A phase I / IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis by Pankit Vachhani, Peter Tan, Anne-Marie Watson, Shang-Ju Wu, Ross Baker, Stanley Cheung, Sung-Eun Lee, Chih-Cheng Chen, Tsai-Yun Chen, Hui-Hua Hsiao, Jae Hoon Lee, Lucia Masarova, Shuh Ying Tan, Jana Baskar, Brett Charlton, Alison Findlay, Dieter Hamprecht, Wolfgang Jarolimek, Joanna Leadbetter, John Miller, Kristen Morgan, Amna Zahoor, Gabriela Hobbs

“…An anti-fibrotic therapy capable of normalising BM microenvironment and function remains a significant gap in the current treatment landscape. …”
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Сhronic kidney disease complications in patients with type 1 diabetes mellitus after simultaneous pancreas-kidney transplantation – potential role of oxidative stress and glycation... by Irina I. Larina, Anastasia S. Severina, Minara S. Shamkhalova, Daria N. Egorova, Larisa V. Nikankina, Natalia I. Sazonova, Ilya V. Dmitriev, Aleksey V. Pinchuk, Michael M. Kaabak, Marina V. Shestakova

“…Despite of stable graft function (estimated glomerular filtration rate (eGFR) CKD-EPI 84 [69; 95] ml/min/1.73m2) 35% of patients still needed antihypertensive therapy, 40% needed treatment with recombinant human erythropoietin (RHuEPO) and 15% – ferrotherapy. …”
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Dipole-dipole interactions mediated by a photonic flat band by Enrico Di Benedetto, Alejandro Gonzalez-Tudela, Francesco Ciccarello

“…Here, we study emergent dipole-dipole interactions between emitters dispersively coupled to the photonic analogue of a FB, a setup within reach in state-of the-art experimental platforms. …”
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Transarterial chemoembolization combined with tyrosine kinase inhibitors and/or immune checkpoint inhibitors induced hypothyroidism is associated with improved overall survival in... by Shengyuan Xu, Ruipeng Zheng, Chenghao Sun, Ri Sa

“…We enrolled 130 HCC patients with baseline thyroid function measurements, and stratified into two cohorts: TACE monotherapy (n = 50) or TACE combined with TKIs/ICIs (n = 80). …”
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Numerical Simulation of Convective Heat Transfer in Gyroid, Diamond, and Primitive Microstructures Using Water as the Working Fluid by Jie Zhang, Xiaoqing Yang

“…In order to improve the heat dissipation effect of liquid cooling, a TPMS structure with a larger specific surface area, which implicit function parameters can control, can be arranged in a shape manner and it is easy to expand the structural design. …”
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Comparison of the Properties of Cold Work Tool Steels with the Same Hardness but Different Manufacturing Processes The required important properties by L. Tóth, R.E. Fábián, P. Pinke, T.A. Kovács, M. Nabiałek, A.V. Sandu, P. Vizureanu

“…The goal of the research was to find the optimal cold work tool steel quality for special applications (as a function of wear resistance, corrosion resistance and toughness). …”
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Risk factors for IgA nephropathy recurrence and impact on graft survival in a cohort of kidney transplanted patients by Angelodaniele Napoletano, Michele Provenzano, Federica Maritati, Valeria Corradetti, Vania Cuna, Elisa Gessaroli, Chiara Abenavoli, Simona Barbuto, Marcello Demetri, Matteo Ravaioli, Giorgia Comai, Gaetano La Manna

“…The aim of this study was to determine incidence, risk factors and impact on renal function and graft survival of IgAN recurrence after KT. …”
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Prognostic value of the ratio between right ventricular free wall longitudinal strain and systolic pulmonary artery pressure in patients with heart failure with reduced ejection fr... by Călin-Dinu Hădăreanu, Călin-Dinu Hădăreanu, Diana-Ruxandra Hădăreanu, Diana-Ruxandra Hădăreanu, Despina-Manuela Toader, Maria-Livia Iovănescu, Maria-Livia Iovănescu, Cristina Florescu, Cristina Florescu, Victor-Cornel Raicea, Victor-Cornel Raicea, Ionuț Donoiu, Ionuț Donoiu

“…BackgroundIn heart failure (HF) with reduced ejection fraction (HFrEF), ventricular secondary mitral regurgitation (V-sMR) leads to progressive impairment of right ventricular (RV) function and adversely affects outcomes. Non-invasive indices of RV–pulmonary artery (RVPA) coupling may offer enhanced prognostic value.MethodsWe retrospectively evaluated advanced echocardiographic surrogates of RVPA coupling in 104 HFrEF patients with V-sMR.ResultsOver a median follow-up of 526 days, 48 patients (46.2%) reached the composite endpoint of rehospitalization for HF decompensation or all-cause mortality. …”
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Feasibility of Early Vestibular Screening and Developmental Changes in Air- and Bone-Conducted Cervical Vestibular Evoked Myogenic Potentials in Infants and Children with Normal He... by Jiali Shen, Xiaobao Ma, Lu Wang, Wei Wang, Jianyong Chen, Qing Zhang, Maoli Duan, Yulian Jin, Jun Yang

“…Age-related changes were found in both latencies and amplitudes of ACS-cVEMP and BCV-cVEMP. ACS-cVEMP latencies reached adult levels at 13–17 years, while BCV-cVEMP latencies normalized by 7–12 years. …”
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Cross temporal scale pig face recognition based on deep learning by Tao Luo, Cheng Wang, Dong Wang, Zihao Zhao, Hao Huang, Shuhong Zhao, Xinggang Wang, Xuewen Xu

