Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration by Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan

“…Abstract Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio‐temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to overcome the strict post‐mitotic state of human adult cardiomyocytes. …”
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IL-33/ST2 Pathway and Classical Cytokines in End-Stage Heart Failure Patients Submitted to Left Ventricular Assist Device Support: A Paradoxic Role for Inflammatory Mediators? by C. Caselli, A. D'Amico, R. Ragusa, R. Caruso, T. Prescimone, M. Cabiati, S. Nonini, P. Marraccini, S. Del Ry, M. G. Trivella, O. Parodi, D. Giannessi

“…Inflammation is a critical process contributing to heart failure (HF). We hypothesized that IL-33/ST2 pathway, a new mechanism regulated during cardiac stress, may be involved in the functional worsening of end-stage HF patients, candidates for left ventricular assist device (LVAD) implantation, and potentially responsible for their outcome. …”
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Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation by Man Yee Cheung, Chunmei Jiang, Imtiaz Ul Hassan, Hui Wang, Donghao Guo, Daniel Wuyang Dio, Huan Yan, Jianmin Sun, Xufeng Qi, Dongqing Cai, Wei Ge, Sheue-yann Cheng, Wai-Yee Chan, Hui Zhao

“…However, a comprehensive understanding of TH and its receptors, thyroid hormone receptors (TRs), orchestrating with other regulatory processes for heart regeneration, such as the hypoxia signaling pathway and post-injury metabolic switches, remains elusive. …”
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Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms by George N Bendzunas, Dominic P Byrne, Safal Shrestha, Leonard A Daly, Sally O Oswald, Samiksha Katiyar, Aarya Venkat, Wayland Yeung, Claire E Eyers, Patrick A Eyers, Natarajan Kannan

“…In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications, including phosphorylation of Ser/Thr residues and oxidation of cysteine (Cys) residues. …”
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Integrating transcriptomic and proteomic analyses of photoperiod-sensitive in near isogenic maize line under long-day conditions by Xiao-heng SONG, Lei TIAN, Shun-xi WANG, Jin-long ZHOU, Jun ZHANG, Zan CHEN, Liu-ji WU, Li-xia KU, Yan-hui CHEN

“…A weak correlation between mRNA- and protein-level changes was observed, suggesting the LP-induced transition between maize growth stages is largely regulated post-transcriptionally. Differentially expressed genes influenced by LP conditions were associated with several regulatory processes in both maize inbred lines, especially phosphate ion transport and the circadian rhythm. …”
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Deubiquitylases MoUbp12 and MoUbp14 modulated by transcription factor MoMsn2 are critical for mitochondrial fusion/fission balance and infectious growth of the rice blast fungus by Xingyu Wang, Yuhan Xiao, Qi Li, Lele Xu, Yayuan Huang, Muxing Liu, Xinyu Liu, Zhengguang Zhang, Haifeng Zhang

“…Abstract Ubiquitination is a critical post-translational modification that regulates various cellular processes, including protein degradation and organelle dynamics. …”
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Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy by Al Samra Lynn, El Nahas Mohamad, Mneimneh Ilham, Tokajian Sima, Nemer Georges, Sinno Aia, Rahy Kelven, Thoumi Sergio, Zibara Zahraa, El Khatib Ahmad, Sabbagh Dalal, Guillot Jacques, Karam Louna, Ali Lazo, Baghdadi Ruqaya, Al Khoury Charbel

“…Moreover, MOX exhibited the lowest resistance acquisition in both promastigotes and intracellular amastigotes after 15 rounds of artificial selection, with resistance ratios of 17.23 and 4.59, respectively. Post-exposure to MOX, differential gene expression profiles showed both stage-specific and stage-unspecific enrichment of gene families involved in crucial biological processes. …”
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Multi-omics based and AI-driven drug repositioning for epigenetic therapy in female malignancies by Annamaria Salvati, Viola Melone, Alessandro Giordano, Jessica Lamberti, Domenico Palumbo, Luigi Palo, Dilia Rea, Domenico Memoli, Vittoria Simonis, Elena Alexandrova, Francesco Silvestro, Francesca Rizzo, Alessandro Weisz, Roberta Tarallo, Giovanni Nassa

