Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Abstract Background MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. …”
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Efek Lama Penyimpanan Asi Terhadap Kadar Protein dan Lemak yang Terkandung Didalam ASI by Indri Putri Sari, Ariadi ., Ety Yerizel

“…</p><p><strong>Kata kunci:</strong> kadar protein ASI, kadar lemak ASI, lama penyimpanan</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Keeping breast milk in cool storage is often done by working mother, may cause biochemical process such as proteolysis and lipolysis. These processes may change nutrition component in breast milk. …”
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Incorporation of tritium by pepper and eggplant cultures with short-term exposure to tritium oxide by E. N. Polivkina, E. S. Sysoyeva, E. V. Romanenko, L. F. Subbotina, A. V. Panitskiy, F. F. Zhamaldinov, L. B. Kenzhina

“…Plants are a key link in the process of tritium migration both in the ecosystem as a whole and in the trophic structure in particular. …”
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Findings from a cluster randomised feasibility study of a school-based physical activity role model intervention (CHARMING) for 9–10-year-old girls by Kelly Morgan, Jordan Van Godwin, Rebecca Cannings‑John, Rhiannon Tudor Edwards, Rachel Granger, Britt Hallingberg, Graham Moore, Bethan Pell, Esther van Sluijs, Holly Whiteley, Jemma Hawkins

“…Methods Between January 2021 and August 2022, a feasibility cluster randomised controlled trial (cRCT), with process and health economic evaluations was conducted in South Wales. …”
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Cryopreservable, scalable and ready-to-use cell-laden patches for diabetic ulcer treatment by Bangrui Yu, Lanlan Peng, Wenjun Dang, Ying Fu, Zhijie Li, Jinteng Feng, Heng Zhao, Tian Wang, Feng Xu, Martin L. Yarmush, Haishui Huang

“…Here we report a stem cell-laden alginate-dopamine hydrogel patch that can be readily cryopreserved, processed, and scaled toward clinical usages. This cell-hydrogel patch not only maintains cell viability and structure integrity during cryopreservation, but also can be directly utilized without centrifugation or incubation post cryopreservation. …”
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LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model by Lucas Blasco-Agell, Meritxell Pons-Espinal, Veronica Testa, Gerard Roch, Jara Montero-Muñoz, Irene Fernandez-Carasa, Valentina Baruffi, Marta Gonzalez-Sepulveda, Yvonne Richaud-Patin, Senda Jimenez, Thais Cuadros, Joana M. Cladera-Sastre, Joan Compte, Zoe Manglano-Artuñedo, Salvador Ventura, Manel Juan, Eduardo Tolosa, Angel Raya, Miquel Vila, Antonella Consiglio

“…Finally, post-mortem analysis of midbrain tissue of LRRK2-PD patients show increased microglia activation around NM-containing neurons, confirming our in vitro findings. …”
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Metabolic Effects of Sodium Thiosulfate During Resuscitation from Trauma and Hemorrhage in Cigarette-Smoke-Exposed Cystathionine-γ-Lyase Knockout Mice by Maximilian Feth, Felix Hezel, Michael Gröger, Melanie Hogg, Fabian Zink, Sandra Kress, Andrea Hoffmann, Enrico Calzia, Ulrich Wachter, Peter Radermacher, Tamara Merz

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Evaluating Interlaboratory Variability in Wastewater-Based COVID-19 Surveillance by Arianna Azzellino, Laura Pellegrinelli, Ramon Pedrini, Andrea Turolla, Barbara Bertasi, Sandro Binda, Sara Castiglioni, Clementina E. Cocuzza, Fabio Ferrari, Andrea Franzetti, Maria Giovanna Guiso, Marina Nadia Losio, Marianna Martinelli, Antonino Martines, Rosario Musumeci, Desdemona Oliva, Laura Sandri, Valeria Primache, Francesco Righi, Annalisa Scarazzato, Silvia Schiarea, Elena Pariani, Emanuela Ammoni, Danilo Cereda, Francesca Malpei

“…Three wastewater samples were analyzed in parallel by four laboratories using identical pre-analytical (PEG-8000-based centrifugation) and analytical processes (qPCR targeting N1/N3 and Orf-1ab). A two-way ANOVA framework within Generalized Linear Models was applied, and multiple pairwise comparisons among laboratories were performed using the Bonferroni post hoc test. …”
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Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis by Juan Hu, Qiao Li, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao, Yansong Li, Yaomin Zhu

“…The findings revealed that in primary neurons exposed to HG/Pal, the expression of copper levels was elevated, and the levels of FDX1, LIAS, and DLAT were reduced. Post-transplantation of platelet-derived mitochondria (Mito-Plt), a significant reversal of these biomarkers was noted, coincident with an improvement in cognitive deficits in T2DM mice. …”
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Telomere biology disorders in lung transplantation: Clinical challenges and management strategies by Farah Mesli, Quentin Philippot, Kinan El Husseini, Vincent Bunel, Caroline Kannengiesser, Marie Pierre Debray, Alice Guyard, Bruno Crestani, Ibrahima Ba, Raphaël Borie

