Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with <i>M. bovis</i> BCG or Other Therapies by Inmaculada Ruiz-Lorente, Lourdes Gimeno, Alicia López-Abad, Pedro López Cubillana, Tomás Fernández Aparicio, Lucas Jesús Asensio Egea, Juan Moreno Avilés, Gloria Doñate Iñiguez, Pablo Luis Guzmán Martínez-Valls, Gerardo Server, Belén Ferri, José Antonio Campillo, María Victoria Martínez-Sánchez, Alfredo Minguela

“…The MM genotype was associated with higher counts of circulating CD56^bright, fewer KIR2DL1/L2⁺ NK cells, and lower NKG2A expression, but not with differential in vitro NK cell functionality. <b>Conclusions</b>: The HLA-B −21M/T is independently associated with BC patient outcomes and can help to optimize the use of new immunotherapies in these patients.…”
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CURRENT LEVELS OF MEDICAL EXPOSURE IN RUSSIA by M. I. Balonov, V. Ju. Golikov, I. A. Zvonova, S. A. Kal’nickij, V. S. Repin, S. S. Sarycheva, L. A. Chipiga

“…Due to replacement of low-dose ‘functional’ nuclear medicine examinations with more informative modern scintigraphy and tomography examination, patient doses substantially increased over the last decade. …”
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Eco‑friendly biosynthesis of gold nanoparticles from Amphimedon compressa with antibacterial, antioxidant, anti-inflammatory, anti-biofilm, and insecticidal properties against dise... by Alsayed E. Mekky, Ebrahim Saied, Mahmoud M. Al-Habibi, Zeinab A. Shouaib, Ahmed I. Hasaballah, Mohammed E. Rashed, Ashjan F. Khaled, Amal Naif Alshammari, Fady Sayed Youssef, Ahmed M. Al-Shahat, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Mohammed Aufy, Tharwat A. Selim

“…FTIR spectroscopy indicated that secondary metabolites featuring –OH functional groups acted as reducing agents in the production of AuNPs. …”
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A new strategy of molecular breeding for optimal heading date and grain yield in rice by modulating elite allelic combinations of Ghd7, Hd3a, RFT1 and Gn1a by Qingmei Su, Rongsheng Wang, Xiaomin Feng, Mengyue Zhao, Guanlin Zhu, Qing Wang, Fang Zhang, Shaoyang Lin, Yuhang Zhang, Li Zhu, Qian Qian, Fan Chen

“…A later heading date generally leads to higher grain yield in favorable ecological regions; however, grain yield reaches a limit as the heading date exceeds a certain threshold. …”
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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…Furthermore, MEVs were able to traverse the intestinal barriers and reach distal organs, including the brain, thereby potentially influencing brain functionality and contributing to mental and behavior.…”
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Lessons learnt in the response to COVID-19 in Mozambique: enabling readiness for the next pandemic by Mariana E. Posse, Grace Njeri Muriithi, Daniel Malik Achala, Elizabeth Naa Adukwei Adote, Chinyere Ojiugo Mbachu, Senait Alemayehu Beshah, Senait Alemayehu Beshah, Chijioke Osinachi Nwosu, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba

“…A validation meeting was held, in which research participants were asked to check the accuracy of the results and interpretations.ResultsKey drivers of the COVID-19 response were strong leadership; a clear plan and strategies; a functional coordination mechanism; the use of evidence to make decisions; a careful consideration of priority groups; investments in the supply chain and surveillance systems; the utilization of pre-existing vaccination structures; and partnership between the government and several stakeholders. …”
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Application of a Hybrid Model Based on CEEMDAN and IMSA in Water Quality Prediction by GUO Li-jin, WU Hao-tian

“…IMSA’s performance was validated using benchmark functions (Rosenbrock for unimodal, Michalewicz for multimodal), confirming improved global search and convergence precision. …”
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Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Furthermore, the system-defined dual-positive responders showed improved median RFS (not reached) than non-responders (7.1 months for AFP-positive group [p=0.043] and 13.3 months for AFP-negative group [p=0.099]).Conclusion: mRECIST was more indicative of pathologic response after combination therapy than RECIST 1.1. …”
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Assessing the latest advances in bone marrow stem cell therapy for Avascular Necrosis hip: A comprehensive systematic review, meta-analysis, and meta-regression of randomized contr... by Robin Novriansyah, Tanti Ajoe Kesoema, Kevin Christian Tjandra, I Nyoman Sebastian Sudiasa, Shakira Amirah, Imke Maria Del Rosario Puling, Prudence Lucianus, Revina Maharani, Danendra Rakha Putra Respati, Laksmana Adi Krista Nugraha, Ismail Hadisoebroto Dilogo

