Metabolic Syndrome: the Influence of Adipokines on the L-Arginine-NO Synthase-Nitric Oxide Signaling Pathway by L. A. Kuznetsova

“…The main questions raised in the review are: how adipokine secretion changes, how the level of their receptors is regulated, and which signaling pathways are involved in the transmission of adipokine signals when coupled to the L-arginine-NO-synthase-NO signaling cascade. …”
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Effects of Angiotensin II Receptor 1 Inhibition by LCZ696 on the Acquisition and Relapse of Methamphetamine-Associated Contextual Memory by Xiaofang Li, Zhiting Zou, Xiangdong Yang, Jinnan Lü, Xiaoyu Zhang, Jiahui Zhou, Dan Zhu, Xinshuang Gong, Shujun Lin, Zhaoying Yu, Zizhen Si, Wenting Wei, Yakai Xie, Yu Liu

“…Angiotensin II type 1 receptor (AT1R) signaling has been implicated in drug reinforcement. …”
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Myopia development: multifactorial interplay, molecular mechanisms and possible strategies by Lihong Huang, Lihong Huang, Dazheng Zhang, Dazheng Zhang, Dazheng Zhang, Jing Zhou, Jing Zhou

“…Myopia is a global visual impairment, and its pathological mechanism involves the complex multifactorial interplay of neurotransmitters, hormones and intracellular signaling pathways. Dopamine inhibits axial growth by activating D2 receptor-CAMP pathway, while GABA energy signals maintain refractive stability by regulating retinal excitation-inhibition balance. …”
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Activation of chicken macrophages by isomalto/malto-polysaccharide (IMMP) is facilitated by toll-like receptor 4 (TLR4) by Adil Ijaz, Max Putman, Femke Broere, Victor P.M.G. Rutten, Christine A. Jansen, Edwin J.A. Veldhuizen

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Role of Urokinase-Type Plasminogen Activator Receptor in the Regulation of Angiogenic Properties of Sca1+ Vasculogenic Progenitor Cells by К. V. Dergilev, Z. I. Tsokolaeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuev, N. B. Kulbitsky, E. V. Parfenova

“…Thus, uPAR deficiency may lead to impaired vasculogenic properties of Sca-1+ rcVCPs, which is likely due to the loss of regulatory influence of specific ligands and the ability to interact with signaling mediators such as integrins. From the viewpoint of regenerative medicine, the modulation of uPAR activity can be considered as a potential targetpromising approach for targeted regulation of vasculogenic progenitor cells properties and postnatal angiogenesis.Highlight   The urokinase-type plasminogen activator receptor is involved in the regulation of the angiogenic properties of Sca1+ vasculogenic progenitor cells.…”
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Activation of cannabinoid CB1 receptors suppresses HCN channels function in dorsal root ganglion neurons of rats by Xiaolu Lei, Meiyun Chen, Xingfeng Liu, Yan Yan, Xupeng Li, Fei Gong, Deqian Yu, Xiaohong Liu

“…Studies have shown that HCN channel function is regulated by cAMP-PKA signaling, and the activation of cannabinoid receptor 1 (CB1R) can inhibit cAMP-PKA activity. …”
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Beyond the surface: P2Y receptor downstream pathways, TLR crosstalk and therapeutic implications for infection and autoimmunity by Lena Rueschpler, Sebastian Schloer

“…This review aims to provide a thorough overview of P2Y receptor downstream signalling and, for the first time, to illustrate the current state of knowledge on the incompletely understood crosstalk of P2Y receptors with Toll-like receptor (TLR) and inflammasome activation respectively. …”
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The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation by Chen Jin, Fei Zhang, Hailang Luo, Boyang Li, Xue Jiang, Christopher J. Pirozzi, Chaozhao Liang, Meng Zhang

