Ca²⁺ Signaling in Cardiac Fibroblasts: An Emerging Signaling Pathway Driving Fibrotic Remodeling in Cardiac Disorders by Francesco Moccia, Antonio Totaro, Germano Guerra, Gianluca Testa

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A free fatty acid receptor 4 signaling cascade leading to activation of ChemR23 protects the heart from ischemic injury by Sara Puccini, Chastity Healy, Brian Harsch, Ahmed Ahmed, Michael Zhang, Gregory Shearer, Timothy O'Connell

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High mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling promotes progression of gastric cancer by Yanqiu Yue, Tao Zhou, Yanjing Gao, Zongli Zhang, Li Li, Lin Liu, Wenna Shi, Lihui Su, Baoquan Cheng

“…High mobility group box 1 and toll-like receptor 4/myeloid differentiation factor 88 signaling pathway have been indicated to have oncogenic effects in many cancers. …”
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Nutritional Omega-3 Deficiency Alters Glucocorticoid Receptor-Signaling Pathway and Neuronal Morphology in Regionally Distinct Brain Structures Associated with Emotional Deficits by Thomas Larrieu, Muna L. Hilal, Véronique De Smedt-Peyrusse, Nathalie Sans, Sophie Layé

“…Rather, glucocorticoid receptor (GR) signaling pathway was inactivated in the PFC but not in the hippocampus of n-3 deficient mice. …”
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Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. by Julie Mirpuri, Ilya Sotnikov, Loren Myers, Timothy L Denning, Felix Yarovinsky, Charles A Parkos, Patricia W Denning, Nancy A Louis

“…LGG did however induce mRNA expression of the IL-10R2 subunit of the IL-10 receptor. IL-10 receptor activation has been associated with signal transducer and activator of transcription (STAT) 3-dependent induction of members of the suppressors of cytokine signaling (SOCS) family. …”
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Involvement of Toll -like receptor 9 signaling in neutrophil extracellular traps-induced epithelial-to-mesenchymal transition in myositis-associated interstitial lung disease by Feng Yingyue, Zhuo Cui, Su Qiyan, Cui Xi, Guo Jin, Zhu Jiarui, Zhang Sigong

“…Objective The study aims to elucidate whether neutrophil extracellular traps (NETs) promote epithelial-mesenchymal transition (EMT) in alveolar epithelial cells via Toll-like receptor 9 (TLR9) signaling,thereby contributing to the development of idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD). …”
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Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice by Johannes Reiner, Nooshin Mohebali, Jens Kurth, Maria Witte, Cornelia Prehn, Tobias Lindner, Peggy Berlin, Nagi Elleisy, Robert H. Förster, Alexander Cecil, Robert Jaster, Jerzy Adamski, Sarah M. Schwarzenböck, Brigitte Vollmar, Bernd J. Krause, Georg Lamprecht

“…Conclusions: The data suggest that GLP-2-pharmacotherapy in mice significantly slows bile acid circulation primarily via hepatic Farnesoid X receptor-signaling.…”
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Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling. by Michiel van Gent, Steven G E Braem, Annemieke de Jong, Nezira Delagic, Janneke G C Peeters, Ingrid G J Boer, Paul N Moynagh, Elisabeth Kremmer, Emmanuel J Wiertz, Huib Ovaa, Bryan D Griffin, Maaike E Ressing

“…Viral infection triggers an early host response through activation of pattern recognition receptors, including Toll-like receptors (TLR). TLR signaling cascades induce production of type I interferons and proinflammatory cytokines involved in establishing an anti-viral state as well as in orchestrating ensuing adaptive immunity. …”
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Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. by Deepika Dogra, Van Anh Phan, Sinan Zhang, Cezar Gavrilovici, Nadia DiMarzo, Ankita Narang, Kingsley Ibhazehiebo, Deborah M Kurrasch

“…Slc13a5 protein co-localizes with excitatory NMDA receptors in wild-type zebrafish and NMDA receptor expression is upregulated in the brain of slc13a5 mutant larvae. …”
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ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats by Mohammed Esawie, Marwa Matboli, Mariam Sameh Bushra, Amany H. Hasanin, Eman Kamal Habib, Reham Hussein Mohamed, Hebatalla Said Ali

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Reduction of Activin Receptor-Like Kinase 4 Expression Ameliorates Myocardial Ischemia/Reperfusion Injury through Inhibiting TGFβ Signaling Pathway by Mantian Chen, Yinggang Sun, Qian Wang, Yigang Li

