Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…The present multiple ascending dose phase 1b study was performed to evaluate the tolerability and pharmacological effects of repeated doses of NX210c in healthy elderly (age: > 55 years) volunteers. Methods This was a randomized, placebo-controlled, double-blind study (EudraCT No. 2022-002868-76), investigating safety/tolerability, pharmacokinetics, and pharmacodynamics (including blood and cerebrospinal fluid biomarkers). …”
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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…<h4>Objective</h4>To determine if men who have sex with men (MSM) with cocaine use disorder (CUD) and actively-using cocaine could be enrolled and retained in a pharmacologic intervention trial of lorcaserin-a novel 5-HT2cR agonist-and determine the degree to which participants would adhere to study procedures.<h4>Methods</h4>This was a phase II randomized, double-blind, placebo-controlled pilot study with 2:1 random parallel group assignment to daily extended-release oral lorcaserin 20 mg versus placebo (clinicaltrials.gov identifier-NCT03192995). …”
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Protocol for a hybrid type I randomized controlled trial evaluating the effectiveness and implementation of a nurse home visiting program for adolescent pregnancy on maternal and i... by Natália Becker, Natália Becker, Vinícius Nagy Soares, Débora Tseng Chou, Débora Tseng Chou, Emilio Abelama Neto, Emilio Abelama Neto, Letícia Aparecida da Silva, Letícia Aparecida da Silva, Ana Alexandra Caldas Osório, Ana Alexandra Caldas Osório, Ana Alexandra Caldas Osório, Ariana Gomes Nascimento, Ariana Gomes Nascimento, Vinnie Marchisio, Alexandro Marcos Menegócio, Alexandro Marcos Menegócio, Adriana Tebaldi Pereira, Adriana Tebaldi Pereira, Andrea Bernardinetti Muller Haas, Andrea Bernardinetti Muller Haas, Alfredo Almeida Pina-Oliveira, Eurípedes Constantino Miguel, Eurípedes Constantino Miguel, Paulo Rossi Menezes, Paulo Rossi Menezes, Arthur Caye, Arthur Caye, Arthur Caye, Lislaine Aparecida Fracolli, Lislaine Aparecida Fracolli

“…Nurse home visiting programs, such as Primeiros Laços, show promise in improving maternal and child health outcomes, yet their integration into primary healthcare remains underexplored, especially in low-resource settings.Aimto evaluate the effectiveness and feasibility of integrating Primeiros Laços into primary healthcare services across two municipalities of the state of São Paulo, Brazil.MethodA hybrid type I randomized controlled trial will be conducted to assess both the clinical effectiveness and implementation feasibility of the program. …”
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In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeuti... by Auwal Salisu Isa, Adamu Uzairu, Umar Meleh Umar, Muhammad Tukur Ibrahim, Abdullahi Bello Umar, Kamal Tabti, Abdussamad Mukhtar Mohammed

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The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a do... by Helya Helali, Nastaran Samani, Faraj Tabeie, Shiva Eiliaei, Ali Kheradmand

“…The purpose of this study was to evaluate the impact of tPBMT on reducing anxiety, depression, and opioid craving in patients undergoing MMT. Methods This randomized controlled clinical trial included two groups of substance-dependent patients undergoing MMT. …”
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Efficacy of ultrasound-guided intensive silver needles in the treatment of shoulder pain by LUO Jia, LIU Jitong, ZHANG Weiwei, LIAO Qian, LIAO Yongqiong

“…Objective To investigate the effects of ultrasound.guided intensive silver needles on the efficacy, pain, shoulder function, inflammatory factors and pain.causing substances in patients with shoulder joint pain. Methods A total of 92 patients with frozen shoulder admitted to Hunan Provincial People..s Hospital from January 2022 to May 2023 were selected, and were divided into two groups with 46 cases in each group by random number table method. …”
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Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer by He J, Akhtar A, Li J, Wei Q, Yuan Y, Ran J, Ma Y, Chen D

“…These findings provide a basis for developing advanced diagnostic tools and targeted therapies, which may ultimately enhance patient prognosis.Keywords: single cell sequencing, breast cancer, scPagwas, Mendelian randomization, bioinformatics…”
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"A man never cries": A mixed-methods analysis of gender differences in depression and alcohol use in Moshi, Tanzania. by Alena Pauley, Mia Buono, Madeline Metcalf, Kirstin West, Sharla Rent, William Nkenguye, Yvonne Sawe, Mariana Mikindo, Joseph Kilasara, Judith Boshe, Brandon A Knettel, Blandina T Mmbaga, Catherine A Staton

