Implementation of a value-based approach for older people who have suffered an acute myocardial infarction: study protocol by Denis Juraga, Tomislav Rukavina, Tomislav Rukavina, Mihaela Marinović Glavić, Lovorka Bilajac, Lovorka Bilajac, Lovorka Bilajac, Aleksandar Racz, Esmee L. S. Bally, Oscar Zanutto, Tamara Alhambra-Borrás, Maite Ferrando, Alen Subotić, Hein Raat, Vanja Vasiljev

“…Using this approach, it could be possible to reduce overall healthcare expenses through the active involvement of both older people and their informal caregivers through a shared decision-making process with healthcare professionals.Clinical trial registrationThe ISRCTN registry number is 25089186. …”
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Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in small cell lung cancer by Xin Wang, Xin Wang, Zhenyi Xu, Zhen Lin, Dawei Wu, Yu Tang, Zhihua Pei, Yibo Gao, Jie He

“…We then conducted association analyses between FRG subtypes and various tumor microenvironment (TME) characteristics, traditional key transcript factor subtypes, clinical features, transcriptional and post-transcriptional regulation, drug response, and the efficacy of immunotherapy. …”
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A CoQ10 analog ameliorates cognitive impairment and early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation by Junhui Chen, Zhonghua Shi, Yuhua Chen, Kun Xiong, Yuhai Wang, Hongqi Zhang

“…However, the precise mechanisms underlying early brain injury (EBI) following SAH remain incompletely understood, and the detailed molecular processes have yet to be completely clarified. This investigation examined the neuroprotective properties of a CoQ10 analog concerning EBI post-SAH and identified potential mechanistic pathways. …”
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Synthetic Modeling of Polarized Dust Emission in Intermediate-mass YSOs. I. Constraining the Role of Iron Inclusions and Inelastic Relaxation on Grain Alignment with ALMA Polarizat... by Nguyen Chau Giang, V. J. M. Le Gouellec, Thiem Hoang, A. J. Maury, P. Hennebelle

“…In this paper, we update the POLARIS code and use it to perform synthetic dust polarization modeling for MHD simulations of an intermediate-mass YSOs. Results will be post-processed with CASA to confront Atacama Large Millimeter/submillimeter Array (ALMA) polarimetric observations. …”
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Mapping Current Studies of tRNA Fragments onto Disease Landscape by Sathyanarayanan Vaidhyanathan, MacKenna Durbin, Adesupo A. Adetowubo, Lisa H. Do, Sheida Kavehmoghaddam, Sai Anusha Jonnalagadda, Bryan Ramirez Aguilar, Tamin Ortiz-Gomez, Yan X. Lin, Asim Dave, Fatmanur Kiliç, Alexa R. Karp, Mohammed Imthiyas Rahmah, Noor F. Riaz, Nikhila Mandava, Aleece Siner, Andrey Grigoriev

“…Research on these molecules has been expanding rapidly, revealing their diverse roles in cellular processes, both in normal physiology and in disease states, often via post-transcriptional regulation of target genes. …”
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Transitional adakite-like to calc-alkaline magmas in a continental extensional setting at La Paz Au-Cu skarn deposits, Mesa Central, Mexico: metallogenic implications by Porfirio J. Pinto-Linares, Gilles Levresse, Jordi Tritlla, Víctor A. Valencia, José M. Torres-Aguilera, Manuel González, David Estrada

“…This age probably represents the last post-Laramide orogenic mineralizing event known to occur in the Sierra de Catorce district. …”
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Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention by Lin Tang, Shao‐Cong Peng, Xiao‐Wan Zhuang, Yan He, Yu‐Xiang Song, Hao Nie, Can‐Can Zheng, Zhen‐Yu Pan, Alfred King‐Yin Lam, Ming‐Liang He, Xing‐Yuan Shi, Bin Li, Wen Wen Xu

“…ABSTRACT Metastasis remains a leading cause of cancer‐related deaths, defined by a complex, multi‐step process in which tumor cells spread and form secondary growths in distant tissues. …”
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Evaluating a brief imagery-based intervention for adolescent depression: study protocol for a Phase IIB randomised control trial (INDIGO) in secondary schools by Victoria Pile, Rose Tinch-Taylor, Ben Carter, Jessica Richardson, Lisa De Rijk, Mary Leamy, Simon E. Blackwell, Richard Meiser-Stedman, Barnaby D. Dunn, Sarah Byford, Emily A. Holmes, Cathy Creswell, Patrick Smith

“…Here, we combine techniques targeting these cognitive processes into a novel, brief psychological intervention for adolescent depression. …”
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Recovery of Perennial Plant Communities in Disturbed Hyper-Arid Environments (Sharaan Nature Reserve, Saudi Arabia) by Sami Youssef, Mohamed Djamel Miara, Stéphane Boivin, Robin Sallio, Jérôme Nespoulous, Hassan Boukcim, Sami D. Almalki, Shauna K. Rees, Benjamin P. Y.-H. Lee, Ahmed H. Mohamed

