The peers expanding engagement in stimulant harm reduction with contingency management study: a protocol paper by Alexis Cooke, Erin Stack, Linda Peng, Ryan Cook, Bryan Hartzler, Gillian Leichtling, Christi Hildebran, Judith M. Leahy, Kelsey Smith Payne, Lynn E. Kunkel, Kim Hoffman, P. Todd Korthuis

“…Every 2 months, two sites are randomly assigned to initiate the experimental CM condition of incentives for achieving client-directed harm reduction activities. …”
Get full text

Response of dissolved organic matter and bacterial community to anthropogenic disturbances in a plateau lake by Yue Meng, Yue Meng, Xin Jiang, Xin Jiang, Yue Li, Chun Qing, Chun Qing, Xingyu Long, Pinhua Xia, Pinhua Xia

“…Methods such as Spearman correlation analysis, null model, neutral community model and random forest analysis were explored how FDOM composition and bacterial communities respond to anthropogenic disturbances in the sediments and water of the Caohai Lake.ResultsThe results indicated that sediment FDOM was sensitive to anthropogenic disturbances, with protein-like substances dominating heavily disturbed areas (69%) and humic-like substances dominating less disturbed areas (63%). …”
Get full text

Intra-articular corticosteroids for treatment of temporomandibular joint internal disorders: protocol for systematic review and network meta-analysis by Aurelio Tobias, Daniela Torres, Carlos Zaror, Verónica Iturriaga

“…Among the minimally invasive therapies, we find the intra-articular infiltration of substances, such as corticosteroids, hyaluronic acid or platelet-rich plasma accompanied or not by an arthrocentesis. …”
Get full text

Machine learning optimization of microwave-assisted extraction of phenolics and tannins from pomegranate peel by Fatemeh Mobasheri, Mostafa Khajeh, Mansour Ghaffari-Moghaddam, Jamshid Piri, Mousa Bohlooli

“…However, there is still a lot of difficulty dealing with the extraction of these substances due to the limitations of traditional methods. …”
Get full text

Multiple chemical sensitivity (MCS) validity, prevalence, tools and interventions: systematic review protocol by Karen A Robinson, Aneesa Motala, Susanne Hempel, Jeremy Miles, Jill Johnston, Sachi Yagyu, Margie Danz, Danica Tolentino, Omid Akbari, Diana Zhang

“…Introduction Multiple chemical sensitivity (MCS) describes reported adverse reactions to exposure to common chemical agents (solvents, odourants, air pollutants, material or substances) in low doses tolerated by most people. Symptoms involve more than one organ system and responses are triggered by multiple, chemically unrelated substances.Methods and analysis The systematic review will aim to answer six questions: Which definitions of MCS have been validated? …”
Get full text

Comparison of the composition, immunological activity and anti-fatigue effects of different parts in sika deer antler by Siqi Chen, Yidan Li, Yichun Yang, Shibo Zhao, Huali Shi, Chengkai Yang, Min Wu, Aiwu Zhang

“…Then, 100 mice were randomly divided into 5 groups. The mice in control group were administered 0.3 mL of saline solution per day. …”
Get full text

Lycium barbarum and Lactobacillus acidophilus synergistically protect against anti-tuberculosis drug-induced male reproductive injury via gut microbiota-independent pathways in mic... by Xiaoyong Song, Wei Guan, Wei Guan, Zhimin Du, Yi Gong, Dan Wang, Yajun Xiong, Yuting Gao, Xinli Shi

“…This study aimed to explore the protective effect and mechanism of wolfberry on the reproductive injury of male mice induced by anti-TB drugs.MethodsForty male Kunming mice were randomly assigned to normal, model, wolfberry, and levocarnitine groups (n = 10/group). …”
Get full text

Transcranial Direct Current Stimulation (tDCS) for Borderline Personality Disorder (BPD): Why and How? by Lionel Cailhol, Kamilia Soltani, Cécilia Neige, Marine Mondino, Jérôme Brunelin, Martin Blay

