Galectin-3: Integrator of Signaling via Hexosamine Flux by Mana Mohan Mukherjee, Devin Biesbrock, John Allan Hanover

“…Gal-3 binds to cell surface glycans to form lattices that modulate surface receptor signaling and internalization. However, the tissue-specific regulation of Gal-3 surface expression remains poorly understood. …”
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PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis by Xuehua Xu, Woo Sung Kim, Arthur Lee, Tian Jin

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Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis by Runze Wang, Shuai Xu, Qionghua Cui, Xin Chen, Xuelian Wang, Jinghao Liu, Jie Liu, Yuxuan Xin, Hao Shen, Fengxiang Lv, Lan Zhu, Xinli Hu, Rui-Ping Xiao

“…Specifically, scRNA-seq revealed a distinct epithelial subcluster with enriched PRL receptor (PRLR) expression. PRL signaling is overactivated in this epithelial subcluster, promoting cellular survival and proliferation, which contributes to lesion formation and expansion in adenomyosis. …”
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Mechanosensitive molecular interactions in atherogenic regions of the arteries: development of atherosclerosis by E. L. Mishchenko, A. M. Mishchenko, V. A. Ivanisenko

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Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth by Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

“…Abstract Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. …”
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CPNE5 overexpression inhibits cardiomyocytes apoptosis by promoting the degradation of FAS receptor by Tingting Zhao, Yangjinming Bai, Yudong Fei, Zhixing Wei, Pengcheng Yao, Qianji Che, Yichao Zhang, Ji Yan, Kaiyan Chen, Zhengyang Wu, Junhao Qiu, Yuepeng Wang, Wei Li, Qian Wang, Yigang Li

“…This process involves CPNE5’s interaction with the autophagy marker LC3 and CALCOCO1, a key receptor in the ER-lysosome-associated degradation (ERLAD) pathway. …”
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Retrograde Ret signaling controls sensory pioneer axon outgrowth by Adam Tuttle, Catherine M Drerup, Molly Marra, Hillary McGraw, Alex V Nechiporuk

“…The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. …”
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Chemistry-informed recommender system to predict optimal molecular receptors in SERS nanosensors by Emily Xi Tan, Yong Xiang Leong, Shan Huei Lim, Mike Wei Kuang Chng, In Yee Phang, Xing Yi Ling

“…Abstract Multiple molecular receptors amplify signal variance from various receptor–analyte interactions, enhancing the specificity of surface-enhanced Raman scattering (SERS) detection. …”
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Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation by Vladislav V Kiselyov, Soetkin Versteyhe, Lisbeth Gauguin, Pierre De Meyts

“…Abstract The insulin and insulin‐like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity. …”
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The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions by Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, Evgeni Ponimaskin

“…Conclusions Interaction with the hyaluronan receptor CD44 modulates both the constitutive activity of 5-HT7R as well as its agonist-mediated signaling. …”
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H5N1 avian influenza virus PB2 antagonizes duck IFN-β signaling pathway by targeting mitochondrial antiviral signaling protein by Zuxian Chen, Bingbing Zhao, Yingying Wang, Yuqing Du, Siyu Feng, Junsheng Zhang, Luxiang Zhao, Weiqiang Li, Yangbao Ding, Peirong Jiao

“…Collectively, our findings contribute to understanding the molecular mechanism by which AIV proteins regulate the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway to evade host antiviral immune responses in ducks.…”
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GROWTH FACTOR AND ADIPOKINE RECEPTORS IN PATHOGENESIS AND PROGNOSIS OF ENDOMETRIAL CANCER IN PATIENTS WITH METABOLIC SYNDROME by N. V. Yunusova, I. V. Kondakova, L. А. Kolomiets, А. L. Chernyshova, Е. V. Shanshashvili