“…Besides, ResNet18 with a triplet loss function reaches 88.5 % accuracy. While pig face recognition performs well, it remains highly sensitive to short-term facial changes, requiring future models to capture temporal features.…”
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SMS text message-delivered pain self-management intervention for patients undergoing total knee replacement surgery: protocol for a randomised controlled type 1 hybrid effectivenes... by Rachelle Buchbinder, Paul Glare, Claire Ashton-James, Ali Gholamrezaei, David Liew, Amy Gray McNeilage, Andrew Hardidge, Elizabeth Walkley, Charlotte Heldreich

“…Implementation outcomes (Reach, Experience, Adoption, Implementation, Maintenance) will be evaluated using mixed (qualitative and quantitative) methods. …”
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Multivitamin Supplementation and Fertility Outcome: A Retrospective Single-Center Cohort Study and the Clinical and Medicolegal Value of Nutritional Counseling by Giuseppe Gullo, Simona Zaami, Adriana Vita Streva, Sofia Burgio, Valentina Billone, Yulia Kotlik, Elena Chitoran, Silvia Ganduscio, Giovanni Baglio, Antonio Perino, Gaspare Cucinella

“…Resveratrol can beneficially affect growth and follicle development and lead to improved sperm function parameters in pre-clinical studies, while information from clinical studies is still inconclusive. …”
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MDPNet: a dual-path parallel fusion network for multi-modal MRI glioma genotyping by Huaizhi Wang, Haichao Liu, Fang Du, Fang Du, Fang Du, Di Wang, Xianhao Huo, Jihui Tian, Lijuan Song, Lijuan Song, Lijuan Song

“…To mitigate the impact of data imbalance, we developed a cross-gene feature-sharing classifier and implemented an adaptive weighted loss function, substantially enhancing the model’s predictive performance.ResultsIn this study, each gene classification task was formulated as a binary classification problem. …”
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Long-Term Patient-Reported Bowel and Urinary Quality of Life in Patients Treated with Intensity-Modulated Radiotherapy Versus Intensity-Modulated Proton Therapy for Localized Prost... by Kimberly R. Gergelis, Miao Bai, Jiasen Ma, David M. Routman, Bradley J. Stish, Brian J. Davis, Thomas M. Pisansky, Thomas J. Whitaker, Richard Choo

“…Methods and Materials: Patients with clinical T1–T2 prostate cancer receiving IMRT or IMPT at a tertiary cancer center from 2015–2018 were analyzed to determine the changes in the prospectively collected bowel function (BF), urinary irritative/obstructive symptoms (UO), and urinary incontinence (UI) domains of EPIC-26. …”
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Luminescent upconverting CsPbBr3 nanocrystals as spectral converter having chemodynamic potential against Pseudomonas bacteria by Ishfaq Abdullah Wani, Laxmi Kurmi, Punam Chorasiya, Lavkesh Kumar, Sandeep Nigam, Vijay Verma, Yogesh Bhargava, Pushpal Ghosh

“…Up-conversion emission intensity increases with Yb3+ ion concentration and reaches a maximum for CsPbBr3: Er3+ (1%)/Yb3+ (20%). …”
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Postprandial triglyceride levels affecting postprandial thyroid stimulating hormone levels may be responsible for the increased postprandial thyroid stimulating hormone levels in p... by Peipei Tian, Peipei Tian, Peipei Tian, Shaojing Zeng, Yilin Hou, Yilin Hou, Dandan Liu, Dandan Liu, Dandan Liu, Yamin Lu, Guangyao Song, Guangyao Song

“…Postprandial TSH levels in both groups reached a trough at 2 h and peaked at 6 h, with a higher peak in the IFT group. …”
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Consensus-based recommendations for the rehabilitation of children with arthrogryposis multiplex congenita: an integrated knowledge translation approach by Noémi Dahan‑Oliel, Sarah Cachecho, Clarice Araujo, Alicja Fąfara, Francis Lacombe, Ani Samargian, Camille Costa, Maureen Donohoe, Ann Flanagan, Bart Kowalczyk, Courtney Krakie, Lisa Wagner, Carolina Navalón, Verity Pacey, Unni Steen, Misha Walker, Trudy Wong, André Bussières

“…The final 16 recommendations reached a mean agreement rate of 96.6% after two Delphi rounds. …”
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Long‐Term Effects of Nusinersen Dosing Frequency on Adult Patients With Spinal Muscular Atrophy: Efficacy of a 6‐Month Dosing Interval by Keita Takahashi, Hitaru Kishida, Misako Kunii, Yosuke Miyaji, Yuichi Higashiyama, Hiroshi Doi, Naohisa Ueda, Hideyuki Takeuchi, Fumiaki Tanaka

“…Methods We assessed 14 adult patients treated with nusinersen every 6 months over a period of up to 39 months using the Hammersmith Function Motor Scale Expanded (HFMSE) and Revised Upper Limb Module (RULM). …”
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Studies on the Virucidal Effects of UV-C of 233 nm and 275 nm Wavelengths by Jessica Kohs, Tom Lichtenthäler, Carolyn Gouma, Hyun Kyong Cho, Andreas Reith, Axel Kramer, Sven Reiche, Paula Zwicker

“…The inactivation of the viruses was a function of the radiation dose. UV-C-radiation at 233 nm (80 mJ/cm²) inactivated from 1.49 ± 0.08 to 4.28 ± 0.18 lg depending on the virus used. …”
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Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women by Stephen J. Carter, Tyler H. Blechschmid, Emily B. Long, Tenzin Yangchen, Marissa N. Baranauskas, Chad C. Wiggins, John S. Raglin, Andrew R. Coggan

“…Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. …”
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