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Exploring Therapeutic Potential of Bi-Qi Capsules in Treatment of Gout by Discovering Crucial Drug Targets by Jing Xie, Yu Zhang, Rong Ren, Ruizhen Bu, Liying Chen, Juezhuo Hou, Dandan Shang, Yadong Liu, Dan Wang, Tao Wang, Hong Zhou

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To smoothie or not to smoothie? A mixed-method approach of nutrition pilot intervention among individuals in opioid agonist treatment by Siv-Elin Leirvaag Carlsen, Einar Furulund, Elaheh Javadi Arjmand, Karl Trygve Druckrey Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Torgeir Gilje Lid, Lars T. Fadnes, for the ATLAS4LAR and FruktBAR study group

“…Abstract Background Patients with substance dependence typically have unhealthy diets and low degree of nutritional awareness. …”
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Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severit... by Arash Mansoori, Amir Bazrafshan, Jamshid Ahmadi, Seyed Hamdollah Mosavat

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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, doub... by Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch

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mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized... by Elenore P. Bhatraju, Devin N. Kennedy, Alexander J. Gojic, Matthew Iles-Shih, Joseph O. Merrill, Jeffrey H. Samet, Kevin A. Hallgren, Judith I. Tsui

“…Methods The study is a two-arm pilot randomized controlled trial (N = 40) comparing the mHealth Incentivized Adherence Plus Patient Navigation (MIAPP) intervention to treatment as usual. …”
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Testing a systematically braided alcohol reduction and HIV status neutral intervention among people receiving STI care in Malawi: study protocol for a pilot hybrid type 1 effective... by Kathryn E. Lancaster, Agatha K. Bula, Mitch M. Matoga, Mina C. Hosseinipour, Mina C. Hosseinipour, Irving F. Hoffman, Irving F. Hoffman, Jaslyn A. Grullon, Eric Umar, Jimmy Msolola, Jessica F. Magidson, Jessica L. Bonumwezi, Judith A. Hahn, Angela M. Parcesepe

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Monte Carlo Simulation of Pesticide Toxicity for Rainbow Trout (<i>Oncorhynchus mykiss</i>) Using New Criteria of Predictive Potential by Alla P. Toropova, Andrey A. Toropov, Emilio Benfenati

“…<i>Aim of the study</i>: We explore the use of advanced Monte Carlo methods to obtain improved results for models testing Rainbow Trout (<i>Oncorhynchus mykiss</i>) acute toxicity. …”
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Effect of COVID-19 Lockdown on Alcohol Consumption Among the Youths in Kampala, Uganda. A Cross-Sectional Study by Namiiro AM, Audo R, Nannungi CD, Pitua I, Kiberu D, Talemwa P, Mujuni E, Lwesabula A, Ageimo P, Khaukha AZ, Kuol MJ, Egaru L, Koire M, Ssewante N

“…This study assessed the impact of the COVID-19 lockdown on alcohol consumption among youths in Kampala, Uganda.Methods: A quantitative cross-sectional study among randomly selected youth aged 18– 35 years living in the five divisions of Kampala. …”
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Estimating mortality attributable to alcohol or tobacco – a cohort study from Germany by Ulrich John, Hans-Jürgen Rumpf, Monika Hanke, Christian Meyer

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Effectiveness of nurse-initiated smoking cessation intervention: a systematic review and meta-analysis by Eun-Hye Lee, Hea-Jin Yu

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Schizophrenia and violence: systematic review and meta-analysis. by Seena Fazel, Gautam Gulati, Louise Linsell, John R Geddes, Martin Grann

“…The risk for homicide was increased in individuals with psychosis (with and without comorbid substance abuse) compared with general population controls (random-effects OR = 19.5, 95% CI 14.7-25.8).…”
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Relation between Brain systems with risk behavior and drug use behaviors amount Youth by Behzad Nader Nejad, Farshad Ataei, Alireza Sedighi

“…Methods: This study was Ali, the events of 115 male adolescents aged 12 to 19 years were selected using random samplingAnd scale brain systems - behavior (BAS / BIS), Iranian Teens Risk Scale (IARS) and the readiness of addiction (IAPS) to complete .Results using Pearson correlation and stepwise regression analysis anddescriptive statistics were analyzed. …”
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