Investigation of the Roles of the Adenosine A(2A) and Metabotropic Glutamate Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis by Anthony M. Cuozzo, Loren D. Peeters, Cristal D. Ahmed, Liza J. Wills, Justin T. Gass, Russell W. Brown

“…The metabotropic glutamate receptor type 5 (mGlu5) and adenosine A(2A) receptor form a mutually inhibitory heteromer with the dopamine D2 receptor, where the activation of either mGlu5 or A(2A) leads to reduced D2 signaling. …”
Get full text

Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β‐Adrenergic Activation by Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao, Yashuo Wang, Haonan Li, Yinghui Qi, Yongliang Yang, Lihong Chen, Youfei Guan, Xiaoyan Zhang

Subjects: Get full text

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery by Conor J Howard, Nathan S Abell, Beatriz A Osuna, Eric M Jones, Leon Y Chan, Henry Chan, Dean R Artis, Jonathan B Asfaha, Joshua S Bloom, Aaron R Cooper, Andrew Liao, Eden Mahdavi, Nabil Mohammed, Alan L Su, Giselle A Uribe, Sriram Kosuri, Diane E Dickel, Nathan B Lubock

“…Using these methods, we performed a DMS of the melanocortin-4 receptor (MC4R), a G-protein-coupled receptor (GPCR) implicated in obesity and an active target of drug development efforts. …”
Get full text

Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mech... by Laura Lagostena, Davide Rotondo, Davide Gualandris, Antonio Calisi, Candida Lorusso, Valeria Magnelli, Francesco Dondero

“…Both PFOS and PFOA caused a significant but reversible reduction in GABA receptor-mediated currents following one-minute pre-treatment. …”
Get full text

Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia by Yifan Wang, Yifan Wang, Yifan Wang, Xinyu Dong, Xinyu Dong, Xinyu Dong, Shandong Tao, Shandong Tao, Shandong Tao, Qiuni Chen, Qiuni Chen, Qiuni Chen, Yue Chen, Yue Chen, Yue Chen, Lijuan Zhang, Lijuan Zhang, Lijuan Zhang, Yuye Shi, Yuye Shi, Yuye Shi, Zhengmei He, Zhengmei He, Zhengmei He, Liang Yu, Liang Yu, Liang Yu, Liang Yu, Chunling Wang, Chunling Wang, Chunling Wang, Chunling Wang

“…The insulin-like growth factor (IGF) signaling system comprises functionally specific ligands (IGF-I and IGF-II), receptor (IR), and binding proteins (IGFBP). …”
Get full text

The Influence of Cell Isolation and Culturing on Natriuretic Peptide Receptors in Aortic Vascular Smooth Muscle Cells by Christine Rager, Tobias Klöpper, Sabine Tasch, Michael Raymond Whittaker, Betty Exintaris, Andrea Mietens, Ralf Middendorff

“…Vascular smooth muscle cell (SMC) relaxation by guanylyl cyclases (GCs) and cGMP is mediated by NO and its receptor soluble GC (sGC) or natriuretic peptides (NPs) ANP/BNP and CNP with the receptors GC-A and GC-B, respectively. …”
Get full text

Circadian rhythm and aryl hydrocarbon receptor crosstalk in bone marrow adipose tissue and implications in leukemia by Bihter Muratoğlu, Cansu Özdemir, Cemil Can Eylem, Tuba Reçber, Emirhan Nemutlu, İdil Yet, Duygu Uçkan-Çetinkaya

“…Particularly noteworthy were the effects observed following the inhibition of aryl hydrocarbon receptor (AhR) signaling by StemRegenin1 (SR1). BMAT-MSCs showed increased expression of epithelial-mesenchymal transition (EMT) genes in FA and AML, suggesting a potential shift towards cancer-associated fibroblasts in the dysregulated marrow microenvironment. …”
Get full text

Precision targeting of androgen receptor–ferroptosis crosstalk in prostate cancer: From mechanisms to therapeutic strategies by Dongfang Lv, Yankang Shi, Luan Kou, Denglu Zhang, Yanxia Guo, Shengtian Zhao

Subjects: Get full text

Nanocluster-mediated signaling crosstalk between FcγR and TLR4 in macrophage inflammatory responses by Seonik Lee, Hunter Richman, Yan Yu