“…Neurobiologically, tDCS modulates the excitability of the dorsolateral and ventrolateral prefrontal cortex and enhances fronto-limbic connectivity, thereby strengthening top-down regulatory control over emotion and behavior. Pilot randomized controlled trials report moderate effect sizes for improvements in emotional regulation, inhibitory control, and rejection sensitivity, along with ancillary gains in executive functioning and reductions in depressive and substance-use symptoms when stimulating the left dorsolateral prefrontal cortex. …”
Get full text

THROMBOLYTIC AND ANTICOAGULANT THERAPY FOR PULMONARY EMBOLISM: AN EFFECT ON PULMONARY PERFUSION (PART 2) by O. V. Nikitina, I. P. Mikhailov, N. Y. Kudryashova, E. V. Migunova, O. A. Alekseyechkina, E. V. Kungurtsev, N. M. Udalova, S. Z. Khusainov, I. B. Kostyuchenko

“…Preliminary analysis of these parameters in the group with anticoagulant therapy a day after the start of administration (by analogy with TLT) revealed no statistically significant differences.Description of the method. Radionuclide and CT studies were performed on a hybrid system SPECT/CT “Discovery NM/CT 670” (GE, USA): perfusion was evaluated with 80–120 MBq of Macrotech 99mTc radiopharmaceutical (RP), CT angiography was performed with 70-100 ml of radiopaque substance “Visipaque.” …”
Get full text

Tobacco use in Northern India–Part 1: The detailed habit by Sandeep Kumar, Varsha Dwivedi, Upendra Pandey, Nidhi Bala, Sheela Vasandani, Kamlesh Singh, Kishore Chaudhry

“…This study depicts the modes of tobacco use, their relative frequency, demographic and psychosocial determinants. Materials and Methods: Random stratified sampling from the list of blocks, villages and urban localities was done. …”
Get full text

The Actual Clinical Situation Ruthlessly Exposes the Challenge of Rational Care for Nosocomial and Community-Acquired Infections and Requires Even More Efforts for Satisfactory Ant... by Hans H. Diebner, A. Melina Wallrafen, Nina Timmesfeld, Tim Rahmel, Hartmuth Nowak

“…<b>Background:</b> Antimicrobial resistance is one of the 10 most pressing health problems worldwide. <b>Methods:</b> First steps toward harnessing the complex dynamics of antibiotic resistance are presented. …”
Get full text

Efficacy and Safety of Glucagon‐Like Peptide‐1 Agonists for Psychiatric Symptoms: A Systematic Review by Shakila Meshkat, Corinna Di Luciano, Alyssa Swiderski, Gloria Li, Reinhard Janssen Aguilar, Benjamin T. Dunkley, Amy C. Reichelt, Yanbo Zhang, Andrew Greenshaw, Eric Vermetten, Rakesh Jetly, Satya Dash, Sri Mahavir Agarwal, Jennifer Swainson, Venkat Bhat

“…This systematic review examined the impact of GLP‐1 RAs on psychiatric symptoms, categorizing studies based on whether psychiatric outcomes were primary or secondary. Methods: A comprehensive search through OVID databases from inception to November 2024 identified 26 studies (n = 3020), with 5 studies evaluating psychiatric symptoms as primary outcomes (e.g., substance use disorders) and 21 studies assessing secondary outcomes across various conditions. …”
Get full text

The social determinants of tuberculosis: a case-control study characterising pathways to equitable intervention in Peru by Matthew J. Saunders, Rosario Montoya, Luz Quevedo, Eric Ramos, Sumona Datta, Carlton A. Evans

“…Controls (n = 981) were people living in randomly selected households in the same communities. …”
Get full text

Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome by Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Chunfang Zhao, Erhui Jin, Erhui Jin, Youfang Gu, Youfang Gu, Hongyu Wang, Feng Zhang, Feng Zhang

