Leveraging allelic imbalance to refine fine-mapping for eQTL studies. by Jennifer Zou, Farhad Hormozdiari, Brandon Jew, Stephane E Castel, Tuuli Lappalainen, Jason Ernst, Jae Hoon Sul, Eleazar Eskin

“…Many disease risk loci identified in genome-wide association studies are present in non-coding regions of the genome. Previous studies have found enrichment of expression quantitative trait loci (eQTLs) in disease risk loci, indicating that identifying causal variants for gene expression is important for elucidating the genetic basis of not only gene expression but also complex traits. …”
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Perceptions of hospital managers regarding the impact of doctors' community service by O.B. Omole, G. Marincowitz, G.A. Ogunbanjo

“…As this was a qualitative study, further quantitative and community-oriented studies are required to validate the results.…”
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JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection. by Keith A Wharton, Catherine Quigley, Marian Themeles, Robert W Dunstan, Kathryn Doyle, Ellen Cahir-McFarland, Jing Wei, Alex Buko, Carl E Reid, Chao Sun, Paul Carmillo, Gargi Sur, John P Carulli, Keith G Mansfield, Susan V Westmoreland, Susan M Staugaitis, Robert J Fox, Werner Meier, Susan E Goelz

“…Nine samples, including three gross PML lesions and normal-appearing adjacent tissues, were characterized by histopathology and subject to quantitative genomic, proteomic, and molecular localization analyses. …”
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Polygenic signals of sex differences in selection in humans from the UK Biobank. by Filip Ruzicka, Luke Holman, Tim Connallon

“…Functional analyses reveal that sex-differentiated sites are enriched in phenotype-altering genomic regions, including coding regions and loci affecting a range of quantitative traits. …”
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Factors Affecting the Indifference of Players in Training for Competitions by Fatemeh Rahmati, Masoud Naderian Jahroni

“…Data analysis was conducted in two phases: initially via open and axial coding of qualitative data, and subsequently using MICMAC software for structural modeling. …”
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Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4. by Nora McFadden, Dalan Bailey, Guia Carrara, Alicia Benson, Yasmin Chaudhry, Amita Shortland, Jonathan Heeney, Felix Yarovinsky, Peter Simmonds, Andrew Macdonald, Ian Goodfellow

“…Here we describe the identification and characterization of a novel open reading frame (ORF4) encoded by the murine norovirus (MNV) subgenomic RNA, in an alternative reading frame overlapping the VP1 coding region. ORF4 is translated during virus infection and the resultant protein localizes predominantly to the mitochondria. …”
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Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci. by Zeinab Mousavi, Marios Arvanitis, ThuyVy Duong, Jennifer A Brody, Alexis Battle, Nona Sotoodehnia, Ali Shojaie, Dan E Arking, Joel S Bader

“…In an application to cardiac electrophysiology with 226 GWAS loci, only 46 (20%) have within-locus evidence from Mendelian genes, protein-coding changes, or colocalization with eQTL signals. …”
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Significant Association Between Increased Abundance of Selected Bacterial Lipopolysaccharides and Norovirus Diarrhea Among South African Infants by Lerato P. Kgosana, Mapaseka L. Seheri, Cliff A. Magwira

“…The average expression of genes coding for selected LPS and their signalling molecule, Toll-like receptor 4 (TLR4), increased 7- and 2.5-fold, respectively, in DNP versus NDNN children. …”
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Pnky Modulates Neural Stem Cell Proliferation and Differentiation Through Activation of Wnt/β-Catenin Signaling Pathway by Haidong Wu, Jing Huang, Xiaojing Li, Yali Song, Xuxiang Chen, Yajie Guo

“…Using cck8 assays, western blot analysis, and quantitative polymerase chain reaction (qPCR), we found that Pnky knockdown significantly enhanced NSC proliferation and promoted their differentiation into neurons. …”
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ATRA-induced NEAT1 upregulation promotes autophagy during APL cell granulocytic differentiation. by Doudou Tang, Huihui Wang, Yafeng Jiang, Mingjie Chen, Guangsen Zhang, Shangjie Wu, Yewei Wang

“…Understanding how ATRA works may lead to new treatments for other types of leukemia. Long non-coding RNA NEAT1 has been implicated in the differentiation of APL cells. …”
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MicroRNA 133A Regulates Squalene Epoxidase Expression in Colorectal Cancer Cells to Control Cell Proliferation and Cholesterol Production by Ji-Su Mo, Santosh Lamichhane, Grinsun Sharma, Soo-Cheon Chae

