Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…PRRG1 knockdown elevated NEDD4, destabilizing the oncoprotein KRAS and receptor EGFR, and attenuating downstream signaling and macropinocytosis under nutrient deprivation. …”
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CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS... by Yu. V. Zhukova, A. A. Alshevskaya, F. D. Kireev, O. A. Chumasova, N. S. Shkaruba, A. E. Sizikov, Yu. A. Lopatnikova, D. V. Demina, A. V. Karaulov, A. N. Silkov, S. V. Sennikov

“…A pleiotropic cytokine TNFα is an important inflammatory mediator of a number of diseases; its biological functions are fulfilled through two different receptors, TNFR1 and TNFR2. Changes in the ratio between these types of receptors shifting the balance between the pro-apoptotic and proliferation signaling pathways play a crucial role in eliciting the cell response to TNFα. …”
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Effects of Rhodotorula mucilaginosa on Growth, Antioxidant, and Immune Function, and Toll/Imd and JAK-STAT Signaling Pathways in Red Claw Crayfish (Cherax quadricanatus) by Qin Zhang, Liuqing Meng, Jiqing Li, Luoqing Li, Qinghui Zeng, Rui Wang, Dapeng Wang, Tong Tong, Yongqiang Liu, Huizan Yang

“…The main results are as follows: Compared with the control group (0.0 g/kg), different R. mucilaginosa levels significantly increased (p<0.05) the specific growth rate (SGR) and weight gain rate (WGR) of red claw crayfish, significantly increased (p<0.05) the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), total AOC (T-AOC), and acid phosphatase (ACP) in hepatopancreas of red claw crayfish, and significantly upregulated (p<0.05) the relative expression levels of tumor necrosis factor receptor-associated protein 6, akirin, immunodeficiency homolog, interferon regulatory factor 4, Toll-like receptor (TLR) 6, TLR 2, Janus kinase, signal transducer activator of transcription, tumor necrosis factor α, interleukin-1β, transforming growth factor-β1 genes in the hepatopancreas of red claw crayfish. …”
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The potential mechanism of action of gut flora and bile acids through the TGR5/TRPV1 signaling pathway in diabetic peripheral neuropathic pain by Peng Chen, Xian Jiang, Jia Fu, Cehua Ou, Yao Li, Jing Jia, Jing Jia, Changli Liao

“…Recent studies have investigated the potential regulatory influence of gut flora and bile acids on DPNP via the TGR5/TRPV1 signaling pathway. Dysbiosis of the gut flora not only directly affects bile acid metabolism but also significantly correlates with diabetes-associated neuropathy through interactions with the bile acid receptor TGR5 and the ion channel TRPV1. …”
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Extracellular Vesicles From Limosilactobacillus johnsonii Enhance Milk Fat Synthesis by Inducing CD36 Dynamic Palmitoylation and Activating PPARγ Signalling by Qihui Li, Baofeng Li, Qianzi Zhang, Dongpang Chen, Siyu Yuan, Hanyu Jing, Haobin Li, Wutai Guan, Shihai Zhang

“…Extracellular vesicles (EVs) released by gut microorganisms function as signalling molecules that influence host physiology. …”
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Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones by Yun Liu, Yun Liu, Dzmitry Padhorny, Dzmitry Padhorny, Rosa Catera, Rosa Catera, Antonella Nicolo, Xiao-Jie Yan, Xiao-Jie Yan, Stan Xiaogang Li, Stan Xiaogang Li, Anastasia Iatrou, Andrea N. Mazzarello, Andrea N. Mazzarello, Noemi Destefani, Noemi Destefani, Steven L. Allen, Steven L. Allen, Jonathan E. Kolitz, Jonathan E. Kolitz, Kanti R. Rai, Kanti R. Rai, Massimo Degano, Massimo Degano, Paolo P. Ghia, Paolo P. Ghia, Charles C. Chu, Charles C. Chu, Florian Krammer, Florian Krammer, Hassan Jumaa, Kostas Stamatopoulos, Dima Kozakov, Dima Kozakov, Nicholas Chiorazzi, Nicholas Chiorazzi

“…Because of the IGs high-affinity homo-dimerization, we asked if the defined foreign- and self-antigenic interactions were mediated by conventional B-cell receptor (BCR) domains or a non-conventional receptor created by homo-dimerization. …”
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Neurosteroids Progesterone and Dehydroepiandrosterone: Molecular Mechanisms of Action in Neuroprotection and Neuroinflammation by Tatiana A. Fedotcheva, Nikolay L. Shimanovsky

“…Among these, mPRs, PGRMC1,2, sigma receptors, and mitochondrial proteins attract comprehensive attention because of strong binding with the P4 and DHEA, but subsequent signaling is poorly studied. …”
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Angiotensin II type 2 receptor–interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway by Ping Huang, Liang Guo, Jie Xi, Donghui Wang

“…In addition, angiotensin II type 2 receptor–interacting protein 3a treatment suppressed the phosphorylation of epithelial-to-mesenchymal transition and extracellular signal–regulated kinase in ovarian carcinoma cells. …”
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TIMP-1 enhances Akt and BDNF signaling in neurons to reduce synaptic and cognitive deficits in 5xFAD mouse model of Alzheimer’s disease by Sukanya Sarkar, Kusumika Gharami, Ananya Mondal, Keerthana Padmanabhan, Ramesh Kumar Paidi, B. N. Srikumar, Subhas C. Biswas

