The Experience of Using a Combination of Febuxostat and Canakinumab in Tophaceous Gout Complicated by Chronic Kidney Disease in a Teenage Patient: A Case Study by Maria I. Kaleda, Irina P. Nikishina, Nurali Z. Zokirov, Alina V. Charlamova, Maxim S. Eliseev

“…Normalization of serum uric acid levels was not reached, repeated attacks of gouty arthritis were noted. …”
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Identifying Medication Review Topics to Be Documented in a Structured Form in Electronic Health Record Systems: Delphi Consensus Survey by Tanja Lindholm, Noora Lias, Kirsi Kvarnström, Anna-Riia Holmström, Terhi Toivo, Marjo Uusitalo, Harri Nurmi, Marja Airaksinen

“…ResultsConsensus was reached on 97.3% (108/111) of predetermined topics to be documented in a structured form in EHRs. …”
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Resisting While Producing: Do-It-Yourself Ethics in Turkiye’s Punk Scene by Ece N. Alparslan, Şengül İnce

“…Scott (1992/2014) stated that the main function of subcultures is to be a space in which people can distribute opposing discourses freely and without fear. …”
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A novel approach to skin disease segmentation using a visual selective state spatial model with integrated spatial constraints by Yu Bai, Hai Zhou, Hongjie Zhu, Shimin Wen, Binbin Hu, Haotian Li, Huazhang Wang, Daji Ergu, Fangyao Liu

“…Additionally, we introduce a spatially-constrained loss function that mitigates gradient stability issues by considering the distance between label and prediction boundaries. …”
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Efficient coding in biophysically realistic excitatory-inhibitory spiking networks by Veronika Koren, Simone Blanco Malerba, Tilo Schwalger, Stefano Panzeri

“…Here, we derive the structural, coding, and biophysical properties of excitatory-inhibitory recurrent networks of spiking neurons that emerge directly from imposing that the network minimizes an instantaneous loss function and a time-averaged performance measure enacting efficient coding. …”
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N-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity by Stefano Comai, Sara De Martin, Andrea Mattarei, Clotilde Guidetti, Marco Pappagallo, Franco Folli, Andrea Alimonti, Paolo L. Manfredi

“…This NMDAR Ca²⁺ quantal hypothesis for the epigenetic code of neural plasticity integrates recent psychopharmacology findings into established physiological and pathological mechanisms of brain function.…”
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Effects of water nutrient concentrations on stream macroinvertebrate community stoichiometry: a large-scale study by Beck, Miriam, Billoir, Elise, Usseglio-Polatera, Philippe, Meyer, Albin, Gautreau, Edwige, Danger, Michael

“…Our results show that assumptions from Ecological Stoichiometry Theory also hold at the community level, at least for two dominant taxa, and on a large spatial scale, with likely consequences for nutrient cycling and ecosystem function.…”
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Efficient and Effective NDVI Time-Series Reconstruction by Combining Deep Learning and Tensor Completion by Ang Li, Menghui Jiang, Dong Chu, Xiaobin Guan, Jie Li, Huanfeng Shen

“…Multidimensional gradient constraints are introduced in the loss function to retain critical information. The experiments conducted on moderate resolution imaging spectroradiometer NDVI data show that the NIT-Net framework is superior to most of the comparison methods. …”
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Antioxidant Bioactive Agents for Neuroprotection Against Perinatal Brain Injury by Virginia Beretta, Elena Scarpa, Silvia Carloni, Chiara Petrolini, Valentina Dell’Orto, Sebastiano Ravenda, Serafina Perrone

“…Additionally, the inability of these agents to reach effective concentrations within the central nervous system, along with inconsistencies across clinical trials in terms of dosage and administration methods, hinders the ability to obtain robust results. …”
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Implementation of a preoperative exercise programme in lung cancer resection: protocol for a mixed-methods study by Meredith King, Garrick Don, Benjamin Harris, Michael Hibbert, Gregory G King, Nicole Roche, Marita Dale, Sally Wootton

“…We aim to describe the protocol to evaluate the implementation of an existing preoperative exercise training programme in people undergoing lung cancer resection in an Australian setting.Methods and analysis This is an evaluation of a secondary objective of a study examining the effect of lung cancer resection on exercise capacity, lung function and symptoms of dyspnoea and quality of life. …”
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Successful Treatment of Transplanted Kidney Patient with 100% Lung Damage Caused by COVID-19 Bilateral Pneumonia: a Clinical Case by R. R. Nuriakhmetov, V. S. Panteleev, A. R. Zagitov, M. A. Nartailakov, M. N. Kornilov, I. I. Biganyakov

