Newborn screening facilitates early theranostics and improved spinal muscular atrophy outcome: five-year real-world evidence from Taiwan by Chen-Hua Wang, Ting-Rong Hsu, Mei-Ying Liu, Li-Yun Wang, I-Jun Chou, Wang-Tso Lee, Wen-Chen Liang, Inn-Chi Lee, Hsiao-Jan Chen, Shu-Min Kao, Hui-Chen Ho, Dau-Ming Niu, Kwang-Jen Hsiao, Ming-Yuh Chang, Hui-Min Hsieh, Yuh-Jyh Jong

“…This study aimed to investigate the long-term outcomes of a 5-year SMA NBS program in Taiwan. Results From September 2017 to August 2022, two NBS centers screened patients for SMN1 homozygous deletion using quantitative real-time polymerase chain reaction (RT-PCR) or the Sequenom MassARRAY platform and subsequently confirmed the findings using multiplex ligation-dependent probe amplification (MLPA). …”
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Effectiveness of an mHealth-based impact exercise program for bone health in postmenopausal women: a randomised controlled trial protocol by Borja Sañudo, Gonzalo Reverte-Pagola, Carol Maher, Job Godino, Luis Carrasco, Miguel Ángel Oviedo, Adrián Feria, Horacio Sánchez-Trigo, Hugo Gamboa, Raquel Domingo-Molina, Alejandro Sánchez-Arteaga, Miguel Ángel Giráldez, Mª Ángeles Martínez-Maestre, Elena Cepeda, Carmen Ladrón-de-Guevara, Carlos Rangel, Javier Pecci, Vahid Farrahi, Sergio Tejero

“…Moreover, poor adherence to structured exercise programs limits their effectiveness. Mobile health (mHealth) technologies offer a promising solution by enabling real-time mechanical loading monitoring in free-living conditions and providing personalized feedback to improve adherence. …”
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Optimizing cocoa biomass density through integrated irrigation and drainage management under water stress: A linear programming approach by Leonardo H. Talero-Sarmiento, Henry Lamos-Diaz, Juan D. Marquez-Gonzalez

“…This study presents a novel linear programming model that combines crop growth and hydrological dynamics to optimize irrigation and drainage schedules, enhancing cocoa biomass density under variable water stress conditions. …”
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Inducing programmed cell death trough MazEF system to combat Staphylococcus aureus: A non-antibiotic treatment candidate. by Shahriar Bakhti, Mohammad Hossein Ahmadi, Parviz Owlia

“…The aim of the present study was to evaluate the role of extracellular death factor (EDF) derived from Escherichia coli in the induction of programmed cell death (PCD) in methicillin-resistant and -susceptible Staphylococcus aureus (MRSA and MSSA). …”
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A New Parameter-Changing Integral ZNN Model With Nonlinear Activation for Solving Inequality Constraint Time-Varying Quadratic Programming by Chongbiao Tang, Yongmei Ding

“…Comprehensive numerical simulations demonstrate that NAPCIZNN significantly outperforms traditional ZNN variants—including the original ZNN, nonlinear activated ZNN, integral ZNN, and piecewise variable parameter ZNN—in solving time-varying quadratic programming problems. Moreover, the practical application of the NAPCIZNN model in controlling the PUMA560 robotic manipulator showcases its robustness and precision in real-world scenarios. …”
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Selection and evaluation of reference genes for expression analysis using quantitative real-time PCR in the Asian Ladybird Harmonia axyridis (Coleoptera: Coccinellidae). by Cheng Qu, Ran Wang, Wunan Che, Xun Zhu, Fengqi Li, Chen Luo

“…Quantitative real-time PCR (qRT-PCR) is a powerful and reliable technique to quantify gene expression. …”
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The Effectiveness of a Question-Embedded Movie Clips Learning Program in Nursing Students: A Quasi-Experimental Pretest-Posttest Study by Chanokruthai Choenarom, Juraipon Samputtanon