“…Meta-regression analyses explored the influence of study-level covariates on outcomes. No predictor reached statistical significance for HHS or THA conversion. …”
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VALIDATION OF LONG-TERM HANDLING AND STORAGE CONDITIONS FOR HEMATOPOIETIC STEM CELL PRODUCTS FOR AUTOLOGOUS TRANSPLANTS by Ahmed Al Bahrani

“…The inclusion of in-vitro assays as part of functionality testing could further enhance the quality assessment of stored PBHSCs products.…”
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Optimasi Laju Alir Pengeringan Semprot Mikropartikel Asiklovir dengan Kitosan dan Natrium Tripolifosfat by Cynthia Marisca Muntu, Jessica Clarissa Selan, Sadono

“…The SD flow rates were set at 7.5 (L1), 6.5 (L2), and 5.5 (L3) mL/min. Functional group identification confirmed cross-linking in all MA samples. …”
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CLINICAL AND BIOCHEMICAL INDICATORS IN WHITE RATS IN THE TREATMENT OF EXPERIMENTAL GENERALIZED PARODONTITIS by Yu.I. Silenko, M.V. Khrebor, Y.M. Silenko, O.A. Pisarenko

“… A number of scientists put forward and confirmed the assumption of the presence in the body of biological regulators, polypeptides, carrying out the transfer of information necessary for the functioning, development and interaction of cell populations. …”
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Automated Digital Safety Planning Interventions for Young Adults: Qualitative Study Using Online Co-design Methods by Jonah Meyerhoff, Sarah A Popowski, Tanvi Lakhtakia, Emily Tack, Rachel Kornfield, Kaylee P Kruzan, Charles J Krause, Theresa Nguyen, Kevin Rushton, Anthony R Pisani, Madhu Reddy, Kimberly A Van Orden, David C Mohr

“…ConclusionsEngaging young adults in the design process of a digital suicide prevention tool revealed critical considerations that must be addressed if the tool is to effectively expand access to evidence-based care to reach young people at risk for suicide-related thoughts and behaviors. …”
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Evidence adaptation and tailored implementation of family bereavement support in specialised palliative care: A multi-method study by Myrta Kohler, Qëndresa Thaqi, Silke Kuske, Torsten Schwalbach, Marco Riguzzi, Rahel Naef

“…Results: The study resulted in an adapted bereavement support pathway with three core functions of evidence-informed practices delivered during dying, at death, three-to-six, and if necessary nine-to-twelve months post-loss: screening and assessing family needs and risks, intervention and support activities for families, and team collaboration and coordination within and across providers. …”
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Kinerja Karbon Aktif Daun Eceng Gondok pada Penurunan Kadar Fosfat Artifisial dan Surfaktan dalam Limbah Detergen by Resa Wulandari, Cucun Alep Riyanto, Yohanes Martono

“…The effectiveness of ACWHL in adsorption of phosphate and surfactant reached 78.35% and 52.99%, respectively.…”
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Study on the characteristics of Cd2+ adsorption of mineral processing wastewater by micro-organisms supported by hydrothermal carbon by Gang ZHOU, Xinyuan ZHANG, Shuailong LI, Qunzhi MENG, Jianjun YAO, Jinhao ZHANG, Hui ZHEN

“…The microscopic morphology, elemental composition, surface functional groups, specific surface area and porosity of HC-PVA-SA-MOI were analyzed by SEM, XPS and BET characterization experiments. …”
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Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…Final assessment in the morning on day 4 showed significant pain reduction by 4.5±2.6 cm VAS in Group 1 vs baseline, and by 3.6±1.4 cm VAS in Group 2 (p=0.545). Functional improvement in both groups reached 3.7±1.9 and 3.3±1.3 cm VAS, respectively (p=0.837). …”
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Experimental analysis on residual ultimate bearing capacity of thin plate with internal explosion dent damage under biaxial compression by Lei AO, Zhizhong SHI, Lei ZHANG, Ziqi DING, Zhiyong PEI, Weiguo WU

“…In some cases, this reduction reached up to 19.96%, demonstrating the severe impact of even minor damage on the structural performance of the plates. …”
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Multi-objective Optimal Scheduling of Water-Carbon in Cascade Reservoirs during Impoundment for Carbon Emission Reduction by ZHOU Yan-lai, NING Zhi-hao, HE Jun-tao

“…Scheduling analyses for both wet (2020) and dry (2022) years demonstrate that the proposed model is well-suited to different hydrological scenarios, achieving a balance between carbon reduction goals and traditional reservoir functions such as flood control, storage, power generation, and drought resistance. …”
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Analysis of the influence of the microbial load of poultry facilities on the development of keel “mins” in turkeys by R. I. Fedyniak, R. A. Peleno

“…The balanced composition of the microflora in the poultry's environment is one factor that ensures the normal functioning of the gastrointestinal tract, immune, and other systems and supports the body's homeostasis. …”
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