Effectiveness of the guided self-change intervention for reducing alcohol use in adolescents with and without history of cannabis use by José Luis Carballo, José Luis Carballo, Miguel Ángel Martínez-León, Ainhoa Coloma-Carmona, Ainhoa Coloma-Carmona, Virtudes Pérez-Jover, Virtudes Pérez-Jover, Álvaro García del Castillo-López, Clara Sancho-Domingo, Antonia Pelegrín-Muñoz, Carlos van-der Hofstadt-Román, Carlos van-der Hofstadt-Román, Carlos van-der Hofstadt-Román

“…The consumer profile, including whether they have consumed one or more substances, may be a key variable in analyzing the effectiveness of interventions.MethodsThis study consists in a secondary analysis of data from a randomized controlled trial (PREVENALC) to examine the effectiveness of a brief intervention based on the Guided Self-Change Program (GSC) and its interaction with substance use profile. …”
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The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial by Cihan Atila, Sara-Jessica Camerin, Matthias E Liechti, Mirjam Christ-Crain

“…Therefore, this analysis aimed to investigate the acute effect of MDMA on the anterior pituitary in healthy adults. Methods: This secondary analysis utilized data from a double-blind, placebo-controlled, crossover, randomized trial. …”
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Cognitive Training for Emotion-Related Impulsivity and Rumination: Protocol for a Pilot Randomized Waitlist-Controlled Trial by K J D Allen, Matthew V Elliott, Eivind Haga Ronold, Liam Mason, Nandini Rajgopal, Åsa Hammar, Sheri L Johnson

“…Secondarily, we will examine whether N-ACT leads to improvements in inhibitory control and, more distally, psychopathology symptoms. MethodsThe final sample will comprise 80 adults who report high ERI or rumination. …”
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Exploratory Impact of iCARE Nigeria, a Combined mHealth and Peer Navigation Intervention, on Depressive Symptoms and Substance Use Among Youth Living With HIV in Nigeria: Single-Ar... by Olusegun Ayomikun Ogunmola, Rita Frinue Tamambang, Kehinde Kuti, Lisa M Kuhns, Olutosin Awolude, Adedotun Adetunji, Bibilola Oladeji, Oladayo Olaleye, Adeola Mary Oyerinde, Robert Garofalo, Babafemi Taiwo, Olayinka Olusola Omigbodun

“…MethodsA single-arm clinical trial was conducted at the Infectious Disease Institute, College of Medicine, University of Ibadan, Nigeria— primarily to improve medication adherence and viral suppression among youth living with HIV attending its HIV clinic. …”
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Comparative clinical performance of stainless steel, zirconia, and Bioflx crowns in primary molars: a randomized controlled trial by Ahmed Abdelhafez, Vineet Dhar

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Medical chart-reported alcohol consumption, substance use, and mental health issues in association with HIV pre-exposure prophylaxis (PrEP) nonadherence among gay, bisexual, and ot... by Paul A. Shuper, Narges Joharchi, Thepikaa Varatharajan, Isaac I. Bogoch, Mona Loutfy, Philippe El-Helou, Kevin Giolma, Kevin Woodward, Jürgen Rehm

“…Abstract Background Although some evidence suggests that alcohol, substance use, and mental health issues diminish adherence to HIV Pre-Exposure Prophylaxis (PrEP) among gay, bisexual, and other men-who-have-sex-with-men (gbMSM), findings are somewhat inconsistent and have primarily derived from studies involving non-random samples. …”
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A preliminary randomized trial of the safety, tolerability, and clinical effects of hemp-derived cannabidiol in alcohol use disorder by Raeghan L. Mueller, Jake F. Hooper, Jarrod M. Ellingson, Aviva K. Olsavsky, Aviva K. Olsavsky, Rachael Rzasa-Lynn, Angela D. Bryan, L. Cinnamon Bidwell, Kent E. Hutchison

“…This study examined the potential therapeutic effects of commercially available products containing CBD with and without a small amount of tetrahydrocannabinol (THC) on alcohol use and craving among individuals with moderate to severe AUD.MethodsIn this feasibility study, a total of 44 participants were randomized to one of three conditions: full-spectrum CBD (n = 13, fsCBD - <0.3% THC), broad-spectrum CBD (n = 15, bsCBD – without THC), or placebo control (n = 16) for 8 weeks. …”
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Acupuncture effects of post-stroke thalamic pain: a systematic review and meta-analysis of randomized controlled trials by Tianwei Zhang, Tianwei Zhang, Junying Zhai, Junying Zhai, Ling Cheng, Ling Cheng, Kaixin Jiang, Kaixin Jiang, Dayang Wang, Huawei Shi, Bin Wang, Xing Chen, Xinglu Dong, Li Zhou

“…This systematic review and meta-analysis aimed to evaluate the efficacy and safety of acupuncture treatment for PS-TP.MethodsAccording to the established search strategy, randomized controlled trials (RCTs) of acupuncture therapy for PS-TP were retrieved from eight Chinese and English databases as well as two clinical trial registration platforms, up to February 2024. …”
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ASSIST in Pitjantjatjara: Protocol for a randomised crossover validation study among Aboriginal and Torres Strait Islander Australians by Matthew W.R. Stevens, Sue Bertossa, Dominic Barry, Chris Holmwood, KS Kylie Lee, John Marsden, Matt Pedler, Mark Thompson, Scott Wilson, Robert L. Ali