“…Shortened telomeres—whether due to inherited telomeropathies or acquired attrition—have emerged as a risk factor for various pulmonary diseases, particularly pulmonary fibrosis, which is a leading indication for lung transplantation.This review provides a comprehensive overview of current knowledge on the impact of short telomeres in lung transplant recipients, encompassing pre-transplant assessment and post-transplant outcomes. Patients with telomere-biology disorder present unique clinical challenges. …”
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White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics by Manxi Yuan, Ruiqi Lu, Yu Liu, Yu Liu, Hui Zhu, Hui Zhu, Hui Zhu, Hui Zhu, Hao Wang, Jingzhi Wang, Jingzhi Wang, Jingzhi Wang, Jingzhi Wang, Yang Song, Yang Song, Yang Song, Lei Yang, Lei Yang, Lei Yang, Lei Yang, Mingzhong Xiao, Mingzhong Xiao, Mingzhong Xiao, Mingzhong Xiao

“…These findings underscore the importance of continued monitoring and tailored interventions to address neurological sequelae as part of the post-COVID-19 recovery process.…”
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Ethylene‐Activated E3 Ubiquitin Ligase MdEAEL1 Promotes Apple Fruit Softening by Facilitating the Dissociation of Transcriptional Repressor Complexes by Tong Li, Li Liu, Guangxin Yang, Yingcong Cai, Yingda Wang, Bowen Sun, Le Sun, Weiting Liu, Aide Wang

“…This study elucidates the interplay between post‐translational modifications of a transcription factor and its epigenetic modification to regulate fruit softening, and highlights the complexity of ethylene‐induced softening.…”
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Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. by Patrick Y Sips, Xu Shi, Gabriel Musso, Anjali K Nath, Yanbin Zhao, Jason Nielson, Jordan Morningstar, Amy E Kelly, Brittney Mikell, Eva Buys, Vikhyat Bebarta, Jared Rutter, V Jo Davisson, Sari Mahon, Matthew Brenner, Gerry R Boss, Randall T Peterson, Robert E Gerszten, Calum A MacRae

“…We found that zebrafish embryos in the first 3 days post fertilization (dpf) are highly resistant to cyanide, becoming progressively more sensitive thereafter. …”
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<i>Plasmodium falciparum</i> Subtilisin-like Domain-Containing Protein (PfSDP), a Cross-Stage Antigen, Elicits Short-Lived Antibody Response Following Natural Infection with <i>Pla... by Jonas A. Kengne-Ouafo, Collins M. Morang’a, Nancy K. Nyakoe, Daniel Dosoo, Richmond Tackie, Joe K. Mutungi, Saikou Y. Bah, Lucas N. Amenga-Etego, Britta Urban, Gordon A. Awandare, Bismarck Dinko, Yaw Aniweh

“…We also discovered that PfSDP protein is immunogenic in children from different endemic areas with antibody levels increasing from acute infection to day 7 post-treatment, followed by a gradual decay. The limited effect of antibodies on erythrocyte invasion could imply that it might be more involved in other processes in the development of the parasite.…”
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The developmental toxicity of bisphenol F exposure on the zebrafish larvae by Biyu Wu, Zirui Cheng, Xiang Li, Minxing Liang, Xue Wang, Duan Pi, Jiayi Liu, Huiling Li, Jun Zhao, Junjie Wang, Fang Liang, Xuegeng Wang

“…Our results demonstrated a significant increase in hatching rates across all treatment groups at 2 days post-fertilization (dpf). The esr1 was significantly upregulated at 2000 µg/L by 5 dpf, while no significant change was observed in ar. …”
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International Survey on Phenylketonuria Newborn Screening by Domen Trampuž, Peter C. J. I. Schielen, Rolf H. Zetterström, Maurizio Scarpa, François Feillet, Viktor Kožich, Trine Tangeraas, Ana Drole Torkar, Matej Mlinarič, Daša Perko, Žiga Iztok Remec, Barbka Repič Lampret, Tadej Battelino, ISNS Study Group on PKU, Francjan J. van Spronsen, James R. Bonham, Urh Grošelj

“…Such a best practice of PKU-NBS parameters and post-screening parameters could then serve as a generally applicable guideline.…”
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The role of deubiquitinases in cardiovascular diseases: mechanisms and therapeutic implications by Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Xiangyu Fei, Chao Song, Chao Song, Chao Song, Chao Song, Jian Cui, Jian Cui, Jian Cui, Jian Cui, Yuqing Li, Yuqing Li, Yuqing Li, Yuqing Li, Yuqing Li, Xiaoyong Lei, Huifang Tang, Huifang Tang, Huifang Tang, Huifang Tang, Huifang Tang

“…The ubiquitination system is a vast and complex. It is an important post-translational modification that plays a crucial role in various cellular processes. …”
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Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…Given its key role in cognitive control and emotion regulation — processes highly relevant for rumination — we focused on the frontoparietal network. …”
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Full-length transcriptome analysis of male and female gonads in Japanese Eel (Anguilla japonica) by Jiangling Li, Jingjie Liang, Mengyang Wang, Yuewen Jiang, Wen Li, Mingxi Huang, Yan Huang, Yangjie Xie, Jianchun Chen, Tiansheng Chen

“…Results PacBio Iso-Seq and Illumina RNA-Seq technologies were combined to conduct a full-length transcriptome analysis of male and female Japanese eel gonads at a post-differentiation, pre-maturation stage. A total of 24,661 unigenes were identified in ovaries and 15,023 in testes, along with genomic regulatory elements such as transcription factors, simple sequence repeats, and long non-coding RNAs. …”
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TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus by Li Chen, Ma Ang, Bai Yu, Liu Zitao, Tian Linghan, Wang Ziyuan, Ma Huaishun, Chen Zhengpu, Gao Zhengheng, Feng Shijie, Fu Ping

“…This post-translational modification prevents the sequestration of STING into autophagosomes, thereby stabilizing the adaptor protein and amplifying downstream type I interferon responses. …”
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