A pharmacovigilance study of thromboembolism events associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors based on FAERS database by Zongwei Tang, Haichi Song, Lingyun Pan, Min Zhang, Siyu Li, Wenrui Li, Wanyi Chen, Xiaoxiao Wang

“…Abstract Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) represent a class of targeted drugs that have changed the cancer therapy landscape. …”
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Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling by Adrián Bartoll, Ana Toledano‐Zaragoza, Josefina Casas, Manuel Guzmán, Edward H Schuchman, María Dolores Ledesma

“…Activation of CB1 receptor signaling, through inhibition of the eCB‐degrading enzyme fatty acid amide hydrolase (FAAH), reduced SM levels in ASM‐KO neurons. …”
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Regulation of hedonic feeding rhythms by circadian clocks in leptin-receptive neurons by Jazmin Osorio-Mendoza, Jana-Thabea Kiehn, Sarah Stenger, Keno O. Heinen, Laura Griewahn, Christiane E. Koch, Undine Haferkamp, Violetta Pilorz, Johanna L. Barclay, Parth Joshi, Lisbeth Harder, Olaf Jöhren, Peter Kühnen, Gregor Eichele, Henrik Oster

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The TaNHLP1-TaRACK1A module regulates tillering via abscisic acid signaling in wheat by Yaoqi Si, Shuiquan Tian, Jianqing Niu, Qiao Lu, Qiushuang Shang, Shengwei Ma, Zhimeng Zhang, Tingting Du, Huilan Wu, Jundong Li, Xiansheng Zhang, Fang Wang, Hong-Qing Ling, Shusong Zheng

“…Furthermore, TaNHLP1 interacts with the Receptor for Activated C Kinase 1 (TaRACK1A), an ABA pathway negative regulator, and influences its subcellular localization. …”
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miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling by Cristina Migliore, Elena Morando, Elena Ghiso, Sergio Anastasi, Vera P Leoni, Maria Apicella, Davide Cora', Anna Sapino, Filippo Pietrantonio, Filippo De Braud, Amedeo Columbano, Oreste Segatto, Silvia Giordano

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Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer by Lidia Moyano‐Galceran, Elina A Pietilä, S Pauliina Turunen, Sara Corvigno, Elisabet Hjerpe, Daria Bulanova, Ulrika Joneborg, Twana Alkasalias, Yuichiro Miki, Masakazu Yashiro, Anastasiya Chernenko, Joonas Jukonen, Madhurendra Singh, Hanna Dahlstrand, Joseph W Carlson, Kaisa Lehti

“…In HGSC patient tumors, this orphan receptor GPRC5A was expressed exclusively in cancer cells and associated with chemotherapy resistance and poor survival. …”
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OsWNK9 regulates the expression of key transcription factors, phytohormonal, and transporters genes to improve salinity stress tolerance in rice by Yogesh Negi, Kundan Kumar

“…RNA-seq analysis revealed that the Oe-OsWNK9 exhibited significant enrichment of GO terms related to biological processes, including “response to abiotic stimulus,” “regulation of protein dephosphorylation,” “protein phosphorylation,” and “cell surface receptor signaling pathways”. The cellular component GO terms were also significantly enriched with “plasmodesma,” “plasma membrane,” “extracellular space,” “apoplast,” and “cell wall” terms. …”
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Immunomodulatory effects of 4-hydroxynonenal by Melina Ioannidis, Johanna Tjepkema, Michael R.P. Uitbeijerse, Geert van den Bogaart

“…This review explores how 4-HNE influences molecular mechanisms involved in inflammation and immune cell functions. 4-HNE modulates inflammation through the interaction with several signaling pathways, including nuclear factor kappa-light-chain enhancement of activated B cells (NF-κB), nuclear factor erythroid 2-related factor (Nrf2), mitogen-activated protein kinases (MAPK), toll-like receptor (TLR) 4, and stimulator of interferon genes (STING), thereby affecting immune responses and modulating cytokine production and inflammasome activation. …”
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Transcriptomic and metabolomic analysis reveals hepatic lipid metabolism disruption in Japanese quail under polystyrene microplastics exposure by Xinxin Zhang, Lingyang Jing, Xiaoqing Pei, Qingyu Zhang, Hongfeng Zhao

“…Especially, lipid metabolism including peroxisome proliferator activated receptor (PPAR) signaling pathway, fatty acid oxidation, primary bile acid synthesis and triglyceride metabolism were disrupted by PS-MPs exposure. …”
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Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non‐Amplification of Activin A‐ACVR2B‐NOX4 Axis Pathway by Jimin Jeon, Hyemi Lee, Min‐Seung Jeon, Seok‐Jung Kim, Cham Choi, Ki Woo Kim, Dong Joo Yang, Sangho Lee, Yong‐Soo Bae, Won Il Choi, Juyeon Jung, Seong‐il Eyun, Siyoung Yang

