Identification of covalent modifications regulating immune signaling complex composition and phenotype by Annika Frauenstein, Stefan Ebner, Fynn M Hansen, Ankit Sinha, Kshiti Phulphagar, Kirby Swatek, Daniel Hornburg, Matthias Mann, Felix Meissner

“…Validation of interdependencies between covalent, reversible, and functional protein complex regulations by knockout or site‐specific mutation revealed ISGylation and phosphorylation of TRAF2 as well as ARHGEF18 interaction in Toll‐like receptor 2 signaling. Moreover, we identify distinct mechanisms of action for small molecule inhibitors of p38 (MAPK14). …”
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ROLE OF GSK-3 IN Wnt/β-CATENIN SIGNALING PATHWAY IN OBESITY by A. S. Kulakova, I. A. Snimshchikova, M. O. Plotnikova

“…As a result of the insulin binding to the cell receptor via inositol-3-phosphate, protein kinase B (Akt1) is activated, which, in turn, phosphorylates and inhibits GSK-3β. …”
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The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology by Ki‐Kwang Oh, Sang‐Jun Yoon, Sang Youn Lee, Satya Priya Sharma, Sung‐Min Won, Jin‐Ju Jeong, Dong Joon Kim, Ki‐Tae Suk

“…A bubble plot and CGSTM networks suggested that the advanced glycation end‐receptor for advanced glycation end products signaling pathway in diabetic complications is inhibited by CKF and peroxisome proliferator–activated receptor (PPAR) signaling pathway is activated by GM. …”
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The role of tumor necrosis factor receptor superfamily in cancer: insights into oncogenesis, progression, and therapeutic strategies by Jiayi Xu

“…Abstract The TNF receptor superfamily (TNFRSF) with extracellular cysteine-rich domains, transmembrane segments, and intracellular signaling motifs, plays crucial roles in cell death, inflammation, growth, and development. …”
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cGAS-like receptors drive a systemic STING-dependent host response in Drosophila by Xianlong Ai, Huimin Deng, Xiaoyan Li, Ziming Wei, Yuqiang Chen, Ting Yin, Junhui Zhang, Jingxian Huang, Haoming Li, Xiaoqing Lin, Long Tan, Di Chen, Xiaohan Zhang, Xiuqing Zhang, Carine Meignin, Jean-Luc Imler, Hua Cai

“…Summary: cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently emerged as an important pathway controlling viral infections in invertebrates. …”
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α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex by Tanzila Mukhtar, Clara-Vita Siebert, Yuejun Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tan Ieng Huang, Guolong Zuo, Jayden Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, Manal A. Adam, Shaohui Wang, Qiuli Bi, Marco F. M. Hoekman, Jingjing Li, Arnold R. Kriegstein

“…This study elucidates the role of nicotinic acetylcholine receptors (nAChRs) in progenitor cells and radial glia (RG) during human cortical development. …”
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Effect of different types of immunosuppressive therapy on the parameters of TNF receptor expression in patients with rheumatoid arthritis by A. A. Alshevskaya, J. V. Zhukova, J. A. Lopatnikova, F. D. Kireev, N. S. Shkaruba, O. A. Chumasova, J. A. Shevchenko, N. A. Ilina, A. E. Sizikov, S. V. Sennikov

“…Background. The balance of TNF receptor expression on immune cells is a key factor determining cytokine-induced activation of proapoptotic or proliferative signaling pathways. …”
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Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway by Mingdi Zhang, Shizhong Cai, Bin Zuo, Wei Gong, Zhaohui Tang, Di Zhou, Mingzhe Weng, Yiyu Qin, Shouhua Wang, Jun Liu, Fei Ma, Zhiwei Quan

“…In gallbladder cancer cells treated with arctigenin, the expression level of epidermal growth factor receptor significantly decreased. The analysis of the activity of the kinases downstream of epidermal growth factor receptor revealed that the RAF-MEK-ERK signaling pathway was significantly inhibited. …”
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Preparation of Trop2-targeted chimeric antigen receptor T cells and study of their exhaustion status in vitro by LIU Xiuying, LI Xinzhan, ZHU Jingjing, ZHU Jingjing

“…Pathways related to immune response and T cell receptor signaling were down-regulated, while apoptosis-related pathways were activated. …”
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A compound produced by Helicoverpa armigera male genitalia activates a conserved pheromone receptor by Dongdong Sun, Yutong Zhang, Song Cao, Xiaoqing Wang, Qian Cao, Sai Zhang, Yang Liu