“…Methods: Recruitment will occur at a variety of Aboriginal health and welfare settings across remote, rural and urban South Australia. …”
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Exploring Gender Differences in Veterans in a Secondary Analysis of a Randomized Controlled Trial of Mindfulness for Chronic Pain by Diana J. Burgess, Emily M. Hagel Campbell, Mariah Branson, Collin Calvert, Roni Evans, Kelli D. Allen, Ann Bangerter, Lee J.S. Cross, Mary A. Driscoll, Sierra Hennessy, John E. Ferguson, Jessica K. Friedman, Marianne S. Matthias, Laura A. Meis, Melissa A. Polusny, Stephanie L. Taylor, Brent C. Taylor

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Comparison of ChatGPT and Internet Research for Clinical Research and Decision-Making in Occupational Medicine: Randomized Controlled Trial by Felix A Weuthen, Nelly Otte, Hanif Krabbe, Thomas Kraus, Julia Krabbe

“…ObjectiveThis study aims to assess the potential suitability of a generative large language model, such as ChatGPT, as a support tool for medical research and even clinical decisions in occupational medicine in Germany. MethodsIn this randomized controlled study, the usability of ChatGPT for medical research and clinical decision-making was investigated using a web application developed for this purpose. …”
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Psychological, social factors, and smoking behavior mediated the effects of cannabis use on personality disorders: A Mendelian randomization study by Yao Ni, Juanmei Li, Zitian Tang, Youqian Zhang, Yanyan Feng

“…Although links between CU and personality disorders (PDs) are documented, their causality remains uncertain.MethodsEmploying Genome-Wide Association Studies (GWAS) data, this study investigated the causal relationship between cannabis use disorder (CUD) and lifetime cannabis use (LCU) with 9 types of PD risk through Mendelian randomization (MR) analysis. …”
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Exploring the Impact of the Caring Contacts Intervention on the Stress and Distress of Veterans and Service Members: Protocol for a Randomized Controlled Trial by Barbara Wright, Anna Evanson, Cameron Casey, Keyne C Law, Andrew H Rogers, Katherine Anne Comtois

“…Using EMA, this study will be the first to investigate mechanisms of the Caring Contacts intervention both in real time, as the messages are received, and over the course of 1 year. MethodsIn this randomized controlled trial, veterans or service members (N=510) experiencing stress or distress recruited via social media advertisements will be offered best available resources and randomized into 1 of 3 study conditions: 12 months of Caring Contacts and monthly EMA, 12 months of Caring Contacts without monthly EMA, or 12 months of monthly EMA alone. …”
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…This study aimed to evaluate the anabolic and performance-enhancing potential of a commercially available 20E and DSG supplement.Methods Twenty-eight resistance-trained young men were recruited for this study. …”
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Is there an alternative to diclofenac i/m injections for rapid relief of severe pain? Results of randomized controlled and partially blind forsage study by A. E. Karateev, E. Yu. Pogozheva, E. S. Filatova, A. M. Lila, V. N. Amirdjanova, V. A. Nesterenko

“…After signing informed consent patients were randomized into DPS 50 mg t.i.d. and Diclofenac 75 mg i/m b.i.d. …”
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LOTUS: Protocol for a double-blind placebo controlled randomized trial of hemp-derived cannabidiol for the treatment of cannabis use disorder. by L Cinnamon Bidwell, Renee Martin-Willett, Samantha N Melendez, Luiza Rosa, Gregory Giordano, Kent E Hutchison, Angela D Bryan

“…<h4>Methods</h4>Design. Double-blind, three-arm randomized placebo-controlled trial. …”
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Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial by Zi-tong Fu, Cun-zhi Liu, Mi-Rim Kim, Yi-duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

“…Objective This study aims to investigate the effects of acupuncture on symptoms, serum hormones, and ANS in PDS patients. Methods This randomized controlled clinical trial was conducted at Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical University. …”
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Modeling biogeochemical processes in the Azov Sea using statistically processed data on river flow by A. I. Sukhinov, Y. V. Belova, A. V. Nikitina, A. M. Atayan

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The Impact of Immune Cells, Metabolites, Inflammatory Factors, and Circulating Proteins on Atopic Dermatitis: Insights from a Mendelian Randomization Study by Zhou D, Gan G, Song S, Zi C, Bao Y, Hao W, Chen Q

“…We identified seven previously unreported circulating substances with causal relationships to AD, filling a current theoretical gap.Keywords: multi-omics, immunomics, metabolomics, proteomics, Mendelian randomization, atopic dermatitis…”
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The impact of a multimodal intervention on physical health factors and lifestyle in patients with affective disorders – results from a randomized controlled trial by Ida Schou Ipsen, Rasmus Schwarz, Lars Vedel Kessing, Kamilla W. Miskowiak, Maj Vinberg

“…Background: Traditional treatment for affective disorders primarily focuses on symptom management through pharmacotherapy and psychotherapy and rarely addresses co-existing physical impairments. Methods: This randomized controlled trial assessed the impact of a six-month multimodal intervention (AWARE) on physical health in patients with bipolar and unipolar depressive disorders. …”
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