Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…A comprehensive assessment was conducted on day 15 post-treatment, including survival analysis, starvation test, motor, learning and memory ability tests, malondialdehyde test, and Smurf test. …”
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Melatonin Implantation Improves the Reproductive Performance of Estrus-Synchronized Ewes During Seasonal Anestrus and Enhances the Antioxidant and Steroidogenic Capacities of Granu... by Zengyi Duan, Menghao Liu, Junjin Li, Kexiong Liu, Qi Qi, Zhixuan Yu, Hadia Akber Samoo, Chunxin Wang, Jian Hou

“…Melatonin (MT) plays a crucial role in reproductive processes. The purpose of this study was to assess the effects of a 5-day MT implant pretreatment on estrus synchronization and reproductive performance in sheep during seasonal anestrus. …”
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Biodegradation and biocompatibility of calcium phosphate-coated magnesium in eye environment, in vitro and in vivo by Yi Chen, Yi Lin, Wangdu Luo, Huanhuan Gao, Yaobo Hu, Liying Qiao, Jia She, Lin Xie, Xiangji Li, Yong Wang, Fusheng Pan

“…HA-coated Mg was fully biodegraded fifteen weeks post-operation, and the scleral drainage channel (SDC) was formed without obvious scarring. …”
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Management of Chlamydia Cases in Australia (MoCCA): protocol for a non-randomised implementation and feasibility trial by Rebecca Guy, Marcus Y Chen, Basil Donovan, Jane S Hocking, Natalie Carvalho, Christopher Fairley, Claudia Estcourt, Meredith Temple-Smith, Jane Tomnay, Julie Simpson, David Regan, David Hawkes, Lena Sanci, Jane L Goller, Jacqueline Coombe, Helen Bittleston, Marion Saville, Lara Roeske

“…Deidentified general practice and laboratory data will be used to measure pre-post chlamydia testing, retesting, reinfection and PID rates, and to estimate MoCCA intervention costs. …”
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Metabolomic and proteomic profiling of a burn-hemorrhagic shock swine model reveals a metabolomic signature associated with fatal outcomes by Bin Wei, Jinguang Zheng, Jiake Chai, Jianxiang Huang, Hongjie Duan, Shaofang Han, Xiaolin Yang, Wenjia Zhang, Fangchao Hu, Yirui Qu, Xiangyu Liu, Tian Liu, Yushou Wu, Yunfei Chi

“…Serum samples collected at 0 h and 2 h post-injury were analyzed using metabolomic and proteomic measurements. …”
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Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity by Amy Dashwood, Ntombizodwa Makuyana, Rob van der Kant, Arman Ghodsinia, Alvaro R. Hernandez, Stephanie Lienart, Oliver Burton, James Dooley, Magda Ali, Lubna Kouser, Francisco Naranjo, Matthew G. Holt, Frederic Rousseau, Joost Schymkowitz, Adrian Liston

“…The design and testing process identified the V106R (murine) / V91R (human) mutation as a Treg-enhancing mutein, creating a cation repulsion to inhibit primary binding to IL2RB, with a post-IL2RA confirmational shift enabling secondary IL2RB binding, and hence allowing the trimeric receptor complex to form. …”
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DIAMONDS—a diabetes self-management intervention for people with severe mental illness: protocol for an individually randomised controlled multicentre trial by Tim Doran, Najma Siddiqi, Simon Gilbody, Rowena Jacobs, Patrick Doherty, Catherine Hewitt, Laura Mandefield, Simon Walker, Ian Kellar, Sarah Alderson, David Osborn, Vicki Johnson, Judith Watson, Gregor Russell, Steve Parrott, Jan Rasmus Boehnke, Peter A Coventry, Jinshuo Li, Richard Ian Gregory Holt, Judy Wright, David Shiers, Michelle Hadjiconstantinou, Keith Double, Claire Carswell, Jennifer V E Brown, Lucy Sheehan, Grace Catherine O’Carroll, Charlie Peck, R A Ajjan, Angela Ross, Mark Dawson

