Axillaridine A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via inhibition of RANKL-mediated RANK signaling pathways by Jin Li, Jing Xu, Zhe Jiang, Meiyan Duan, Yingqi Yin, Zemin Xiang, Xuanjun Wang, Jun Sheng, Titi Liu, Huanhuan Xu

“…This was achieved by blocking RANKL-RANK interaction and inhibiting RANKL-mediated RANK signaling pathways, including NF‍-‍κB, AKT, and mitogen-activated protein kinases (MAPKs) in osteoclast precursors. …”
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Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha... by Tianjiao Mao, Wei Wei, Bo Chen, Yixin Chen, Shuqi Liang, Guiping Chen, Zhuoyuan Liu, Xiaodan Wu, Lihong Wu, Xiaomeng Li, Nobumoto Watanabe, Kevin H. Mayo, Janak L. Pathak, Jiang Li

“…This study aimed to explore the underlying mechanism by which genistein–estrogen receptor alpha (ERα) complex targets X-inactive specific transcript (Xist) then leads to the inhibition of ferroptosis by regulating acyl-CoA synthetase long-chain family member 4 (ACSL4) expression in salivary gland epithelial cells (SGECs) to attenuate SS. …”
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Gut-derived Faecalibaculum rodentium exerts anti-cancer effects on colorectal cancer by modulating PDPN-CLEC-2 signaling pathway by Xiaojuan Yang, Miao Liu, Ting Wang, Xinjuan Ma, Zhirong Guan, Bin Ma, Xiangguo Duan, Chunxia Su

“…Mechanistically, F. rodentium produced acetate, which suppressed the expression of PDPN on CD8+ T cells and that of C-type lectin-like receptor 2 (CLEC-2) on tumor cells. As a consequence, CD8+ T-cell immunity was increased both in vivo and in vitro. …”
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Transcriptome Analysis Reveals Hyperglycemic Hormone and Excitatory Amino Acid Transporter 3 Are Involved in the Thermal Adaptation of <i>Eriocheir sinensis</i> by Xi Li, Runlin Zhou, Ruiqi Zhang, Zhen He, Mingzhi Zhang, Ran Li, Tong Hao, Jinsheng Sun

“…Through Gene Ontology (GO) enrichment analysis of these DEGs, 11 significantly temperature-regulated signaling pathways were identified, including the estrogen and androgen receptor signaling pathways, and two neurotransmission signaling pathways. …”
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Investigation of potential relationship between glucagon-like peptide 1 receptor agonists with suicide/self-injury: disproportionality analysis using WHO-VigiBase by Ye Young Kim, Ju Hwan Kim, Ju-Young Shin

“…Purpose As global interest in glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has increased owing to weight loss effect, concerns regarding the risk of suicide/self-injury associated with GLP-1 RAs have garnered considerable attention. …”
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EGFR EXPRESSION IN RECTAL CANCER, RELATION TO THE FREAQUENCY OF LYMPH NODE METASTASIS by I. V. Stepanov, S. R. Altybaev, N. V. Krakhmal, К. V. Rachkovsky, D. A. Sorokin, S. G. Afanasyev, S. V. Vtorushin, М. V. Zavyalova

“…Normally, binding of EGFR ligands and transforming growth factor alpha (TGFα) induces receptor activation, which triggers erk and PI3K signaling pathways that control cell proliferation, migration, invasion and many other processes. …”
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Features and Practical Aspects of Radiochemical Purity Determination of Receptor-Specific Lu-177 Radiopharmaceuticals as Exemplified by [¹⁷⁷Lu]Lu–PSMA-617 by A. A. Larenkov, Yu. A. Mitrofanov, M. G. Rakhimov

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Exploring the biological functions and immune regulatory roles of IRAK3, TNFRSF1A, CX3CR1, and JUNB in T2DM combined with MAFLD: integrated bioinformatics and single-cell analysis by Qin Wang, Xiaoqi Li, Kaidierdan Wushoulaji, Jinyang Wang, Li Wan, Ye Yang, Xueli Gong

“…Enrichment analysis indicated associations of T2DM combined with MAFLD pathogenesis with pathways such as the NF-kappa B signaling pathway, MAPK signaling pathway, Fluid shear stress and atherosclerosis, Insulin resistance, and Cytokine-cytokine receptor interaction. …”
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MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8+ T cells by Andreas Pavlou, Luca Ghita, Felix Mulenge, Inken Waltl, Olivia Luise Gern, Pia-Katharina Larsen, Bibiana Costa, Veronica Duran, Lena Mareike Busker, Shelly J. Robertson, Yvonne Lueder, Stephan Halle, Reinhold Förster, Sonja M. Best, Martin Stangel, Ulrich Kalinke

