Milk fatty acids and rumen composition as proxy measures of enteric methane by Timothy P. Bilton, Sharon M. Hickey, Arjan Jonker, Kathryn McRae, Melanie K. Hess, Benjamin J. Perry, Brooke Bryson, Hannah Henry, Wendy Bain, Fern Booker, Barry Veenvliet, Jacqueline Peers-Adams, Gerrard Pile, Erin Waller, Peter H. Janssen, Kathryn M. Tiplady, Peter Reid, Stefan Muetzel, Michael Agnew, Ken G. Dodds, John C. McEwan, Suzanne J. Rowe

“…Four hundred genotyped lactating ewes from a sheep research flock bred specifically for high and low-methane emissions had methane measured and rumen and milk samples collected approximately 6 wk post-lambing across 4 lactation years. Rumen samples were processed to generate VFA and metagenomic profiles of the rumen microbial community, and fatty acid profiles and mid-infrared spectra were generated for the milk samples. …”
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Geochemical Characteristics and Environmental Risk Assessment of Heavy Metals in Weathering Profiles of Alkali-enriched Porphyry in Central Yunnan by Lei XU, Mengsheng ZHAO, Jie XU, Yanxun CHENG, Qiang QU, Weizhi CHEN, Ya ZHANG, Haoyu WANG, Yong BA, Fangping WEN, Kun QIAN

“…BACKGROUNDThe contents of many heavy metals in soil in many areas of southwest China are much higher than the national soil background value, and related studies show that most heavy metals in soil are in a state of “high background and low activity”, which is closely related to the special geological process in the area. Most scholars have concentrated more on the weathering process and post-weathering heavy metals of granite, basalt, carbonate rocks and other geological bodies with high background value of heavy metals in southwest China. …”
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Modified Bloom's Taxonomy: Perspective of a Doctor of Philosophy Scholar by Wafa Omer

“…As a doctor of philosophy, I suggest a revised Bloom's Taxonomy that leads to the highest learning objective: integration into practice-based systems. As a PhD and post-doc, I regularly develop original ideas, but I think the hardest part is integrating them into practice-based systems. …”
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Students’ Mastering of Structural Analysis of Substance as a Method to Form Future Specialists’ Scientific Thinking. Part II by L. A. Baikova, M. A. Kosareva, E. A. Nikonenko, V. V. Vaitner, A. Majee

“…The research materials can be useful for methodologists of the higher school, for experts engaged in methodological development and the organisation of educational process, for high school teachers of chemistry and related disciplines, for post-graduate students and master’s students of chemical and chemico-technological specialties as well.…”
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Developing a European Psychotherapy Consortium (EPoC): Towards Adopting a Single-Item Self-Report Outcome Measure Across European Countries by Miguel M. Gonçalves, Wolfgang Lutz, Brian Schwartz, João Tiago Oliveira, Suoma E. Saarni, Orya Tishby, Julian A. Rubel, Jan R. Boehnke, Adrian Montesano, Dario Paiva, Davide Ceridono, Emmanuelle Zech, Jochem Willemsen, Samuli I. Saarni, Katarina Kompan Erzar, Luís Janeiro, Omar C. G. Gelo, Paula Errázuriz, Pawel Holas, Rafał Styła, Tatjana Rožič, Tom Rosenström, Vera Békés, Zsolt Unoka, Michael Barkham

“…[Results] A survey identified one of the main problems in the development of a common data set to be the heterogeneity of measures used by members (e.g., 87 different pre-post outcomes). We report on the results of the survey and the initial stage of identifying a single-item – the Emotional and Psychological Outcome (EPO-1) – measure and the process of its translation into multiple European languages. …”
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Julius Kruopis – the pioneer of applied statistics in Lithuania by Vilijandas Bagdonavičius, Vydas Čekanavičius, Rūta Levulienė, Pranas Vaitkus

“…Kruopis became evident through  mathematical and statistical modeling of real processes. PhD thesis ``Estimation of Markov processes parameters'' by J. …”
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Challenges and opportunities for real-world evidence in clinical oncology—a view from the UK: proceedings of a national workshop by M. Craddock, C. Dempsey, D. Abdulwahid, J.P.C. Baldwin, K. Banfill, A. Carver, A. Chaturvedi, S. Cheeseman, G.W. Cowell, M. Daly, A. Dekker, S.R. Dubash, S. Duffield, I. Fornacon-Wood, M.A.C. Garcia, P. Goodley, H. Green, R.J. Holley, S. Ingram, S. Jones, J. Kennedy, A. Lighterness, C.K. McGarry, O. McLaughlin, R. Mir, B.W. Papiez, D.E.J. Snelling, S. Theophanous, S. Warren, K. Zucker, G. Price, C. Faivre-Finn

