Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment by Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter

“…Abstract Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of transcription factor binding and thereby play an important role in controlling transcriptional responses to the tissue environment. …”
Get full text

Automated EEG background analysis to identify neonates with hypoxic-ischemic encephalopathy treated with hypothermia at risk for adverse outcome: A pilot study by Anneleen Dereymaeker, Vladimir Matic, Jan Vervisch, Perumpillichira J. Cherian, Amir H. Ansari, Ofelie De Wel, Paul Govaert, Maarten De Vos, Sabine Van Huffel, Gunnar Naulaers, Katrien Jansen

“…Results: Dynamic IBI values reached the best prognostic value between 18 and 24 h (AUC of 0.93). …”
Get full text

Evaluation of the impact of a digital care navigator on increasing patient registration with digital mental health interventions in routine care by Brittany Jaso-Yim, Mara Eyllon, Pratha Sah, Mariesa Pennine, George Welch, Keke Schuler, Laura Orth, Heather O'Dea, Elizabeth Rogers, Lily H. Murillo, J. Ben Barnes, Georgia Hoyler, Gabrielle Peloquin, Kevin Jarama, Samuel S. Nordberg, Soo Jeong Youn

“…Change in registration likelihood as a function of DCN outreach latency was investigated using a Kaplan-Meier plot. …”
Get full text

Effect of lower-body ischemia duration in aortic arch surgery under mild-to-moderate hypothermic circulatory arrestCentral MessagePerspective by Giacomo Murana, MD, Chiara Nocera, MD, Luca Zanella, MD, Luca Di Marco, MD, Silvia Snaidero, MD, Sabrina Castagnini, MD, Carlo Mariani, MD, Davide Pacini, MD, PhD

“…The link between visceral ischemic times and in-hospital outcomes, and visceral function biomarker levels were retrospectively analyzed through chi-square test, nonparametric analysis of variance, and cubic spline interpolation. …”
Get full text

Validation of Revised Chinese Version of PD-CRS in Parkinson’s Disease Patients by Yuyan Tan, Weiguo Liu, Juanjuan Du, Miaomiao Hou, Cuiyu Yu, Yang Liu, Shishuang Cui, Lei Yan, Yizhou Lu, Hong Lv, Lijun Han, Xi Wang, Shengyu Zha, Xiaoguang Luo, Huidong Tang, Shengdi Chen

“…All the frontal-subcortical and instrumental-cortical functions showed significant decline in PDD compared with the PD-NC group (p≤0.001). …”
Get full text

Safety and effectiveness analysis of proximal extended excision Bacon (PE-Bacon) in the treatment of late complications of radiation-induced rectal injury by Lin Zihong, Huang Binjie, Zhen Chaohui, Qin Qiyuan, Luo Jielong, Yang Zhiyong, Xiu Fengmin, Liang Rui, Ma Tenghui

“…Surgical indicators (surgical approach, operative time, intraoperative blood loss, intraoperative blood transfusion), postoperative complications, stoma reversal, and defecation function after stoma reversal were collected and analyzed. …”
Get full text

Serial casting for contractures in SMA: consensus derived guidelines for treatment by Laurey Brown, Katie Hoffman, Chiara Corbo-Galli, Carolyn Kelley, Terri Carry, Matt Civitello, Giorgia Coratti, Roberto DeSanctis, Tina Duong, Brigid Driscoll, Jean Flickinger, Allan M. Glanzman, Jennifer Jones, Elizabeth Maczek, Dionne Moat, Jacqueline Montes, Robert Muni-Lofra, Leslie Nelson, Leslie Nelson, Amy Pasternak, Melanie Valle, Kristin J. Krosschell, Kristin J. Krosschell

“…Serial casting has been used in a variety of other peripheral nerve, muscle, and central nervous system disorders to improve knee and ankle range of motion limitations and functional performance in both ambulatory and non-ambulatory individuals.ObjectiveThe goal of this study was to reach a consensus about the parameters, considerations and general guidelines that should inform practice when serial casting to improve flexibility in individuals with SMA.MethodsThis international effort was conducted between August 2020 and May 2023. …”
Get full text

Psychotherapies for adults with complex presentations of PTSD: a clinical guideline and five systematic reviews with meta-analyses by Ole Jakob Storebø, Sophie Juul, Stephen Fitzgerald Austin, Maria Quistgaard, Julie Perrine Schaug, Lise Møller, Nina Reinholt, Dyveke Bové Illum, Frida Lau Græbe, Line Bang Mikkelsen, Nina Nørrelykke Paulsen, Adrian Maria Tremel Porsing, Oliver Rumle Hovmand, Mie Sedoc Jørgensen, Ida-Marie Terese Pereira Arendt, Magnus Tang Kristensen, Sidsel Christine Buskbjerg Døssing, Bent Rosenbaum, Nicole Gremaud Rosenberg, Sidse Marie Arnfred

Get full text

Disparities in dolutegravir utilisation in children, adolescents and young adults (0–24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort by Valériane Leroy, Anandi Sheth, Julie Jesson, Jean Jacques Koffi, Antoine Jaquet, François Dabis, Didier Koumavi Ekouevi, Karen Malateste, Olivia Keiser, Lehila Bagnan, Simon Boni, Madeleine Amorissani Folquet, Mariam Sylla, Olivier Marcy, Raoul Moh, Gildas Boris Hedible, Sophie Desmonde, Joycelyn Dame, Agatha David, Madeleine Amorissani-Folquet, Sylvie N'Gbeche, Elom Takassi, François Tanoh Eboua, Kouadio Kouakou, Lehila Bagnan Tossa, Caroline Yonaba, Jocelyn Dame, Sylvie Marie N’Gbeche, Fatoumata Dicko Traore, Oliver Ezchechi, Rosemary Audu, Charlotte Bernard, Caroline Couturier, Marie Kerbie Plaisy, Elodie Rabourdin, Thierry Tiendrebeogo, Désiré Dahourou, Emile Sodinyessi, Jean-Claude Azani, Kadidja Diarra, Maika Bengali, Abdoulaye Cissé, Guy Gnepa, Eric Komena, Séverin Lenaud, Eulalie Kangah, Igho Ofotokun, Cecile Delille Lahiri, Noëlle Benzekri, Geoffrey Gottlieb