“…The role of growth factor receptors (insulin-like growth factor and transforming growth factor-beta) and adipokine receptors (leptin and adiponectin) in pathogenesis of endometrial cancer under conditions of metabolic syndrome is discussed. …”
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Molecular mechanisms of novel selective glucocorticoid receptor agonist action in breast cancer cells by E. M. Zhidkova, V. P. Maksimova, D. D. Grigoreva, V. Z. Shirinian, M. G. Yakubovskaya, E. A. Lesovaya

“…Additionally, the ability of the new SEGRA to induce transactivation-associated translocation of the receptor to the nucleus was evaluated by Western blotting.Results. …”
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Bidirectional crosstalk between microglia and serotonin signaling in neuroinflammation and CNS disorders by Yangchen Zheng, Limin Xu, Limin Xu

“…Activation of microglia toward a pro-inflammatory phenotype can disrupt serotonergic neurotransmission by altering the expression and function of the serotonin transporter (SERT) and modulating downstream 5-HT receptor signaling pathways. Conversely, serotonergic neurotransmission—mediated through receptor subtypes such as 5-HT1A, 5-HT2A/2B, and 5-HT7—can regulate microglial phenotypic polarization and cytokine production, thereby influencing the inflammatory milieu and CNS homeostasis. …”
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All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants by Florian Freudenberg, Christine Reif-Leonhard, Gerard R. Dawson, Ruth M. McKernan, Andreas Reif

“…This involves increased AMPA receptor activation, triggering BDNF release and mTOR signalling, promoting synaptic strengthening through enhanced AMPA receptor trafficking and dendritic spine formation. …”
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Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3Research in context by Alexandra Oliveira Carvas, Andrea Leuthardt, Patricia Kulka, Greta Lommi, Shad Hassan, Bernd Coester, Sofia Lundh, Tune Pers, Anna Secher, Kirsten Raun, Thomas A. Lutz, Christelle Le Foll

“…Amylin binds to a heterodimeric receptor composed of CTR and the receptor activity modifying proteins 1, 2 or 3 (RAMP1-3). …”
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Finding spatially variable ligand-receptor interactions with functional support from downstream genes by Shiying Li, Ruohan Wang, Sitong Liu, Shuai Cheng Li

“…Abstract Spatial transcriptomics has emerged as a groundbreaking tool for the study of intercellular ligand-receptor interactions (LRIs) that exhibit spatial variability. …”
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Innate immune recognition of Mycobacterium tuberculosis: receptor engagement and inflammatory outcomes at the site of infection by N.E. Mvubu

“…The interaction between host Pathogen Recognition Receptors (PRRs) and M. tuberculosis PAMPs results in the activation of several signalling pathways that initiate an inflammatory response through the production of cytokines and chemokines at the site of infection. …”
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Planar-electroporated cell biosensor for investigating potential therapeutic effects of ectopic bitter receptors by Changming Chen, Jianguo Wu, Chunlian Qin, Yong Qiu, Nan Jiang, Qifei Wang, Mengxue Liu, Deming Jiang, Qunchen Yuan, Xinwei Wei, Liujing Zhuang, Ping Wang

“…In comparison to conventional biosensors that utilize extracellular action potentials (EAPs) for data analysis, the IAPs recorded by the PECB provided high-resolution insights into action potentials, characterized by increased amplitudes and an enhanced signal-to-noise ratio (SNR). The PECB successfully monitored IAPs induced by the activation of bitter receptors by using three bitter substances: diphenidol, denatonium benzoate, and arbutin in cardiomyocytes. …”
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INFLUENCE OF ANTIBODIES AGAINST CTLA-4 AND PD-1 UPON QUANTITIES OF THEIR TARGET RECEPTORS by I. O. Chikileva, I. Zh. Shubina, I. V. Samoylenko, A. V. Karaulov, M. V. Kiselevsky

“…Inhibitory receptors CTLA-4 and PD-1 (immune checkpoints) play a key role in regulation of immune reactions. …”
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