Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation by Chunli Wang, Zongtao Liu, Tingwen Zhou, Jiaqin Wu, Fan Feng, Shunshun Wang, Qingjia Chi, Yongqiang Sha, Shuai Zha, Songren Shu, Linghang Qu, Qianqian Du, Huiming Yu, Li Yang, Anna Malashicheva, Nianguo Dong, Fei Xie, Guixue Wang, Kang Xu

“…Isotope labeling and 13C flux analyses confirmed that butyric acid produced in the intestine can reach heart tissue, where it reshapes glycolysis by specifically modifying GAPDH. …”
Get full text

Protocol for a Field Trial of a Hearing and Vision Support Intervention for People Living in Long‐Term Care in Australia by Carly Meyer, Najwan El‐Saifi, Naomi Rose, Kasia Bail, Colette Browning, Dayna Cenin, Antonio Ahumada‐Canale, Megan Campbell, Tim England, Melanie Ferguson, Yuanyuan Gu, Reema Harrison, Chyrisse Heine, Lisa Keay, Sheela Kumaran, Iracema Leroi, Gerald Liew, Angelita Martini, Ralph Martins, John Newall, Smriti Raichand, Emma Scanlan, Hamid R. Sohrabi, Melinda Toomey, Johanna Westbrook, Piers Dawes

“…This protocol involves a systematic evaluation of the effectiveness and implementation challenges of a pragmatic SSI to optimise hearing and vision function and improve the quality of life for long‐term care residents and their caregivers.…”
Get full text

Lecanemab in clinical practice: real-world outcomes in early Alzheimer’s disease by Noa Bregman, Talya Nathan, Dror Shir, Nurit Omer, Mori Hai Levy, Aya Bar David, Orna Aizenstien, Eyal Lotan, Yifat Alcalay, Anan Abu Awad, Avi Gadoth, Elissa Ash, Tamara Shiner

“…At 12 months, 31 patients had reached follow-up, with no significant change in MMSE scores observed (F(1, 17.18) = 2.49, p =.133). …”
Get full text

De macrostructuur van het boek Samuël en de theologische implicaties daarvan by HJ Koorevaar

“…The begetting of Samuel and its function. a. 1.1. The begetting of Samuel. b. 1.2:1-11. …”
Get full text

Contribution of the major HCHO metabolic pathways to HCHO-uptake by geranium leaves under liquid HCHO stress by Han Shuang, Xiao Suqin, Sun Zhen, Xuan Xiuxia, Li Kunzhi, Chen Limei

“…Results suggested that the HCHO-absorption by geranium leaves was a power function in relation with the treatment time. In 2 mmol/L HCHO treatment, during the early stage (0-24 h), the primary functioned metabolic pathway was the Cit produced pathway in geranium leaves. …”
Get full text

The dynamics of the content of immunoglobulins in the blood serum of piglets according to the actions of immunostimulating agents by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, I. V. Dvyliuk, N. V. Magrelo, H. V. Sus, V. V. Voroniak, A. O. Vysotskyi, U. M. Vus, T. V. Martyshuk

“…We believe that the increase in the content of class A immunoglobulins, most likely the secretory form of the piglets themselves, when using Globigen® Jump Start, which reached the mark of 1.48 mg/ml, indicates the formation of immune resistance mechanisms. …”
Get full text

Adsorption kinetics of tea waste to catechins by Hu Shuqin, Tang Yi, Liu Li

“…Catechins, the main functional components in tea, were generally recognized as possessing desirable biological and physiological effects, such as ant-i oxidation, ant-i cancer, reducing the risk of cardiovascular diseases etc. …”
Get full text

The Impact of High Canopy Vegetation-Atmosphere Storage on Surface Energy Closure over the Eastern Slope of the Qinghai-Xizang Plateau by Yuchen LIU, Maoshan LI, Na CHANG, Yonghao JIANG, Ting WANG, Pei XU

