Overexpression of the apple expansin-like gene MdEXLB1 accelerates the softening of fruit texture in tomato by Yan-hui CHEN, Bin XIE, Xiu-hong AN, Ren-peng MA, De-ying ZHAO, Cun-gang CHENG, En-mao LI, Jiang-tao ZHOU, Guo-dong KANG, Yan-zhen ZHANG

“…The biological function of the EXLB subfamily gene, MdEXLB1, was further identified, and its subcellular localization on the cell wall was confirmed by transient transformation experiments. …”
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Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study by Michael Smith, Ignacio Garrido-Laguna, Aung Naing, Lance Leopold, Jason J Luke, Kai Ding, Solmaz Sahebjam, Ryan Geschwindt, John D Powderly, John J Nemunaitis, Aaron S Mansfield, Wells A Messersmith, Patricia M LoRusso, Jordan D Berlin

“…The maximum tolerated dose was not reached for either the combination of itacitinib plus epacadostat (n=47) or itacitinib plus parsaclisib (n=90). …”
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Exergy and energy-based sustainability evaluation of diesel-biodiesel-ethanol blends with emission forecasting using advanced machine learning models by Harish Venu, V. Dhana Raju, Jayashri N. Nair, Sameer Algburi, Ali E. Anqi, Ali A. Rajhi, Mohammed Kareemullah

“…To optimize fuel parameters, the Desirability Function Approach (DFA) integrated with Response Surface Methodology (RSM) was employed. …”
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Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries. by Andrew B Linden, Robert Clarke, Imen Hammami, Jemma C Hopewell, Yu Guo, William N Whiteley, Kuang Lin, Iain Turnbull, Yiping Chen, Canqing Yu, Jun Lv, Alison Offer, Derrick Bennett, Robin G Walters, Liming Li, Zhengming Chen, Sarah Parish, China Kadoorie Biobank Collaborative Group

“…In addition, genetically determined height was also positively associated with atrial fibrillation (available only in UKB), and with lean body mass and lung function, and inversely associated with low-density lipoprotein (LDL) cholesterol in both British and Chinese ancestries. …”
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Plasma cell targeting with the anti-CD38 antibody daratumumab in myalgic encephalomyelitis/chronic fatigue syndrome—a clinical pilot study by Øystein Fluge, Øystein Fluge, Ingrid Gurvin Rekeland, Kari Sørland, Kine Alme, Kristin Risa, Ove Bruland, Karl Johan Tronstad, Olav Mella

“…For all 10 patients, mean SF-36 Physical Function (SF-36 PF) increased from 25.9 to 55.0 at 8–9 months (p = 0.002). …”
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Human and Machine: A View through Kant's Use of Regulative Reason by Ümit Taştan

“…According to Kant, the regulative function of reason supplies the concepts of pure reason that guide scientific inquiry. …”
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Influence of structural surface roughness on the strength of layered fill bodies based on PFC2D by Jinxing WANG, Zongsheng HU, Huazhe JIAO, Xiaolin YANG, Qi ZHANG, Xiaohui LIU, Ping XU, Junqiang XU, Xun CHEN

“…Linear and quadratic polynomial fittings of strength versus roughness reveal a quadratic polynomial relationship between strength and roughness, indicating that this function effectively characterizes the correlation between the compressive strength and bonding surface roughness of the backfill. …”
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Effects of the efficacy of the Yi Shen Tiao Gan formula on aromatase inhibitor associated musculoskeletal syndrome: a randomized controlled trial by Yan Zhang, Meiling Chu, Meina Ye, Yiqin Cheng, Hui Cong, Yulian Yin, Hongfeng Chen

“…After applying Bonferroni correction for multiple testing, these associations did not reach statistical significance. No serious adverse events were observed in either group.ConclusionThe YSTG formula significantly reduced WOMAC scores, improving pain, stiffness, physical function in patients with AIMSS, and alleviating the traditional Chinese medicine symptoms and signs of liver and kidney deficiency, thereby enhancing the overall quality of life for patients.Clinical Trial Registrationhttp://www.chictr.org.cn, identifer ChiCTR2200057785.…”
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Construction of water injection seepage model for coal body and microscopic dominant influence law by Enmao WANG, Gang WANG, Shuliang XIE, Hongzhao WEI, Jing FENG, Handan LIANG

“…This technique is crucial for managing dust in underground operations. As mining operations reach greater depths and face diverse geological challenges, understanding the impact of various factors on coal seam water injection becomes crucial. …”
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Clinical and Radiological Comparison of Unilateral Biportal Endoscopic and Percutaneous Transforaminal Endoscopic Discectomy in the Treatment of Lumbar Spinal Degenerative Disease by Hongtao Ding, Xiao Han, Yonggang Xing, Yajun Liu, Da He, Xiaoguang Han

