A preliminary randomized trial of the safety, tolerability, and clinical effects of hemp-derived cannabidiol in alcohol use disorder by Raeghan L. Mueller, Jake F. Hooper, Jarrod M. Ellingson, Aviva K. Olsavsky, Aviva K. Olsavsky, Rachael Rzasa-Lynn, Angela D. Bryan, L. Cinnamon Bidwell, Kent E. Hutchison

“…This study examined the potential therapeutic effects of commercially available products containing CBD with and without a small amount of tetrahydrocannabinol (THC) on alcohol use and craving among individuals with moderate to severe AUD.MethodsIn this feasibility study, a total of 44 participants were randomized to one of three conditions: full-spectrum CBD (n = 13, fsCBD - <0.3% THC), broad-spectrum CBD (n = 15, bsCBD – without THC), or placebo control (n = 16) for 8 weeks. …”
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Acupuncture effects of post-stroke thalamic pain: a systematic review and meta-analysis of randomized controlled trials by Tianwei Zhang, Tianwei Zhang, Junying Zhai, Junying Zhai, Ling Cheng, Ling Cheng, Kaixin Jiang, Kaixin Jiang, Dayang Wang, Huawei Shi, Bin Wang, Xing Chen, Xinglu Dong, Li Zhou

“…This systematic review and meta-analysis aimed to evaluate the efficacy and safety of acupuncture treatment for PS-TP.MethodsAccording to the established search strategy, randomized controlled trials (RCTs) of acupuncture therapy for PS-TP were retrieved from eight Chinese and English databases as well as two clinical trial registration platforms, up to February 2024. …”
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ASSIST in Pitjantjatjara: Protocol for a randomised crossover validation study among Aboriginal and Torres Strait Islander Australians by Matthew W.R. Stevens, Sue Bertossa, Dominic Barry, Chris Holmwood, KS Kylie Lee, John Marsden, Matt Pedler, Mark Thompson, Scott Wilson, Robert L. Ali

“…This protocol describes a study aimed at validating a culturally-adapted screening tool — the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) — into Pitjantjatjara, to detect risk of substance-related harm. …”
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Exploring Gender Differences in Veterans in a Secondary Analysis of a Randomized Controlled Trial of Mindfulness for Chronic Pain by Diana J. Burgess, Emily M. Hagel Campbell, Mariah Branson, Collin Calvert, Roni Evans, Kelli D. Allen, Ann Bangerter, Lee J.S. Cross, Mary A. Driscoll, Sierra Hennessy, John E. Ferguson, Jessica K. Friedman, Marianne S. Matthias, Laura A. Meis, Melissa A. Polusny, Stephanie L. Taylor, Brent C. Taylor

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Comparison of ChatGPT and Internet Research for Clinical Research and Decision-Making in Occupational Medicine: Randomized Controlled Trial by Felix A Weuthen, Nelly Otte, Hanif Krabbe, Thomas Kraus, Julia Krabbe

“…ObjectiveThis study aims to assess the potential suitability of a generative large language model, such as ChatGPT, as a support tool for medical research and even clinical decisions in occupational medicine in Germany. MethodsIn this randomized controlled study, the usability of ChatGPT for medical research and clinical decision-making was investigated using a web application developed for this purpose. …”
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Psychological, social factors, and smoking behavior mediated the effects of cannabis use on personality disorders: A Mendelian randomization study by Yao Ni, Juanmei Li, Zitian Tang, Youqian Zhang, Yanyan Feng

“…Although links between CU and personality disorders (PDs) are documented, their causality remains uncertain.MethodsEmploying Genome-Wide Association Studies (GWAS) data, this study investigated the causal relationship between cannabis use disorder (CUD) and lifetime cannabis use (LCU) with 9 types of PD risk through Mendelian randomization (MR) analysis. …”
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Exploring the Impact of the Caring Contacts Intervention on the Stress and Distress of Veterans and Service Members: Protocol for a Randomized Controlled Trial by Barbara Wright, Anna Evanson, Cameron Casey, Keyne C Law, Andrew H Rogers, Katherine Anne Comtois

“…Using EMA, this study will be the first to investigate mechanisms of the Caring Contacts intervention both in real time, as the messages are received, and over the course of 1 year. MethodsIn this randomized controlled trial, veterans or service members (N=510) experiencing stress or distress recruited via social media advertisements will be offered best available resources and randomized into 1 of 3 study conditions: 12 months of Caring Contacts and monthly EMA, 12 months of Caring Contacts without monthly EMA, or 12 months of monthly EMA alone. …”
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…Participants were randomized into two groups: a 20E and DSG (EcDi) group, and a placebo (Plac) group. …”
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The Determination of Parkinson’s Drugs in Human Urine by Applying Chemometric Methods by Guzide Pekcan Ertokus

