Model for predicting risk of developing drug-induced liver injury during remdesivir therapy: observational prospective open case-control study by Yu. V. Shevchuk, A. V. Kryukov, I. I. Temirbulatov, I. V. Sychev, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev

“…According to a number of studies, the incidence of adverse reactions during remdesivir therapy reaches 66%, with the most common is an increase in liver function tests.The aim of the work was to study the influence of clinical, demographic and pharmacogenetic factors on the development of drug-induced liver damage during remdesivir therapy in COVID-19 patients.Materials and methods. …”
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Digital Therapeutics in China: Comprehensive Review by Nan Jiang, Xiru Yu, Yuxi Yang, Guanqiao Li, Chanchan He, Man Ping Wang, Yih Chung Tham, Tien Yin Wong, Keqin Rao

“…Meta-analysis for diabetes DTx showed a trend toward improved hemoglobin A1c levels in digital intervention groups compared to controls (SMD −0.96, 95% CI −2.03 to 0.11) but did not reach statistical significance (I²=97%). Meta-analysis for cognitive disorder DTx showed significant improvement in global cognitive function in DTx-treated participants (SMD 0.65, 95% CI 0.37-0.94), despite notable heterogeneity (I²=71.7%). …”
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Video game-based application for fall risk assessment: a proof-of-concept cohort studyResearch in context by Antao Ming, Tanja Schubert, Vanessa Marr, Jaqueline Hötzsch, Sebastian Stober, Peter R. Mertens

“…Funding: This project was funded by the Ministry of Science, Economics, and Digitalization of the State of Saxony-Anhalt and the European Fund for Regional Development under the Autonomy in Old Age Program (Funding No: ZS/2016/05/78615, ZS/2018/12/95325) and Healthy Cognition and Nerve function (HeyCoNer, ZS/2023/12/183088).…”
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Landscape Planning and Design of Urban Rivers with Environmental Approach (Case Study: Farahzad River Valley in Tehran) by Zahra Sadrazamnouri, Jafar Nouri, Farah Habib, Mojtaba Rafieian

“…At the present time, structure and function of these valuable elements have been ruined due to non-planning growth and regardless to environmental subjects in municipal management and landscape planning that they have been converted to the runoff canal network or effluent. …”
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Establishment of political and diplomatic relations between Lithuania and France in 1918-1920: Exchange of mistrust by Vilma Bukaitė

“…The Cabinet of Alexandre Millerand, in function from 20 January 1920, was less tolerant towards the Polish political pressure on Lithuania. …”
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Total neoadjuvant chemoradiotherapy plus anti PD-1 for mid-to-low locally advanced rectal cancer: study protocol of a prospective, single arm, phase II study (STARS - RC06) by Meichen Gu, Yuchen Guo, Liang He, Xuan Sun, Tingting Liang, Zhuo Wang, Ying Li, Zheng Liu, Jingyu Wang, Xiang Qiu, Liang Guo, Pengyu Chang, Quan Wang

“…TNT not only increases the pathological complete response (pCR) rate, but also provides patients with more opportunities to preserve organ function. However, TNT mode seems to have reached a plateau. …”
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Selective Brain Hypothermia in the Comprehensive Rehabilitation of Patients with Chronic Consciousness Disorders by M. V. Petrova, O. A. Shevelev, M. Yu. Yuriev, M. A. Zhdanova, I. Z. Kostenkova, M. M. Kanarskii

“…In the control group, scores of patients in VS rose from 4.3 ± 0.37 to 6.8 ± 0.49 (P < 0.001) points with the most significant changes in auditory and visual functions (P<0.001). In the control group of patients in MCS the oromotor function improved (P < 0.05), overall CRS-R scores changed insignificantly from 9.1 ± 0.57 to 10.1 ± 0.86 (P < 0.1). …”
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Identification of polyphosphate-binding proteins in Escherichia coli uncovers targets involved in translation control and ribosome biogenesis by Kanchi Baijal, Brianna Kore, Iryna Abramchuk, Alix Denoncourt, Shauna Han, Abby Simms, Amy Dagenais, Abagail R. Long, Adam D. Rudner, Mathieu Lavallée-Adam, Michael J. Gray, Michael Downey

“…These chains of inorganic phosphates are joined by high-energy bonds and can reach hundreds of residues in length. PolyP plays diverse functions in helping bacteria adjust to changing environmental conditions. …”
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ASIATIC SMELT OSMERUS DENTEX STEINDACHNER ET KNER, 1870 OF THE UDA RIVER (NORTHWESTERN OKHOTSK SEA) — BIOLOGY, ECOLOGY, FISHERY by V. P. Ovsyannikov, A. Yu. Nemchenko, A. N. Kanzeparova

“…The body weight depends on age as the function: Wt = 2.974t 2.136. Individual absolute fecundity of the smelt in the Uda varies from 11300 to 141300 eggs, on average 52500 eggs in 2016 and 50400 eggs in 2007; these values are close to the smelt fecundity in the Ulbeya and Inya rivers. …”
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Application of Jane Jacobs’ Theory in the Analysis of the Borders of Territory Monitoring in Urban Spaces from Citizens’ Points of View in Bandar Abbas by Amirhamzeh Shahbazi, Esmaeil zakerimnabi, Alireza Shahbazi

