Causal Relationships Between the Gut Microbiota, Inflammatory Cytokines, and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Analysis by Li Changqing, Yu Leying, Ma Caiyun, Wen Hebao, Han Laiguo, Zhao Xiaojiang

“…Methods We performed Mendelian randomization (MR) analyses utilizing data derived from genome‐wide association studies (GWAS) of GM, ICs, and ALS. …”
Get full text

Efficacy and safety of mineralocorticoid receptor antagonists in kidney transplant patients: an updated meta-analysis of randomized controlled trials by Paula Dibo, Naga Sai Rasagna Mareddy, Giovana Schlichta Adriano Kojima, Mohamad Ershed, Ogechukwu Samuel Obi, Saeed Razaq, Vineeta Kumar

“…Heterogeneity was examined with I2 statistics. A random-effects model was used for outcomes with high heterogeneity. …”
Get full text

Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites by Siyuan Zhao, Jinghao Jiang, Jianwu Zhang, Xiaoqing Jin

“…This study employed mediation Mendelian randomization analysis to explore the relationships between immune cell phenotypes, cerebrospinal fluid metabolites, and glioma, aiming to uncover potential mechanisms of tumor progression and immune evasion. …”
Get full text

Efficacy of Alpha Lipoic Acid Supplementation in Sperm Parameters: A Systematic Review and Meta-Analysis of Randomized Trials by Iago Zang Pires, Marília Oberto da Silva Gobbo, Renan Yuji Ura Sudo, Tanize Louize Milbradt, Nilson Marquardt Filho, Gustavo Franco Carvalhal, Carlos Teodosio Da Ros

“…Purpose: We aimed to perform a systematic review and meta-analysis of the currently available randomized trials comparing the effects of ALA supplementation versus placebo on sperm function in infertile male patients. …”
Get full text

Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study by Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu

“…Abstract Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. …”
Get full text

Voice as a Health Indicator: The Use of Sound Analysis and AI for Monitoring Respiratory Function by Nicki Lentz-Nielsen, Lars Maaløe, Pascal Madeleine, Stig Nikolaj Blomberg

Get full text

Effect of Acupuncture on Functional Connectivity of the Limbic Network in Patients with Knee Osteoarthritis: A Resting State Functional Magnetic Resonance Imaging Study by Wu N, Lou XS, Chang YN, Li JY, Zhang ZH, Hu JH, Fan Y, Feng XD, Yin S

“…In contrast, placebo acupuncture exerts its placebo effects primarily through engagement of the reward circuitry.Keywords: acupuncture, functional magnetic resonance imaging, independent component analysis, limbic system, osteoarthritis, knee…”
Get full text

The clinical efficacy and mechanism of gamma frequency electroacupuncture stimulation on the rehabilitation of upper limb motor function in stroke patients: study protocol of a ran... by Xiaoyu Tian, Xiaoyu Tian, Xiaoyu Tian, Xiaoyu Tian, Xiaoming Yu, Hongli Ma, Hongli Ma, Hongli Ma, Hongli Ma, Minghui Lai, Ruiren Wu, Ruiren Wu, Ruiren Wu, Ruiren Wu, Xinglin Zhang, Jingjing Zhang, Zifan Luo, Zifan Luo, Zifan Luo, Zifan Luo, Wang Fu, Wei Feng, Wei Feng, Jun Hu, Chunlei Shan, Chunlei Shan, Chunlei Shan, Cong Wang, Cong Wang, Cong Wang, Cong Wang, Cong Wang, Feng Wang

“…At present, there is a lack of research on the clinical efficacy and mechanism of applying gamma frequency (40-Hz) ES, a new neuromodulation mode of integrated Chinese and Western medicine, to induce gamma oscillations and promote the rehabilitation of upper limb motor function in stroke patients.Methods and analysisThis trial uses a randomized, double-blind and controlled method to evaluate the effect of 40-Hz ES of LI11 (Quchi) acupoint on upper limb motor functional rehabilitation in stroke patients. …”
Get full text

Back-Analysis of Parameters of Jointed Surrounding Rock of Metro Station Based on Random Forest Algorithm Optimized by Cuckoo Search Algorithm by Xinping Guo, Annan Jiang, Xiang Liu

“…In this paper, a new back-analysis method of joint parameters of the ubiquitous-joint model is proposed. …”
Get full text

Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study by Lu Wang, Xiaomin Wang, Dong Chen

“…To address issues of heterogeneity, pleiotropy, and outliers, we incorporated sensitivity analyses and Mendelian randomization (MR) techniques.Results The IVW analysis suggests that a faster WP reduces the risk of COPD hospitalization (OR = 0.3559, 95% CI: 0.22-0.52; p = 5.197 × 10−5). …”
Get full text