“…A concentration set including binary mixtures of levodopa and carbidopa in 15 different combinations was randomly prepared in acetate buffer (pH 3.5).). UV spectrophotometry is a relatively inexpensive, reliable, and less time-consuming method. …”
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Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…After signing informed consent patients were randomized into DPS 50 mg t.i.d. and Diclofenac 75 mg i/m b.i.d. …”
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LOTUS: Protocol for a double-blind placebo controlled randomized trial of hemp-derived cannabidiol for the treatment of cannabis use disorder. by L Cinnamon Bidwell, Renee Martin-Willett, Samantha N Melendez, Luiza Rosa, Gregory Giordano, Kent E Hutchison, Angela D Bryan

“…<h4>Methods</h4>Design. Double-blind, three-arm randomized placebo-controlled trial. …”
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Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial by Zi-tong Fu, Cun-zhi Liu, Mi-Rim Kim, Yi-duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

“…Objective This study aims to investigate the effects of acupuncture on symptoms, serum hormones, and ANS in PDS patients. Methods This randomized controlled clinical trial was conducted at Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical University. …”
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Modeling biogeochemical processes in the Azov Sea using statistically processed data on river flow by A. I. Sukhinov, Y. V. Belova, A. V. Nikitina, A. M. Atayan

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The Impact of Immune Cells, Metabolites, Inflammatory Factors, and Circulating Proteins on Atopic Dermatitis: Insights from a Mendelian Randomization Study by Zhou D, Gan G, Song S, Zi C, Bao Y, Hao W, Chen Q

“…We identified seven previously unreported circulating substances with causal relationships to AD, filling a current theoretical gap.Keywords: multi-omics, immunomics, metabolomics, proteomics, Mendelian randomization, atopic dermatitis…”
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The impact of a multimodal intervention on physical health factors and lifestyle in patients with affective disorders – results from a randomized controlled trial by Ida Schou Ipsen, Rasmus Schwarz, Lars Vedel Kessing, Kamilla W. Miskowiak, Maj Vinberg

“…Background: Traditional treatment for affective disorders primarily focuses on symptom management through pharmacotherapy and psychotherapy and rarely addresses co-existing physical impairments. Methods: This randomized controlled trial assessed the impact of a six-month multimodal intervention (AWARE) on physical health in patients with bipolar and unipolar depressive disorders. …”
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Effect of combination hepatoprotective therapy with sulfur-containing drugs on oxidative homeostasis in the blood of patients with alcoholic hepatitis: A randomized prospective stu... by I. M. Bykov, G. A. Ermakova, K. A. Popov, M. A. Popova, A. G. Zavgorodnyaya, E. S. Ustinova

“…To determine the effect of the combined use of ademetionine and lipoic acid on the cytolytic syndrome and oxidative metabolism in the blood of patients with alcoholic hepatitis. Methods. A randomized prospective study was conducted examining 30 patients diagnosed with alcoholic liver disease and 15 healthy individuals. …”
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Integrated treatment of depression and moderate to severe alcohol use disorder in women shows promise in routine alcohol use disorder care – a pilot study by Anna Persson, Anna Persson, Daniel Wallhed Finn, Alice Broberg, Amanda Westerberg, Åsa Magnusson, Åsa Magnusson, Olof Molander

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Adapting the alcohol and alcohol problems perception questionnaire and the drug and drug problems perception questionnaire: A psychometric analysis of a person-centred approach by Andrea RAYNAK, Michel Bédard, Brianne Wood, Christopher Mushquash

“…Participants were randomly assigned to complete either the original Alcohol and Alcohol Problems Perception Questionnaire and Drug and Drug Problems Perception Questionnaire or the revised person-centred versions. …”
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Comparative analysis of PFASs concentrations in fur, muscle, and liver of wild roe deer as biomonitoring matrices by Susanna Draghi, Giulio Curone, Roberta Risoluti, Stefano Materazzi, Giuseppina Gullifa, Angela Amoresano, Angela Amoresano, Michele Spinelli, Michele Spinelli, Carolina Fontanarosa, Carolina Fontanarosa, Radmila Pavlovic, Alberto Pellegrini, Marco Fidani, Petra Cagnardi, Federica Di Cesare, Francesco Arioli

“…This study aimed to compare the levels of 12 PFASs in the fur, liver, and muscle of wild roe deer to evaluate the feasibility of using fur as a non-invasive biomonitoring matrix.MethodsA total of 20 male and 20 female roe deer aged between 12 and 24 months were randomly sampled from a hunting area in Northern Italy. …”
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Comparative effectiveness of short-term psychodynamic psychotherapy and cognitive behavioral therapy for major depression in psychiatric outpatient clinics: a randomized controlled... by Anders Malkomsen, Theresa Wilberg, Bente Bull-Hansen, Toril Dammen, Julie Horgen Evensen, Benjamin Hummelen, André Løvgren, Kåre Osnes, Randi Ulberg, Jan Ivar Røssberg

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