“…To investigate these mechanisms, we used mice with conditional deletions of the mitochondrial antiviral-signaling protein (MAVS), an adaptor for RIG-I-like receptor (RLR) signaling. …”
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Membrane proteome analysis identifies key components of sensing in Phytophthora parasitica zoospores by C. A. Lupatelli, A. Seassau, M. Magliano, M. L. Kuhn, A. Rey, M. Poët, L. Counillon, E. Evangelisti, P. Thomen, A. Attard, X. Noblin, E. Galiana

“…Major classes of membrane proteins (receptors, transporters and enzymes) were identified and their subcellular distribution between flagella and cell bodies quantified. …”
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Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions by María Aránzazu Penedo, María Aránzazu Penedo, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Esther Gramage, Esther Gramage, Esther Gramage, Gonzalo Herradón, Gonzalo Herradón, Gonzalo Herradón

“…Microglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors. Recently, the signaling pathway initiated by the interaction of the neurotrophic factors pleiotrophin (PTN) and midkine (MK) with receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) has emerged as a pharmacological target in ethanol-induced neuroinflammatory and neurodegenerative processes. …”
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Fermented defatted rice bran-derived gut Clostridium butyricum improved the gut barrier function by regulating HIF-1 signaling pathway by Weifa Su, Zipeng Jiang, Tao Gong, Man Du, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang

“…Overall, FR-derived C. butyricum and butyrate might improve gut barrier function through the HIF-1 signaling pathway, which provides a reference for the application of fermented DFRB as a potential functional food for improving of gut barrier function.…”
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Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine by Zhenzhen Fan, Dandan Su, Zi Chao Li, Songtang Sun, Zhaoming Ge

“…Central sensitization is one of the important pathophysiological mechanisms underlying CM, and microglia-induced neuroinflammation conduces to central sensitization. Triggering receptor expressed on myeloid cells 2 (TREM2) is presented solely in microglia residing within the central nervous system and plays a key role in neuroinflammation. …”
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G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis by Srinivas Pittala, Dhanush Haspula, Yinghong Cui, Won-Mo Yang, Young-Bum Kim, Roger J. Davis, Allison Wing, Yaron Rotman, Owen P. McGuinness, Asuka Inoue, Jürgen Wess

“…Abstract Altered hepatic glucose fluxes are critical during the pathogenesis of type 2 diabetes. G protein-coupled receptors represent important regulators of hepatic glucose production. …”
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TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing by Min Kyu Son, Hyo-Jung Lee, Eunho Cho, Se Jin Oh, Tae Woo Kim

“…Mechanically, TRPV1 enhances autophagy-dependent secretion of epidermal growth factor (EGF), which in turn activates epidermal growth factor receptor (EGFR) signaling, ultimately leading to tumor cell resistance to CTL-mediated cytotoxicity. …”
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ITK overexpression enhances T cell cytotoxicity against DLBCL through the TCR-Ca2+-Calcineurin-NFAT-IFN-γ pathway by Huifang Liu, Mengyang Zhang, Xianguang Zhu, Guanghui Chen

“…Through bioinformatics analysis, it was found that ITK, as a key molecule in the T Cell Receptor (TCR) signaling pathway, is significantly underexpressed in DLBCL. …”
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MyD88 polymerization and association to cellular membranes in a yeast heterologous model by Elba del Val, Alejandro Fernández-Vega, María Molina, Víctor J. Cid

“…Abstract MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs). …”
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The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent... by Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

“…Conclusions Our findings indicate that TZPD, with its multifaceted role, has beneficial effects on cardiac cells by positively modulating β-ARs signaling and glucose metabolism rather than on-target receptor action. …”
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Therapeutic targeting of protein arginine methyltransferases reduces breast cancer progression by disrupting angiogenic pathways by Kamohelo Maphalala, Dakalo Portia Ramali, Lorraine Tshegofatso Maebele, Thanyani Victor Mulaudzi, Peace Mabeta, Zodwa Dlamini, Botle Precious Damane

“…PRMTs regulate various tumor angiogenesis pathways, including vascular endothelial growth factor receptor-2 (VEGFR-2) signaling. PRMT1, PRMT4, and PRMT5 activate distinct stages of angiogenesis. …”
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Characterization of Netrin-1 and Its Receptors UNC5B and Neogenin-1 in a Rat Rotator Cuff Tear Model: Associations with Inflammatory Mediators and Neurite Extension by Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, Akito Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue, Masashi Takaso

“…Rotator cuff tears are a leading cause of shoulder pain and dysfunction, yet the molecular mechanisms that link tendon injury to inflammation and nociceptive signaling remain poorly understood. Netrin-1, a classical axon guidance cue signaling through dependence receptors UNC5B and Neogenin-1, has been implicated in both neuronal plasticity and inflammatory processes, but its role in tendon pathology has not been explored. …”
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