“…The Question-Embedded Movie Clips Learning program used in this study was developed based on the drill and practice learning principle, aiming to facilitate nursing students’ skills and build their confidence before entering real clinical settings. …”
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Student Perceptions of Project-Based Learning When Studying ‘Information Systems’ in an ICT Engineering Program: Taking Advantage of Active Learning by Josep Petchamé, Ignasi Iriondo, Odalys Torné, Francesc Solanellas

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Teaching Analytical Instrumental Analysis to Undergraduates in Specialized Degree Programs with Heterogeneous Prior Knowledge: Reflections on Inquiry Based Lecture Activities by Kirsten A. Tucker, Peter L. Pingerelli

“…The increased need for interdisciplinary scientific programs now has an AIA course serving multiple Bachelor of Science degrees in environmental sciences, forensic sciences, molecular biology, and secondary science education. …”
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A multi-objective supply chain model for disaster relief optimization using neutrosophic programming and blockchain-based smart contracts by Alisha Roushan, Amrit Das, Anirban Dutta, Uttam Kumar Bera

“…The model leverages Dijkstra’s algorithm to identify the shortest emergency routes and integrates Neutrosophic Compromise Programming (NCP) and the Weighted Sum Method (WSM) to optimize drone deployment for cost-effectiveness and timely intervention. …”
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The Effects of a 24-Week Combined Circuit Training and Mobility Program on the Physical Fitness and Body Composition of an Adult Academic Community by Lorenzo Pugliese, Chiara Tuccella, Gabriele Maisto, Emanuele D’Angelo, Simona Delle Monache, Maria Scatigna, Maria Helena Rodrigues Moreira, Valerio Bonavolontà, Maria Giulia Vinciguerra

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Beyond traditional training: a comprehensive CIPP evaluation of medical internships: assessing program design, implementation, and clinical competency outcomes by Nooshin Yoshany, Seyed Saeed Mazloomy Mahmoodabad, Leila Moradi, Manoj Sharma

“…Abstract Aim Internship programs are important components of teaching and learning that provide medical students with opportunities for real-life learning. …”
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Composite cardiovascular risk factor control in US adults with diabetes and relation to social determinants of health: The All of Us research program by Frances Golden, Johnathan Tran, Nathan D. Wong

“…This study aims to identify disparities in cardiovascular risk factor control based on most recent recommendations and relationships to social determinants of health in a large-scale real-world cohort of US adults. Methods: We analyzed data from 88,416 participants with T2DM in the NIH Precision Medicine Initiative All of Us Research Program 2018–2022. …”
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Improving Balance and Technical Skills of Young Alpine Skiers: Outcomes of a 10-Week Complex Dry-Land Training Program by Alexandru Zadic, Mircea-Nicolae Ordean, Dan Monea, Vlad Teodor Grosu, Rareș-Mihai Pop, Cornelia Popovici, Emilia Florina Grosu, Sorin Simon

“…This study underscores the value of balance training for enhancing young skiers’ performance metrics and highlights wearable technology as an effective tool for real-time feedback. Integrating balance-focused programs into alpine skiing preparation can boost performance.…”
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Enabling FAIR data stewardship in complex international multi-site studies: Data Operations for the Accelerating Medicines Partnership® Schizophrenia Program by Tashrif Billah, Kang Ik K. Cho, Owen Borders, Yoonho Chung, Michaela Ennis, Grace R. Jacobs, Einat Liebenthal, Daniel H. Mathalon, Dheshan Mohandass, Spero C. Nicholas, Ofer Pasternak, Nora Penzel, Habiballah Rahimi Eichi, Phillip Wolff, Alan Anticevic, Kristen Laulette, Angela R. Nunez, Zailyn Tamayo, Kate Buccilli, Beau-Luke Colton, Dominic B. Dwyer, Larry Hendricks, Hok Pan Yuen, Jessica Spark, Sophie Tod, Holly Carrington, Justine T. Chen, Michael J. Coleman, Cheryl M. Corcoran, Anastasia Haidar, Omar John, Sinead Kelly, Patricia J. Marcy, Priya Matneja, Alessia McGowan, Susan E. Ray, Simone Veale, Inge Winter-Van Rossum, Jean Addington, Kelly A. Allott, Monica E. Calkins, Scott R. Clark, Ruben C. Gur, Michael P. Harms, Diana O. Perkins, Kosha Ruparel, William S. Stone, John Torous, Alison R. Yung, Eirini Zoupou, Paolo Fusar-Poli, Vijay A. Mittal, Jai L. Shah, Daniel H. Wolf, Guillermo Cecchi, Tina Kapur, Marek Kubicki, Kathryn Eve Lewandowski, Carrie E. Bearden, Patrick D. McGorry, René S. Kahn, John M. Kane, Barnaby Nelson, Scott W. Woods, Martha E. Shenton, the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Justin T. Baker, Sylvain Bouix