“…The activation of activin receptor-like kinase 4 (ALK4) signaling plays a pivotal role in the pressure-overloaded heart, and haplodeficiency of ALK4 can alleviate cardiac fibrosis secondary to myocardial infarction and preserve cardiac function through partially inactivating the Smad3/4 pathway. …”
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Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer by Michael Hudecek, Achim Wöckel, Jörg Wischhusen, Tanja Stüber, Razieh Monjezi, Lars Wallstabe, Johanna Kühnemundt, Sarah Louise Nietzer, Gudrun Dandekar, Hermann Einsele

“…Analyses were performed in co-culture assays of ROR1-CAR T-cells and MDA-MB-231 cells with addition of exogenous TGF-β.Results The data show that exposure to TGF-β engages TGF-β-receptor signaling in CD8+ and CD4+ ROR1-CAR T-cells as evidenced by phosphorylation of small mothers against decapentaplegic homolog 2. …”
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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. by Ricardo C Ferreira, Daniel F Freitag, Antony J Cutler, Joanna M M Howson, Daniel B Rainbow, Deborah J Smyth, Stephen Kaptoge, Pamela Clarke, Charlotte Boreham, Richard M Coulson, Marcin L Pekalski, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Adam S Butterworth, Anders Malarstig, John Danesh, John A Todd

“…Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, the variant's effect on IL-6 signaling is not known. …”
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TRAF2 and RIPK1 redundantly mediate classical NFκB signaling by TNFR1 and CD95-type death receptors by Jennifer Wagner, David Vredevoogd, Xin Yu, Dong Lu, Daniel S. Peeper, Heike M. Hermanns, Jin Wang, Harald Wajant, Daniela Siegmund

“…These findings argue for a non-obligatory role of TRAF2 in death receptor-induced classical NFκB signaling. Similar as in TRAF2-deficient cells, TNF- and CD95L-induced NFκB signaling was found to be only poorly affected in RIPK1KO cells and in cells treated with the RIPK1-specific PROTAC LD4172. …”
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Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID. by Wasim Talib Mahdi Al Masoodi, Sami Waheed Radhi, Habiba Khdair Abdalsada, Mengqi Niu, Hussein Kadhem Al-Hakeim, Michael Maes

“…<h4>Methods</h4>In a cohort of 90 individuals, categorized into those with and without LC, we evaluated, 3-6 months following acute SARS-CoV-2 infection, the correlations between the Hamilton Depression (HAMD), Hamilton Anxiety (HAMA), and Fibro-Fatigue (FF) Rating Scale scores, and serum C-reactive protein (CRP), prostaglandin E2 (PGE2), galanin-galanin receptor 1 (GAL-GALR1) signaling, insulin resistance, insulin-like growth factor (IGF-1), plasminogen activator inhibitor-1 (PAI1), S100B and neuron-specific enolase (NSE).…”
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Vascular endothelial growth factor-receptor 1 inhibition aggravates diabetic nephropathy through eNOS signaling pathway in db/db mice. by Keun Suk Yang, Ji Hee Lim, Tae Woo Kim, Min Young Kim, Yaeni Kim, Sungjin Chung, Seok Joon Shin, Beom Soon Choi, Hyung Wook Kim, Yong-Soo Kim, Yoon Sik Chang, Hye Won Kim, Cheol Whee Park

“…The manipulation of vascular endothelial growth factor (VEGF)-receptors (VEGFRs) in diabetic nephropathy is as controversial as issue as ever. …”
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Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion by Jennifer E. Tuokkola, Lyndsay E. Reese, Ying Wang, Christine H. O’Connor, Jillian G. VanTreeck, Annisa H. Rumahorbo, Kathryn L. Schwertfeger

“…Abstract Signaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells. …”
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Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia by Tong Sun, Haiyang Yu, Dingning Zhang, Dan Zhang, Danni Li, Jianhua Fu

“…Background: Many studies have reported the important role of glucagon-like peptide-1 receptor (GLP-1R) in regulating glucose homeostasis. …”
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IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis by Jennifer Claire Hoving, Roanne Keeton, Maxine A. Höft, Mumin Ozturk, Patricia Otieno-Odhiambo, Frank Brombacher

“…In contrast, mice deficient in the shared receptor of IL-4 and IL-13, IL-4 receptor-alpha (IL-4Rα), on all cells develop an exacerbated disease phenotype. …”
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Mutation within the transmembrane domain of oxidized low-density lipoprotein receptor 1 influences oxidized low-density lipoprotein-induced signal transduction by Zhen Ma, Ran Xu, Jing Lu, Xiong Huang, Hao Jia, Zhiwen Ding, Jie Yuan, Yunzeng Zou

“…Conclusion These findings emphasize the vital role of the TM in the interactions between OLR1 and ox-LDL and point to an exciting possibility that signal transduction induced by ox-LDL through its receptor OLR1 may involve complex interactions with cytoskeletal proteins.…”
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