Design principles of nuclear receptor signaling: how complex networking improves signal transduction by Alexey N Kolodkin, Frank J Bruggeman, Nick Plant, Martijn J Moné, Barbara M Bakker, Moray J Campbell, Johannes P T M van Leeuwen, Carsten Carlberg, Jacky L Snoep, Hans V Westerhoff

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Yeast GPCR signaling reflects the fraction of occupied receptors, not the number by Alan Bush, Gustavo Vasen, Andreas Constantinou, Paula Dunayevich, Inés Lucía Patop, Matías Blaustein, Alejandro Colman‐Lerner

“…We developed a complete mathematical model of this step, which suggested the ability to compute fractional occupancy depends on the physical interaction between the inhibitory regulator of G‐protein signaling (RGS), Sst2, and the receptor. Accordingly, replacing Sst2 by the heterologous hsRGS4, incapable of interacting with the receptor, abolished robustness. …”
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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex by Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu

“…Structural analyses of APJR-Gi complexes have clarified the structural basis of receptor dimerization and activation4,5, yet the absence of structural data on APJR-arrestin complexes has impeded a comprehensive understanding of APJR stoichiometry in the dual signaling pathways and biased agonism. …”
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Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions by Ping Jin, Xirui Duan, Zhao Huang, Yuan Dong, Jianmei Zhu, Huiming Guo, Hui Tian, Cheng-Gang Zou, Ke Xie

“…Dysregulation of nuclear receptor signaling is implicated in the pathogenesis of numerous diseases, including cancers, metabolic disorders, cardiovascular diseases, and autoimmune conditions. …”
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Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling by Nikolay Borisov, Edita Aksamitiene, Anatoly Kiyatkin, Stefan Legewie, Jan Berkhout, Thomas Maiwald, Nikolai P Kaimachnikov, Jens Timmer, Jan B Hoek, Boris N Kholodenko

“…Abstract Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways. We exploit experimental and computational approaches to reveal how a concordant interplay between the insulin and epidermal growth factor (EGF) signaling networks can potentiate mitogenic signaling. …”
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The use of intuitive AF-based modelling for the understanding of activation and signalling through insulin-like receptors by Andrzej M. Brzozowski, Talha Shafi, Olga V. Moroz, Pierre De Meyts

“…It also seems that the diverse natures of receptors:membrane lipid interactions require more experimental attention for the full understanding of the signal transduction through Insulin-like Receptors.…”
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Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure by Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter

“…Evidently, perturbation of insulin/IGF‐1 receptor signaling contributes to tissue damage in mitochondrial disease, which may allow therapeutic intervention against a wide spectrum of diseases.…”
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Variable sizes of Escherichia coli chemoreceptor signaling teams by Robert G Endres, Olga Oleksiuk, Clinton H Hansen, Yigal Meir, Victor Sourjik, Ned S Wingreen

“…This variation of signaling‐team size shows that receptor cooperativity is dynamic and likely optimized for sensing noisy ligand concentrations.…”
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Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum by Maxwell B. Madden, Chloe Schaefgen, Binita Vedak, Jian Kwon, Kiara S. Dresp Pedra, Samuel H. Sheats, Adam C. Puche, Steffen B. E. Wolff, Brian N. Mathur

“…Additionally, we demonstrate that psilocybin injection also activates anterior cingulate cortex presynaptic 5-HT1B receptors to suppress cortical signaling through the claustrum. …”
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Signal and modulating role of enzymes of digestive glands by G. F. Korotko

“…They carry out also signaling role in modulation of exo- and endocrine secretions of digestive glands and motor activity of gastro-intestinal tract. …”
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Correction: IL-1beta Signals through the EGF Receptor and Activates Egr-1 through MMP-ADAM

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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…Recent studies describe bile acids as messenger molecules with diverse functions that have a wide range of receptors in the body. Due to these receptors, bile acids can modulate the rate of self-synthesis, lipid, and glucose and energy metabolism. …”
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Theoretical and experimental analysis links isoform‐ specific ERK signalling to cell fate decisions by Marcel Schilling, Thomas Maiwald, Stefan Hengl, Dominic Winter, Clemens Kreutz, Walter Kolch, Wolf D Lehmann, Jens Timmer, Ursula Klingmüller

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Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses by Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek, Boris N Kholodenko

“…To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB receptors with epidermal growth factor (EGF) and heregulin (HRG) leads to activation of two critical downstream proteins, extracellular‐signal‐regulated kinase (ERK) and Akt. …”
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Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties by Tainara Cristina Michelotti, Valérie Lamothe, Frédéric Jean-Alphonse, Frédéric Jean-Alphonse, Eric Reiter, Eric Reiter, Muriel Bonnet, Guillaume Durand, Guillaume Durand

Subjects: “…cell signaling…”
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Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species by Mohamad K. Hammoud, Celina Meena, Raimund Dietze, Nathalie Hoffmann, Witold Szymanski, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller

“…Results AA (i) disrupts interleukin-2/15-mediated expression of pro-inflammatory genes by inhibiting STAT1-dependent signaling, (ii) hampers signaling by cytotoxicity receptors through disruption of their surface expression, (iii) diminishes phosphorylation of NKG2D-induced protein kinases, including ERK1/2, LYN, MSK1/2 and STAT1, and (iv) alters reactive oxygen species production by transcriptionally upregulating detoxification. …”
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Precision targeting of androgen receptor–ferroptosis crosstalk in prostate cancer: From mechanisms to therapeutic strategies by Dongfang Lv, Yankang Shi, Luan Kou, Denglu Zhang, Yanxia Guo, Shengtian Zhao

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Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats by Emma Cogo, Edwin Fouché, Charline Buisson, Adenike Omotoyinbo, Fabrice Pierre, Françoise Guéraud, Pascale Plaisancié

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Leptin receptor signaling mediates the distinct tendon–bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears by Dongxu Zhu, Xinrui Zhu, Yingze Zhang, Xiaohong Huang

“…Osteoporosis poses a significant risk for rotator cuff tears (RCTs) and re-tears after arthroscopic rotator cuff repair (ARCR). Activating Leptin receptor (Lepr) mediated Stat3 signaling transduction facilitates the transcription of Runx2 and Sox9, respectively, and promotes osteogenesis and chondrogenesis. …”
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Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models by Saige K. Power, Sridevi Venkatesan, Sarah Qu, JoAnne McLaurin, Evelyn K. Lambe

“…We identified a significant and selective increase in post-synaptic nicotinic receptor signalling on prefrontal cortical neurons. …”
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