Regulation of EMT-MET and chemoresistance by the Lc3Cer-synthase B3GNT5 by Laura E. Clark, Katherine Hylton Rorie, Amanda J. G. Dickinson, Santiago Lima

“…Functional depletion reveals its key role in regulating glycosphingolipid metabolism, signaling, and malignant phenotypes. These findings support B3GNT5 as an important target for therapeutic intervention in cancer.…”
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Xenobiotic-induced liver injury: Molecular mechanisms and disease progression by Lu Wang, Zigong Shao, Xiaobei Wang, Wenqiu Lu, Hong Sun

“…We further explore how these chemicals disrupt critical signaling pathways involving nuclear receptors such as peroxisome proliferator-activated receptor alpha (PPARα), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR), ultimately interfering with lipid homeostasis and bile acid metabolism. …”
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Adipositas & körperliche Aktivität by Furrer R, Handschin C

“…In recent years, the peroxisome proliferator-activated receptor coactivator 1(PGC-1) has emerged as a regulatory nexus of muscle adaptation to endurance exercise. …”
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Linking Short-Chain Fatty Acids to Systemic Homeostasis: Mechanisms, Therapeutic Potential, and Future Directions by Yueru Zhao, Jing Chen, Yunlong Qin, Jinguo Yuan, Zixian Yu, Rui Ma, Fude Liu, Jin Zhao

“…This review synthesizes current knowledge on SCFA biosynthesis, absorption dynamics, and their multifaceted regulatory mechanisms, spanning epigenetic modulation, G protein–coupled receptor (GPR) signaling, and immune cell crosstalk. …”
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Fusion protein of retinol‐binding protein and albumin domain III reduces liver fibrosis by Hongsik Lee, Hyeyeun Jeong, Sangeun Park, Wonbaek Yoo, Soyoung Choi, Kyungmin Choi, Min‐Goo Lee, Mihwa Lee, DaeRyong Cha, Young‐Sik Kim, Jeeyoung Han, Wonkon Kim, Sun‐Hwa Park, Junseo Oh

“…R‐III treatment and albumin expression downregulated retinoic acid (RA) signaling which was involved in HSC activation. RA receptor agonist and retinaldehyde dehydrogenase overexpression abolished the anti‐fibrotic effect of R‐III and albumin, respectively. …”
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Identified candidate genes for pig mental health: Insights from intensive farming systems by Xingyu Wei, Lingyao Xu, Jinyun Jiang, Jian Miao, Fen Wu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang

“…In-depth functional analyses revealed that candidate PMH genes were significantly overrepresented in signaling-related pathways (e.g., the dopaminergic synapse, neuroactive ligand‒receptor interaction, and calcium signaling pathways) or Gene Ontology terms (e.g., dendritic tree and synapse). …”
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Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana by Minoru Ueda, Rina Saito, Yuho Nishizato, Tsumugi Kitajima, Nobuki Kato

“…It was proposed as an endogenous chemical signal independent of the JA-Ile receptor COI1-JAZ in Arabidopsis thaliana. …”
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Soluble immune checkpoint molecules: mechanism of formation, function, role in malignant neoplasms by T. V. Glazanova, I. E. Pavlova, E. V. Kuzmich, L. N. Bubnova

“…Initially, ICs have been considered solely as cell membrane-bound receptor and ligand systems, triggering or blocking immune cell function. …”
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Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C by Kaiqin Lu, Yuan Hong, Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang, Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo, Yan Liu

“…In this study, we generated induced pluripotent stem cells (iPSC) from five sMDD patients and differentiated the iPSCs to GABAergic interneurons (GINs) and ventral forebrain organoids. sMDD GINs exhibited altered neuronal morphology and increased neural firing, as well as weakened calcium signaling propagation, compared with controls. Transcriptomic sequencing revealed that a decreased expression of serotoninergic receptor 2C (5‐HT2C) may cause the defected neuronal activity in sMDD. …”
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Candida albicans and Staphylococcus aureus reciprocally promote their virulence factor secretion and pro-inflammatory effects by Raymond Pasman, Bastiaan P. Krom, Martijs J. Jonker, Wim C. de Leeuw, Gertjan Kramer, Stanley Brul, Sebastian A. J. Zaat, Jianbo Zhang, Jianbo Zhang

“…Moreover, the secretome of C. albicans–S. aureus co-culture increased pro-inflammatory pathways including promoting TNF-, NFKB-, and Toll-like receptor signaling pathways, as well as cytokine–cytokine receptor interactions in macrophages. …”
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Severity-specific immune landscape of COVID-19 revealed by single-cell sequencing by Hongying Zhao, Meiting Fei, Wentong Yu, Zhichao Geng, Jing Bai, Li Wang

