TRANSCRIPTION FACTOR BRN-3α AND PROSTATE CANCER, RELATION WITH HORMONE RECEPTORS AND AKT/M-TOR SIGNALING PATHWAY ACTIVATION by L. V. Spirina, A. K. Gorbunov, I. V. Kondakova, E. M. Slonimskaya, E. A. Usynin

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Transcriptional, growth factors, components of the AKT/mTOR signaling pathway, receptors and ligands of programmed cell death expression in melanoma by K. V. Nikulnikov, V. A. Bogdanova, L. V. Spirina, S. Yu. Chizhevskaya, I. V. Kondakova, E. L. Choynzonov, V. I. Chernov

“…Transcriptional and growth factors, components of the AKT/mTOR signaling pathway, receptors and ligands of programmed cell death are involved in significant processes of oncogenesis.Aim. …”
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Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species by Mohamad K. Hammoud, Celina Meena, Raimund Dietze, Nathalie Hoffmann, Witold Szymanski, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller

“…Results AA (i) disrupts interleukin-2/15-mediated expression of pro-inflammatory genes by inhibiting STAT1-dependent signaling, (ii) hampers signaling by cytotoxicity receptors through disruption of their surface expression, (iii) diminishes phosphorylation of NKG2D-induced protein kinases, including ERK1/2, LYN, MSK1/2 and STAT1, and (iv) alters reactive oxygen species production by transcriptionally upregulating detoxification. …”
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Integrated bioinformatics and network pharmacology analysis to reveal the therapeutic targets and potential molecular mechanism of Traditional Chinese Medicine Lianhua-Qingwen caps... by Lijuan Fang, Caiyan Li, Haimai Ding, Jinjin Tao

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Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance by Xue Yang, Yang Gu

“…Targeted delivery of estrogen receptor antagonists enables modulation of estrogen signaling pathways, addressing key resistance pathways such as DNA damage repair pathways, cancer stem cells, autophagy, and metabolic reprogramming. …”
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Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats by Emma Cogo, Edwin Fouché, Charline Buisson, Adenike Omotoyinbo, Fabrice Pierre, Françoise Guéraud, Pascale Plaisancié

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Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models by Saige K. Power, Sridevi Venkatesan, Sarah Qu, JoAnne McLaurin, Evelyn K. Lambe

“…We identified a significant and selective increase in post-synaptic nicotinic receptor signalling on prefrontal cortical neurons. …”
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Leptin receptor signaling mediates the distinct tendon–bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears by Dongxu Zhu, Xinrui Zhu, Yingze Zhang, Xiaohong Huang

“…Osteoporosis poses a significant risk for rotator cuff tears (RCTs) and re-tears after arthroscopic rotator cuff repair (ARCR). Activating Leptin receptor (Lepr) mediated Stat3 signaling transduction facilitates the transcription of Runx2 and Sox9, respectively, and promotes osteogenesis and chondrogenesis. …”
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Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to long COVID. by Wasim Talib Mahdi Al Masoodi, Sami Waheed Radhi, Habiba Khdair Abdalsada, Mengqi Niu, Hussein Kadhem Al-Hakeim, Michael Maes

“…<h4>Methods</h4>In a cohort of 90 individuals, categorized into those with and without LC, we evaluated, 3-6 months following acute SARS-CoV-2 infection, the correlations between the Hamilton Depression (HAMD), Hamilton Anxiety (HAMA), and Fibro-Fatigue (FF) Rating Scale scores, and serum C-reactive protein (CRP), prostaglandin E2 (PGE2), galanin-galanin receptor 1 (GAL-GALR1) signaling, insulin resistance, insulin-like growth factor (IGF-1), plasminogen activator inhibitor-1 (PAI1), S100B and neuron-specific enolase (NSE).…”
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Interference of estrogen signaling by endocrine disruptors in male and female cells: Potential implications of BPS and PFOS in human development by Giulia Gaggi, Andrea Di Credico, Sandra Bibbò, Barbara Corneo, Alberto Ferlin, Angela Di Baldassarre, Barbara Ghinassi

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Developmental effects of sulfated thyroid hormones in sea urchin skeletogenesis suggest activation of non-canonical thyroid hormone signaling pathway by Katherine Tieman, Andreas Heyland