“…Within 5 months since discharge, there were observed a general well-being improvement, 98% oxygen saturation, absent oedema, satisfactory transplanted kidney function.Conclusion. Post-kidney-transplant patients are particularly susceptible to infection due to inherent chronic immunosuppression. …”
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MSUD-YOLO: A Novel Multiscale Small Object Detection Model for UAV Aerial Images by Xiaofeng Zhao, Hui Zhang, Wenwen Zhang, Junyi Ma, Chenxiao Li, Yao Ding, Zhili Zhang

“…Finally, the WIoU v3 loss function is used to make the model more focused on low-quality examples, thereby improving the model’s object localization ability. …”
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Centrifugal Test Study on the Vertical Uplift Capacity of Single-Cylinder Foundation in High-Sensitivity Marine Soil by Mingzhe Wei, Yanghui Ye, Wei Zhao, Zehao Wang, Fuhao Ge, Tingkai Nian

“…It was found that the secant stiffness exhibits a logarithmic function relationship with both the number of cycles and sensitivity. …”
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The Prelacrimal Recess Approach: A Review of Surgical Applications, Outcomes, and Recent Advances by Yeon Hee Im, Soo Whan Kim, Chan-Soon Park, Dong-Hyun Kim

“…Clinical outcomes from multiple investigations validate the PLRA’s efficacy in maintaining sinonasal function while achieving comprehensive lesion removal. …”
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Improved YOLOv8-Based Method for the Carapace Keypoint Detection and Size Measurement of Chinese Mitten Crabs by Ke Chen, Zhuquan Chen, Changbo Wang, Zhifan Zhou, Maohua Xiao, Hong Zhu, Dongfang Li, Weimin Liu

“…Furthermore, we refined the loss function to model spatial correlations between keypoint locations accurately and thus improve detection accuracy for dorsal carapace dimension key points in Chinese mitten crabs. …”
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Repressed Wnt Signaling Accelerates the Aging Process in Mouse Eyes by Yujin Zhang, Joseph Jeffrey, Fei Dong, Jianhua Zhang, Winston W.-Y. Kao, Chia-Yang Liu, Yong Yuan

“…Ocular aging is a natural process of functional decline in vision. When the process reaches a point that compromised vision affects normal daily activity, it manifests as age-related ocular diseases, such as age-related macular degeneration, cataracts, glaucoma, and pseudoexfoliation syndrome. …”
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Research on the therapeutic effectiveness of the veterinary medicinal product “Surfadev” in complex therapy for stimulating sexual desire in cows by O. A. Katsaraba, R. M. Sachuk, Ye. Ye. Kostyshyn, Y. S. Stravskyy, L.-M. Ye. Kostyshyn

“…Vitamins included in the preparation take part in biochemical processes in animal organisms (in the form of enzyme vitamins, hormone vitamins, antioxidants). When ovarian function is stimulated or corrected, 90.0 % of the treated animals show the arousal stage of the sexual cycle within 3–15 days, and their fertilization rate from the first insemination is 70.0 % on average. …”
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Global, Regional, and National Temporal Trends in Incidence for Type 2 Diabetes Mellitus Related Chronic Kidney Disease from 1992 to 2021 by Yu Cao, Huiting Chen, Hui Liu, Hao Wu, Wei Gao

“…Background Type 2 diabetes mellitus (T2DM) is a major cause of declining renal function. Methods Temporal trends in T2DM-related chronic kidney disease (CKD-T2DM) incidence across 204 countries and territories from 1992 to 2021 were analyzed using data from the Global Burden of Disease 2021. …”
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Topology Optimization Design of Phase Change Liquid Cooling Composite Plate by Xinqiang Xia, Jiancheng Luo, Jiabao Li, Lixia Wei

“…To address the challenges of high flow resistance and poor temperature uniformity in conventional PCM–liquid cooling hybrid heat exchangers—which significantly impair the performance and lifespan of electronic devices—a topology optimization approach was adopted. A dual-objective function, aimed at minimizing the average temperature and pressure drop, was introduced to reconstruct the cooling channel layout and PCM filling region. …”
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Comparison of Outcomes of Live and Deceased Donor Renal Transplantation-A Retrospective Study from a single center in South India by Bharathi Kasinaboina, Swarnalatha Guditi, Gangadhar Taduri

“…Results: Of 210 recipients, live donor renal transplant (LDRT) recipients were 176(83.80%) and deceased donor renal transplants (DDRT) were 34(16.19%). Delayed graft function was common in DDRT (64.7%) compared to LDRT (3.40%). …”
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