RADICAL CORRECTION OF COMBINED CONGENITAL HEART DISEASE IN PATIENT WITH EXTRAHEPATIC PORTAL HYPERTENSION by A.S. Ivanov, O.M. Tsirulnikova, S.V. Glamazda, A.V. Lebedeva, N.N. Abramova, V.V. Kuzmin, E.K. Galnykina

“…Circulatory failure II A., functional class III. Extrahepatic portal hypertension. …”
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A Multidata Approach to Open Clusters: Roslund 3 and Ruprecht 174 in CCD UBV and Gaia DR3 Context by Hülya Karagöz, Talar Yontan, Selçuk Bilir, Olcay Plevne, Tansel Ak, Serap Ak, Remziye Canbay, Timothy Banks

“…The present-day mass function slopes were found to be 1.18  ±  0.13 for Roslund 3 and 1.53  ±  0.30 for Ruprecht 174, consistent with the canonical Salpeter value within uncertainties. …”
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Hybrid kinetic analysis of FR-2 and FR-4 type printed circuit boards: A thermogravimetric analysis by Anuj Thukral, Adhithiya Venkatachalapati Thulasiraman, Arun K. Vuppaladadiyam, Savan Kumar Patel, Manoj Kumar Jena, Kalpit Shah, Neha Gupta, Rahul Saha, Anuushka Pal, Parveen Saini

“…For FR-4 NMFs, the reaction function f(α) is between random nucleation with three nuclei on the individual particle (F3) and random nucleation with one nucleus on the individual particle (F1) over the selected range of conversion. …”
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Anti-factor Xa during unfractionated heparin therapy in critically ill patients: Development of prediction models using machine learning by Boris Delange, Guillaume Bouzillé, Pauline Guillot, Anaëlle Bichon, Océane Bernard de Lajartre, Isabelle Gouin, Yoann Launey, Alexandre Mansour, Mathieu Lesouhaitier, Jean-Marc Tadié, Arnaud Gacouin, Marc Cuggia, Adel Maamar

“…Models incorporated UFH rate, bolus, prior anti-Xa, kidney function, inflammation, volemic state, extracorporeal membrane oxygenation, and bilirubinemia. …”
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Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT by Merve Postalcioglu, Ronit Katz, Simon B. Ascher, Trenton Hall, Pranav S. Garimella, Stein I. Hallan, Joachim H. Ix, Michael G. Shlipak

“…Introduction: Urine epidermal growth factor (uEGF) has been found to be inversely associated with kidney function loss, whereas its associations with cardiovascular disease (CVD) and mortality have not been studied. …”
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Prognostic value of left atrial strain in acute and chronic heart failure: A meta‐analysis by Maria Concetta Pastore, Mariangela Vigna, Andrea Saglietto, Maria Alma Iuliano, Giulia Elena Mandoli, Andrea Stefanini, Chiara Carrucola, Laura Fusini, Luna Cavigli, Flavio D'ascenzi, Marta Focardi, Serafina Valente, Matteo Cameli

“…Over a median follow‐up of 903 [321; 1062] days, 2688 patients reached the primary endpoint (944 all‐cause mortality and 1963 hospitalizations). …”
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Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts by Arbi Guetat, Slimen Selmi, Abdelrhman T. Abdelwahab, Marwa A. Abdelfattah, Abd Ealrhman M. Elhaj, Roaa T. Mogharbel, M. J. A. Abualreish, Abdullah F. Alanazi, Karim Hosni, Naceur Mejri, Abdennacer Boulila

“…IntroductionDiabetes is a major health issue that has reached alarming levels worldwide. Although their effectiveness, the antidiabetic drugs have many side effects such as cardiovascular diseases, kidney failure, and hepatic complications. …”
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Efficacy of P62-expressing plasmid in treatment of canine osteoarthritis pain: a pilot study by Vladimir Gabai, Evgeny Bakin, Maxim Langs, Robert Devlin, Sergei Krasny, Yauheni Baranou, Sergey Polyakov, Maksim Patapovich, Sergey Gvozdev, Maksim Kardash, Aliaksei Bazyleuski, Andrei Yeliseyeu, Egor Lelikov, Andrei Borodko, Alexander Shneider, Alexander Shneider

“…IntroductionOsteoarthritis (OA) is a progressive degenerative disease of synovial joints which is highly prevalent in dogs and results in lameness, loss of joint function and mobility, chronic pain, and reduced quality of life. …”
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Fatty acid composition and biological activity of four olive oils from Kabylia (Algeria) against Rhyzopertha dominica (Coleoptera: Bostrychidae) infesting wheat seeds by Safia KERBEL, Ines ABDELLI, Hakim AZZI, Jean-Francois DEBRAS, Abdellah KELLOUCHE

“…The toxicity of the oils varied as a function of the dose and the duration of treatments. …”
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Improving gene editing of CRISPR/Cas9 using the callus-specific promoter pYCE1 in cassava (Manihot esculenta Crantz) by Yuanchao Li, Yuanchao Li, Ruxue Bao, Ruxue Bao, Mengtao Li, Mengtao Li, Changying Zeng, Haojie Yang, Haojie Yang, Yuan Yao, Yuan Yao, Yuan Yao, Youzhi Li, Wenquan Wang, Xin Chen, Xin Chen, Xin Chen