“…The phenomenon of near-surface energy budget imbalance is widespread， especially in the complex underlying surface such as mountain lakes.Due to the heterogeneity of the surface， the energy closure is poor， and the influence of the energy storage term between the atmosphere of the high canopy vegetation in the mountain on the energy closure is often ignored.This paper is based on the gradient tower meteorological data， radiation observation data and turbulence observation data of the eddy covariance system of Mount Emei Atmosphere and Environment Comprehensive Observation Experimental Station of Chengdu University of Information Technology （hereinafter referred to as "Mount Emei Station"） from June 2022 to October 2022.The Ogive function was used to analyze the average time suitable for the turbulent flux calculation at the forest station， and the soil heat flux and energy storage between vegetation and atmosphere were calculated， and the changes of near-surface energy balance after considering the storage terms between vegetation and atmosphere were analyzed.The results show that extending the average time to calculate turbulent flux to 60 minutes can capture larger turbulent vortices at some moments to a certain extent， but the energy balance ratio is lower than the average time of 30 minutes， so it is considered that the average time of 30 minutes is still suitable for the calculation of turbulent flux at Emei Mountain Station.The energy storage item of vegetation atmosphere improves the energy balance ratio by about 3.65%.Considering that this item has the effect of improving energy closure in most of the time， the energy storage item of photosynthesis contributes the most to improving energy closure， followed by the heat storage item of vegetation canopy， followed by the sensible heat storage item， and the latent heat storage item contributes the least.All the energy storage items in the atmosphere of high canopy vegetation have obvious single-peak diurnal variation characteristics.The peak value of heat storage items in vegetation canopy can reach up to 26 W·m-2， and the energy balance ratio can be increased by 1.57% when the heat storage items in vegetation canopy are considered.The peak value of the photosynthetic storage term can reach about 8 W·m-2， and the average daily storage capacity is about 141.6 W·m-2， which is the main energy storage term.Considering the photosynthetic storage term， the energy balance ratio can be improved by 1.65%， accounting for 45% of the overall effect.The peak value of sensible heat storage term is about 5 W·m-2， the magnitude of latent heat storage term is very small， and the effect on energy closure is also small.Vegetation-atmosphere storage terms cannot be ignored except latent heat storage terms which are very small.When considering the energy storage between vegetation and atmosphere， the energy closure problem still exists.Therefore， in addition to the energy storage term， the influence of large-scale vortices induced by the underlying mountain surface on the near-surface energy budget also needs to be further studied.…”
Get full text

Multi-Objective Optimization of Machine Learning-Based Nonlinear Equalizers for Digital Coherent Optical Interconnects by Lucas C. Dantas, Hildo Guillardi Junior, Plinio Dester, Rafael A. Penchel, Jose Augusto de Oliveira, Marcelo L. F. Abbade, Leandra I. Abreu, Jinlong Wei, Ivan Aldaya

“…Traditional nonlinear compensation techniques, such as the Inverse Volterra Series Transfer Function (IVSTF) and Digital Back Propagation (DBP), are computationally expensive and require oversampling. …”
Get full text

Effect of age and body condition score on reproductive organ size and sperm parameters in captive male African lion (Panthera leo): Suggesting a prime breeding age by Imke Lueders, Johanna Reuken, Ilse Luther, Gerhard van der Horst, Antoinette Kotze, Adrian Tordiffe, Harald Sieme, Ulrike Jakop, Karin Mueller

“…Physical maturity appeared to be reached between the ages of three and five years, which is later than sexual maturity in male lions.Lions that far exceeded the normal body weight range and had a BCS of 8 or 9 had lower semen quantity and quality. …”
Get full text

Abrasion Resistance and Mechanism Analysis of Polyethylene Fiber-reinforced Cementitious Composite by ZI Jinjia, LI Weibin, WANG Jihong, WANG Zhiwen, LIU Yunjun, NONG Qingshun, LI Bixiong

“…ObjectiveIn hydraulic structures of the Qinghai–Xizang Plateau region, abrasion damage caused by sediment-laden water flows severely undermines the durability of hydraulic spillways, posing a significant challenge to the long - term stability and functionality of water conservancy infrastructure. Although previous studies have explored methods to enhance the abrasion resistance of concrete, the specific influence mechanism of fibers on the mechanical properties, abrasion resistance remains unclear. …”
Get full text

Analyzing the Impact of the Presence of Foreign Tourists in Religious Places on Their Attitude Towards Shiism by Marziyeh Farshiddost, Behrooz Badkoo, Mohamad Ghasemisiani

“…The research interviews continued until reaching theoretical saturation (saturation was achieved by conducting 15 interviews). …”
Get full text

Time to treat the climate and nature crisis as one indivisible global health emergency by Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski

“…This has allowed ecosystems to be pushed further to the brink, greatly increasing the risk of arriving at ‘tipping points’, abrupt breakdowns in the functioning of nature.2,24 If these events were to occur, the impacts on health would be globally catastrophic. …”
Get full text

Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1: Results from a Phase III Clinical Trial by Jeffrey M. Saland, John C. Lieske, Jaap W. Groothoff, Yaacov Frishberg, Hadas Shasha-Lavsky, Daniella Magen, Shabbir H. Moochhala, Eva Simkova, Martin Coenen, Wesley Hayes, Julien Hogan, Anne-Laure Sellier-Leclerc, Richard Willey, John M. Gansner, Sally-Anne Hulton

“…Introduction: Patients with primary hyperoxaluria type 1 (PH1), a genetic disorder associated with hepatic oxalate overproduction, frequently experience recurrent kidney stones and worsening kidney function. Lumasiran is indicated for the treatment of PH1 to lower urinary and plasma oxalate (POx). …”
Get full text

Self-Correction Sensor for Measuring Medium DC Voltage Based on Resistance Voltage Divider by Xiaojun Tang, Pan Pan, Feng Zhang, Ling Yan, Yangyu Lyu, Yi Wu, Mingzhe Rong, Berihun Gebreyohannes Teklu

“…The experimental results show that the sensor can perform self-correction without manual operation, and the sensor's accuracy can reach 0.12%. Sensors with a self-calibration function can realize long-term high-precision measurement without manual maintenance, showing a good application prospect.…”
Get full text

A Ralstonia solanacearum effector regulates plant cell death by disrupting the homeostasis of the BPA1-ACD11 complex by Bingbing Xue, Yan Zhou, Yongxiao Xie, Xiaocheng Huang, Jinye Zhang, Yang Zhang, Wenyan Zhong, Jinjia Zhao, Dehong Zheng, Lifang Ruan

“…Visualization of RipD delivery by R. solanacearum indicated that it reaches levels sufficient to promote ACD11 accumulation and inhibit cell death. …”
Get full text

Joint risk assessment of drought and heat stroke in rainfed maize in Córdoba, Argentina by Antonio de la Casa, Gustavo Ovando, Guillermo Díaz, Pablo Díaz, Fernando Soler, Juan Clemente, Karina Torterolo, Lorenzo Gabba

“…According to the bivariate normal probability function, the joint risk of both factors occurs in approximately 7–10 % of the years in both December and January, corresponding to roughly half of the drought and heat stroke episodes considered independently.…”
Get full text

Population Pharmacokinetics and Model-Informed Precision Dosing of Clobazam Based on the Developmental and Genetic Characteristics of Children with Epilepsy by Yali Tuo, Xiaolong Yu, Sichan Li, Jun Wang, Maochang Liu, Xinwen Song, Jiehui Ma, Yang Wang, Zhisheng Liu, Dan Sun

“…The developmental characteristics, CYP2C19 genotype, concomitant medications, and liver and kidney function indicators of the children with epilepsy were considered potential factors affecting the pharmacokinetic characteristics of CLB and N-CLB and analyzed using a PPK modeling approach. …”
Get full text

Bisphenol S interrupted axonogenesis on a human embryonic stem cells derived neural differentiation model: Conserved axon guidance and WNT signaling pathway involved by Wanqing Guo, Wei Xiong, Liang Wang, Xiaoya Wang, Yongru Zhou, Yili Chen, Xiaomeng Li, Lishi Zhang, Mengmei Ni, Jinyao Chen

“…The results revealed that BPS exposure interrupted axonogenesis, manifesting a trend of initial stimulating followed by inhibition, and peaked at the intermediate dose (3.75 μM) significantly, then reached the nadir at the high dose (375 μM) significantly in the precursor to maturation stage and the whole differentiation stage. …”
Get full text

Design and methodology of the ‘endometriosis and pelvic floor dysfunction’ (EndoPFD) multicenter cross-sectional study by Eleonora Russo, Maria F. Brancalion, Tiziana Fidecicchi, Maria M. Montt-Guevara, Giulia Misasi, Clara Baroni, Riccardo Morganti, Cristina Zito, Elena Pisacreta, Sara Gorini, Alessandro Sturiale, Giorgio Pomara, Jessica Ottolina, Andrea Scalera, Angela Maria Di Puoti, Salvatore Tolone, Gaetano Scalzone, Marco Torella, Stefano Salvatore, Tommaso Simoncini

“…Moreover, it demonstrates the validity of the method used (online survey and recruitment) to reach a high number of patients.…”
Get full text