Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Similarly, little is known on the differential effects of dual, compared with single, checkpoint inhibition.Methods We here performed in-depth characterization, including multicolor flow cytometry, single cell RNA sequencing and multiplex supernatant analysis, using tumor single cell suspensions from patients with cancer treated ex vivo with novel bispecific antibodies targeting programmed cell death protein 1 (PD-1) and TIM-3 (PD1-TIM3), PD-1 and LAG-3 (PD1-LAG3), or with anti-PD-1.Results We identified patient samples which were responsive to PD1-TIM3, PD1-LAG3 or anti-PD-1 using an in vitro approach, validated by the analysis of 659 soluble proteins and enrichment for an anti-PD-1 responder signature. …”
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Pyroptosis regulation by Salmonella effectors by Yuan Meng, Yuan Meng, Qianjin Zhang, Qianjin Zhang, Mengen Xu, Mengen Xu, Ke Ding, Ke Ding, Ke Ding, Zuhua Yu, Zuhua Yu, Jing Li, Jing Li

“…Pyroptosis, a proinflammatory form of programmed cell death, is involved in many disease processes. …”
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A lattice-mechanical metamaterial with tunable two-step deformation, tunable stiffness, tunable energy absorption and programmable properties by Chenyang Liu, Zexin Gao, Jiahui Chang, Jianan Zhao, Song Qiu, Peiran Yu, Xi Zhang

“…Metamaterials built from these unit cells can also achieve the same properties. These properties can exist in multiple directions and are not affected by the number of unit cells. …”
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Heart Rate, Hematological, and Biochemical Responses to Exercise on Water Treadmill with Artificial River in School Horses by Urszula Sikorska, Małgorzata Maśko, Barbara Rey, Małgorzata Domino

“…WT exercise with AR represents a low-to-moderate intensity aerobic workload for horses, which increases with water depth from fetlock to carpal levels. However, further research is required to evaluate its inclusion in training or rehabilitation programs for athletic horses and its potential beneficial effects.…”
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Acoustic Detection and Quantification of Fish in Lancang Waters of Seribu Islands, Indonesia by Syahrul Purnawan, Henry M. Manik, Agustina Sartika Manik, La Elson, Myounghee Kang

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Prospects for Use of Heptral in Hemoblastoses by V. B. Larionova, E. G. Gorozhanskaya

“…At the same time a hepatocyte, the principal hepatic parenchymal cell, is likely to be the focus of organ pathology. …”
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Genome wide association analysis for body measurements in Jabal Akhdar Omani goats

“…Some of these genes were involved in cell growth (ISM1), early brain development (ADK), and muscle development (ATP2A1). …”
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Perencanaan Sistem Informasi Akademik Menggunakan Zachman Framework by Rosmiati Rosmiati

“…Analysis of the needs required in the planning of Academic Information System using Zachman Framework approach. Each cell of the matrix Zachman discussed in depth to analyze the needs of Academic Information Systems of SMK Isen Mulang Palangkaraya. …”
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Small molecule modulation of protein corona for deep plasma proteome profiling by Ali Akbar Ashkarran, Hassan Gharibi, Seyed Amirhossein Sadeghi, Seyed Majed Modaresi, Qianyi Wang, Teng-Jui Lin, Ghafar Yerima, Ali Tamadon, Maryam Sayadi, Maryam Jafari, Zijin Lin, Danilo Ritz, David Kakhniashvili, Avirup Guha, Mohammad R. K. Mofrad, Liangliang Sun, Markita P. Landry, Amir Ata Saei, Morteza Mahmoudi

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Role of haptic feedback technologies and novel engineering developments for surgical training and robot-assisted surgery by Imán Laga Boul-Atarass, Imán Laga Boul-Atarass, Mercedes Rubio Manzanares Dorado, Andrés Padillo-Eguía, Jesús Racero-Moreno, Ignacio Eguía-Salinas, Sheila Pereira-Arenas, Sheila Pereira-Arenas, Rosa María Jiménez-Rodríguez, Javier Padillo-Ruiz, Javier Padillo-Ruiz

