Blood Т-cell subpopulations dynamics in asthma under suspended particulate load <i>in vitro</i> by E. V. Kondratyeva, T. I. Vitkina, S. I. Kolesnikov

“…The intensification of receptor expression is observed with an increase in the severity of the disease. …”
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P71 | THE EXTRACELLULAR VESICLE POPULATIONS UNDERWENT ALTERATIONS SUBSEQUENT TO THE PRETREATMENT OF ADIPOSE-DERIVED STEM CELLS WITH MELATONIN RECEPTOR AGONIST

“…In this context, the use of tasimelteon, a selective melatonin receptor agonist, offers a novel approach to modulating melatonin receptor mediated pathways in ADSCs. …”
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Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization by Colin Niaudet, Bongnam Jung, Andrew Kuo, Steven Swendeman, Edward Bull, Takahiro Seno, Reed Crocker, Zhongjie Fu, Lois E H Smith, Timothy Hla

“…Abstract Sphingosine‐1‐phosphate (S1P), the circulating HDL‐bound lipid mediator that acts via S1P receptors (S1PR), is required for normal vascular development. …”
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Multivalent fusion protein targeting VEGFR2 and DR5 receptors: assessing the antiangiogenic and antitumor effects via multimodal microangiography by Irina N. Druzhkova, Anna G. Orlova, Anastasiia S. Fedulova, Arina V. Avakiants, Alina A. Isakova, Ekaterina V. Kukovyakina, Yuan Zijian, Ekaterina A. Plotnikova, Galina V. Trunova, Andrey A. Pankratov, Anton A. Plekhanov, Alexey A. Kurnikov, Pavel V. Subochev, Alexey K. Shaytan, Marine E. Gasparian, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Daniel Razansky, Anne V. Yagolovich

“…It was previously revealed that concurrent targeting of angiogenic and death receptor signaling pathways by a multivalent DR5-specific cytokine TRAIL variant DR5-B genetically fused with the effector peptides, SRH-DR5-B-iRGD, enhances solid tumor suppression and prolongs survival. …”
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Early life stress and hormonal status influence orexin‐1 receptor expression in structures regulating cardiorespiratory responses to CO2 by Stéphanie Fournier, Julie Plamondon, Denis Richard, Richard Kinkead

“…Neonatal maternal separation (NMS; 3 h/day, postnatal days 3–12) augments the ventilatory response to CO2 by ∼35% relative to controls; this effect is most notable during pro‐oestrus but is not observed in males. Orexin‐1 receptor (OX1‐R) antagonism attenuates the CO2 response of NMS females. …”
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Baxdrostat and finerenone: new aldosterone synthase-aldosterone-mineralocorticoid receptor hormonal system inhibitors for the drug treatment of resistant arterial hypertension by O. B. Kuzmin, N. V. Buchneva, V. V. Belyanin, V. V. Zhezha, M. V. Stolbova

“…Its assumed that in this pathological process, in addition to aldosterone, is also involved the small Rho GTFase Rac1 — regulatory G-protein, which can enter into a direct ligand-independent interaction with mineralcorticoid receptors, performing the function of a powerful nonsteroidal activator of the transmission of their intracellular signals. …”
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Characterization and Analysis of the Role of Corazonin in Regulating Ovarian Development in the Mud Crab <i>Scylla paramamosain</i> by Shiying Yang, Liangjie Liu, Yiwei Tang, An Liu, Haihui Ye

“…In this study, the cDNAs encoding Crz and its putative receptor were isolated from the mud crab <i>Scylla paramamosain</i>. …”
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Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases by Yaqi Zhou, Yaowen Zhang, Wei Yu, Yufen Qin, Heng He, Fengxian Dai, Yibo Wang, Fengqin Zhu, Guangxi Zhou

“…Splenic tyrosine kinase (SYK) is a non–receptor tyrosine kinase that plays an important role in immune receptor signalling in immune and inflammatory responses. …”
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Mechanism of NOTCH2 in promoting intrahepatic bile duct development by Chen Dong, Sheng-xuan Liu, Biao Zou, Sai-nan Shu, Ben-ping Zhang

“…Abstract Background The Notch signaling pathway plays a crucial role in intrahepatic bile duct development. …”
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Research progress on the regulation of signal pathways related to lung injury in sepsis by the active components of traditional Chinese medicine by RONG Jilintai*，SU He，ZHANG Ruifen，ZHANG Hairong，JIA Tingting，GUO Sihan，ZHAO Jian，LI Xiao，ZHONG Xin