Meta‐analysis of cardiac magnetic resonance in prognosticating left ventricular function in peripartum cardiomyopathy by Hawani Sasmaya Prameswari, William Kamarullah, Raymond Pranata, Iwan Cahyo Santosa Putra, Alberta Claudia Undarsa, Mohammad Iqbal, Triwedya Indra Dewi, Nuraini Yasmin Kusumawardhani, Mohammad Rizki Akbar, Astri Astuti

“…Diagnostic‐test accuracy meta‐analysis revealed that LGE had a sensitivity of 73% (95% CI, 56–85%), specificity of 79% (95% CI, 45–95%), and AUC of 0.78 (95% CI, 0.75–0.82) in predicting poor LV recovery when performed in the later phase, whereas significant myocardial oedema in those with non‐recovered LV function had a sensitivity of 12% (95% CI, 2–52%), specificity of 68% (95% CI, 39–88%), and AUC of 0.40 (95% CI, 0.36–0.44) while undertaken in the latter phase. …”
Get full text

Treatments for rotator cuff calcific tendinitis: a systematic review and network meta-analysis of randomized-controlled trials by Yuming Yao, Guang Yang, Shide Jiang, Bingzhou Ji, Hongfu Jin, Peiyuan Tang, Hengzhen Li, Bangbao Lu, Yusheng Li

Get full text

Exploring potential therapeutic targets for small cell lung cancer based on transcriptomics combined with Mendelian randomization analysis by Zhicheng Liao, Pengcheng Jia, Yifan Li, Zhihui Zheng, Jizhou Zhang

“…ObjectiveThe main objective of this study was to explore and identify new genetic targets in small-cell lung cancer (SCLC) through transcriptomics analysis and Mendelian randomization (MR) analysis, which will help in the subsequent development of new therapeutic interventions.MethodsIn this study, we extracted the SCLC dataset from the Gene Expression Omnibus (GEO) database, processed the data, and screened out differentially expressed genes (DEGs) using R software. …”
Get full text

Injection therapy for carpal tunnel syndrome: A systematic review and network meta-analysis of randomized controlled trials. by Fu-An Yang, Hsun-Yi Wang, Tien-Yu Kuo, Chih-Wei Peng, Tsan-Hon Liou, Reuben Escorpizo, Hung-Chou Chen

Get full text

Efficacy and safety of arthroscopy in femoroacetabular impingement syndrome: a systematic review and meta-analysis of randomized clinical trials by José María Lamo-Espinosa, Gonzalo Mariscal, Jorge Gómez-Álvarez, Mikel San-Julián

“…Randomized clinical trials were included in the study. …”
Get full text

Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…Systems biology approaches including tissue-specific expression profiling, pathway enrichment, and protein interaction network analysis revealed spatial and functional drivers of irAE pathogenesis. …”
Get full text

Statin treatment for cerebral small vessel disease: A systematic review and meta-analysis of randomized controlled trials by David Fresnais, Brynjar Fure

“…Aim: This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the impact of statin therapy on CSVD. …”
Get full text

Efficacy and safety of Tai Chi for Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. by Xiaojia Ni, Shaonan Liu, Fuchang Lu, Xiaogeng Shi, Xinfeng Guo

“…The tool from the Cochrane Handbook 5.1 was used to assess the risk of bias. A standard meta-analysis was performed using RevMan 5.2 software.<h4>Results</h4>Ten trials with PD of mild-to-moderate severity were included in the review, and nine trials (n = 409) were included in the meta-analysis. …”
Get full text

Combined Analysis of Transcriptome and Mendelian Randomization Reveals AKT1 and PPARG as Biomarkers Related to Glucose Metabolism in Sepsis by Ma J, Li W, Ma Q, Ding L, Wang Z, Wang R, Huang Y, Ma G, Gao J

“…A nomogram model was developed, and biomarker functions were explored through enrichment analysis, immunoinfiltration analysis, transcription factors (TFs) and microRNA (miRNA) prediction, and drug prediction. …”
Get full text

Right ventricular function in athletes engaged in endurance exercise using speckle tracking echocardiography: a meta-analysis by Chenzan Guo, Hebin Zhang, Cunxin Yang, Peipei Hu, Hui Ma, Ying Ma, Feng Gao

“…In addition, a random-effects meta-analysis revealed significant impairments in RV function when assessed by comparing RV GLS pre-endurance versus post endurance exercise WMD = 2.51, 95% CI (1.634 ~ 3.40), p < 0. 001. …”
Get full text