“…The study sought to identify and analyze the mental boundaries and functional areas of monitoring that manifested in citizens' behavioral patterns. …”
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Network segregation is associated with processing speed in the cognitively healthy oldest-old by Sara A Nolin, Mary E Faulkner, Paul Stewart, Leland L Fleming, Stacy Merritt, Roxanne F Rezaei, Pradyumna K Bharadwaj, Mary Kate Franchetti, David A Raichlen, Cortney J Jessup, Lloyd Edwards, G Alex Hishaw, Emily J Van Etten, Theodore P Trouard, David Geldmacher, Virginia G Wadley, Noam Alperin, Eric S Porges, Adam J Woods, Ron A Cohen, Bonnie E Levin, Tatjana Rundek, Gene E Alexander, Kristina M Visscher

“…Examining the relationship between individual differences in brain organization and cognitive function in older adults who have reached oldest-old ages with healthy cognition can help us understand how these networks support healthy cognitive aging. …”
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F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair by Xu Xu, Feng Gao, Qixin Chen, Bairu Chen, Wenyu Liang, Runzhi Huang, Yuchen Liu, Zhibo Liu, Yanjing Zhu, Gufa Lin, Bei Ma, Letao Yang, Shaorong Gao, Rongrong Zhu, Liming Cheng

“…Importantly, axons grew through the epicenter and reached a length of more than 2.4 mm 56 days post-SCI, significantly improving motor function and reconstructing the neural circuit. …”
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Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a m... by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

“…Unlike vaccinations, AZD7442 reaches effective levels within the body a few hours after a single dose. …”
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The MaNGA Dwarf Galaxy Sample (MaNDala): Stellar Profiles and Gradients Characterization by M. Cano-Díaz, A. Rodríguez-Puebla, A. C. Robleto-Orús, V. Ávila-Reese, H. M. Hernández-Toledo, J. A. Vázquez-Mata, O. Valenzuela, J. J. González, H. J. Ibarra-Medel, J. C. Clemente-González, L. Pavón-Alvarez

“…While the point-spread function has a minor impact on the SP gradients, the choice of methodology for characterizing radial profiles significantly affects them. …”
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Effectiveness of different physical activity programs in improving older adults’ physical capacities: a randomized controlled trial by Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Carolina A. Cabo, Víctor Hernández-Beltrán, Orlando Fernandes, Orlando Fernandes, Cláudia Mendes, Cláudia Mendes, Cláudia Mendes, José M. Gamonales, José M. Gamonales, José M. Gamonales, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, Mário C. Espada, José A. Parraca, José A. Parraca

“…The analysis of the moment*group interaction effect revealed significant differences among the groups, except for the Timed Up and Go (TUG) test.ConclusionIn conclusion, sensorimotor and aquatic training significantly improved physical function, especially balance, strength, and mobility, in older people.…”
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Higher vasoactive usage despite hemodynamic goals is associated with higher mortality in acute myocardial infarction-related cardiogenic shock by Jorge A. Ortega-Hernández, Héctor González-Pacheco, Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, Daniel Sierra-Lara-Martínez, Daniel Manzur-Sandoval, José Luis Briseño-De-La-Cruz, Salvador Mendoza-García, Álvaro Montañez-Orozco, Arturo Arzate-Ramírez, José Omar Arenas-Díaz, César A. Gómez-Rodríguez, Hector Antonio Santos-Alfaro, Jaime Hernández-Montfort, Alexandra Arias-Mendoza

“…The median age was 61 years; most were men (82%), and 82.8% had ST-segment elevation myocardial infarction. End-organ function showed progressive deterioration with escalating vasoactive use. …”
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Clinical efficacy of Ni-Ti memory alloy four-corner arthrodesis concentrator in the treatment of scaphoid nonunion advanced collapse: a follow-up of over 10 years by Baochuang Qi, Minzheng Guo, Chen Meng, Teng Wang, Chuan Li, Yongqing Xu

“…Grip strength in the affected side of all patients recovered to 81.96% compared to the healthy side, while wrist joint mobility in the affected side reached over 60% of the healthy side’s functionality. …”
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Active left atrial ejection fraction as a non-invasive marker in pulmonary hypertension secondary to heart failure by Di Zhou, Xin Li, Jing Xu, Yining Wang, Weichun Wu, Arlene Sirajuddin, Shihua Zhao, Zhihong Liu, Minjie Lu

“…ABSTRACT: Background: Patients with pulmonary hypertension (PH) secondary to left heart failure (HF) exhibit a complex pathophysiological profile and poor prognosis. Left atrial (LA) function is pivotal in the progression of this disease, yet its predictive significance remains exclusive. …”
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An open-label, multiple ascending dose study of the anti-CTLA-4 antibody ipilimumab in viremic HIV patients. by Elizabeth Colston, Dennis Grasela, David Gardiner, R Pat Bucy, Blisse Vakkalagadda, Alan J Korman, Israel Lowy

“…Expression of cytotoxic T-lymphocyte antigen 4 (CTLA-4), a negative regulator of T-cell function, is increased in chronic HIV-1 infection. …”
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A “proto” type galectin expressed in striped bass (Morone saxatilis) tissues is released to epidermal mucus and binds to bacterial and mucus glycans by Davin E. Henrikson, Davin E. Henrikson, Hafiz Ahmed, Hafiz Ahmed, Satoshi Tasumi, Satoshi Tasumi, Mahesh Gokara, Chiguang Feng, Chiguang Feng, Kelsey Abernathy, Kelsey Abernathy, Muddassar Iqbal, Muddassar Iqbal, Mario A. Bianchet, Gerardo R. Vasta, Gerardo R. Vasta

“…M. marinum would evade this defense mechanism to reach and infect the fish skin epithelial layer.…”
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