“…This approach paves the way for advanced gene function research and genetic breeding in cassava.…”
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KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism by Cheng Xu, Andrea Messina, Emmanuel Somm, Hichem Miraoui, Tarja Kinnunen, James Acierno, Nicolas J Niederländer, Justine Bouilly, Andrew A Dwyer, Yisrael Sidis, Daniele Cassatella, Gerasimos P Sykiotis, Richard Quinton, Christian De Geyter, Mirjam Dirlewanger, Valérie Schwitzgebel, Trevor R Cole, Andrew A Toogood, Jeremy MW Kirk, Lacey Plummer, Urs Albrecht, William F Crowley, Moosa Mohammadi, Manuel Tena‐Sempere, Vincent Prevot, Nelly Pitteloud

“…Peripheral FGF21 administration could indeed reach GnRH neurons through circumventricular organs in the hypothalamus. …”
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Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy? by Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis

“…Preclinical models indicate that vaccines targeting specific atherosclerosis-related autoantigens can slow disease progression while preserving systemic immune function. In this context, numerous experimental studies have advanced the understanding of vaccine development by exploring diverse targeting pathways. …”
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Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardi... by Ke Shi, Ge Zhang, Rong Xu, Xue-Ming Li, Li Jiang, Yue Gao, Hua-Yan Xu, Yuan Li, Ying-Kun Guo, Zhi-Gang Yang

“…Obesity in conjunction with a SMI lower than the median is referred to as SO. The LV volume and function, as well as the systolic strain, were measured. …”
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Genome-wide CRISPR knockout screen identifies activating transcription factor (ATF1) as an activator of HIV gene expression by Alona Kuzmina, Seraj Wattad, Praveenkumar Murugavelu, Noa Amir, Nili Tickotsky, Liron Levin, Ran Taube

“…Additional gain and loss-of-function experiments show that depletion of ATF1 promotes latency. …”
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A prospective randomized controlled trial comparing biphasic cartilage repair implant with microfracture in small chondral lesions of knee: findings at five-year-follow-up by Yao-Yi Kuo, Si-Qi Chiu, Wen-Pei Chang, Chih-Yu Chen, Chih-Hwa Chen, Chen-Kun Liaw, Cheng-Aun Tan, Pei-Wei Weng

“…Abstract Background Full-thickness cartilage defects have a significant impact on the function of joints in young adults, and the treatment of cartilage defects has been a challenge, as cartilage tissue is an avascular tissue. …”
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Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease by Sun C, Sha S, Shan Y, Gao X, Li L, Xing C, Guo Z, Du H

“…In a 5xFAD mouse model, Exos selectively targeted microglial and neuronal cells after nasal delivery under the action of neural cell-targeting peptide rabies virus glycoprotein 29 (RVG29).Results: BACE1 siRNA and berberine (BBR) loading enhanced the effectiveness of Exos in improving cognitive function, promoting nerve repair and regeneration, reducing inflammatory cytokine expression, and suppressing glial responses. …”
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Effects of Bojungikki-Tang on immune response and clinical outcomes in NSCLC patients receiving immune checkpoint inhibitors: a randomized pilot study by Mi Mi Ko, Se Won Na, Jin-Mu Yi, Ho Jang, Chang Min Choi, Seung Hyeun Lee, Sung Yong Lee, Mi-Kyung Jeong

“…Immune profiling suggested that BJIKT may activated CD4 + T cells, increased the proportion of CD3 + CD4 + cells, and enhanced T cell function while reducing immune exhaustion. Notably, a statistically significant decrease in PD-1 + CD8 + T cells was observed, while the reduction in PD-1 + CD4 + T cells did not reach significance. …”
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Mavacamten maintenance dose determination: insights into individualised therapy for hypertrophic cardiomyopathy by Kawa Mohemed, Smita Scholtz, Volker Rudolph, Jan-Christian Reil, Max Potratz, Cédric Coppée, Vasco Sequeira, Werner Scholtz

“…Mean time to reach maintenance dose was 14 weeks, with the necessity of dose adjustments in more than 50% of cases.Conclusion Mavacamten therapy is safe and effective in the initiating phase. …”
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Enhanced early rehabilitation and pain management with all‐arthroscopic medial patellofemoral ligament reconstruction: A comparative study by Yi‐Fan Song, Hai‐Jun Wang, Xin Yan, Zi‐Jie Xu, Xin‐Jie Wang, Fei Wang, Jia‐Kuo Yu

“…Knee function was assessed using Kujala and Lysholm scores at post‐operative 12 months. …”
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Prognostic factors associated with achieving minimal disease activity in early psoriatic arthritis patients treated according to “treat-to-target” st rategy within 12 months by E. Yu. Loginova, T. V. Korotaeva, E. E. Gubar, S. I. Glukhova

“…It is a combination of features on first visit – oligoarthritis, moderate activity, absent of entesitis, dactylitis, nail psoriasis, significant impact on function and fatigue – that constitutes a clinical prognostic factors for achievement MDA after 12 mo of treatment in pts with early PsA according T2T.…”
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