“…Abstract Receptor crosstalk, the interaction between different receptors to modulate signaling, is crucial for fine-tuning the inflammatory responses of innate immune cells. …”
Get full text

Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells by D. V. Sorokin, O. E. Andreeva, E. I. Mikhaevich, Yu. Yu. Shchegolev, A. M. Scherbakov, M. V. Gudkova, M. A. Krasil’nikov

Get full text

Wnt5a augments intracellular free cholesterol levels and promotes castration resistance in prostate cancer by Yuqi Guo, Zhiyuan Zhang, Lintao Dong, Xinyi Shi, Xiaohan Li, Mingxiu Luo, Yajuan Fu, Yujing Gao

Subjects: Get full text

Sacubitril/Valsartan partially alleviates myocardial infarction injury by activating the FGF21 signaling pathway via PPARs by Wenjuan Wei, Guangsen Xu, Jiaer Gao, Guiyun Wang, Ye Wang, Caiyan Li, Junwei Zheng, Huiying Lu, Yunyan Lu, Kun Wang, Hongtao Xu, Cong Wang, Xuebo Pan

Get full text

Investigation of effect of NADPH inhibitors on ischemic reperfusion injury based on the NOD2 signaling pathway by ZHANG Xiao-lin, LIU Wen-li, LI Guang-yuan, MA Fang, XIA Tian-yu, LI Di, ZHANG Zhe, TAN Zhi-cheng

“…Conclusions Inhibition of oxidative stress can attenuate renal ischemia-reperfusion injury by blocking the NOD2 receptor signaling pathway.…”
Get full text

Deciphering adenosine signaling in hepatocellular carcinoma: Pathways, prognostic models, and therapeutic implications by Huihai Yang, Martina Mang Leng Lei, Longfei Xie, Yinuo Shou, Terence Kin Wah Lee

Subjects: Get full text

A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms by Adrián Alacreu-Crespo, Emilie Olié, Maxime Manière, Jeremy Deverdun, Emmanuelle Lebars, Maithé Corbani, Gilles Guillon, Philippe Courtet

Subjects: Get full text

CLE peptides act via the receptor-like kinase CRINKLY 4 in Physcomitrium patens gametophore development by Alain Shumbusho, C. Jill Harrison, Viktor Demko

“…In Arabidopsis, CLAVATA 3-like signaling peptides (CLEs) act via receptor-like kinases CLAVATA 1 and CRINKLY 4 (CR4). …”
Get full text

Tumor necrosis factor receptor 2 in allergen tolerance: a perspective view by Guillem Montamat-Garcia, Guillem Montamat-Garcia, Murilo Luiz Bazon, Agnieszka Demczuk, Agnieszka Demczuk, Cathy Leonard, Markus Ollert, Markus Ollert

Subjects: Get full text

Dap10 co-stimulation enhances the anti-HCC efficacy of NKp30 chimeric antigen receptor T cells by JieYu Li, LiMei Chen, MingShui Chen, Miao Lin, Zineng Xie, HuiLing Wu, ZhiFeng Zhou, WanSong Lin

Subjects: “…DAP 10 signaling domain…”
Get full text

G protein-coupled receptors: pivotal hubs in gastric cancer malignancy—from multidimensional crosstalk to precision therapeutics by Rong Qin, Xirui Fan, Yun Huang, Yiyao Duan, Hui Wang

Subjects: “…G protein-coupled receptors…”
Get full text

Shuangshen Granules Suppress Myeloid-derived Suppressor Cell-mediated Lung Premetastatic Niche Development by Targeting Sphingosine-1-Phosphate Receptor-1/Signal Transducer, Activator of Transcription 3 Signaling by Rui Liu, Jia-Qi Hu, Xing Zhang, Xiao-Yi Wu, Hua-Min Wei, Yuan-Chen Zhao, Shu-Lin He, Jing Yu, Xin Qi, Ying-Xia Pei, Hong Chen, Wei-Dong Li, Bao-Jin Hua

Subjects: “…sphingosine-1-phosphate receptor-1/signal transducer activator of transcription 3 axis…”
Get full text