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MODEL OF ORGANIZATION OF KIDNEY CANCER EARLY DIAGNOSIS by V. G. Moreva, G. N. Alekseeva, P. F. Kiku, L. I. Gurina, K. M. Sabirova, V. N. Rasskazova

“…To improve the early detection of kidney cancer, a prognostic model with computer program for assessing the individual risk of developing kidney cancer was developed. population survey using the ARKC computer program allowed us to narrow the diagnostic search, form risk groups and effectively route patients with suspected kidney cancer for in-depth examination in accordance with the «road map».…”
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Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

“…The analysis focused on identifying fine-scale interactions within topologically associated domains (TADs) while incorporating histone modification landscapes (H3K27ac, H3K4me3) and transcriptomic signatures from CRC cell lines and the TCGA database. For experimental validation, ChIP-quantitative PCR was performed at the promoters of target genes using the highly malignant colorectal cell line HT29 and compared it to an embryonic cell line NT2D1.Results:Our integrated analysis revealed significant genomic structural instability in CRC cells, closely associated with tumor-suppressive transcriptional programs. …”
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Research Progress on Cancer Risk and Its Pathogenesis of Gastric Precancerous Conditions by WANG Yuxin, PENG Wenwan, ZHOU Zheng, HUANG Haiyang, LU Xiaomin, DONG Mingguo

“…In the microenvironment of gastric mucosa, imbalance and disorder of oxidation and antioxidant effect, energy metabolism, immune homeostasis, cell proliferation and death are the pathogenesis of gastric precancerous conditions. …”
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Effects of targeted care using a risk warning model on burn site infection by Chenchen Sun, Xiaowu Wang, Dong Wu

“…This study aimed to establish an infection risk warning model based on the clinical characteristics of burn patients, by formulating targeted care programs according to the risk warning factors, and analyzing the effects of these programs on wound infection in burn patients. …”
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Application of marine bacterial alginate lyases in wastewater treatment, biofilm removal and green technology by M.U.K. Anjung, H. Nursyam, A.A. Prihanto, E. Chasanah

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Molecular analysis of immune checkpoint inhibitor associated erythema nodosum-like toxicity by Xiaopeng Sun, Margaret L. Axelrod, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Violeta Sanchez, Yu Wang, Jonathan L. Curry, Elizabeth J. Phillips, Yaomin Xu, Douglas B. Johnson, Justin M. Balko

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Virseqimprover: an integrated pipeline for viral contig error correction, extension, and annotation by Haoqiu Song, Saima Sultana Tithi, Connor Brown, Frank O. Aylward, Roderick Jensen, Liqing Zhang

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Machine learning modeling and analysis of prognostic hub genes in cervical adenocarcinoma: a multi target therapy for enhancement in immunosurveillance by Madiha Jabeen Abbasi, Rashid Abbasi, ShuPeng Wu, Md Belal Bin Heyat, Ding Xianfeng, Huijie Jia, Aiwen Zheng

“…Results indicate high binding affinity of Imatinib compound into active pockets of BIRC5 which is confirmed by cell viability lab experiment. Current study demonstrates novel biomarkers and therapeutic drugs for in depth understanding of endocervical carcinogensis.…”
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Application of [18F]FLT‐PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type... by Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton Vonk Noordegraaf, Jurjan Aman, Hans Harms, Frances S. deMan, Marc C. Huisman, Lan Zhao, Harm J. Bogaard

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The outcast of medicine: metals in medicine--from traditional mineral medicine to metallodrugs by Donghan Bai, Michal Nowak, Dajun Lu, Qiaochu Wang, Martin Fitzgerald, Hui Zhang, Remy MacDonald, Ziwen Xu, Lu Luo

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