“…Abstract Histone post-translational modifications (PTMs) have long been recognized as critical regulators of chromatin dynamics and gene expression, with aberrations in these processes driving tumorigenesis, immune escape, metastasis, and therapy resistance. …”
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Analysis of microstructural evolution and mechanical properties of FGH101 powder superalloy and IN718 deformed superalloy via inertia friction welding by Jun Zhou, Jun Zhou, Yongqiang Zhang, Yongqiang Zhang, Yongqiang Zhang, Feng Qin, Feng Qin, Xuelong Zhang, Xuelong Zhang, Hao Wang, Hao Wang, Ze Liu, Ze Liu, Wenhan Zhang, Wenhan Zhang, Caiyan Huang, Caiyan Huang, Chunbo Zhang, Chunbo Zhang

“…Nickel-based superalloys are indispensable in aerospace engines due to their exceptional high-temperature strength, oxidation resistance, and corrosion resistance, making them critical for joining processes such as inertia friction welding (IFW), which is favored for its efficiency and superior joint quality. …”
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The evaluation of equipment remote operation and pyroprocessing verification in hot cell by NIU Yongsheng, SUN Lixin, WANG Baozhu, ZHANG Han, FU Haiying, DOU Qiang, ZHOU Wei, QIAN Yuan, LI Qingnuan

“…The hot cell is an important guarantee for the practical application of nuclear fuel reprocessing technology, therefore, a remote operation system suitable for reprocessing post-treatment process equipment is developed so that the pyroprocessing experiments of molten salt can be conducted in hot cell.PurposeThis study aims to evaluate equipment remote operation and pyroprocessing verification in hot cell.MethodsMain focus of this study was the fluoride volatility and vacuum distillation process of molten salt reactor fuel salts, and the remote operation evaluation of hot cell equipments and pyroprocessing verification experiments were carried out using multi-view coordination. …”
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An Inclusive Civil Society Dialogue for Successful Implementation of the EU HTA Regulation: Call to Action to Ensure Appropriate Involvement of Stakeholders and Collaborators by Thomas Desmet, Elaine Julian, Walter Van Dyck, Isabelle Huys, Steven Simoens, Rosa Giuliani, Mondher Toumi, Christian Dierks, Juliana Dierks, Antonella Cardone, Francois Houÿez, Mira Pavlovic, Michael Berntgen, Peter Mol, Anja Schiel, Wim Goettsch, Fabrizio Gianfrate, Stefano Capri, James Ryan, Pierre Ducournau, Oriol Solà-Morales, Jörg Ruof

“…HTA point of view, capacity building, and standardization of processes. The most important actions for regulators are to develop joint regulatory-HTA guidance documents, align processes and interfaces under the regulation, and share discussions on post-licensing evidence generation. …”
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Educational effectiveness of cognitive and metacognitive strategies on educational self-destructive behaviors and negative self-evaluation thinking in Arabic lessons by Ali Nourihamid Altome, Mohammad hassani, Masoumeh Talebi

“…Negative self-evaluative belief is a multifaceted concept and includes knowledge (beliefs), processes and strategies that negatively evaluate, monitor or control cognition (MacBeth et al, 2019). …”
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Gaawaadhi Gadudha: understanding how cultural camps impact health, well-being and resilience among Aboriginal adults in New South Wales, Australia—a collaborative study protocol by Stephanie M Topp, Anthony B Zwi, Aryati Yashadhana, Ted Fields, Jonathan Kingsley, Evelyne de Leeuw, Brooke Brady, Michelle O'Leary, Miri Raven, Nina Serova, Warren Foster, Wendy Jopson, Brett Biles

