Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA‐HCM by Caroline J. Coats, Ahmad Masri, Michael E. Nassif, Roberto Barriales‐Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Hans‐Dirk Düngen, Pablo Garcia‐Pavia, Albert A. Hagège, James L. Januzzi, Matthew M. Y. Lee, Gregory D. Lewis, Chang‐Sheng Ma, Martin S. Maron, Zi Michael Miao, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T. Owens, John A. Spertus, Scott D. Solomon, Jacob Tfelt‐Hansen, Marion van Sinttruije, Josef Veselka, Hugh Watkins, Daniel L. Jacoby, Polina German, Stephen B. Heitner, Stuart Kupfer, Justin D. Lutz, Fady I. Malik, Lisa Meng, Amy Wohltman, Theodore P. Abraham

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Healing the Past by Nurturing the Future: trauma-aware, healing-informed care to improve support for Aboriginal and Torres Strait Islander families – implementation and evaluation... by Raymond Lovett, Helen Herrman, Catherine Chamberlain, Rhonda Marriott, Graham Gee, Judith Atkinson, Yvonne Clark, Caroline Atkinson, Helen McLachlan, Tanja Hirvonen, Tess Bright, Jane Fisher, Alison Elliot, Leonie Segal, Sandy Campbell, Amanda Jones, Della Anne Forster, Kimberley Ann Jones, Helen Henderson, Olivia Mauerhofer, Katherine Jane Lake, Jhodie Duncan, Anita Raymond, Danielle Cameron, Doseena Fergie, Shawana Andrews, Skye Stewart, Belinda Crawford, Janine Mohammed, Gina Bundle, Emmanuel Gnanamanickam, Elise Davis, Rebekah Julian

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Effect of the time factor on the hydraulic activity of mechanically activated saponin-containing powder by Marina V. Morozova, Maria A. Frolova

“…A number of direct analytical methods are available to monitor the change in Ca(OH)2 content over time during the course of the hydraulic reac tion. …”
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Quaternary gas hydrate dissociation promotes the formation of Shenhu Canyon Group in the South China Sea by Hui Pan, Hui Pan, Hui Xie, Hui Xie, Hui Xie, Zhongxian Zhao, Jinlong Liu, Guozhong Jiang, Guozhong Jiang, Ruilong Li, Yuanping Li, Eun Young Lee, Wen Yan

“…Since ~2.5 Ma, there have been three combinations of sea level and bottom water temperature (BWT) changes that can significantly reduce the thickness of the GHSZ. …”
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Construction and application of a model for drainage via directional boreholes against water hazards in deep vertical shafts by Chunhu ZHAO, Mingcheng ZHU, Yadong JI, Shidong WANG, Wenzhong ZHANG, Kaipeng ZHU, Yingfeng LIU, Hongbo SHANG, Chaofeng LI, Min FAN, Kai LI

“…Using this model, this study quantitatively explored the changes in water inrush and water reduction effects in vertical shafts under the condition of advance regional drainage via surface directional boreholes.Results and ConclusionsThe simulation results of water inrush in the shafts studied indicate that the water inflow in drainage boreholes ZX1‒ZX4 was 34 m3/h, 27 m3/h, 38 m3/h, and 42 m3/h, respectively, as determined by the numerical processing of the four drainage boreholes and the integral of groundwater flow velocity around borehole and shaft walls. …”
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Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs by Aidan C. Manning, Mahmoud M. Bashir, Kyle Rapchak, Calyssa J. Huff, Ariana R. Jimenez, Sheila Gonzalez, Courtney L. Woodruff, Heather E. Upton, Kathleen Collins, Todd M. Lowe, Jessica M. Tucker

“…OTTR-tRAX revealed not only host tRNAome changes, but also the expression patterns of virally encoded tRNAs (virtRNAs) and virtRFs made from the MHV68 genome. …”
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Revealing the dynamics of a local Alpine windstorm using large-eddy simulations by N. Krieger, H. Wernli, M. Sprenger, C. Kühnlein

“…We investigate the mechanism of this local windstorm and its sensitivity to changes in the prescribed ambient wind using large-eddy simulation (LES). …”
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Review of Research on Foundation Scour of River-Crossing Bridges by WANG Lu, LIU Hong-wei, WEI Kai, Bruce Melville, NIE Rui-hua

“…To date, there is a lack of predictive formulas or analytical models that quantitatively consider the scale effects on bridge foundation scour. …”
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Pengaruh Perlakuan Awal Ampas Biji Jewawut (Setaria italica L.) dengan Microwave Irradiation Untuk Produksi Bioetanol by Sefrinus Maria Dolfi Kolo, Noviana Mery Obenu, Natalia Tige Rohy

“…The qualitative test of the fermentation and distillation results shows the samples containing bioethanol marked by the changes in potassium dichromate colors from orange to bluish-green. …”
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INTERCULTURAL COMMUNICATIVE COMPETENCE: A CASE STUDY ON ACADEMIC EXCHANGE PROGRAMMES by Raluca POP

“…The COVID-19 pandemic has brought considerable changes in the educational field and many academic exchange programmes have been ceased. …”
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Estudio Piloto de la Evaluación de la Ansiedad y la Atención a través de la Percusión Corporal y Neuromotricidad en Alumnado de Secundaria en las clases de Educación Física, Música... by Francisco Javier Romero Naranjo, Roberto Sayago-Martínez, Jesús Baldomero Jiménez-Molina, Antonio Francisco Arnau-Mollá

