Online Group–Based Dual-Task Training to Improve Cognitive Function of Community-Dwelling Older Adults: Randomized Controlled Feasibility Study by Pui Hing Chau, Denise Shuk Ting Cheung, Jojo Yan Yan Kwok, Wai Chi Chan, Doris Sau Fung Yu

“…MethodsA randomized controlled feasibility study was conducted with 76 participants in Hong Kong, randomly assigned to the intervention and attention control groups in a ratio of 2:1 (n=50, 66% and n=26, 34%, respectively). …”
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Multi-species probiotic supplement enhances vagal nerve function – results of a randomized controlled trial in patients with depression and healthy controls by Sabrina Mörkl, Martin Narrath, Daria Schlotmann, Marie-Therese Sallmutter, Julia Putz, Julia Lang, Andreas Brandstätter, Rene Pilz, Helmut Karl Lackner, Nandu Goswami, Bianca Steuber, Jasmin Tatzer, Sonja Lackner, Sandra Holasek, Annamaria Painold, Emanuel Jauk, Julian Wenninger, Angela Horvath, Nicolai Spicher, Asmus Barth, Mary I Butler, Jolana Wagner-Skacel

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Artificial intelligence–enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial by Zhandos Kurban, Didar Khassenov, Didar Khassenov, Zhandos Burkitbaev, Sholpan Bulekbayeva, Azat Chinaliyev, Serik Bakhtiyar, Samat Saparbayev, Tokan Sultanaliyev, Ulzhalgas Zhunissova, Natalia Slivkina, Elena Titskaya, Luis Arias, Dana Aldakuatova, Gulfairus Yessenbayeva, Zhanerke Ermakhan

“…BackgroundMobile health applications and artificial intelligence (AI) are increasingly utilized to streamline clinical workflows and support functional assessment. The International Classification of Functioning, Disability and Health (ICF) provides a standardized framework for evaluating patient functioning, yet AI-driven ICF mapping tools remain underexplored in routine clinical settings.ObjectiveThis study aimed to evaluate the efficiency and accuracy of the MedQuest mobile application—featuring integrated AI-based ICF mapping—compared to traditional paper-based assessment in hospitalized patients.MethodsA parallel-group randomized controlled trial was conducted in two medical centers in Astana, Kazakhstan. …”
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Water quality evaluation in Liaoning Province large reservoirs: a new method integrating random forest-TOPSIS and Monte Carlo simulation by Chong Zhang, Mo Chen, Yi Wang

“…The model integrates the technique for order preference by similarity to ideal solution with Monte Carlo simulation and employs the random forest method for weight allocation. Utilizing monthly water quality data, the model generates normally distributed datasets that are processed through the TOPSIS model, incorporating RF-derived weights and a membership function, for a comprehensive evaluation. …”
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High resolution soil moisture mapping in 3D space and time using machine learning and depth functions by Mo Zhang, Yong Ge, Gerard B.M. Heuvelink, Yuxin Ma

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Physical education exercise improves physical fitness and working memory function: a randomized controlled trial study of Uyghur adolescents in Xinjiang, China by Xiaodi Cai, Yuefeng Liu, Yanhong Li, Zhiqiang Chen

“…The effects of physical education exercise on physical fitness and working memory function of Uyghur adolescents were analyzed. Methods Randomly selected 222 Chinese Xinjiang Uyghur secondary school students were randomly divided into a control group and an exercise intervention group. …”
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Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii by Fei Xie, Lifeng Wang, Song Li, Long Hu, Yanhua Wen, Xuming Li, Kun Ye, Zhimei Duan, Qi Wang, Yuanlin Guan, Ye Zhang, Qiqi Shi, Jiyong Yang, Han Xia, Lixin Xie

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Efficacy and safety of visnadine in the treatment of symptoms of sexual dysfunction in heterosexual women: a systematic review of randomized clinical trials by Brenda Caira-Chuquineyra, Daniel Fernandez-Guzmán, Humberto Garayar-Peceros, Vicente A. Benites-Zapata, Faustino R. Pérez-López, Juan E. Blümel, Edward Mezones-Holguín

“…However, future better-designed randomized studies with larger sample numbers are required.…”
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Comparative analysis of cardioprotective effects of two renal denervation techniques by T. M. Ripp, S. E. Pekarskiy, A. E. Baev, T. R. Ryabova, E. I. Yaroslavskay, A. Yu. Falkovskaya, E. S. Sitkova, V. A. Lichikaki, I. V. Zubanova, M. A. Manukian, L. I. Gapon, V. F. Mordovin

