Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. by Guoyan Yang, Yuyi Wang, Jinzhou Tian, Jian-Ping Liu

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Purpose in life and lung function: an individual-participant meta-analysis of six cohort studies by Angelina R. Sutin, Yannick Stephan, Martina Luchetti, Justin Brown, Tiia Kekäläinen, André Hajek, Brice Canada, Sébastien Kuss, Antonio Terracciano

“…Results In each cohort and aggregated in a random-effects meta-analysis, higher purpose in life was associated with better peak expiratory flow (meta-analytic effect = 0.07, p <.001). …”
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Acupuncture for stroke survivors with cardiovascular comorbidities: protocol of a pooled analysis of randomized controlled trials by Lanfang Zhang, Lanfang Zhang, Lanfang Zhang, Zubing Mei, Zhenhua Xu

“…This protocol outlines a pooled analysis of randomized controlled trials (RCTs) aimed at evaluating the effectiveness and safety of acupuncture in improving neurological function, quality of life, and reducing stroke recurrence in stroke survivors with cardiovascular comorbidities.Methods and analysisThis pooled analysis will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. …”
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Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two‐Sample, Two‐Step Mendelian Randomization Study by Baizhi Qiu, Shuyang Wen, Zifan Li, Yuxin Cai, Qi Zhang, Yuting Zeng, Shuqi Zheng, Zhishan Lin, Yupeng Xiao, Jihua Zou, Guozhi Huang, Qing Zeng

“…We aimed to investigate the causal effects of epigenetic age on stroke and its functional outcomes. Methods We conducted a two‐sample Mendelian randomization (MR) analysis to explore the causal relationships between epigenetic age and stroke and its outcomes. …”
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Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials by Jiaxing Dai, Jiaxing Dai, Huili Shui, Huili Shui, Huili Shui, Yuan Wu, Huanghui Zhang, Huanghui Zhang, Yuanyin Li, Yuanyin Li, Shaowang Zhang, Shaowang Zhang, Bing Yang, Bing Yang, Bing Yang, Dongxin Tang, Dongxin Tang, Dongxin Tang

“…The extracted data were subjected to analysis using Stata (Version 15.1), with the selection of either a random-effects or fixed-effects model based on the heterogeneity among studies. …”
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The effects of vivifrail-based multicomponent training on physical and cognitive function in frail older adults: a systematic review and meta-analysis by Jiping Chen, Haojie Liu, Haojie Zhao, Jiawei Yao, Yanyu Lu

“…Data were analyzed using random-effects meta-analysis.ResultsTwelve studies, including 1,026 participants, were included in the meta-analysis. …”
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Polycystic ovary syndrome and epithelial-mesenchymal transition: Mendelian randomization and single-cell analysis insights by Dong Liu, Dan Liu, Kunyan Zhou

“…Abstract Background The process of epithelial-mesenchymal transition (EMT) may promote fibrosis in ovarian tissue related to polycystic ovary syndrome (PCOS), thus affecting ovarian function and hormonal balance. Objective This study aimed to explore key genes associated with EMT in PCOS and their potential molecular regulatory mechanisms, exclusively from the perspective of transcriptomics and single-cell RNA sequencing (scRNA-seq), combined with Mendelian Randomization (MR) analysis. …”
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Efficacy of aerobic exercises for knee osteoarthritis: a network meta analysis of randomized clinical trials by Yuan Luo, Xiao Chen, Haibo Gong, Li Chen, Liyue Zhang, Shuqiang Li

“…Results The network meta-analysis included 67 randomized controlled trials comprising 4,944 patients with knee osteoarthritis (KOA), assessing 10 aerobic exercise interventions: walking (WK), weight-loss walking (LK), retro walking (RW), cycling (CY), aquatic training (AT), yoga (YG), Tai Chi (TC), Baduanjin (BD), Wuqinxi (WQ), and Pilates (PT). …”
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Intelligent Robot Interventions for People With Dementia: Systematic Review and Meta-Analysis of Randomized Controlled Trials by Wenqi Fan, Rui Zhao, Xiaoxia Liu, Lina Ge

“…Subgroup analysis was performed according to the intelligent robot type and the intervention duration. …”
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Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis by Xiudao Song, Jin Ma, Ting Zou, Rong Xin Lu, Wei Ji, Fei Huang, Meiqi Yin