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Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescentsResearch in context by Qiong Wu, Bingyu Zhang, Jiayi Tong, L. Charles Bailey, H. Timothy Bunnell, Jiajie Chen, Elizabeth A. Chrischilles, Dimitri A. Christakis, Stephen M. Downs, Kathryn Hirabayashi, Aaron D. Mishkin, Abu S.M. Mosa, Nathan M. Pajor, Suchitra Rao, Hanieh Razzaghi, Hayden T. Schwenk, Marion R. Sills, Huiyuan Wang, Linbo Wang, Yudong Wang, Dazheng Zhang, Ting Zhou, Ravi Jhaveri, Eric J. Tchetgen Tchetgen, Jeffrey S. Morris, Christopher B. Forrest, Yong Chen

“…Methods: We conducted real-world vaccine effectiveness study and mediation analysis using data from twenty health systems in the RECOVER PCORnet electronic health record (EHR) Program. …”
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The role and place of federal state unitary enterprises in the sphere of state property management. by E. V. Gavrilin

“…The proposed ways and methods of management may allow using a more flexible mechanism for the extra-budgetary maintenance of federally owned real estate objects, their commercial use, involvement in economic turnover, with the transfer of part of the income received to the federal budget or their use for the purchase of both real estate objects for state needs based on a decision of the Government of the Russian Federation and movable property with subsequent transfer to the Treasury of the Russian Federation.…”
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A digitally enabled home-based wound care program using the PEDALs model: a mixed-methods study protocol by Lili Chen, Lili Chen, Xuefang Zhuo, Xuefang Zhuo, Hong Cai, Hong Cai, Penghua Zeng, Penghua Zeng, Hongyu Chen, Gang Chen

“…The PEDALs (Problem, Evidence, Determinants, Actions, Long-term, Scales) model, a theoretical framework used in implementation research, as a rational framework for the DE-HBWC program in this study. Unlike conventional approaches, the PEDALs model emphasizes iterative adaptation and long-term scalability, ensuring alignment with real-world clinical needs and technological advancements.MethodsWe designed a combined quantitative and qualitative study consisting of five phases and one monitoring step, following the PEDALs model. …”
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Investigating Google Trends to forecast acute febrile illness outbreaks in North India reported through the Integrated Disease Surveillance Program by Madhur Verma, Kamal Kishore, Pragyan Paramita Parija, Soumya Swaroop Sahoo, Dolly Gambhir, Usha Gupta, Rakesh Kakkar

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Transcriptional, growth factors, components of the AKT/mTOR signaling pathway, receptors and ligands of programmed cell death expression in melanoma by K. V. Nikulnikov, V. A. Bogdanova, L. V. Spirina, S. Yu. Chizhevskaya, I. V. Kondakova, E. L. Choynzonov, V. I. Chernov

“…To study the expression of components of the AKT/mTOR (mTOR – mammalian target of rapamycin) signaling pathway, transcription and growth factors, expression of AMPK, LC3B, programmed cell death 1 (PD-1), programmed death-ligand 1 PD-L1 and programmed death-ligand 2 (PD-L2) in skin and mucosal tumor tissues.Materials and methods. …”
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