“…A survey assessing connection to culture, access to cultural resources, resilience, self-rated health and quality of life will be administered to participants pre-camp and post-camp participation, and to a comparative group of Aboriginal adults who do not attend the camp (n=105). …”
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Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors by Yi Yang, Yi Yang, Yi Wu, Yi Wu, Hui Chen, Hui Chen, Zehai Xu, Zehai Xu, Ruisi Lu, Ruisi Lu, Sijie Zhang, Sijie Zhang, Rui Zhan, Rui Zhan, Qinghua Xi, Qinghua Xi, Yunfeng Jin, Yunfeng Jin

“…Lactylation represents a newly identified post-translational modification (PTM) that occurs due to lactate accumulation and is observed in various proteins, encompassing both histone and non-histone types. …”
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Modulating food craving-related neural oscillations using tACS: study protocol for a randomized sham-controlled trial by Milos Ljubisavljevic, Milos Ljubisavljevic, Fransina C. King, Fransina C. King, Fatima Yousif Ismail, Yauhen Statsenko, Yauhen Statsenko, Shahid Bashir, Osama Abdullah, Osama Abdullah, Bas Rokers, Bas Rokers

“…Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) will be conducted pre- and post-intervention. Primary outcomes include changes in craving intensity and inhibitory control. …”
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Negative frequency-dependent selection through variations in seedling fitness due to genetic differentiation of parents’ pair in a tropical rainforest tree, Rubroshorea curtisii (D... by Naoki Tani, Naoki Tani, Chin Hong Ng, Soon Leong Lee, Chai Ting Lee, Norwati Muhammad, Toshiaki Kondo, Yoshihiko Tsumura, Saori Sugiyama, Kaoru Niiyama, Azizi Ripin, Abdul Rahman Kassim, Samsudin Musa

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A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy by Mingzhu Tang, Dade Rong, Xiangzheng Gao, Guang Lu, Haimei Tang, Peng Wang, Ning-Yi Shao, Dajing Xia, Xin-Hua Feng, Wei-Feng He, Weilin Chen, Jia-Hong Lu, Wei Liu, Han-Ming Shen

“…Abstract PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy. Previous studies on PINK1 mainly focused on its post-translational modifications, while the transcriptional regulation of PINK1 is much less understood. …”
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Herpes simplex virus-induced upregulation of inflammatory cytokines in human gingival fibroblasts by Yu Zhang, Kalam Lo, Chunmei Wang, Guoliang Zhou, Xiping Feng, Jing Ni, Xi Chen

“…At the early stage of infection (12 h post-infection), the most upregulated genes were interferon (IFN) regulatory factor family members, toll-like receptor (TLR) family members, IFN-β1, interleukin (IL)-1, C-C motif ligands, chemokine (C-X-C motif) ligands (CXCLs), and tumor necrosis factor (TNF). …”
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Altered Lactylation Myocardial Tissue May Contribute to a More Severe Energy-Deprived State of the Tissue and Left Ventricular Outflow Tract Obstruction in HOCM by Ruoxuan Li, Jing Wang, Jia Zhao, Jiao Liu, Yuze Qin, Yue Wang, Yiming Yuan, Nan Kang, Lu Yao, Fan Yang, Ke Feng, Lanlan Zhang, Shengjun Ta, Bo Wang, Liwen Liu

“…In cardiovascular diseases, this post-translational modification can exacerbate cardiac dysfunction, and it can also promote the cardiac repair process after myocardial infarction. …”
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The Conceptual Comparison Between Vecdi Akyüz’s Work Titled Kur’an’da Siyasi Kavramlar and Manzooriddin Ahmad’s Work Titled Islamic Political System in the Modern Age: Theory and P... by Ayşe Aytekin

“…In this manner, it is much more necessary and obligatory to analyze and understand the focal concepts in the process of understanding and making sense of the sacred texts, in which the divine messages that are desired to be conveyed to people are presented in various conceptual patterns, compared to other texts. …”
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