An Activity Network Design and Charging Facility Planning Model Considering the Influence of Uncertain Activities in a Game Framework by Zechao Ma, Xiaoming Liu, Weiqiang Wang, Shangjiang Yang, Yuqi Yang, Yingjie Zhao, Hanqing Xia, Yuanrong Wang

“…Finally, the efficacy of the model and the solution algorithm is illustrated by a simulation example in a real urban space.…”
Get full text

Evaluation of polymorphism in BCL-2, PD-1, and PD-L1 genes in myelodysplastic neoplasms by Bartłomiej Kuszczak, Piotr Łacina, Marta Dratwa-Kuźmin, Katarzyna Bogunia-Kubik, Tomasz Wróbel, Justyna Rybka

“…B-cell CLL/lymphoma 2 (BCL-2) family proteins regulate apoptosis, while programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) act as negative regulators of the immune system. …”
Get full text

Predicting Object Communication Errors in Constructor Development by Abdul Majid Soomro, Awad Bin Naeem, Susama Bagchi, Babul Salam KSM Kader Ibrahim, Sanjoy Kumar Debnath

“…Earlier researchers studied various methods for predicting and mitigating software defects in object-oriented programming. We propose a defect prediction model that categorizes problematic classes based on inheritance defects to overcome the gaps in existing methodologies by introducing them. …”
Get full text

Neural ODE-Based Dynamic Modeling and Predictive Control for Power Regulation in Distribution Networks by Libin Wen, Jinji Xi, Hong Hu, Li Xiong, Guangling Lu, Tannan Xiao

“…To ensure computational tractability for real-time applications, a local linearization technique is applied to the NODE dynamics within the MPC, transforming the optimization problem into a standard Quadratic Programming (QP) problem that can be solved efficiently. …”
Get full text

Computational modeling of infectious diseases: insights from network-based simulations on measles by Francesco Branda, Pierangelo Veltri, Francesco Chiodo, Massimo Ciccozzi, Fabio Scarpa, Pietro Hiram Guzzi

“…Our simulations incorporate high and low vaccination coverage to reflect real-world trends and explore various conditions under which disease spread can be effectively blocked. …”
Get full text

Effect of decitabine on PD-L2 methylation in whole blood of iodine-induced autoimmune thyroiditis rats by Baiming Jin, Yanbo Qi, Hong Chao, Xiaolei Yang, Hongjie Li, Siyuan Wan

“…Excessive iodine intake can induce autoimmune thyroiditis (AIT), and the methylation of programmed death receptor 2 (PD-L2) may be involved in the development of iodine-induced AIT. …”
Get full text

Advancing Energy Transition: A Circular Economy Framework for Co-Optimizing Energy, Water, and Emissions in Low-Carbon Systems by Mohamed Elsir, Ameena Saad Al-Sumaiti, Mohamed Shawky El Moursi

“…This paper introduces an innovative solution providing a systemic, co-optimized strategy that balances not only intermittent energy generation and water demand but also integrates risk-based demand response (DR) tailored for desalination plants, a first-of-its-kind approach that minimizes emissions and operational costs in real-time. We employ a novel risk-multi-objective stochastic (RMOBS) optimization method, coupled with a two-stage stochastic programming model, to address uncertainties through hidden Markov processes and conditional value-at-risk (CVaR) techniques. …”
Get full text

Results of a 12-week open-label, non-interventional study of the efficacy and safety of olokizumab therapy in patients with rheumatoid arthritis after switching from anti-B-cell th... by A. A. Akimova, N. E. Banshchikova, A. E. Sizikov, A. A. Mullagaliev, E. A. Letyagina, N. A. Ilina, Yu. D. Kurochkina, Yu. B. Ubshaeva, V. O. Omelchenko, O. A. Chumasova, N. S. Shkaruba, M. A. Korolev

“…At the same time, the analysis of real clinical practice data dictated the need to establish a number of restrictions on the use of certain classes of biological DMARDs and to search for alternative therapy programs to maintain control over disease activity.Purpose of the study – to evaluate the efficacy and safety of the drug Artlegia® (olokizumab), solution for subcuta neous injection, 160 mg/ml – 0.4 ml, manufactured by R-Pharm JSC, Russia) for the treatment of patients with rheuma toid arthritis in real clinical practice after switching with rituximab during the COVID-19 pandemic.Materials and methods. …”
Get full text

Mefloquine enhances the efficacy of anti-PD-1 immunotherapy via IFN-γ-STAT1-IRF1-LPCAT3-induced ferroptosis in tumors by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng

“…RNA sequencing, Real-time quantitative PCR (qRT-PCR), western blotting, chromatin immunoprecipitation-qPCR and flow cytometry were used to determine the molecular mechanisms by which Mef regulates lysophosphatidylcholine acyltransferase 3 (LPCAT3). …”
Get full text

The OpenMindat v1.0.0 R package: a machine interface to Mindat open data to facilitate data-intensive geoscience discoveries by X. Que, J. Zhang, W. Chen, J. Ralph, X. Ma

“…Through a project called OpenMindat, an application programming interface (API) to enable open data query and access from Mindat was set up in 2023. …”
Get full text

Scenario Modelling for Reproducing Investment Potential of Institutional Sectors in the Regions of the Siberian Federal District by I. V. Naumov, A. V. Trynov, A. O. Safonov

“…To prevent this, the Central Bank of the Russian Federation, must change its policy of regulating the financial and economic activities of the banking sector: to limit the speculative activities of credit institutions that facilitate the withdrawal of financial resources from the domestic economy, to support investment programs for developing of enterprises of the real sector. …”
Get full text

Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MKN45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene by Khadijeh Sadegh, Amirhossein Ahmadi, Ahmad Shadi, Ahmad Ghasemi

“…HLBS also upregulated the expression of CDH1, as a highly ranked hub gene associated with GC (P < 0.05).Conclusion: The inhibitory effect of HLBS on MKN45 cells suggests HLBS as a candidate for further drug discovery programs in GC research, and paves the way to introduce new anticancer HLBS synthetic derivatives.…”
Get full text

Presenting a model for solving lot-streaming hybrid flow shop scheduling problem by considering independent setup time and transportation time by Roja Ruhbakhsh, Esmaeil Mehdizadeh, Mohammad Amin Adibi

“…But important assumptions that exist in the real-world scheduling environment are always ignored. …”
Get full text

Models and automation technologies for the curriculum development by V. N. Volkova, A. A. Efremov, A. V. Loginova, D. A. Kabinetskaja, M. A. Tambaum

“…To implement the models, the automated dialogue procedures were developed.Models have been tested during the process of the development and the adjustment of the working curriculum for bachelor’s and master’s degree programs in the fields «System Analysis and Management», «Information Systems and Technologies», «Applied Informatics».…”
Get full text

Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus) by Jiale Shi, Congji Yang, Yuanyuan Qin, Qingqing Liu, Shengqi Hua, Defeng Wu, Wei Dong

“…According to quantitative real-time PCR analysis, the expression level of ClCG04G001930 was significantly higher in the clalm mutant than in normal watermelon. …”
Get full text

Associations of genetic markers of the sympathoadrenal system and endothelial dysfunction with coronary heart disease on the example of a small Shoriya population by E. V. Mikhalina, T. A. Mulerova, V. N. Maksimov, M. I. Voevoda, M. Yu. Ogarkov

“…Statistical processing was carried out using the programs STATISTICA 6.1 (StatSoft Inc., USA) and SNPStats. …”
Get full text

Containment of a carbapenem-resistant Klebsiella pneumoniae in an intensive care unit during the COVID-19 pandemic by Renhua Li, Zuli Zhang, Zhongjie Wang, Keli Qian

“…It is also need to implement antimicrobial stewardship programs in order to reduce the occurrence of microbial resistance.…”
Get full text

Deconstructing Digital Transformation: A Multidimensional Analysis of Digital Literacy’s Role in Shaping Human Capital and Driving Organizational Success by Meena G, Santhanalakshmi K.

“…Through a rigorous mixed-methodology approach combining quantitative surveys and real-time digital usage tracking, we analyzed data from 250 employees across 23 organizations spanning multiple sectors (technology 26.5%, finance 16.7%, healthcare 13.6%). …”
Get full text

Prediction and validation of anoikis-related genes in neuropathic pain using machine learning. by Yufeng He, Ye Wei, Yongxin Wang, Chunyan Ling, Xiang Qi, Siyu Geng, Yingtong Meng, Hao Deng, Qisong Zhang, Xiaoling Qin, Guanghui Chen

“…Anoikis, a special form of programmed cell death, is closely related to the progression of NP. …”
Get full text

Leveraging geographic information system for dengue surveillance: a scoping review by Prathiksha Prakash Nayak, Jagadeesha Pai B., Sreejith Govindan

“…Strengthening collaborative data-sharing frameworks and incorporating machine-learning approaches could further improve the effectiveness of GIS-driven surveillance programs.…”
Get full text