“…Abstract Although activin receptor IIB (ACVR2B) is emerging as a novel pathogenic receptor, its ligand and assembled components (or assembly) are totally unknown in the context of osteoarthritis (OA) pathogenesis. …”
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Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma by Sayuri Kondo, Akinobu Ota, Takayuki Ono, Sivasundaram Karnan, Md Wahiduzzaman, Toshinori Hyodo, Md Lutfur Rahman, Kunihiro Ito, Akifumi Furuhashi, Tomio Hayashi, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa, Yoshiaki Kazaoka

“…In addition, Toll‐like receptor 2 (TLR2) knockdown readily inactivated KRAS‐responsive gene sets as well as increases caspase activities, suggesting that TLR2 signaling may mediate cell survival signaling in ameloblastoma cells. …”
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Pharmacokinetics of Atogepant in Healthy Lactating Female Participants: Results from a Phase 1 Lactation Study by Ramesh R. Boinpally, Jonathan H. Smith, Rosa L. De Abreu Ferreira, Joel M. Trugman

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Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles by Yoshitoku Watabe, Sakurako Kobayashi, Satoru Takahashi, Masaharu Yoshihara

“…Among the four Notch receptors, the frequency, rather than the peak level, of Notch1-mediated signaling has been suggested to promote the activation of neural progenitor cells. …”
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Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement by Oliver J. Gerken, Nicola Catone, Daniel F. Legler

“…Current state-of the art methods to study βarrestin recruitment, signaling and trafficking of ACKRs - and G-protein-coupled receptors in general - rely heavily on C-terminally tagged receptors with unknown consequences for receptor functions. …”
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Toll-like receptor 4-mediated inflammatory stimulation in Kupffer cell enhances arsenite-induced liver fibrosis by triggering hepatic stellate cell activation by Qian Song, Meitong Zhou, Rui He, Heng Diao, Lili Fan, Chenglong Tu, Xiong Chen, Dapeng Wang

“…However, the specific functions of these cells in As-induced LF remain to be elucidated. Toll-like receptor 4 (TLR4) triggering the release of inflammatory cytokines via activating downstream nuclear transcription factor-κB (NF-κB) signaling pathways. …”
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THE RATIO OF TrkA AND p75 RECEPTORS ON THE CELL NEUROEPITHELIAL TUMORS – A NEW TARGET EFFECT OF NERVE GROWTH FACTOR WITH CISPLATIN AND TEMOZOLOMIDE AND THE COMBINATIONS by A. N. Chernov

“…Relative expression of TrkA/p75 receptor, and its coefficient of correlation with index of cytotoxicity point to a mechanism (signaling pathway), on which there is cell death.…”
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Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data by William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger

“…Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affected by oncogenic mutations. To quantify signal flow through ErbB‐activated pathways we have constructed, trained and analyzed a mass action model of immediate‐early signaling involving ErbB1–4 receptors (EGFR, HER2/Neu2, ErbB3 and ErbB4), and the MAPK and PI3K/Akt cascades. …”
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Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma by Ilona Berestjuk, Margaux Lecacheur, Alexandrine Carminati, Serena Diazzi, Christopher Rovera, Virginie Prod’homme, Mickael Ohanna, Ana Popovic, Aude Mallavialle, Frédéric Larbret, Sabrina Pisano, Stéphane Audebert, Thierry Passeron, Cédric Gaggioli, Christophe A Girard, Marcel Deckert, Sophie Tartare‐Deckert

“…MMDR is mediated by drug‐induced linear clustering of phosphorylated DDR1 and DDR2, two tyrosine kinase collagen receptors. Depletion and pharmacological targeting of DDR1 and DDR2 overcome ECM‐mediated resistance to BRAF‐targeted therapy. …”
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Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis by Shatha AlOmar, Joanne L Mitchell, Eman AlZahrani

“…Abstract Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on the nature of stimulating ligand type. …”
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Staphylococcus aureus biofilm-associated component PNAG stimulates the secretion of the immunomodulatory chemokine CXCL10 via Dectin-1 signaling by Reza Gheitasi, Daniel Weiss, Mario M. Müller, Karolin Sommer, Daniela Röll, Alexander Mosig, Mathias. W. Pletz, Oliwia Makarewicz

“…This secretion was interrupted by blocking the Dectin-1 receptor or tyrosine kinase Syk. PNAG exposure resulted in increased Dectin-1 and CARD9 expression as well as increased NF-κB and CXCL10 expression, which may be related to the long-term memory processes of T cells. …”
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