Study protocol for a randomized controlled trial to adapt a posttraumatic stress disorder intervention of patients with opioid-stimulant polysubstance use receiving methadone maint... by Tanya Renn, Brittany Griffin, Vinodini Kumaravelu, Ana Ventuneac, Michele Santacatterina, Amanda M. Bunting

“…The massed version created includes four 60-min sessions of skill building and two weeks of four 60-min sessions of narrative therapy. A preliminary randomized controlled trial (RCT) with 80 participants, randomized 1:1, will be conducted to assess the intervention's implementation and impact on primary short-term outcomes of polysubstance use and PTSD symptoms. …”
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Effects of propolis supplementation on prooxidant-antioxidant balance, oxidative stress biomarkers, and body composition in obese patients with NAFLD: A double-blind randomized con... by Hamideh Nazari-Bonab, Mahlagha Nikbaf-Shandiz, Helda Tutunchi, Mehrangiz Ebrahimi-Mameghani

“…The present clinical trial investigated the effect of Iranian PRP on prooxidant-antioxidant balance (PAB), oxidative stress biomarkers, and body composition in obese patients with NAFLD. Methods: In the present double-blind, randomized controlled clinical trial, 44 obese patients with NAFLD were randomly allocated to either Iranian PRP (1500 mg/d) or placebo (1500 mg/d) accompanied by a calorie-restricted diet (CRD) for eight weeks. …”
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PEPsy-CM study protocol: impact of a 3-year program for early psychosis based on case-management on relapse rate, a French multicenter randomized trial by Aurélie Schandrin, Julie Jourdan, Sihame Chkair, Sophie Bouvet, Pascale Fabbro-Peray, Mocrane Abbar, for the PEPsy-CM working group

“…Abstract Background Early intervention services (EIS) for early psychosis can help reduce the patient-specific and economic impacts of mental illness, but they are underdeveloped and practices are poorly harmonized in many countries. Methods The aim of the study is to evaluate in France the effectiveness of a three-year Program for Early Psychosis based on Case Management (PEPsy-CM) compared to TAU in young people with a first episode of psychosis (FEP). …”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…The present multiple ascending dose phase 1b study was performed to evaluate the tolerability and pharmacological effects of repeated doses of NX210c in healthy elderly (age: > 55 years) volunteers. Methods This was a randomized, placebo-controlled, double-blind study (EudraCT No. 2022-002868-76), investigating safety/tolerability, pharmacokinetics, and pharmacodynamics (including blood and cerebrospinal fluid biomarkers). …”
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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…<h4>Objective</h4>To determine if men who have sex with men (MSM) with cocaine use disorder (CUD) and actively-using cocaine could be enrolled and retained in a pharmacologic intervention trial of lorcaserin-a novel 5-HT2cR agonist-and determine the degree to which participants would adhere to study procedures.<h4>Methods</h4>This was a phase II randomized, double-blind, placebo-controlled pilot study with 2:1 random parallel group assignment to daily extended-release oral lorcaserin 20 mg versus placebo (clinicaltrials.gov identifier-NCT03192995). …”
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Protocol for a hybrid type I randomized controlled trial evaluating the effectiveness and implementation of a nurse home visiting program for adolescent pregnancy on maternal and i... by Natália Becker, Natália Becker, Vinícius Nagy Soares, Débora Tseng Chou, Débora Tseng Chou, Emilio Abelama Neto, Emilio Abelama Neto, Letícia Aparecida da Silva, Letícia Aparecida da Silva, Ana Alexandra Caldas Osório, Ana Alexandra Caldas Osório, Ana Alexandra Caldas Osório, Ariana Gomes Nascimento, Ariana Gomes Nascimento, Vinnie Marchisio, Alexandro Marcos Menegócio, Alexandro Marcos Menegócio, Adriana Tebaldi Pereira, Adriana Tebaldi Pereira, Andrea Bernardinetti Muller Haas, Andrea Bernardinetti Muller Haas, Alfredo Almeida Pina-Oliveira, Eurípedes Constantino Miguel, Eurípedes Constantino Miguel, Paulo Rossi Menezes, Paulo Rossi Menezes, Arthur Caye, Arthur Caye, Arthur Caye, Lislaine Aparecida Fracolli, Lislaine Aparecida Fracolli

“…Nurse home visiting programs, such as Primeiros Laços, show promise in improving maternal and child health outcomes, yet their integration into primary healthcare remains underexplored, especially in low-resource settings.Aimto evaluate the effectiveness and feasibility of integrating Primeiros Laços into primary healthcare services across two municipalities of the state of São Paulo, Brazil.MethodA hybrid type I randomized controlled trial will be conducted to assess both the clinical effectiveness and implementation feasibility of the program. …”
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In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeuti... by Auwal Salisu Isa, Adamu Uzairu, Umar Meleh Umar, Muhammad Tukur Ibrahim, Abdullahi Bello Umar, Kamal Tabti, Abdussamad Mukhtar Mohammed