“…The secondary outcomes include measures of physical and mental health, diabetes complications and physical activity. Economic and process evaluations will also be performed. Outcomes will be collected at baseline and at six and 12 month post-randomisation.Ethics and dissemination This study received ethics approval by the West of Scotland Research Ethics Committee 3 (22/WS/0117). …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Design A feasibility, cluster randomised controlled trial that aimed to recruit and randomise 12 special schools to either deliver the intervention over 1 academic year or continue with practice as usual and to collect data from 96 pupils at baseline (pre randomisation) and 12 months post randomisation. Setting Special schools in England and Scotland. …”
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Oxidative genomic damage in pediatric patients exposed to mercury released by dental amalgam by Guadalupe Nalleli Macías-Lamas, Yveth Marlene Ortiz-García, Blanca Patricia Lazalde-Ramos, Guillermo Moisés Zúñiga-González, Belinda Claudia Gómez-Meda, Cristina Hermila Martínez-Bugarín, Susana Vanessa Sánchez-De-La-Rosa, Saulo Oswaldo Sánchez-Rivera, Gabriela Morales-Velazquez, Celia Guerrero-Velázquez, Ana Lourdes Zamora-Perez

“…Hg from dental amalgam fillings has been shown to be released into the buccal cavity due to processes such as abrasion and corrosion, and which could represent a continuous source of oxidative damage to mouth tissues. …”
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Team climate, job satisfaction, burnout and practice performance: results of a national survey of staff in general practices in England by Peter Williams, Heather Gage, Bridget Jones, Carole Aspden, Jessica Smylie, Thomas Bird, Morro M. L. Touray, Phelim Brady, John Campbell, Rupa Chilvers, Catherine Marchand, Stephen Peckham, Suzanne H. Richards, Karen Spilsbury, Mark Joy, Simon de Lusignan

“…A good team climate, the relational processes of team working, can mitigate pressured work environments, but little is known about it. …”
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Repurposing Olive Oil Mill Wastewater into a Valuable Ingredient for Functional Bread Production by Ignazio Restivo, Lino Sciurba, Serena Indelicato, Mario Allegra, Claudia Lino, Giuliana Garofalo, David Bongiorno, Salvatore Davino, Giuseppe Avellone, Luca Settanni, Luisa Tesoriere, Raimondo Gaglio

“…OOMW did not significantly affect the growth of yeasts and lactic acid bacteria (LAB) or the acidification process. However, in terms of the specific volume and alveolation, breads from the <i>S</i> process and OOMW had poor quality, while those from the <i>B</i> process had better quality. …”
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Protecting Against Postsurgery Oral Cancer Recurrence with an Implantable Hydrogel Vaccine for In Situ Photoimmunotherapy by Lan Chen, Qiqi Yin, Handan Zhang, Jie Zhang, Guizhu Yang, Lin Weng, Tao Liu, Chenghui Xu, Pengxin Xue, Jinchao Zhao, Han Zhang, Yanli Yao, Xin Chen, Shuyang Sun

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Modelling the liver’s regenerative capacity across different clinical conditions by Anh Thu Nguyen-Lefebvre, Soumita Ghosh, Cristina Baciu, Bima J. Hasjim, Sara Naimimohasses, Graziano Oldani, Elisa Pasini, Michael Brudno, Nazia Selzner, Jeffrey Wrana, Mamatha Bhat

“…Background &amp; Aims: Liver regeneration is essential for recovery following injury, but this process can be impaired by factors such as sex, age, metabolic disorders, fibrosis, and immunosuppressive therapies. …”
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Embryo reintroduction to enhance genetic diversity in a Marsh deer population: first attempt, outcomes, challenges, and future perspectives by David Javier Galindo, David Javier Galindo, Pedro Henrique de Faria Peres, Eveline dos Santos Zanetti, Márcio Leite de Oliveira, Márcio Leite de Oliveira, Luciana Diniz Rola, José Maurício Barbanti Duarte