“…Conclusion Both PTED and UBE surgeries can achieve satisfactory improvement in symptoms and function for patients with lumbar spinal degenerative disease and can be well‐maintained as a first‐line minimally invasive treatment. …”
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Assessment of the effectiveness and safety of fixed-dose combination of alogliptin and pioglitazone in real clinical practice: results of the PROsperity study by M. V. Shestakova, M. I. Kharakhulakh, Y. A. Belolipetsky

“…This allows the new combination to be considered the next step in the treatment for all groups of patients with type 2 diabetes mellitus who have not reached the target glycemic control on previous therapy.…”
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Dependence of reactions of the external respiratory system in athletes on the orientation of the training process by S. M. Kanyhina, M. S. Potapenko, L. O. Kurilets

“…Issues of improving the functional training (different orientation of the training process) of athletes due the development of the respiratory system, including the respiratory system, as well as increasing the body's resistance to hypoxic stress remain extremely relevant at the present stage of sport development. …”
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Ischemic heart disease burden attributable to inadequate omega-3 fatty acid intake in Chinese adults, 1990–2021: an Age-Period-Cohort analysis of the Global Burden of Disease study... by Lin Luo, Lin Luo

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Construction of prediction model for water retention of forest ecosystem in alpine region based on vegetation spectral features by Teng Niu, Zhongze Hou, Jiaxin Yu, Jie Lu, Qiang Yu, Linzhe Yang, Jun Ma, Yafei Liu, Hui Shi, Xuyang Jin

“…The water retention service of the forest ecosystem has ecological functions such as adjusting the climate and maintaining the ecological water balance. …”
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The impact of scleral contact lenses correction of keratoconus on wave-front and accommodation parameters by E. P. Tarutta, A. T. Khandzhyan, N. A. Tarasova, S. G. Harutyunyan, O. V. Guryanova, A. V. Ivanova

“…With scleral contact lenses that correct the shape of the anterior surface of the cornea, the level of all corneal aberrations dropped to nearly normal values, while the coefficient of asphericity dropped below normal values, and the point spread function parameter (PSF) increased by fifteen times (to reach 0.06).Conclusions. …”
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INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“… The main task of modern orthodontics is to create a balanced and morphologically stable occlusion in harmony with facial aesthetics and functional adaptation. Over the last decade, there has been a clear trend towards an increase in the prevalence of malocclusion, which reaches 80% according to current scientific literature and sometimes it exceeds this percentage. …”
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Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism by Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli, Farhad Motavalli Khiavi

“…In this paper, with a greater emphasis on CAR-T cell application in the treatment of MM, we will discuss and introduce CAR-T cell’s history and functions, their limitations, and the solutions to defeat the limitations and different types of modifications on CAR-T cells.…”
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Engineered iNKNKG2A KO cells possess HLA-E specific anti-tumor activity by QIAO Wenhua, XU Yi, DONG Peng, HE Wei, CHEN Hui, ZHANG Jianmin

“…This result highlights their potential function as a novel adoptive cell therapy strategy for cancers reliant on HLA-E-mediated immune evasion.…”
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Enteric glia regulate Paneth cell secretion and intestinal microbial ecology by Aleksandra Prochera, Anoohya N Muppirala, Gavin A Kuziel, Salima Soualhi, Amy Shepherd, Liang Sun, Biju Issac, Harry J Rosenberg, Farah Karim, Kristina Perez, Kyle H Smith, Tonora H Archibald, Seth Rakoff-Nahoum, Susan J Hagen, Meenakshi Rao

“…Whether these interactions are important in vivo, however, is unclear because previous studies reached conflicting conclusions (Prochera and Rao, 2023). …”
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Mechanisms of Flavor Substance Formation in Pengqi Sauce Based On an Integrated Analysis of Absolute Microbial Quantification and Volatomics by Xiaojie Hou, Hongmei Yin, Xiaodie Qin, Jingjing Zhang, Yangyang Wang, Weiming Su, Hui Cao, Hui Wang

“…ABSTRACT Pengqi sauce is a traditional Chinese naturally fermented aquatic product, and its unique flavor formation mechanism is closely related to microbial function. In this study, we combined metabolomics and microbiomics techniques to analyze the flavor evolution and the rules and mechanisms of bacterial flora action during the natural fermentation process of Wedelia sauce. …”
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