“…In many moth species, males find compatible mates through the reception of sex pheromones which are released by females. Pheromone receptors (PRs) are key elements in sensing these chemical signals. …”
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Exploring the Antifibrotic Mechanisms of Ghrelin: Modulating TGF-β Signalling in Organ Fibrosis by Mei Li, Chang Zheng, Huiyi Wang, Shan Wang

“…By binding to the growth hormone secretagogue receptor type 1a (GHSR-1a), ghrelin has shown potential in attenuating the fibrotic process, particularly through its interaction with the TGF-β signalling pathway. …”
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Silencing P2Y12 and P2Y13 receptors rehabilitates the ADP-induced P2Y1-mediated osteogenic commitment of post-menopausal mesenchymal stromal cells by Catarina Bessa-Andrês, Rui Pinto-Cardoso, Maria Adelina Costa, Fátima Ferreirinha, José Marinhas, Rolando Freitas, Rui Lemos, Diogo Catelas, Adélio Vilaça, António Oliveira, Paulo Correia-de-Sá, José Bernardo Noronha-Matos

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Identifying G-Protein Coupled Receptors Using Mixed-Feature Extraction Methods and Machine Learning Methods by Chunyan Ao, Lin Gao, Liang Yu

“…G-protein-coupled receptors (GPCRs) are important protein molecules in the field of cell signaling and are widely found in various organisms. …”
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Formyl Peptide Receptors 1 and 2: Essential for Immunomodulation of Crotoxin in Human Macrophages, Unrelated to Cellular Entry by Luciana de Araújo Pimenta, Ellen Emi Kato, Ana Claudia Martins Sobral, Evandro Luiz Duarte, Maria Teresa Moura Lamy, Kerly Fernanda Mesquita Pasqualoto, Sandra Coccuzzo Sampaio

“…These effects are completely blocked by Boc-2, a selective formyl peptide receptors (FPRs) antagonist. Despite the correlation between FPRs and CTX-mediated effects, their involvement in mediating CTX entry into macrophages remains unclear. …”
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Human-relevant doses of bisphenol a induce insulin resistance by downregulating Irs1 expression in skeletal muscle through estrogen receptor-α by Zhang-Hong Ke, Yue-Hong Li, Ai-Li Yu, Xue-Fen Cai, Yan-Ying Lin, Shun-He Lin, Chu-Chu Zheng, Chen-Xi Yu, Bei-Hong Zheng, Yan Sun

“…Furthermore, BPA within and around human-relevant concentrations reduced Irs1 expression and impaired insulin signaling in skeletal muscle in a dose-dependent manner, both in vivo and in C2C12 myotubes. …”
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Identification of tumor necrosis factor receptor 1 and its association with LPS-induced apoptosis in Onchidium reevesii by Kai Wang, Heding Shen

“…Like other members of the TNF receptor superfamily, OrTNFR1 contains a signal peptide, TNF homologous domain, and death-related domain. qPCR results showed that OrTNFR1 was highly expressed in the hepatopancreas, blood, and intestines of sea slug. …”
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Time course of fluorescent-labelled oligonucleotide accumulation in cells with the use of folate receptor-targeted cationic liposomes by E. V. Shmendel, O. V. Markov, M. A. Zenkova, M. A. Maslov

“…In the first few minutes of cell transfection, fluorescence and confocal microscopy data on the distribution of liposome–FITC-ODN complexes showed that cationic liposome fluorescence signals colocalised with FITC-ODN signals. Later, FITC-ODN accumulation in the cytoplasm was observed.CONCLUSIONS. …”
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Breast cancer is detectable from peripheral blood using machine learning over T cell receptor repertoires by Miriam Zuckerbrot-Schuldenfrei, Ari Raphael, Alona Zilberberg, Sol Efroni

“…Abstract The immune system’s defense abilities rely on the diversity of T and B lymphocytes. T Cell Receptors (TCRs) are generated through V(D)J recombination, where distinct genetic elements combine and undergo modifications, creating extensive variability. …”
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Type-specific molecular signaling architectures and synaptic plasticity of Drosophila olfactory sensory neurons by Namrata Acharya, Eric Wiesel, Mareike Selcho, Nadine Ehmann, Marius Lamberty, Bill S. Hansson, Dieter Wicher, Robert J. Kittel

“…We focused on a highly sensitive OSN type that expresses the receptor Or56a and is exclusively activated by geosmin, an odorant signalling ecologically harmful microorganisms. …”
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Predicting subjective sleepiness during auditory cognitive testing using voice signaling analysis by Tue T. Te, Mary Regina Boland, Sara Ghadimi, Joseph M. Dzierzewski, Cathy Alessi, Jennifer L. Martin, Sarah Kremen, Alex A. T. Bui, Arash Naeim, Constance H. Fung

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