“…The control group continued with their programme without any changes. A quasi-experimental between-subjects design was used with pre- and post-intervention assessment measures. …”
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Bridging the gap in Chagas disease management: a mixed-methods study using an implementation science approach within the Brazilian primary health care system—‘Implementa-Chagas/SaM... by Carlos Henrique Valente Moreira, Laura Azevedo, Ariela Mota Ferreira, Ana Carolina Gonçalves Oliveira, Andréia Brito de Souza, Desirée Sant’Ana Haikal, Cláudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Matthew Spinelli, Ana Luiza Bierrenbach, Nayara Dornela Quintino, Nayara Ragi Baldoni, Renata Fiuza Damasceno, Malu Ribeiro Drumond, Thallyta Maria Vieira, Dardiane Santos Cruz, Sâmara Fernandes Leite, Ana Clara de Jesus Santos, Léa Campos de Oliveira Silva, Renata Buccheri, Antônio Luiz Pinho Ribeiro, Ester Cerdeira Sabino

“…Intervention strategies were developed using the Behaviour Change Wheel (BCW) framework, emphasizing educational programmes, hands-on training, and infrastructural improvements. …”
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The Analysis and Prioritization of Social Sustainability of Rural Environments (Case Study: Ghal’eh Biaban District Darab Sub-Province) by Saeid Reza Akbarian Ronizi, Rana Shaykh-Baygloo

“…B) Demographic, including components such as population density, change of population structure, migration patterns among village and city and cultural issues. …”
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How public health teams navigate their different roles in alcohol premises licensing: ExILEnS multistakeholder interview findings by Rachel O’Donnell, Andrea Mohan, Richard Purves, Nason Maani, Matt Egan, Niamh Fitzgerald

“…Reducing health harms was felt to necessitate a focus on reducing availability and generating longer-term culture change, citing international evidence on the links between availability and alcohol-related harms. …”
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Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…Materials & MethodsThis research employed a mixed quantitative-qualitative approach. To address the central research question, relevant indicators were extracted through a multi-stage interview process involving 30 elite experts and an elite panel and then refined using structural analysis. …”
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Using Implementation Science to Evaluate the Implementation of Patient-Reported Outcome Measures (PROMs) in a Clinical Heart Failure Care Setting by Sarah V.C. Lawrason, MSc, PhD, Heather Ross, MSc, MD, Michael McDonald, MD, Juan Duero Posada, MD, Samantha Engbers, BAH, Anne Simard, MHSc

“…The PROM was the Kansas City Cardiomyopathy Questionnaire-12, which captures 4 domains related to HF: symptom frequency, physical limitations, social limitations, and quality of life. Quantitative data were analyzed using descriptive statistics, and qualitative data were analyzed using behaviour-change frameworks and latent content analysis. …”
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Plasma proteomic signature for preoperative prediction of microvascular invasion in HCC by Xinrui Shi, Yunzheng Zhao, Ke Li, Qingyu Li, Yifeng Cui, Yuhang Sui, Liang Zhao, Haonan Zhou, Yongsheng Yang, Jiajun Li, Meng Zhou, Zhaoyang Lu

“…Principal component analysis and differential protein abundance analysis were used to assess the proteomic changes between the two groups of patients. Protein biomarker candidates were further quantitatively validated by ELISA. …”
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A group psychological intervention for postnatal depression in British mothers of South Asian origin – the ROSHNI-2 RCT by Nusrat Husain, Karina Lovell, Carolyn A Chew-Graham, Farah Lunat, Penny Bee, Matthias Pierce, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Deepali Sharma, Jahanara Miah, Waqas Ahmed, Joe Kai, Ilyas Mirza, Jillian Morrison, Naeem Mohmed, Atif Rahman, Shanaya Rathod, Najma Siddiqi, Waquas Waheed, Christopher Williams, Nosheen Zaidi, Richard Emsley, Richard Morriss

“…The objectives of the quantitative study To evaluate the short-term and long-term clinical and cost-effectiveness of the PHP intervention on rates of recovery from PND in BSA women compared to TAU. …”
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Molecular determinants of response to neoadjuvant pembrolizumab plus chemotherapy in patients with high-risk, early-stage, triple-negative breast cancer: exploratory analysis of th... by Rebecca Dent, Javier Cortés, Yeon Hee Park, Eva Muñoz-Couselo, Sung-Bae Kim, Joohyuk Sohn, Seock-Ah Im, Esther Holgado, Theodoros Foukakis, Sherko Kümmel, Jennifer Yearley, Anran Wang, Michael Nebozhyn, Lingkang Huang, Razvan Cristescu, Petar Jelinic, Vassiliki Karantza, Peter Schmid

“…Other associations with pCR included baseline CD11c+/MHCII−/CD163−/CD68− (nonactivated/immature DC) within the total tumor (AUROC, 0.76; 95% CI 0.51–1.00) and the baseline CD11c/CD3 ratio within the tumor compartment (0.75; 95% CI 0.52–0.98). Changes in immune subsets following one cycle of pembrolizumab were not strongly associated with pCR. …”
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Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in type 2 diabet... by Sineenart Sanpinit, Acharaporn Issuriya, Oraphan Sakulkeo, Palika Wetchakul, Surasak Limsuwan, Pinanong Na-Phatthalung, Siriwan Kantisin, Jian Tang, Sasitorn Chusri

“…Despite its traditional use, scientific validation of the mechanisms underlying diabetic wound healing remains limited.AimThis study aims to develop a novel gauze dressing impregnated with an ointment containing T-YaSP (YaSP) to enhance its practical application and elucidate the mechanisms of action in promoting wound healing in both non-diabetic and type 2 diabetic wounds of this ointment.Materials and methodsYaSP was developed and tested for stability and dermal irritation. Changes in chemical markers during storage were measured both qualitatively and quantitatively. …”
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