A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mu... by Manutsanun Inthawong, Piyanate Sunyakumthorn, Sirima Wongwairot, Tippawan Anantatat, Susanna J Dunachie, Rawiwan Im-Erbsin, James W Jones, Carl J Mason, Luis A Lugo, Stuart D Blacksell, Nicholas P J Day, Piengchan Sonthayanon, Allen L Richards, Daniel H Paris

“…<h4>Methodology/principle findings</h4>We evaluated the clinical outcomes and host immune responses of the two most relevant human pathogenic strains of O. tsutsugamushi; Karp (n = 4) and Gilliam (n = 4) in a time-course study over 80 days post infection (dpi) in a standardized scrub typhus non-human primate rhesus macaque model. …”
Get full text

Occurrence characteristics and utilization potential of scarce coking coal resources in Huaibei coalfield by Run ZHAN, Wenyong ZHANG, Feng HAN, Fengtang SUI, Jiayi GU, Guijian LIU, Tian ZHAO

“…The scarce coking coal is distributed sporadically in the northern part of the coalfield, and continuously distributed in the southern part of the coalfield, and the metamorphism degree of coal is increasing from southwest to northeast in the area.The formation and spatiotemporal distribution of scarce coking coal were controlled by the fault activity in different directions and magmatic coupling in the post−Yanshanian period. The scarce coking coal is divided into three grades: Low−ash−ultra−low−sulfur coal, ultra−low−ash−low−sulfur coal, low−ash−low−sulfur coal, and low−ash−low−sulfur coal from the perspective of clean and green development.It is estimated by classification, classification and zoning that the reserved resources of shallow scarce coking coal at −1500 m are about 10.165 million tons, accounting for 78.13% of the total reserved resources in the coal field, and the resource potential is huge. …”
Get full text

Methylation of a group of microRNA genes as a marker for the diagnosis and prognosis of non-small cell lung cancer by V. I. Loginov, M. S. Gubenko, A. M. Burdennyy, I. V. Pronina, P. V. Postnikov, Yu. A. Efimova, F. V. Radus, E. S. Mochalova, T. P. Kazubskaya

“…MicroRNAs, which function as post-transcriptional regulators of the expression of protein-coding genes, including those associated with oncogenesis, are involved in the processes of cell proliferation, differentiation, and apoptosis. …”
Get full text

Community health assessment of needs and continuous empowerment (CHANCE): a quantitative cross-sectional survey targeting primary health care nurses in Lebanon by Gladys Honein-AbouHaidar, Reem Hoteit, Sarah Chehayeb, Nuhad Dumit, Tamar Avedissian, Bahia Abdallah, Randa Hamadeh

“…Future steps would be to develop interventions to empower nurses with the competencies they requested as priorities and to conduct a post intervention assessment to test the effect of the training on nursing adoption of those skills.…”
Get full text

A Retrospective Longitudinal Study on Venous Thromboembolisms: The Impact of Active Monitoring on the Venous Thromboembolism Management Practices of Healthcare Providers to Improve... by Rateb Abd Alrazak Daowd, Ateeq Mohamad Algarni, Majed Abdulhadi Almograbi, Sara Majed Saab, Naif Mansour Alrashed, Maryam Mohammad Harthi, Amira Fatmah Paguyo Quilapio, Ibrahim Numan Alnajjar, Shahzad Ahmad Mumtaz, Raed Fahad Albusayyis, Dalya Ali Aljumaiah, Yazeed Alsalamah, Huda Ibrahim Almulhim

“…Lastly, we recommend addressing the risk factors associated with the occurrence of hospital-acquired VTE and performing post-discharge follow-ups of patients.…”
Get full text

Recycling waste for energy: Reusing methyl orange dye-adsorbed polythiophene/Fe3O4 nanorods/reduced graphene oxide nanocomposite as a supercapacitor electrode by Ahmad Husain, Asim Ali, Sara A. Alqarni, Khalid Ansari, Mohtaram Danish, Prem Gunnasegaran, Mohammad Kanan, Jayant Giri, M. Kandasamy, M.M.A. Khan, Kyeong Tae Kang

“…Post-adsorption, the material still retained significant supercapacitor properties, with a specific capacitance of 380.9 Fg−1 at 1 Ag−1 and 83.2% cyclic stability over 5000 GCD cycles. …”
Get full text

Revolutionizing bone regeneration and wound healing: Mechanical stromal vascular fraction and hyaluronic acid in a mouse calvarial defect model by Riccardo Ossanna, Lindsey Alejandra Quintero Sierra, Sara Ghazanfar Tehrani, Vivekanand Jha, Chiara Curatola, Alice Busato, Anita Conti, Giamaica Conti, Nicola Zingaretti, Pier Camillo Parodi, Francesco De Francesco, Michele Riccio, Andrea Sbarbati

“…Studies showed that hyaluronic acids are usually involved in healing processes. This study was focused on the healing potency of stromal stem cells isolated from adipose tissues by mechanical digestion, and the role of low-molecular-weight hyaluronic acid (LMW-HA, ACP) in the healing process was tested in calvarial defeatures in a mouse model, in comparison with the enzymatic digestion method.MethodsThe bone healing and remodeling process was evaluated in vivo using magnetic resonance imaging (MRI) up to 15 days post-treatment, and differences in the quality of bone regeneration were assessed by ex vivo histological analysis, immunofluorescences, and ultrastructural analysis. …”
Get full text