“…Potential solutions include streamlining information governance processes, training staff in data science skills, and demonstrating clinical benefit. …”
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Vaccine decision-making among pregnant women: a protocol for a cross-sectional mixed-method study in Brazil, Ghana, Kenya and Pakistan [version 2; peer review: 1 approved, 2 approv... by Prachi Singh, Jessica L Schue, Emily S Miller, Berhaun Fesshaye, Ruth A Karron, Shanelle Quinn, Maria Laura Costa, Renato T Souza, Kwasi Torpey, Jose Guilherme Cecatti, Emefa Modey, Caroline Dinam Badzi, Ferdinand Okwaro, Chris Guure, Sarah Saleem, Muhammad Asim, Saleem Jessani, Haleema Yasmeen, Sidrah Nausheen, Vanessa Brizuela, Grace Belayneh, Rupali J Limaye, Sami Gottlieb, Marleen Temmerman

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On the path toward cervical cancer elimination in Canada: a national survey of factors influencing women's intentions to participate in human papillomavirus test-based primary cerv... by Ovidiu Tatar, Ben Haward, Samara Perez, Patricia Zhu, Julia Brotherton, Kathleen Decker, Aisha K. Lofters, Marie-Hélène Mayrand, Emily McBride, Gina Ogilvie, Gilla K. Shapiro, Laurie W. Smith, Marc Steben, Jo Waller, Gregory D. Zimet, Zeev Rosberger

“…In other countries, women's unpreparedness and concerns hindered the transition and post-implementation screening uptake. We investigated psychosocial correlates of intentions of screening in eligible individuals to participate in HPV-based primary cervical screening. …”
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A standards-based application for improving platelet transfusion workflow by William Gordon, Maria Aguad, Layne Ainsworth, Samuel Aronson, Jane Baronas, Edward Comeau, Rory De La Paz, Justin B.L. Halls, Vincent T. Ho, Michael Oates, Adam Landman, Wen Lu, Shawn N. Murphy, Fei Wang, Indira Guleria, Sean R. Stowell, Melissa Y. Yeung, Edgar L. Milford, Richard M. Kaufman, William J. Lane

“…We looked at application usage over time and developed a multivariable logistic regression model to compute odds ratios that a patient undergoing HSCT would have a complicated thrombocytopenia course, with several model covariates including pre-/post-application deployment. Results: Usage of the application has been consistent since launch, with a slight dip during the first COVID wave. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Median maximum flow rate and post-void residual volume were predictors for detrusor underactivity. …”
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Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model by Shin-Yi Liu, Shin-Yi Liu, Shin-Yi Liu, Yung-Ju Yeh, Yung-Ju Yeh, Ting-Yin Xue, Ting-Yin Xue, Fei-Hung Hsieh, Fei-Hung Hsieh, Ya-Wun Wu, Ya-Wun Wu, Meng-Zhen Wu, Meng-Zhen Wu, Wei-Jing Li, Wei-Jing Li, Jun-Chieh J. Tsay, Jun-Chieh J. Tsay, Shu-Yao Tsai, Chung-Ming Huang, Chung-Ming Huang, Hen-Hong Chang, Hen-Hong Chang, Hui-Chen Chen, Chun-Ping Lin, Gregory J. Tsay, Gregory J. Tsay, Gregory J. Tsay

“…Efferocytosis, a crucial process for tissue homeostasis by transmitting immune-suppressive signals, is frequently impaired in SLE. …”
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Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer by Bo Yin, Wei Wang, Ang Li, Mengjie Li, Huijuan Zhou, Haoran Hu, Jianyi Ding, Yashi Zhu, Xinxin Xu, Meiqin Yang, Tiefeng Huang, Yifan Kou, Zilale Rahim, Baoyou Huang, Lingfei Han