“…To further characterize the biological relevance of identified cathepsins, we conducted multi-omics investigations including gene set enrichment analysis, CIBERSORT, single-cell RNA sequencing analysis to explore the expression level, immune infiltration and biological function of identified cathepsins. …”
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Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. by Yaoyao Lu, Meng Chen, Zhiyin Huang, Chengwei Tang

“…<h4>Background</h4>Antidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. …”
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Predictor Importance for Hydrological Fluxes of Global Hydrological and Land Surface Models by João Paulo L. F. Brêda, Lieke A. Melsen, Ioannis Athanasiadis, Albert VanDijk, Vinícius A. Siqueira, Anne Verhoef, Yijian Zeng, Martine van derPloeg

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STABILITY ANALYSIS OF DISC BRAKE SYSTEMS WITH UNCERTAINTY PARAMETERS by HUANG Ya, YU DeJie, LV Hui, PENG Long

“…The limit state function used to value system stable reliability was built up,and the reliability analysis was carried out for the uncertain brake system with random and fuzzy parameters. …”
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Pragmatic Randomized Controlled Trial of Pharmacopuncture Therapy for Cervical Disc Herniation: A Pilot Study by Lee SW, Ahn YJ, Kim S, Lee Y, Cho HW, Hong Y, Nam D, Park YC, Kim EJ, Lee YJ, Ha IH

“…No serious adverse events occurred; four patients experienced mild adverse events.Conclusion: In CDH, pharmacopuncture was more effective in reducing pain and achieving functional recovery than acupuncture and usual care.Keywords: neck pain, non-invasive therapy, pain management, functional recovery…”
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Spillover effect of a dietary intervention on physical activity in a randomized controlled trial with colorectal cancer patients by Hege Berg Henriksen, Åshild Kolle, Andreas Stenling, Ingvild Paur, Siv Kjølsrud Bøhn, Pernille Brøto, Tuva Syrdal Tronstad, Rune Blomhoff, Sveinung Berntsen

“…In particular, the isolated impact of the dietary intervention may be difficult to separate due to spillover effects from changes in physical activity and physical function. Therefore, the aim of this study was to investigate the spillover effect of a one-year dietary intervention in post-surgery colorectal cancer patients by comparing the changes in physical activity and physical function between the diet intervention group and the control group in a randomized controlled trial, called the CRC-NORDIET study. …”
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The effect of exercise intervention on inhibitory function in obese and overweight children and adolescents: a systematic review and meta-analysis by Aona Chen, Chenggen Guo, Shuhua Qu

“…Results The analysis included 24 randomized controlled trials (RCTs) with a total of 1,247 participants. …”
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Brain Connectivity Yields Insights into the Pathogenesis of Epilepsy and Subtypes: Evidence from Mendelian Randomization Analysis by Zhipeng He, Shishi Tang, Yurong Hu, Yuxuan Li, Junhao Liang, Li Fang, Miaoxin Li, Ziyi Chen, Yi Zhou

“…However, the causal relationship between epilepsy and structural connectivity (SC)/functional connectivity (FC) within RSNs remain unclear. …”
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Mendelian Randomization and Transcriptomics Analysis Reveal Potential Relationships Between Lipids, Immune Cells and PCOS by Xie Y, Zhang Z, Zhao Y, Zhang J, Yin Q

“…Functional enrichment analysis revealed that PCOS was strongly associated with numerous immune pathways. …”
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Mendelian Randomization Analysis of the Possible Causal Relationships Between Neurodevelopment‐Related Proteins and Bipolar Disorder by Yanyan Li, Qianqian Gui, Shurong Ren, Zhifen Liu, Aixia Zhang, Penghong Liu, Xueping Zhou, Ning Sun, Chunxia Yang

“…ABSTRACT Background Bipolar disorder (BD) is a complex mental condition of which the mechanism of onset remains unclear. Mendelian randomization (MR) allows evaluation of the causal effects of biomarkers by minimizing the risks of reverse causation and confounding factors. …”
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Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes by Run-Sen Liang, Jin-Qi Su, Xiang-Qi Wu, Qi Wang, Yong-Mei Cai, Hong-Yong Su, Ji-Xin Tang, Cui-Wei Yao

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