targeting Smad3 by Xueting Fan, Kai Feng, Yonghui Liu, Leixi Yang, Yizhuo Zhao, Liping Tian, Yiqun Tang, Xiaozhi Wang

“…This study is aimed at investigating the function and regulatory network of miR-135a in AF. …”
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Effect of high and low flux hemodialysis on vascular endothelial cell growth factor and interleukin-1 beta levels in maintenance hemodialysis patients by WANG Wen-zheng, ZHANG Jin-ping, WANG Jia, YANG Xiao-ping

“…Objective To invesigate the effects of the different dialysis procedures on vascular endothelial growth factor(VEGF) and interleukin-1 beta(IL-1β) levels in maintenance hemodialysis(MHD) patients to provide a theoretical basis for a reasonable choice for dialysis,and for improving the prognosis of patients with hemodialysis.Methods From June 2012 to June 2014 in the Blood Purification Center of the First Affiliated Hospital of Shihezi University,32 patients with MHD were selected,including high flux hemodialysis group of 16 cases,and low flux hemodialysis group of 16 cases.The 16 healthy volunteers served as control group.Related biochemical indexes were determined,and ELISA was used to detect the plasma levels of VEGF and IL-1β.Results As compared with control group,the plasma VEGF level in patients with MHD was significantly increased(P<0.05),and that in HFHD group was significantly lower than in LFHD group(P<0.05).The single factor correlation analysis showed that plasma VEGF level was positively correlated with dialysis age,intact parathyroid hormone(iPTH),and low density lipoprotein(r= 0.65,0.605,and 0.284,P<0.05).As compared with control group,plasma IL-1β was significantly increased,and that was statistically reduced in HFHD group as compared with LFHD group(P<0.05).The single factor correlation analysis showed there was a negative correlation between IL-1β and age(r=-0.261,P<0.05),but a positive correlation between IL-1β with low density lipoprotein,dialysis age,iPTH and VEGF(r =0.274,0.722,0.658,and 0.783,P<0.01).Single factor correlation analysis showed that plasma VEGF and IL-lβ levels showed a positive correlation(r = 0.783,P<0.01).Conclusions As compared with LFHD,HFHD can reduce micro-inflammatory state in MHD patients and protect endothelial function more effectively,and improve the prognosis of patients.…”
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ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans. by Lina Zhao, Lorenz A Fenk, Lars Nilsson, Niko Paresh Amin-Wetzel, Nelson Javier Ramirez-Suarez, Mario de Bono, Changchun Chen

“…The ability to detect and respond to acute oxygen (O2) shortages is indispensable to aerobic life. …”
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