Endoscopic third ventriculostomy in idiopathic normal pressure hydrocephalus. Efficacy and possible positive predictors: a systematic review by Karel Pištěk, Martin Sameš, Tomáš Radovnický

“…Further studies with robust randomized cohorts comparing ETV to shunting are necessary.…”
Get full text

Integration of multi-omics quantitative trait loci evidence reveals novel susceptibility genes for Alzheimer’s disease by Jinyang Gao, Xiaochan Bi, Wenjing Jiang, Yanqing Wang

“…Summary-data-based Mendelian Randomization (SMR), colocalization analysis and Heterogeneity in Dependent Instruments (HEIDI) analyses were conducted to establish causality between genetic variants and AD risk. …”
Get full text

Structured, multifactorial randomised controlled intervention to investigate physical activity levels, body composition and diet in obese and overweight adolescents by Prateek Srivastav, Vaishali K, Vinod H Bhat, Suzanne Broadbent

“…The participants will be overweight and obese male and female adolescents aged 11–16 years and will be randomly assigned by school into three groups: group A (multifactorial intervention, exercise and dietary advice); group B (exercise only); and group C (controls, no interventions). …”
Get full text

The efficiency of metabolic impact of S-adenosylmethionine and meldonium on parameters of lipid profile and insulin resistance during comorbid course of nonalcocholic steatohepatit... by O. S. Khukhlina, A. A. Antoniv, O. S. Voievidka, O. B. Kuzminska

“…The third group (25 people) received hypocaloric diet, metformin 500 mg twice daily, rosuvastatin 10 mg 1 time per day, canephron N (50 mg 3 times a day), SAM (Agepta) (200 mg 3 times a day sublingually) and meldonium (Vazonat) (250 mg 2 times a day) during 90 days. The analysis of clinical manifestations of NASH and CKN of the III stage, biochemical, laboratory parameters of the functional state of the liver, kidneys, endothelium, ultrasonographic data were studied in dynamics in 30 and 90 days during treatment and in 3 months after the treatment. …”
Get full text

Depression in older adults: prevalence and risk factors in a primary health care sample by Uschenka Padayachey, S Ramlall, J Chipps

“…Data analysis: Data were analysed using SPSS version 23®. …”
Get full text

Evaluation of the effectiveness and prognostic significance of the use of CMR in determining the viability of the myocardium by Ya. K. Rustamova, V. A. Azizov

“…А total of 148 patients participated in the analysis of the study. Inclusion criteria: myocardial infarction in past medical history; myocardial ischemia according to stress tests; occlusion or subtotal stenosis of one or more coronary arteries according to digital angiography (SYNTAX score < 32); viable myocardium in the zone of the occluded/stenotic artery; heart failure of I–III functional class (NYHA); left ventricular ejection fraction (LVEF) of less than 50%. …”
Get full text

Examining the effect of a sexual self-efficacy based educational intervention on postmenopausal sexual satisfaction and sexual distress: a parallel quasi-experimental study by Ata Torkamani, Mansoureh Jamshidimanesh, Sally Pezaro, Elahe Amirkhalili

“…Abstract Objective Menopause is associated with changes that affect sexual functioning. We evaluated the effect of a sexual self-efficacy-based educational intervention on postmenopausal sexual satisfaction and distress. …”
Get full text

Intravitreal bevacizumab for neovascular age-related macular degeneration by Junn R. Pajarillo, MD, Harvey S. Uy,MD, Milagros H. Arroyo MD, MPH

“…Methods: A prospective, interventional, placebo-controlled, randomized clinical trial was done involving patients with active subfoveal neovascular ARMD. …”
Get full text

Comparing the Effects of a Series of Ischaemic Compression Therapy and Muscle Energy Techniques on Pain Threshold and Muscle Tension in People with Upper Crossed Syndrome by Dawid Janczarzyk, Krzysztof Jamka, Edyta Mikołajczyk, Bartosz Zając

Get full text

Protective effects of lemon and orange peels and olive oil on doxorubicin-induced myocardial damage via inhibition of oxidative stress and inflammation pathways by Amal I. El-Refaiy, Zainab A. Salem, Abdelnaser A. Badawy, Naief Dahran, Muhammad A. Desouky, Muhammad A. Desouky, Mohammed A. El-Magd

“…After 28 days, cardiac biomarkers (AST, LDH, CK, cTnT), oxidative stress markers (NO, MDA), antioxidant enzyme activities (SOD, CAT, GPx), apoptotic genes (Bax, caspase 3, Bcl2), NFκB and inflammatory cytokines (TNFα, IL1β) were assessed. Histopathological analysis of the heart was also conducted.ResultsDOX-treated rats showed significant functional and structural cardiac damage, characterized by elevated AST, LDH, CK, cTnT, NO, MDA, Bax, caspase 3, NFκB, TNFα, IL1β and reduced SOD, CAT, GPx, and Bcl2 levels. …”
Get full text