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The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a do... by Helya Helali, Nastaran Samani, Faraj Tabeie, Shiva Eiliaei, Ali Kheradmand

“…The purpose of this study was to evaluate the impact of tPBMT on reducing anxiety, depression, and opioid craving in patients undergoing MMT. Methods This randomized controlled clinical trial included two groups of substance-dependent patients undergoing MMT. …”
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Efficacy of ultrasound-guided intensive silver needles in the treatment of shoulder pain by LUO Jia, LIU Jitong, ZHANG Weiwei, LIAO Qian, LIAO Yongqiong

“…Objective To investigate the effects of ultrasound.guided intensive silver needles on the efficacy, pain, shoulder function, inflammatory factors and pain.causing substances in patients with shoulder joint pain. Methods A total of 92 patients with frozen shoulder admitted to Hunan Provincial People..s Hospital from January 2022 to May 2023 were selected, and were divided into two groups with 46 cases in each group by random number table method. …”
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Integration of Bulk and Single-Cell Transcriptomics Reveals BCL2L14 as a Novel IGKC+ T Cell-Associated Therapeutic Target in Breast Cancer by He J, Akhtar A, Li J, Wei Q, Yuan Y, Ran J, Ma Y, Chen D

“…This study focuses on identifying a novel IGKC+ T Cell subpopulation and its related biomarkers to pave the way for innovative targeted therapies and improved clinical outcomes.Methods: We first performed single-cell RNA sequencing (scRNA-seq) analysis to characterize immune cell heterogeneity within the tumor microenvironment, leading to the identification of series cell subpopulation. …”
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Exploring Therapeutic Potential of Bi-Qi Capsules in Treatment of Gout by Discovering Crucial Drug Targets by Jing Xie, Yu Zhang, Rong Ren, Ruizhen Bu, Liying Chen, Juezhuo Hou, Dandan Shang, Yadong Liu, Dan Wang, Tao Wang, Hong Zhou

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Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severit... by Arash Mansoori, Amir Bazrafshan, Jamshid Ahmadi, Seyed Hamdollah Mosavat

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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, doub... by Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch

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mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized... by Elenore P. Bhatraju, Devin N. Kennedy, Alexander J. Gojic, Matthew Iles-Shih, Joseph O. Merrill, Jeffrey H. Samet, Kevin A. Hallgren, Judith I. Tsui

“…Methods The study is a two-arm pilot randomized controlled trial (N = 40) comparing the mHealth Incentivized Adherence Plus Patient Navigation (MIAPP) intervention to treatment as usual. …”
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Testing a systematically braided alcohol reduction and HIV status neutral intervention among people receiving STI care in Malawi: study protocol for a pilot hybrid type 1 effective... by Kathryn E. Lancaster, Agatha K. Bula, Mitch M. Matoga, Mina C. Hosseinipour, Mina C. Hosseinipour, Irving F. Hoffman, Irving F. Hoffman, Jaslyn A. Grullon, Eric Umar, Jimmy Msolola, Jessica F. Magidson, Jessica L. Bonumwezi, Judith A. Hahn, Angela M. Parcesepe

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Effect of COVID-19 Lockdown on Alcohol Consumption Among the Youths in Kampala, Uganda. A Cross-Sectional Study by Namiiro AM, Audo R, Nannungi CD, Pitua I, Kiberu D, Talemwa P, Mujuni E, Lwesabula A, Ageimo P, Khaukha AZ, Kuol MJ, Egaru L, Koire M, Ssewante N

“…This study assessed the impact of the COVID-19 lockdown on alcohol consumption among youths in Kampala, Uganda.Methods: A quantitative cross-sectional study among randomly selected youth aged 18– 35 years living in the five divisions of Kampala. …”
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Estimating mortality attributable to alcohol or tobacco – a cohort study from Germany by Ulrich John, Hans-Jürgen Rumpf, Monika Hanke, Christian Meyer

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Effectiveness of nurse-initiated smoking cessation intervention: a systematic review and meta-analysis by Eun-Hye Lee, Hea-Jin Yu

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Schizophrenia and violence: systematic review and meta-analysis. by Seena Fazel, Gautam Gulati, Louise Linsell, John R Geddes, Martin Grann

“…The risk for homicide was increased in individuals with psychosis (with and without comorbid substance abuse) compared with general population controls (random-effects OR = 19.5, 95% CI 14.7-25.8).…”
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أثر استخدام طریقة التعیینات في تحصیل مادة طرائق تدریس التربیة الریاضیة وتنمیة التفكیر العلمي by طارق محمد نهاد

“…The researcher used the experimental method consisted sample of students stage Cycle- Department of Physical Education-College of Basic Education - Mustansiriya University where he formed the research sample of 32 students, was Achtaahm simple random way, were divided into two groups, experimental, one studied in accordance with the method of appointments The other officer was taught according to the method used. …”
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