“…TIMP-1 regulated both neuronal apoptosis and autophagy by binding to CD63 receptors in an AD model. Synaptosomal and electrophysiological studies revealed that TIMP-1 reduces AD-related synaptic deficits, likely by promoting post-synaptic long-term potentiation in the hippocampus, independent of pre-synaptic activity. …”
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The effect of <i>NOTCH1</i> knockdown on the phenotype of human lung and colon cancer stem cells by M. V. Vasileva, N. V. Khromova, S. V. Boichuk, P. B. Kopnin

“…In particular, the oncogenic role of NOTCH1 receptor of Notch signaling pathway has been proven for various cancer types, including lung and colorectal cancers. …”
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Microbiome-derived bile acids as endogenous regenerative mediators in liver repair by Surya Nath Pandey, Kavita Goyal, Mohit Rana, Soumya V. Menon, Subhashree Ray, Haider Ali, Popat S. Kumbhar, John Disouza, Sachin Kumar Singh, Gaurav Gupta, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

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Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway by Weiwei Li, Doudou Huang, Zichen Luo, Ting Zhou, Ziwen Jin

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Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plas... by Maximilian Lenz, Paul Turko, Pia Kruse, Amelie Eichler, Zhuo Angel Chen, Juri Rappsilber, Imre Vida, Andreas Vlachos

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Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway by Yang Yu, Liang Kong, Rui-bo Guo, Ya-ni Zhang, Shu-tong Li, Feng-yuan Zhang, Xin Wang, Yang Liu, Xiu-Ying Li, Xue-tao Li

“…Results FA-PPI-Ms showed enhanced cellular uptake via FA receptor–mediated endocytosis and effectively eliminated reactive oxygen species (ROS), reduced inflammatory cytokine production, and exhibited good biosafety. …”
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Meprin β activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury by Shaymaa Abousaad, Faihaa Ahmed, Ayman Abouzeid, Christine Adhiambo, Elimelda Moige Ongeri

“…Existing data from in vitro and in vivo studies show that meprins modulate interleukin-6 (IL-6)-mediated inflammation via proteolytic processing of IL-6 and its receptor. IL-6 trans-signaling induces proliferation through either Mitogen-activated protein kinase /extracellular signal-regulated kinase (MAPK/ERK) or Phosphatidylinositol 3-Kinase/ protein kinase B (PI3K/AKT) pathway or in crosstalk with AKT/ERK. …”
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Redox-dependent activation of protein kinase G1α contributes to transient receptor potential cation channel subfamily V member 1-mediated acute nociceptive pain behavior by Tim Berg, Katharina Metzner, Nabil Bahrami, Elena Wang, Maximilian Koch, Philip Eaton, Achim Schmidtko, Wiebke Kallenborn-Gerhardt

“…Background Sensory neurons relay the pain signals to the brain via the nociceptive system. Notably, reactive oxygen species (ROS) serve as signaling molecules in the somatosensory system; however, their contribution to sensing noxious stimuli remains poorly understood.Methods Herein, the role of protein kinase G (PKG)1α, which is highly expressed in sensory neurons and serves as a ROS target, was investigated in sensory neurons in the processing of acute nociceptive pain. …”
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Engineered single‐ and multi‐cell chemotaxis pathways in E. coli by Shalom D Goldberg, Paige Derr, William F DeGrado, Mark Goulian

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Empagliflozin Attenuates Neointima Formation After Arterial Injury and Inhibits Smooth Muscle Cell Proliferation and Migration by Suppressing Platelet‐Derived Growth Factor–Related... by Gwo‐Jyh Chang, Wei‐Jan Chen, Yu‐Juei Hsu, Ying‐Hwa Chen

“…Empagliflozin suppressed PDGF‐related signaling, including phosphorylation of PDGF receptor β, Akt, and STAT3 (signal transducer and activator of transcription 3). …”
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Chronic lipopolysaccharide exposure promotes cognitive impairments by activating TRPC6-AIM2 inflammasome signaling and the regulation of ginsenoside Rg1 in Trpc6 −/− mice by Yinglin Fu, Hui Zhang, Xing Zhu, Haoyu Liang, Lei Fan, Yong Su, Weiping Li, Weizu Li

“…Abstract Background Chronic neuroinflammation is a pivotal pathogenesis in neurodegenerative diseases (NDDs). Transient receptor potential canonical protein 6 (TRPC6) has an essential role in the maintenance of calcium homeostasis in cells. …”
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MED12 mutation induces RTK inhibitor resistance in NSCLC via MEK/ERK pathway activation by inflammatory cytokines by Hyun-Min Ryu, Deokhoon Kim, Jun Young Choi, Shinkyo Yoon, Ho-Su Lee, Ji Eun Park, Eunjin Lee, Yunkyung Sung, Chang Hoon Lee, Eun-Young Lee, Wanlim Kim, Seyoung Seo, Sang-We Kim, Kang-Seo Park, Dae Ho Lee

“…Abstract Non-small cell lung cancer (NSCLC) is frequently associated with mutations in receptor tyrosine kinases (RTKs), such as EGFR and ALK. …”
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