“…Mechanistic studies revealed that CCL5 interacts with the CCR5 receptor, promoting M1 macrophage polarization and activating key inflammatory signaling pathways, including Stat1 and NF-κB, as indicated by increased phosphorylation of Stat1 and p65. …”
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Effect of a Farnesoid X-receptor Agonist on Postprandial Lipemia in Rats Fed a Supraphysiological Fat Dozes by Yu. N. Alekhin, O. S. Popova, V. S. Ponamarev, P. A. Parshin

“…One of the most progressive directions of the modern stage of development of biology is the deepening of knowledge about the mechanisms of regulation of metabolic processes, in particular about signal molecules that transmit information to the cell through ion channels and nuclear receptors associated with G-protein or with enzymatic activity. …”
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The Role of Apelin in the Functioning of the Reproductive System by A. O. Shpakov, K. V. Derkach

“…Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…IntroductionAlthough Interleukin (IL)-6-type cytokine signaling is critical for maintaining the body's homeostasis, aberrant signaling has been observed in numerous diseases including autoimmunity and cancer. …”
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Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone–GPCR–arrestin complex by Jonathan Pacheco, Karina A. Peña, Sofya Savransky, Alexandre Gidon, Gerald R. V. Hammond, John Janetzko, Jean-Pierre Vilardaga

“…Abstract The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling. …”
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Endocytosis of the IFNAR1 chain of Type 1 interferon receptor is regulated by diverse E2 ubiquitin conjugation enzymes

“…Ubiquitination of signaling receptors triggers their endocytosis to restrict the extent of cell signaling. …”
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Blockade of the interleukin-6 signaling pathway in rheumatoid arthritis: Effects on obesity, adipocytokines and glucose metabolism by L. V. Kondratyeva, Yu. S. Gorbunova, T. V. Popkova, E. L. Nasonov

“…The review provides information on the effects of IL-6 and blocking its signaling pathway on adipose tissue, glucose metabolism and adipocytokine levels in RA. …”
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RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease by Huiyuan Zhu, Fangzhou Lou, Qianqian Yin, Yuanyuan Gao, Yang Sun, Jing Bai, Zhenyao Xu, Zhaoyuan Liu, Wei Cai, Fang Ke, Lingyun Zhang, Hong Zhou, Hong Wang, Gang Wang, Xiang Chen, Hongxin Zhang, Zhugang Wang, Florent Ginhoux, Chuanjian Lu, Bing Su, Honglin Wang

“…Thus, our data suggest that the dysregulation in the antiviral immune responses of hosts through the innate pattern recognition receptors may trigger the skin inflammatory conditions in the pathophysiology of psoriasis.…”
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Bile Acids and Their Value for Central Nervous System by Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin

“…Bile acids act as pleiotropic signalling molecules affecting various tissues. The presence in CNS of various bile acid synthesis-related receptors and enzymes indicates their value in brain functioning and warrants research into their metabolism.…”
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UBE2D1 as a key biomarker in systemic juvenile idiopathic arthritis: a new perspective on diagnosis and disease activity assessment by Qiang Luo, Han Hao, Luo Xiwen, Xiang Qiu, Dawei Liu, Yun Liu, Fengning Li, Kening Lu, Xiya Luo, Chenxi Ma, Xiaodong Zhao, Yunfei An, Xuemei Tang

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RNA-seq dataset of the estrogen-dependent regulation of the transcriptome in mouse mammary gland organoidsGene Expression Omnibus by Aurélie Lacouture, Mame Sokhna Sylla, Lucas Germain, Étienne Audet-Walsh

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Cysteine leukotrienes as key mediators of immune-dependent diseases and the therapeutic potential of the leukotriene receptor antagonist (montelukast). Part 2 by N. G. Astafieva, I. E. Mikhailova, E. O. Gaisina, I. A. Perfilova, E. N. Udovichenko

“…The drug interferes with molecular signalling pathways produced by leukotrienes in various cells and tissues of the human body. …”
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Post-marketing safety signals of anifrolumab in systemic lupus erythematosus: a pharmacovigilance study based on FAERS by Yuzhe Cheng, Jingyi Ma, Jun Niu

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