“…RGD peptides, potential ligands for the sea urchin integrin αPβG, can inhibit T4-induced effects, suggesting a role for integrin-mediated MAPK signaling (ERK1/2). This study examines whether STHs have developmental roles in sea urchin embryonic skeletogenesis and whether they bind to the αPβG integrin dimer in silico, a TH receptor candidate in sea urchins. …”
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Non-canonical Gq activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations by Paulina Dragan, Valerie Gratio, Thierry Voisin, Alain Couvineau, Dorota Latek

Subjects: “…Orexin receptors…”
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Identification and characterization of mRNAs of receptor-like kinases MhyGSO1 and MhyGSO2 in flowering parasitic plant Monotropa hypopitys by A. V. Shchennikova, E. Z. Kochieva, A. V. Beletsky, M. A. Filyushin, O. A. Shulga, N. V. Ravin, K. G. Skryabin

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Copper oxide nanoparticles exacerbate chronic obstructive pulmonary disease by activating the TXNIP-NLRP3 signaling pathway by Woong-Il Kim, So-Won Pak, Se-Jin Lee, Sin-Hyang Park, Je-Oh Lim, Dong-il Kim, In-Sik Shin, Sung-Hwan Kim, Jong-Choon Kim

“…Conclusions We elucidated the exacerbating effect of CuONPs exposure on the respiratory tract with underlying COPD, as well as related signaling transduction via TXNIP regulation. CuONPs exposure significantly increased inflammatory responses in the respiratory tract, which was correlated with elevated TXNIP-NLRP3 signaling.…”
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The gut commensal Faecalibacterium hominis attenuates indole—AhR signaling and restores ASD—like behaviors with BTBR mice by You Yu, Yujing Wang, Yujing Wang, Jie Zhang, Shucheng Li, Yulin Wang, Xin You, Xue Chen, Mengxuan Du, Lisheng Xie, Shuang-Jiang Liu, Shuang-Jiang Liu

“…Furthermore, the decreased levels of IPA in brain contributed to the attenuated aryl hydrocarbon receptor (AhR) signaling characterized by increased expression of downstream elements, including glutamate transporters and GABA receptors. …”
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Modulation of neuronal α1-adrenergic receptor reduces tauopathy and neuroinflammation by inhibiting the STING/NF-κB/NLRP3 signaling pathway in Alzheimer’s disease mice by Bo Li, Li Wang, Yan Xiao, Zhi Tang, Yang Wang, Ting Sun, Xiaolan Qi

“…Abstract Background Neuroinflammation is closely associated with the pathological progression of Alzheimer's disease (AD). The α1-adrenergic receptor (ADRA1), a G protein-coupled receptor, has been identified as a critical therapeutic target in inflammatory disorders. …”
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The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation by Antje Isernhagen, Dörthe Malzahn, Elena Viktorova, Leslie Elsner, Sebastian Monecke, Frederike von Bonin, Markus Kilisch, Janne Marieke Wermuth, Neele Walther, Yesilda Balavarca, Christiane Stahl‐Hennig, Michael Engelke, Lutz Walter, Heike Bickeböller, Dieter Kube, Gerald Wulf, Ralf Dressel

“…Abstract The MHC class I chain‐related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK)‐cell receptor NKG2D. A single nucleotide polymorphism causes a valine to methionine exchange at position 129. …”
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Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth by Mohammed Ali, Mariia Adler, Antonin Libra, Ivan Vokral, Rona Karahoda, Eva Cifkova, Miroslav Lisa, Jakub Tomek, Magdalena Novotna, Frantisek Staud, Lukas Cerveny

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Decidual natural killer cells and trophoblast cells: cellular, humoral and molecular mechanisms of interaction by P. V. Grebenkina, V. A. Mikhailova, A. A. Oshkolova, S. O. Vershinina, M. S. Dukhinova, D. O. Bazhenov, S. A. Selkov, D. I. Sokolov

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The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model by A. Fidilio, M. Grasso, S. Spoto, S. Varrasi, M. Al-Khrasani, F. Caraci, C. Parenti, L. Pasquinucci

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