“…The overall cumulative incidence of DTG initiation reached 22.7% (95% CI 21.3 to 24.2) and 56.4% (95% CI 54.4 to 58.4) at 12 and 24 months, respectively. …”
Get full text

Estudio del empleo de un convertidor catalítico para las emisiones gaseosas en un motor de ignición por chispa usando etanol como combustible. // Study of the employment of a catal... by K. C. R. Martins, F. Soto Pau, J. A. Silva, A. M. dos Santos, R. F. E. Santos

“…The catalytic convector reaches 75%<br />of efficiency when the ignition advance angle of the engine increased to 16o. …”
Get full text

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…For many, pain significantly impairs quality of life and everyday functioning. Behavioral interventions have shown utility, but access remains limited. …”
Get full text

Influência de um protocolo de criopreservação no rendimento in vitro de células-tronco derivadas do tecido adiposo Effect of a cryopreservation protocol on the in vitro yield of ad... by Fernanda Ginani, Diego Moura Soares, Carlos Augusto Galvão Barboza

“…Cryopreservation maintains stem cells in a live state for long periods of time, without impairing their function. The aim of this study was to assess the effect of a cryopreservation protocol on the proliferation of adipose-derived stem cells. …”
Get full text

The first experience of using upadacitinib in the treatment of rheumatoid arthritis in real clinical practice (results of the multicenter project “RACURS”) by V. N. Amirjanova, A. E. Karateev, E. Y. Pogozheva, A. A. Baranov, V. I. Mazurov, R. R. Samigullina, O. N. Anoshenkova, N. A. Lapkina, T. Yu. Grineva, E. L. Nasonov, A. M. Lila

“…A pronounced improvement in joint function (70% improvement according to the criteria of the American College of Rheumatology) was noted by 33.3% of patients, population indicators of functional state (HAQ≤0.5) had 15.8% of patients. …”
Get full text

Frictional Characteristics and Mechanical Model of PTFE Against Stainless Steel Under Low Loads by ZHAO Shoujiang, DAI Junwu

“…Based on the test results concerning the relationship between friction coefficient and sliding velocity, the proposed exponential function model proves to be more suitable for simulating the friction behavior under low loads and for accurately evaluating the isolation effect of sliding isolation bearings. …”
Get full text

Evaluation of the efficacy of high molecular weight hyaluronic acid with chondroitin sulfate in post-traumatic knee osteoarthritis by E. I. Bialik, M. A. Makarov, V. A. Nesterenko, V. E. Bialik, A. E. Karateev, A. A. Bialik, V. I. Stadnik

“…The maximum pain reduction and functional improvement were observed in the first 3 months after local injection therapy.…”
Get full text

Immunobiological status of the organism of young pigs during their triphasic period cultivation and actions of corrective factors by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, I. V. Dvylyuk, N. V. Magrelo, H. V. Sus, U. M. Vus, T. V. Martyshuk, V. V. Voroniak, A. O. Vysotskyi, O. O. Dashkovskyi

“…Research data prove that the specificity of the action of Ig Y has a positive effect on the preservation of the integrity of the villi of the intestinal mucosa, which is reflected by the strengthening of its protective and barrier function, which in general contributes to the increase in the percentage of animal survival: using Globigen®Pig Doser 80.0 % and 86.7 % using Globigen®Jump Start. …”
Get full text

Un Nuevo Método de Identificación Basado en la Respuesta Escalón en Lazo Abierto de Sistemas Sobre-amortiguados by Luis A. Mora, Jhon E. Amaya

“…Initially the transient behavior of transfer functions with multiple real poles is analyzed, establishing analytical formulas to estimate the time it takes for these systems to reach certain points of his reaction curve to stimuli of the step type, including settling time for error criteria of 2% and 5%. …”
Get full text

GWAS combined with transcriptomics revealed key regulatory genes for inflorescence traits and fruit set rate in Litchi (Litchi chinensis Sonn.) by Fachao Shi, Kan Huang, Yonghua Jiang, Hailun Liu, Yingjie Wen, Qian Yan

Get full text

Impact of Urban-Rural Integrated Development on Carbon Emission Intensity of Land Use: A Case Study of the Changsha–Zhuzhou–Xiangtan Urban Agglomeration by Li Xiaoqing, Zhou Guohua, Cui Shuqiang, Wang Hua, Liu Hui, Yu Xuexia

“…Against the backdrop of intensifying global climate change, an international consensus has been reached on the realization of the "dual carbon" goal. …”
Get full text

Application of augmented reality technology in the surgery of skull base tumor and cerebrovascular disease by GUO Yi⁃ding, ZHAO Ben⁃qi, ZHANG Pei⁃hai, LIU Yong, CHEN Gang, YANG Xue⁃jun, GUO Yi

“…Results 1) Vestibular schwannoma resection: compared to the preoperative AR assisted simulation, we fully replicated the procedures of retrosigmoid approach craniotomy, removal of the posterior wall of internal auditory canal, and the exposure and removal of the internal auditory canal tumor during surgical practice. Facial nerve function was preserved intact during the surgery and reached House⁃Brackmann grade Ⅰ , but effective hearing was not preserved. …”
Get full text