“…IntroductionThe loss of genetic diversity is a critical factor in the extinction process, exacerbated by anthropogenic pressures and demographic stochasticity, particularly in small populations. …”
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Molecular subtyping of stage I lung adenocarcinoma via molecular alterations in pre-invasive lesion progression by Jun Shang, He Jiang, Yue Zhao, Jingcheng Yang, Yicong Lin, Naixin Zhang, Luyao Ren, Qingwang Chen, Ying Yu, Leming Shi, Yuan Li, Haiquan Chen, Yuanting Zheng

“…Our model may help reliably identify high-risk stage I patients for more intensive post-surgery treatment.…”
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Microphysiological gut-on-chip enables extended in vitro development of Cryptosporidium hominis by Samantha Gunasekera, Benjamin Thierry, Brendon King, Paul Monis, Jillian M. Carr, Abha Chopra, Mark Watson, Mark O’Dea, Edward Cheah, Ramesh Ram, Peta L. Clode, Nawal Hijjawi, Una Ryan

“…Scanning electron microscopy of infected monolayers identified trophozoites, meronts, merozoites, macrogamonts, microgamonts, and possible gamont-like stages at 48 h post-infection. The potential role of gamonts in the Cryptosporidium life cycle remains unclear and warrants further investigation. …”
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Life cycle assessment of facile applicable biodiesel production by Mohamed A. Hanafy, Rehab M. Ali, Abdallah S. Elgharbawy, Ahmed I. Osman, Mohamed A. Farrag, Abdulaziz H. Al-Anazi

“…When using WCO or high free fatty acid (FFA) oils, K2CO3 has the advantage of effective direct transesterification, while KOH requires post-treatment process (esterification), which means extra usage of methanol besides the acid catalyst, which is commonly H2SO4, to decrease the FFA content and avoid the saponification reaction. …”
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Mapping of quorum sensing interaction network of commensal and pathogenic staphylococci by Bengt H. Gless, Benjamin S. Sereika-Bejder, Iben Jensen, Martin S. Bojer, Katerina Tsiko, Sabrina H. Schmied, Ludovica Vitolo, Bruno Toledo-Silva, Sarne De Vliegher, Hanne Ingmer, Christian A. Olsen

“…We identified six of these ribosomally synthesized and post-translationally modified peptides (RiPPs) in this study and compiled the full collection of AIPs by chemical synthesis. …”
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ACTivity as medicine In Oncology for Head and Neck (ACTIOHN): a feasibility study investigating a patient-centred approach to exercise for head and neck cancer patients by Joanne M. Patterson, Mary G. Cherry, Andrew Levy, Simon N. Rogers, Rachel C. Brooker, Valerie M. Bryant, Steven Lane, Michael M. Nugent, Ruth Price, Andrew G. Schache, Jennifer A. Kirton, Bridget Young, Debra Fisher, Adrian W. Midgely

“…ObjectiveTo determine the feasibility and acceptability of integrating a remote, personalised, collaborative, and flexible exercise programme into the head and neck cancer (HNC) care pathway.DesignA single arm mixed-methods feasibility study across two UK NHS hospitals.ProcedureEligible HNC patients (aged ≥ 16 years old, treated with curative intent and classified as low/medium risk according to an exercise risk stratification tool) were invited to participate between diagnosis and 8 weeks post-treatment. Patients treated with palliative intent and those identified as high risk on an exercise risk stratification tool were excluded. …”
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Good Arts, Good Mental Health®: the effectiveness of an Australian health promotion media campaign in promoting community mental wellbeing via the arts by Christina R. Davies, Melanie T. Pescud, Rhonda Clifford, Richard McGrath, Annie Thomson, Mia Jeffrey, Melissa Stoneham, Terri Pikora, Peter Wright, Sonya Girdler, Sonya Girdler, Loretta Baldassar, Stephen Clift

“…For paid media channels, the highest reach (948,106 people) and best cost-per-reach ($0.02) were delivered by Meta (Facebook and Instagram).Measured as both (1) a proportion of total respondents and (2) a sub-set analysis of each preceding level in the cognitive impact hierarchy, post-campaign, one-in-four respondents were aware of Good Arts, Good Mental Health®. …”
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