“…This study investigated the preventive effect of dietary berberine on the intestinal mucosal barrier induced by ETEC and the microbial community within the intestines of weaned piglets.MethodsTwenty-four piglets were randomly divided into four groups. …”
Get full text

Metallophosphide poisoning, a rising public health problem in Ethiopia: a systematic review and meta-analysis by Kassaye Demeke Altaye, Bethelhem Yenenew Assefa, Adina Worku Teka, Saron Mulugeta Worku, Geta Bayu Genet, Bikis Liyew, Nahom Worku Teshager

“…This systematic review and meta-analysis aim to determine the pooled prevalence and mortality rate from metallophosphide poisoning in Ethiopia. Methods As of August 2024, PUBMED, EMBASE, SCOPUS, and GOOGLE SCHOLAR were inclusively searched. …”
Get full text

Characteristic of nicotine delivery devices – electronic cigarettes – as a tool to fight against tobacco dependence by A. Ye. Bogomolov

“…Attention is paid to the fact that the actual physical nicotine dependence in the vast majority of cases is combined with psychological dependence, which reduces the effectiveness of other nicotine delivery devices. Data from randomized clinical trials show that further development of methods for studying the effects of the EC on the organism is very actual. …”
Get full text

Comparative effect of nutraceuticals on lipid profile: a protocol for systematic review and network meta-analysis by Maciej Banach, Lukas Schwingshackl, Mariusz Gasior, Jakub Morze, Tadeusz Osadnik, Kamila Osadnik, Mateusz Lejawa, Grzegorz Jakubiak, Natalia Pawlas

“…The aim of this study was to compare the effect of different nutraceuticals on lipid profiles in a systematic review with pairwise and network meta-analyses.Methods and analysis Three databases, including PubMed, Embase and the Cochrane Central Register of Controlled Trials, will be searched without time or publication language restrictions. …”
Get full text

Rapid tests to inform triage and antibiotic prescribing decisions for adults presenting with suspected acute respiratory infection: a rapid evidence synthesis of clinical effective... by Katie Scandrett, Jill Colquitt, Rachel Court, Fiona Whiter, Bethany Shinkins, Yemisi Takwoingi, Emma Loveman, Daniel Todkill, Paramjit Gill, Daniel Lasserson, Lena Al-Khudairy, Amy Grove, Yen-Fu Chen

“…Meta-analysis using a random-effects model using the DerSimonian and Laird method was undertaken. …”
Get full text

Identification and Expression Analysis of the ADH Gene Family in Chinese Pepper(Capsicum chinense) by Chu YE, Wei LIN, Chuan WANG, Bingchun XIE, Xiaowan XU, Xiaomei XU, Hengming WANG, Junheng LYU, Minghua DENG, Zhiming WU, Tao LI, Zhou HENG

“…Identifying the members of the ADH gene family in C. chinense, and analyzing their expression patterns in different parts of the plant will provide references for the aroma synthesis mechanism of pepper fruit.【Method】Through bioinformatics analysis, real-time fluorescent quantitative PCR, and gaschromatography-mass spectrometry, the volatile substances and the ADH gene family in C. chinense were identified and analyzed for expression characteristics.…”
Get full text

A caffeine and theacrine combination improves cognitive performance in tactical personnel under physically fatiguing conditions by Blaine S. Lints, Adam T. Harrison, Sten O. Stray-Gundersen, Gianna F. Mastrofini, Riccardo F. Romersi, Noah K. Nakagawa, Mackenzie B. Yoder, Chimaobim E. Martin-Diala, Alexa J. Chandler, R. Davis Moore, Shawn M. Arent

“…Theacrine, a purine alkaloid similar in structure to caffeine but with a longer half-life, less habituation, and fewer side effects, is proposed as a caffeine-alternative to enhance cognitive resilience.Methods Tactically trained participants (n = 20; F = 5; M = 16; age = 21.5 ± 3.8 y) completed one baseline and three experimental visits. …”
Get full text