Investigating the prevalence of cognitive impairment and dementia in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): the Harmonised Cognitive Assessment... by Bernadette Mcguinness, Frank Kee, David Weir, Leeanne O'Hara, Charlotte Neville, Calum Marr, Michael McAlinden

“…The NICOLA-HCAP substudy is funded by the National Institute on Aging as part of a network for enhancing cross-national research within a worldwide group of population-based, longitudinal studies of ageing, all of which are centred around the US-based Health and Retirement Study.Methods and analysis The NICOLA-HCAP study will draw on the main NICOLA cohort (of 8283 participants) and randomly sample 1000 participants aged 65 and over to take part in the substudy. …”
Get full text

High-salt diets provoke phosphorus absorption from the small intestine in mice by Mingxin Yang, Huaizhou You, Li Ni, Jianping Mao, Jing Chen

“…Given NHE3’s pivotal role in sodium (Na+) metabolism, there is a suspected functional link between Na+ and Pi metabolism. High-salt diets (HSD) have been demonstrated to disrupt calcium (Ca2+) metabolism. …”
Get full text

Tongue Muscle Training App for Middle-Aged and Older Adults Incorporating Flow-Based Gameplay: Design and Feasibility Pilot Study by Kuan-Chu Su, Ko-Chiu Wu, Kuei-Ru Chou, Chia-Hsu Huang

“…Next, we aim to conduct a randomized pilot trial, improve app functions, offer alternative rehabilitation options, and encourage long-term participation. …”
Get full text

Reliability of the Cutting Alignment Scoring Tool (CAST) to Assess Trunk and Limb Alignment During a 45-Degree Side-Step Cut by Lauren S Butler, Eryn K Milian, Amie DeVerna, Kevin Latz, Henry B Ellis, Alexa R Martinez, Kristin Hayden, Christian Gerstenkorn, Sara C Carpenito, Charles W Wyatt, Dai Sugimoto

“…# Background Three-dimensional (3D) motion analysis is considered the gold standard for evaluating human movement. …”
Get full text

Exploring the Anti-Menopausal Potential of Rhizophora mucronata Lam. Ethanol Extract: A Comprehensive Study on Estrogen Receptor β Agonist Activity by Ernawati Ernawati, Moh. Awaludin Adam, Irawati Mei Widiastuti, Era Insivitawati, Muhammad Nikmatullah, Putut Har Riyadi, Mohamad Nor Azra

“…The extract was administered orally, and various measurements were taken, including flavonoid content, using densitometry thin layer chromatography (TLC) and FTIR for functional group characterization. The study found a high rutin content (13.29%) in the fruit. …”
Get full text

Neuroimaging studies of acupuncture for depressive disorder: a systematic review of published papers from 2014 to 2024 by Dezhi Lin, Qiang Ren, Yangxu Ou, Longlong Li, Dezhong Peng, Sha Yang

“…The methodological quality of the studies was assessed utilizing the Risk of Bias 2.0 and Risk of Bias in Non-Randomized Studies of Interventions tools. Following a qualitative analysis of the studies, relevant information regarding acupuncture interventions and brain imaging data was extracted.ResultsA total of 26 studies met the inclusion criteria. …”
Get full text

Respiratory muscle strength and oxygenation as predictors of length of hospital stay in patients with COVID-19 by E. S. Pan’ko, S. V. Zhavoronok, A. M. Solovchuk, S. V. Pan’ko

“…The aim was to analyze the prognostic value of ventilation/ gas exchange dissociation markers to predict the treatment length in patients with the acute phase of COVID-19.Materials and methods: The analysis was performed using a database of 384 randomly selected patients from December 2021 to May 2022 with a confirmed diagnosis of the acute phase of COVID-19, aged 61±16 years. …”
Get full text

The study of difference in alpha and theta band in divergent and convergent thinking in the posterior of the right hemisphere by Sepideh Shahmoradi, Mohammad Reza Zoghi Paydar, Mehran Farhadi, Shahryar Yar Mohammadivasel

“…The sample included 32 participants (16 men and 16 women) selected using purposive sampling and randomly assigned to experimental conditions (divergent and convergent). …”
Get full text

Effects of Thermal Manipulation and Serotonin Modulation on Brain HSP70 and HSP90 Gene Expression in Late Embryogenesis of Broilers by Hamed KHasti, Ladan Emadi, Shahrzad Azizi, Elham Mohammadi, Hadi Tavakkoli

“…Methods A total of 120 fertilized eggs were randomly divided into control and serotonin (20 µg/egg) groups. …”
Get full text

Systematic Literature Review of the Efficacy and Safety of Khan Kinetic Treatment for Neck and Back Pain by Yazid Maghrabi, Lamair Albakri, Hana Alsebaeyl, Saleh Baeesa

“…The studies included three Randomized controlled trials (RCTs) and two case reports. …”
Get full text