“…Methods: Through the luciferase reporter assay, quantitative RT-PCR (qRT-PCR), and Western blot analysis. …”
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DIAGNOSIS AND PREDICTION OF CHOLECYSTITIS DEVELOPMENT ON THE BASIS OF NEURAL NETWORK ANALYSIS OF RISK FACTORS by V. A. Lazarenko, A. E. Antonov

“…The training of the artificial neural network with a quantitative output coding the age of probable hospitalization made it possible to generate an array of values, signifficantly (α ≤ 0.001) not differing from the empirical data. …”
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EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA by Yu. A. Veryaskina, G. V. Kakurina, E. S. Zhuravlev, S. E. Titov, I. V. Kondakova, O. V. Cheremisina, D. A. Shishkin, I. F. Zhimulev, E. L. Choynzonov, N. N. Kolesnikov

“…Using real-time quantitative polymerase chain reaction analysis, we have shown a change in the expression miRNA in tumor tissue compared to unmodified tissue. …”
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The effect of exposure to a high-fat diet on microRNA expression in the liver of blunt snout bream (Megalobrama amblycephala). by Dingdong Zhang, Kangle Lu, Zaijie Dong, Guangzhen Jiang, Weina Xu, Wenbin Liu

“…The aim of this study was to investigate the potential roles of microRNAs (miRNAs) in diet-induced hepatic steatosis in this species. MiRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level, are involved in diverse biological processes, including lipid metabolism. …”
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Impacts of message sensation value and message appeal on viewer responses to YouTube anti-bullying videos by Wen-Chi Wu, Meng-Jung Lee, Hsi-Ping Nieh

“…Abstract This study explored the impact of message sensation value (MSV) and message appeal on viewers’ responses to anti-bullying videos on YouTube from various sources. Through quantitative content analysis, 1431 videos were coded by trained coders based on predefined coding schemes. …”
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Investigating Preschool Children’s Metapragmatic Awareness Development Through Force-Dynamics Model by Lulu Cheng, Xiaomeng Xue, Haoran Mao, Yang Gao, Jianxin Zhang, Yanqin Liu

“…Using conversation data from 60 Mandarin-speaking children aged 4 to 6, obtained from the International Child Language Data Exchange System (CHILDES), the research employs a custom coding framework to analyze how children’s interactions reflect seven core force-schemata. …”
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Joint attention and exogenous attention allocation during mother-infant interaction at 12 months associate with 24-month vocabulary composition by Elena Capelli, Serena Grumi, Luisa Vercellino, Livio Provenzi, Livio Provenzi

“…This study explored how specific early attention mechanisms-namely, exogenous attention allocation and joint attention initiation-during mother-infant interactions at 12 months may influence language development at 24 months.MethodsA sample of 46 typically developing children was observed at 12 months during mother-infant interactions obtained through remote videotaping. Quantitative measures of exogenous attention allocation to external auditory stimuli and joint attention initiation by the infant were obtained through micro-analytical coding. …”
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Expression evaluation of exogenous and endogenous alcohol dehydrogenase genes in transgenic Arabidopsis by Haoqiang Yu, Hong Lv, Fengzhong Lu, Qingqing Yang, Huaming Duan, Wanchen Li, Fengling Fu

“…To detect the differences in expression, protein accumulation, and enzyme activity between transformed exogenous and endogenous genes, the coding sequences (CDSs) of the alcohol dehydrogenase (ADH) genes were cloned from dicotyledonous Arabidopsis, monocotyledonous maize, and prokaryotic Escherichia coli, constructed into expression vector pBI121-cMycNY, and used to transform wild-type Arabidopsis, respectively. …”
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Transcriptome sequencing and screening of anthocyanin related genes in purple potato tubers (Solanum tuberosum L.) by Xiaojuan Wu, Yanhong Ma, Peijie Wang, Juan Wu, Nan Li, Zhicheng Zhang, Rui Xie, Dan Wang, Hushuai Nie

“…We demonstrated that DEGs or transcription factors (TFs) which related to flavonoid metabolism were involved in the anthocyanins biosynthesis, such as the protein-coding genes PAL, CHS, CHI, 4CL, F3H, UFGT, LAR, and the TFs MYB, bHLH, and HY5. …”
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Bioinformatics of 1-aminocyclopropane-1-carboxylic acid synthase gene from eggplant and its expression analysis in response to adversity stresses by WAN Faxiang, WANG Lianzhen, GAO Jun

“…The SmACS gene was located on the chromosome 8, and the full length of this gene was 3 550 bp, whose length of coding sequence (CDS) region was 1 437 bp. It contained three introns and four exons, which belonged to a typical ACS gene structure. …”
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