Effects of electroacupuncture on central insulin signal transduction-related proteins in insulin resistance model rats via the mTORC1/S6K1 pathway by Xiu-feng GU, Jing-zhi WANG, Ming KONG, Li CHEN, Jie SONG, Tao QU

“…Objective: To investigate the effects of electroacupuncture (EA) on the expression and phosphorylation of insulin signal transduction-related proteins in the hypothalamus of insulin resistance (IR) rats. …”
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Chaperone-mediated autophagy dysfunction in imiquimod-induced psoriasiform dermatitis by Wei Zhao, Kainan Liao, Wei Song, Jing Wang, Chunlin Cai, Fusheng Zhou, Dandan Zang, Deping Xu, Haisheng Zhou

“…Mechanistically, toll-like receptor 7 (TLR7), containing a specific KFERQ-like motif, is a substrate for CMA-mediated degradation. …”
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CAR: Discovery and development by the pharmacogenetics laboratory at NIEHS, NIH by Tatsuya Sueyoshi, Masahiko Negishi

“…It also functionally and physically interacts with other nuclear receptors and factors in cell signaling pathways, controlling many genes and biological responses. …”
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Heat Stress Upregulates the Expression of TLR4 and Its Alternative Splicing Variant in Bama Miniature Pigs by Xiang-hong JU, Han-jin XU, Yan-hong YONG, Li-long AN, Ying-mei XU, Pei-rong JIAO, Ming LIAO

“…It plays an important role in several diseases and cellular signal regulation. Heat stress is a major factor that induces immunosuppression in pigs. …”
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SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer by Jingming Zhuang, Yang Wang, Xinyong Wu, Zijing Peng, Zhengnan Huang, Chao Zhao, Bing Shen

“…Abstract Background Bladder cancer (BC) is one of the most common malignancies worldwide. G protein-coupled receptors (GPCRs) are a large family of transmembrane proteins that are increasingly recognised as key players in cancer biology, affecting cell signalling and the tumour microenvironment. …”
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Dynamic changes in the tumor microenvironment under the effect of estradiol as a diagnostic tool and target for targeted cancer therapy by A. I. Stukan, A. Yu. Goryainova, A. A. Meshcheryakov, V. A. Porkhanov, R. A. Murashko, S. V. Sharov, V. N. Bodnya

“…Activation of the estrogen receptor-α (ER-α) signaling pathway is a significant factor in the initiation of carcinogenesis in various types of tumors due to the genomic and non-genomic effects of estradiol in cancer cells. …”
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C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma by Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan

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PLATELETS AND PLATELET-DERIVED MICROVESICLES: PHENOTYPE, CONTENT, IMPACT ON ENDOTHELIAL CELLS by Olga I. Stepanova, Marina A. Pereviazkina, Markova L. Kseniia, Sergey A. Selkov, Dmitriy I. Sokolov

“…Intercellular adhesion molecules, Toll-like receptors, chemokine and cytokine receptors are represented on their surface. …”
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Nuclear localization and upregulation of BAI1 in alveolar macrophages during LPS-Induced acute lung injury by A-Guo Li, Xiao-Ye Huang, Ken-Qi Zhang, Ping Xu, Hong-Yan Wang, Ye-Ping Yao, Yong-Sheng Tu

“…Abstract Brain-specific angiogenesis inhibitor-1 (BAI1) is an endocytic scavenger receptor that mediates macrophage clearance of apoptotic or phosphatidylserine-expressing cells. …”
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Vagus nerve stimulation: a promising strategy to combat pyroptosis and inflammation in traumatic brain injury through the OX-A/NLRP3/caspase-1/GSDMD signaling pathway by Junwei Kang, Binkai Ren, Jia Wang, Yunliang Tang, Xiaoyang Dong

“…This study aims to determine in an animal model whether VNS enhances neural functional recovery post-TBI by inhibiting pyroptosis via the Orexin-A (OX-A)/NLRP3/Caspase-1/GSDMD signaling pathway, the role of OX-A was addressed via administration of the OX-A receptor antagonist SB334867. …”
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Caveolin-1 inhibits the proliferation and invasion of lung adenocarcinoma via EGFR degradation by Jiahui Dong, Ruiping Du, Yani Zhang, Bo Hong, Gengyun Sun

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Nanoparticles as Potential Agents of Chemical and Biological Weapons by Ján Lakota

“…Being non-biological objects, interacting with cell receptors, distorting intracellular signaling pathways and affecting the genetic regulation of the cell, they can cause a variety of pathological effects (oxidative stress, neuroinflammation, neurodegeneration, etc.). …”
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The effects of 5-HT on vascular endothelial dysfunction in patients with panic disorder by Yueqi Feng, Xixi Li, Zijia Li, Xinyi He, Yanqing Tang, Wen Tian

“…The review also highlights the role of the PI3K/Akt/eNOS signaling pathway in 5-HT's influence on vascular endothelial function. …”
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Hepatoprotective effect of lotus leaf against non-alcoholic fatty liver disease in rats via alteration of AMPK/SIRT1 and Nrf2/HO-1 signaling pathway by Qingxia Shen, Junqian Wang, Na Yao, Xiyan Niu, Mi Liu, Xiaohui Li

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Early intervention of baicalin suppresses obesity-induced adipose tissue fibrotic remodeling through Interfering NF-κB/HIF-1ɑ/GRK2 Signaling Pathway by Ying Zeng, Wenting Li, Tingting Ma, Honglei Zhang, Jiaxing Xu, Kang Liu

“…Obesity-induced adipose tissue (AT) fibrosis is difficult to reverse, indicating the importance of early intervention. G protein-coupled receptor kinase 2 (GRK2) is a potential regulator of energy metabolism. …”
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LPS pretreated dental follicle stem cell derived exosomes promote periodontal tissue regeneration via miR-184 and PPARα-Akt-JNK signaling pathway by Liangrui Chen, Jiaxiang Zhang, Jialu Yu, Shujuan Guo, Weidong Tian

“…Conclusion Inhibition of miR-184 facilitates periodontal regeneration, which targets the PPARα-Akt-JNK signaling pathway to suppress oxidative stress in periodontal tissues.…”
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Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management by Rongrong Deng, Shiqian Zheng, Shengjun Xie, Gengjiu Huang, Zhiwen Ou, Zhibin Shen

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The effect of vitamin D supplementation and high-intensity interval training on BDNF-TrkB expression in rats fed a high-fat and high-carbohydrate diet by Zainulabden Zainulabden Ali Abdulrahim1, Amir Ghanbarpour Nosrati, Mousa Khalafi

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Mechanisms of innate immunity in pathogenesis of psoriasis: approaches to targeted therapy by E. D. Merkushova, E. M. Khasanova, L. V. Gankovskaya

“…The interaction of PAMP/DAMP ligands with specific PRR receptors leads to signal activation of effector components of immune system, i.e., assembly of inflammasome complex, caspase activation, synthesis of inflammatory cytokines and processing of their immature forms. …”
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miRNA regulation of the Akt/mTOR pathway in oral squamous cell carcinoma: a focused review by Shazia Fathima Jaffer Hussain, Mohammad Fareed, Mohmed Isaqali Karobari

“…Central to this progression is the Akt/mTOR signaling pathway, which regulates cell proliferation and survival. …”
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