“…Subsequently, scV(D)J-seq analysis showed a decreasing trend in the number of clonotypes, repertoire diversity and clonotypes overlap of monoclonal B cell receptor (BCR) and T cell receptor (TCR) as the SARS-CoV-2 progresses. …”
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Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypes by Huiyan Deng, Qingyi Liu, Ziqiang Tian, Guangjie Liu, Shize Wang, Di Liang, Yun Wang, Yaqing Han, Shaonan Xie

“…We noted significant spatial correlations between various immune cells and found that different histological subtypes displayed unique cell composition profiles, particularly in the micropapillary subtype, which exhibited higher macrophage proportions and distinct gene expression pathways related to extracellular matrix organization and receptor tyrosine kinase signaling. Additionally, we explored the dedifferentiation states within these subtypes, identifying that region with higher dedifferentiation scores corresponded to increased tumor invasiveness and potential drug resistance. …”
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Clinical and Molecular Insights Into Anti-MDA5 Antibody-Positive Dermatomyositis: A Single-Center Retrospective and Transcriptomic Study by Ren Y, Wu T, Shi W

“…Transcriptomic profiling revealed upregulation of IL-17, Toll-like receptor, and cytokine–receptor interaction pathways.Conclusion: MDA5-DM presents formidable diagnostic challenges with high misdiagnosis rates and substantial mortality risk predominantly driven by RP-ILD. …”
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Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…Differentially expressed PRGs are enriched in immune related pathways, such as inflammasome assembly and NOD like receptor signaling pathways. The seven gene prognostic model we constructed (CXCL2, SLC7A5, CAV1, IFNG, EPAS1, TNFAIP3, CYBB) can effectively distinguish high-risk LUAD patients. …”
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Ecotoxicological hazards of sea star-derived asterosaponins: mechanistic insights into embryotoxicity and cardiotoxicity in marine medaka by Ranran Zhang, Zhen Lu, Derui Wang, Zhi Yan, Xueting Sun, Xiaodong Li, Xiuli Yin, Ke Li

“…Transcriptomic analysis uncovered pronounced activation in pathways, including those involved in adrenergic signaling within cardiomyocytes, cardiac muscle contraction, calcium-mediated signaling, and neuroactive ligand-receptor interactions. …”
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Research Progress on the osteogenic differentiation of ADSCs induced by epimedium in the prevention and treatment of osteoporosis by Hai-Quan LIU, Mei-Jian-Zong WU, Zu-Yu MENG

“…Peroxisome proliferator-activated receptor gamma (PPARγ) is the key protein of adipocyte differentiation. …”
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On the anticoagulant and antiaggregatory properties of a glucosamine sulfate molecule by I. Yu. Torshin, A. M. Lila, O. A. Gromova, A. V. Naumov, A. N. Gromov

“…The main molecular mechanisms of its antithrombotic effects are most probably the mGS molecular mimicry of heparan sulfate activity, the activation of CD44 receptor, and the inactivation of the NF-KB signaling pathways in platelets. …”
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CHAC1 in urological tumors: contextual dualism and therapeutic implications by Deyu Wang, Yongquan Wan, Yunxiang Li, Yuan Ren, Jiakai Ma, Si Ge, Ziqiang Zeng, Zuoping Wang, Lei Zhen

“…Mechanistically, CHAC1 intersects critical pathways by regulating redox homeostasis through glutathione catabolism, mediating potential crosstalk with androgen receptor signaling, and serving as an independent prognostic determinant in ccRCC (FPTOS_score model: HR = 2.028, 95% CI: 1.640-2.507). …”
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Molecular characterization and expression analysis of hypoxia inducible factor-1α during hypoxic stress in speckled blue grouper (Epinephelus cyanopodus) by Along Gao, Qiaoyi Chen, Yukun Huang, Zhiya Yu, Wenjie He, Jinhui Wu, Jinxiong Huang, Tiangaung Cai, Hu Shu

“…GO and KEGG enrichment analyses revealed that the DEGs were mainly involved in processes such as transmembrane signal receptor activity, G protein-coupled receptor activity, and molecular transducer activity, involving the HIF-1, PI3K-Akt, and AMPK signaling pathways. …”
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RETRACTED: Calycosin inhibits hepatocyte apoptosis in acute liver failure by suppressing the TLR4/NF‐κB pathway: An in vitro study by Le Chang, Aiqing Zhang, Wenjuan Liu, Ping Cao, Lixian Dong, Xiaoxue Gao

“…Additionally, the effect of CA on ALF was inhibited via transfection of a toll‐like receptor 4 (TLR4)‐plasmid to elucidate the relationship between CA and TLR4/nuclear factor (NF)‐κB signaling pathway in ALF. …”
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