A eletropirexia no tratamento da neurossífilis by Iracy Doyle

“…This being postulated, the best pyretotherapeutic process will be recognized as the one which allows the operator to obtain an optimum temperature, maintain it for an optimum length of time, with the least danger towards the patient - and this process is electropyrexy.…”
Get full text

Status and prospects of research on HCl removal from blast furnace gas by Gang LU, Yi XING, Hualong ZHOU, Liqianxin QIAN, Lin DING, Qiulin ZHANG, Tingshuang LENG, Wei SU, Rongzhi ZHAO

“…To address the harm caused by chlorine ions in blast furnace gas, and without altering the fundamental blast furnace ironmaking process, this article conducts an in-depth study focused on various strategies. …”
Get full text

Methods to Quantitatively Evaluate the Effect of Shale Gas Fracturing Stimulation Based on Least Squares by DENG Cai, SUN Kexin, WEN Huan, HU Chaolang

“…Conventional approaches rely predominantly on post-fracturing active perforation counts as a proxy for stimulation effectiveness. …”
Get full text

Measurement and Evaluation of Social Resilience Indicators in the Historical Neighborhoods of Tabriz City (Case Study: Sorkhab Neighborhood of Tabriz) by Leila Rahimi, Mahta Choobineh

“…Natural disasters have profound social repercussions in cities, making it imperative to promote social resilience as a capability that not only maintains cities' initial performance, but also fosters their post-disaster improvement and prosperity (Brown et al., 2012: 24). …”
Get full text

Evaluation of a patient decision aid for opportunistic salpingectomy and salpingectomy as sterilization method to prevent ovarian cancer by Malou E. Gelderblom, Charlotte Fisch, Jurgen M. J. Piek, Laura A. M. vanLieshout, Justine Briet, Lauren Bullens, Sjors F. P. J. Coppus, Inge Ebisch, Alexandra A. vanGinkel, Rafli van deLaar, Natascha deLange, Marloes Maassen, Huy Ngo, Angele L. M. Oei, Brenda Pijlman, Brigitte Slangen, Regina The, Dineke Smedts, Caroline Vos, Joanna IntHout, Joanne A. deHullu, Rosella P. M. G. Hermens

“…Digital questionnaires were used to evaluate the decision aid, the decision process, and patients' decisions 6–8 weeks post‐surgery. …”
Get full text

Effects of histone acetyltransferase and deacetylase inhibitors on the expression of S100A genes after TLR4 and TLR2 stimulation in human dental pulp cells by Holger Jungbluth, Dominik Kraus, Diana Lalaouni, Sarah Hossam Fahmy, Jochen Winter, Søren Jepsen

“…S100 proteins are closely linked to processes affected by inhibitors of histone acetylation (HATi) and deacetylation (HDACi) (e.g. differentiation and mineralization). …”
Get full text

Bridging the gap in mental health literacy: co-adapting and feasibility testing a digital intervention to improve mental health literacy amongst young people aged 12–14 in the UK by Emily Vicary, Helen Brierley, Jack Wilkinson, Melody Adesina, Penny Bee, Karina Lovell, Naz Uzun, Emily Bee, Helen Brooks

“…Then, Phase 2 was a multi-site, cluster-randomized feasibility trial with a nested mixed-methods process evaluation conducted at two community sites (N = 19, 12 completing 4-week post-intervention data and 11 completing 3-month follow-up). …”
Get full text

Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of sen... by Agnieszka Gadecka, Marta Koblowska, Helena Kossowska, Roksana Iwanicka-Nowicka, Dorota Janiszewska, Grażyna Mosieniak, Krzysztof Bojakowski, Krzysztof Goryca, Anna Bielak-Zmijewska

“…Abstract Background Cellular senescence is a fundamental process leading to organismal aging and age-related diseases. …”
Get full text

Lateral Bearing Characteristics of Bucket Foundation Breakwaters in Soft Soil of Port Areas by WANG Shuai, ZHANG Jia-lin, HU Shao-wei, YOU Jian-hua, YANG Yu-ming

“…[Methods] Based on the actual structural configurations, a 1∶20 large-scale test model was designed, along with a foundation bed model simulating the sandy soil conditions of port areas, to simulate the service performance of bucket foundation breakwaters. The loading process covered the entire phase from post-installation to failure. …”
Get full text

Evidence adaptation and tailored implementation of family bereavement support in specialised palliative care: A multi-method study by Myrta Kohler, Qëndresa Thaqi, Silke Kuske, Torsten Schwalbach, Marco Riguzzi, Rahel Naef

“…Drawing on implementation mapping methodology, a systematic and participatory process was used to develop an implementation plan that specified activities needed to address identified barriers and support integration into palliative care services. …”
Get full text

Comparative historical analysis of the foundation of classical gymnasium in the first quarter of the 19th century: Russian and international experience by A. N. Dzhurinskiy, N. V. Troshkova

“…Turning to such experience allows us to more successfully solve not only the specific problems of the revived gymnasiums and gymnasium classes in modern Russia, but also, in general, to comprehend the prospects of classical education in the post-industrial era.…”
Get full text

The Theoretical Approaches to Defining the Essence of the Concept of «National Security» and Its Components by Khaustova Viktoriia Ye., Trushkina Nataliia V.

“…In recent decades, the concept of security has occupied a special place concerning life processes and various spheres of the economy of the countries of the world. …”
Get full text

The Overlooked Threat of Hospital Falls During the Discharge Period: A Statewide Retrospective Analysis of Patient Safety Event Reports by Christine E. Sanchez, Rebecca Jones

“…While previous research has primarily focused on inpatient or post-discharge falls, the transitional period surrounding discharge has been understudied…”
Get full text