“…Mechanistically, CMTM4 interacts and stabilizes PHB2 (prohibitin 2) through post-translational modification, which further induces activation of the STING (stimulator of interferon genes)/TBK1 (TANK-binding kinase 1)/STAT6 (signal transducer and activator of transcription 6) pathway, facilitating the nuclear translocation of STAT6 which binds to the CCL2/IL-6 promoter, leading to the upregulation of CCL2/IL-6 transcription expression. …”
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Mechanism-based modular psychotherapy versus cognitive behavioural therapy for adolescents and young adults with childhood trauma experiences: study protocol for a feasibility tria... by Till Bärnighausen, Hanna Zimmermann, Christian Schmahl, Stephanie Bauer, Beate Ditzen, Hans-Christoph Friederich, Markus W Haun, Astrid Berner-Rodoreda, Elisabeth Schramm, Svenja Taubner, Corina Aguilar-Raab, Sabine C Herpertz, Manuel Feisst, Frank Enning, Katja I Seitz, Niklas Schouler, Jan Hundertmark, Maximilian Wilhelm, Svea Franz, Christoph W Korn, Ruben Vonderlin, Eva Vonderlin, Josef Bailer, Elias Bopp, Sophia von Stockert, Laura Tabea Kristalis, Claudia Calvano

“…This proof-of-concept study aims to provide initial evidence for acceptability, feasibility and changes in self-rated and diagnostician-rated psychopathology (post-treatment and 3 months follow-up) of MeMoPsy and elucidate the mechanisms of change using psychotherapy process research, Ecological Momentary Assessment and functional magnetic resonance imaging (fMRI).Ethics and dissemination This RCT obtained approval from independent ethics committees of participating centres and is accompanied by a data and safety monitoring board. …”
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NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections by Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen

“…5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism. …”
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Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…As iron deficiency (ID) anaemia in men and post-menopausal women is mostly caused by gastrointestinal blood loss or malabsorption, the initial evaluation of a patient with ID anaemia involves referral to a gastroenterologist. …”
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Analysis of Factors Influencing the Development of Community-Based Tourism in Rural Areas, Case Study: Villages Targeted by Tourism in the Markazi Province by Hamid Afshari, Behrouz Mohammadi Yeganeh, Hossein Farahani, Mehdi Cheraghi

“…Out of the total number of interviewees, 6 people (24%) have diplomas and post-diplomas, 11 people (44%) have bachelors, 6 people (24%) have post-graduate degrees, and 2 people (8%) have PhDs. …”
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The effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extract on the antioxidant capacity, and immune status of goslings under stress conditions by Qing Qu, Qing Qu, Qing Qu, Yihong Sun, Yihong Sun, Yihong Sun, Yayan Liang, Yayan Liang, Yayan Liang, Yongsheng Nie, Yongsheng Nie, Yongsheng Nie, Yongsheng Nie, Ming Gao, Ming Gao, Ming Gao, Yaohui Yuan, Wei Wang, Wei Wang, Wei Wang, Shuo Zhou, Shuo Zhou, Shuo Zhou

“…Supplementing with AEF and LP post-stress alleviated stress-induced the expression of inflammatory factors (TGF-β, TNF-α, IL-1β, IL-6), and improve L*, a*, b*, Ph45 (min), Ph24 (h) and drip loss in pectoral (p < 0.05). …”
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SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer by Xudong Li, Jingjing Ge, Mengdi Wan, Tongtong Feng, Xiaoqian Li, Haibo Zhang, Zhangyan Wang, Yongsheng Gao, Meiting Chen, Fei Pan

“…Significantly, ER-positive breast cancer tissues in patients with recurrence post-TAM treatment exhibited considerably stronger SLC31A1 expression levels. …”
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Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally—Early Interventions to Support Trajectories for Healthy Life in India (EIN... by Mary Barker, Janis Baird, K S Joseph, Cindy-Lee Dennis, Zulfiqar A Bhutta, Prakesh S Shah, Saumyadipta Pyne, Nalini Singhal, Murali Krishna, Prabhat Jha, Harshpal Singh Sachdev, Kalyanaraman Kumaran, Caroline H D Fall, Stephanie Atkinson, Stephen Lye, Stephen G Matthews, Daniel Sellen, Ghattu V Krishnaveni, Kumar Gavali Suryanarayana, Manohar Prabhu Prasad, Antonisamy Belavendra, Ramaswamy Balasubramaniam, Robert H J Bandsma, Giriraj Ratan Chandak, Elena M Comelli, Sandra T Davidge, Geoffrey L Hammond, Sadhana R Joshi, Kang Lee, Patrick McGowan, Pablo Nepomnaschy, Vivek Padvetnaya, Sirazul Ameen Sahariah, Jacquetta Trasler, Chittaranjan S Yajnik, Marie-Claude Martin, Nusrat Husain

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