“…We assessed structural and functional cardiac characteristics using two-dimensional speckle-tracking echocardiography (STE).Results. …”
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Feasibility, safety and preliminary effect of exercise prehabilitation in patients with esophageal cancer undergoing surgery: an open-label, randomized, parallel-group pilot and fe... by Chen Gong, Beibei Feng, Huashe Wang, Yafei Wang, Jiadan Yu, Biru Wang, Shi Chen, Junsheng Peng, Yuling Wang

“…Results Twenty-one patients were randomized, and 16 were included in the primary analysis. …”
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Bidirectional Two-Sample Mendelian Randomization Study Reveals Causal Associations Between Aging and Endometriosis by Chen L, Yan H, Nie J

“…The lack of replication in independent datasets highlights the potential influence of population heterogeneity and dataset-specific factors, warranting further validation in diverse cohorts.Keywords: Mendelian randomization analysis, causal association, endometriosis, aging…”
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Stochastic parameter-optimized car-following model considering heterogeneous traffic flow by PAN Yiyong, QUAN Yongjun, GUAN Xingyu

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Exploring the predictive values of SERP4 and FRZB in dilated cardiomyopathy based on an integrated analysis by Bin Qi, Hai-Yan Wang, Xiao Ma, Yu-Feng Chi, Chun Gui

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, disease ontology, gene ontology annotation and protein-protein interaction (PPI) network analysis were then performed, while a random forest was constructed to explore central genes. …”
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Causal Links Between Brain Functional Networks and Endometriosis: A Large-Scale Genetic-Driven Observational Study by Feng S, Wang Y, Liu S, Zhang Y, He L

“…This study aims to explore these relationships using Mendelian Randomization (MR) analysis.Methods: Data from 191 resting-state functional MRI (rsfMRI) phenotypes and endometriosis genetic datasets were analyzed using both forward and reverse MR approaches. …”
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Causal relationship among immune cells, basal cell carcinoma, and gut microbiome: a two-sample Mendelian randomization analysis and mediation analysis by Hequn Li, Liang Chen

“…Methods A two-sample Mendelian randomization (MR) analysis was undertaken to assess the influence of 412 GMs on BCC using data from a genome-wide association study (GWAS) of individuals with European ancestry. …”
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Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses by Xiaolong Li, Cheng-hao Yang, Min Zhou, Min-yi Yin

“…Functional enrichment analyses and molecular docking were conducted to explore biological mechanisms and predict potential therapeutic compounds. …”
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Acupressure for older people with cognitive impairment: a systematic review and meta-analysis of randomized controlled trials by Hongkun Zhang, Luwen Zhu, Luwen Zhu, Minmin Wu, Wenjing Song, Jinting Li, Qiang Tang, Jiongliang Zhang

“…Its therapeutic effects are achieved by stimulating specific points to restore balance in the flow of qi along the meridians, thereby enhancing the physiological functions of body systems and organs. This study aimed to conduct a meta-analysis to evaluate the effects of acupressure on cognitive function, mood, and activities of living (ADL) in older adults with CI.MethodsA comprehensive database search was performed using PubMed, Embase, Cochrane Library, Web of Science, Sinomed, CNKI, Wanfang, and VIP databases to identify randomized controlled trials (RCTs) investigating the effects of acupressure versus non-acupressure in elderly patients with CI. …”
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Training of Executive Functions in Children: A meta-analysis of cognitive training interventions by Efsun Birtwistle, Olga Chernikova, Miriam Wünsch, Frank Niklas

“…We investigated the effect of cognitive training of executive functions on children’s cognitive outcomes. To address this issue, a systematic meta-analysis of published research articles on cognitive training interventions was performed considering children’s age, training duration, -procedure, and -technology in moderator analyses. …”
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Effect of probiotics on prognosis in patients with hepatectomy: a systematic review and meta-analysis of randomized controlled trial by Qinghu Jiang, Hua Zou, Furui Zhong, Jian Ma

“…Method By conducting a computer-based search of electronic databases to collect randomized controlled trials (RCTs) on the use of probiotics in the perioperative period for patients undergoing liver resection. …”
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Glucose homeostasis and cognitive functions in schizophrenia: a systematic review and meta-analysis by Alexander Kancsev, Eszter Éva Virág-Tulassay, Marie Anne Engh, Szilvia Kiss-Dala, András Attila Horváth, Péter Hegyi, Szabolcs Kéri

“…Of the 26 studies included, 9 were meta-analyzed with random effects model. The search was completed on November 23, 2023 and updated on April 2, 2025. …”
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