“…Recent studies have shown that active components of traditional Chinese medicine（TCM）can exert anti⁃inflammatory，anti⁃oxidative stress，anti⁃pyroptosis，and anti⁃ferroptosis effects by regulating signaling pathways such as Toll⁃like receptor 4（TLR4）/nuclear factor κB（NF⁃κB），mitogen⁃activated protein kinase（MAPK），NOD⁃like receptor family pyrin domain containing 3（NLRP3）/caspase⁃1，phosphatidylinositol 3⁃kinase/protein kinase B，and nuclear factor E2⁃related factor 2/heme oxygenase⁃1，thereby alleviating sepsis⁃induced lung injury. …”
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IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia by Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama

“…Mechanistically, IMPDH inhibition induced overactivation of Toll‐like receptor (TLR)‐TRAF6‐NF‐κB signaling and upregulation of an adhesion molecule VCAM1, which contribute to the antileukemia effect of IMPDH inhibitors. …”
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GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration by Dan Pascal Jean Albers, Sofya Novikova, Julio Vieyto-Nuñez, Yasser Almeida-Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, Christian Buske, Ulrich Stifel, Julia Zinngrebe, Pamela Fischer-Posovszky, Andy Chevigné, Frank Kirchhoff, Elsa Sanchez-Garcia, Jan Münch, Mirja Harms

“…Abstract Background GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. …”
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A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice by Jonathan D. Douros, Aaron Novikoff, Barent DuBois, Rebecca Rohlfs, Jacek Mokrosinski, Wouter F.J. Hogendorf, Robert Augustin, Myrte Merkestein, Lene Brandt Egaa Martini, Lars Linderoth, Elliot Gerrard, Janos Tibor Kodra, Jenny Norlin, Nikolaj Kulahin Roed, Anouk Oldenburger, Stephanie A. Mowery, Maria Waldhoer, Diego Perez-Tilve, Brian Finan, Steffen Reedtz-Runge, Timo D. Müller, Patrick J. Knerr

“…These data suggest that drug discovery screening strategies which take a holistic approach to target receptor signaling may provide more efficacious candidate molecules. …”
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Mouse enteric neurons control intestinal plasmacytoid dendritic cell function via serotonin-HTR7 signaling by Hailong Zhang, Yuko Hasegawa, Masataka Suzuki, Ting Zhang, Deborah R. Leitner, Ruaidhrí P. Jackson, Matthew K. Waldor

“…Mechanistically, this neuro-immune crosstalk is achieved through a serotonin-5-HT receptor 7 (HTR7) signaling axis that ultimately facilitates the pDC-mediated differentiation of IgA+ B cells from IgD+ precursors in the gut. …”
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P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES

“… Olfactory bulb (OB) exhibits high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. …”
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PLGA/BK microspheres targeting the bradykinin signaling pathway as a therapeutic strategy to delay intervertebral disc degeneration by Xiaoming Qiu, Yizhi Zhang, Ziyan Wei, Zhangbin Luo, Zhuanping Wang, Xuewen Kang

“…These effects were mediated through B2R (BK receptor 2) and the downstream PI3K pathway. Following this, we developed sustained-release BK microspheres with an optimized manufacturing process. …”
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Effects of different pre-conditioning exercise on leptin synthesis and its downstream signalling pathway in T2DM rats by Sen Lin, Yuzhi Hu, Shuqiao Ding, Yazhe Hu

“…Free fatty acids (FFA) and triglycerides (TG) contents in gastrocnemius muscle were measured using a biochemical assay.Results: In the HIIT group, glucose tolerance and leptin receptor expression increased, as did the expression and phosphorylation of AMPK protein. …”
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The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer by Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Jesse J. Reardon, Daniel Stover, Robert Wesolowski, Uma Borate, Ting-Yuan David Cheng, Patrick M. Schnell, Bhuvaneswari Ramaswamy, Gina M. Sizemore, Mark P. Rubinstein, Mathew A. Cherian

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The oxytocin-oxytocin receptors system — a new pathogenetic mechanism in the development of diabetic phenotype of heart failure with preserved ejection fraction in women by A. D. Starchenko, Yu. V. Liskova, A. A. Stadnikov

“…Myocardium biopsies of the right atrium auricle obtained during coronary bypass surgery were studied by microscopy, morphometry and immunohistochemistry (the expression of oxytocin receptors (OxR), a marker of proliferation ki-67).Results. …”
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The wheat receptor-like cytoplasmic kinase TaRLCK1B is required for host immune response to the necrotrophic pathogen Rhizoctonia cerealis by Tian-ci WU, Xiu-liang ZHU, Liang-jie LÜ, Xi-yong CHEN, Gang-biao XU, Zeng-yan ZHANG

“…Receptor-like cytoplasmic kinases (RLCKs) represent a large family of proteins in plants. …”
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