“…This study aimed to assess the diversity and recovery of post-agriculture plant communities in the Sharaan Nature Reserve (SNR), located in northern Saudi Arabia. …”
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Proactive dynamic flooding regulations for river basins in China’s arid and semi-arid region of Xinjiang by Xintong Gong, Qiang Zhang, Senlin Tang, Yungang Bai, Vijay P. Singh, Zhenlin Lu

“…Seasonal flash floods due to heavy rainfall and snowmelt processes necessitate reservoir regulations in arid regions, whereas previous studies have focused mainly on humid regions. …”
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Cytotoxic Potencies of Zinc Oxide Nanoforms in A549 and J774 Cells by Nazila Nazemof, Dalibor Breznan, Yasmine Dirieh, Erica Blais, Linda J. Johnston, Azam F. Tayabali, James Gomes, Premkumari Kumarathasan

“…Cytotoxicity was examined 24 h post-exposure by measuring CTB (viability), ATP (energy metabolism), and %LDH released (membrane integrity). …”
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Hydrological and ecological effects of floating photovoltaic systems: a model comparison considering mussel, periphyton, and macrophyte growth by Ilgen Konstantin, Goulart Camila Bergmann, Hilgert Stephan, Schindler Dirk, van de Weyer Klaus, de Carvalho Bueno Rafael, Bleninger Tobias, Lastrico Raffaello, Gfüllner Leonhard, Graef Alexander, Fuchs Stephan, Lange Jens

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Protocol for the implementation evaluation of an integrated paediatric and primary care model: Strengthening Care for Children (SC4C) by Yvonne Zurynski, Susan Woolfenden, Peter D Hibbert, Harriet Hiscock, Raghu Lingam, Karen Wheeler, Michael Hodgins, Jade Burley, Rachel Pelly, Jane Le, Sonia Khano, Tammy Meyers Morris, Stephanie Germano

“…Importantly, we have embedded data collection post intervention to enable assessment of the sustainable adoption of the intervention. …”
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Securing a just and healthy future for all: Bringing a planetary health lens to the Earth System Governance research framework by Annabelle Workman, Giorgia Dalla Libera Marchiori, Godfred Boateng, Scott Carlin, Sharon Friel, Elise Moo, Rebecca Patrick, Alexandre San Martim Portes, Rosalind Warner, Kathryn Bowen

“…Common topics included food systems and land use change, climate change, post-pandemic opportunities, as well as curriculum and research activities relating to planetary health. …”
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Exploring Photoreceptor Gene Expression and Seasonal Physiology in Mediterranean Swordfish (<i>Xiphias gladius</i>) by Giorgia Gioacchini, Sara Filippi, Chiara Cardillo, Kevin De Simone, Matteo Zarantoniello, Alessia Mascoli, Oliana Carnevali, Sabrina Colella, Giulia Chemello

“…The high energy demands of reproduction may cause mature female swordfish to become more susceptible to environmental stressors/changes, potentially affecting their health post-reproduction. The modulation of melatonin and opsin expression may also influence swordfish biology, impacting basal metabolism and stress responses. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…Succinylation represents an emerging class of post-translational modifications (PTMs), characterized by the enzymatic or non-enzymatic transfer of a negatively charged four-carbon succinyl group to the ϵ-amino group of lysine residues, mediated by succinyl-coenzyme A. …”
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Geochemical characteristics of the Shuanghu crystalline graphite deposit in East China: implications for original rocks, sedimentary environments and carbon sources by Feng Liu, Feng Liu, Wenbo Rao, Yangyang Zhang, Yangyang Zhang, Weijun Yao, Weijun Yao, Lin Shi, Lin Shi, Mingzuan Xu, Mingzuan Xu, Sipu Ren, Xiaohui Li, Ziyi Li

“…A three-stage metallogenic model for the Shuanghu crystalline graphite deposit was proposed: (1) late Proterozoic organic deposition, (2) Triassic metamorphic mineralization, (3) post-200 Ma tectonic activation. These findings enhance understanding of graphite genesis in the Sulu orogen and provides guidance for regional exploration strategies.…”
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Digitising the on-call medical team's patient list system: a QIP by Fahad-Bin Zahid

“…Feedback was collected after each cycle to address challenges and refine functionality, including: • Removal of unnecessary columns • Removal of the ‘low-priority’ category (eg, falls, social issues), because such patients were delayed for extended periods, raising clinical safety concerns; • Improved navigation by fixing headers and introducing alternate row colouring to support dyslexic users1–3; • Enhanced visibility for same-day emergency care department (SDEC) and patients who were post-take; • Created a video guide for staff and clarified the log-in process; • Created a secure folder for archived spreadsheets to improve data storage; • Developed an automatic timestamp for when details were entered.Efficiency gains: • Reduced handover times by 13.5 min (on average) per handover; • 73% of registrars reported improved workflow efficiency; • Features, such as live updates and centralised tracking, minimised information loss and streamlined referral management.Environmental impact: • Eliminated 100% of official paper-based referral list, aligning with NHS sustainability goalsUser satisfaction: • 91% of registrars preferred the electronic system. • 73% rated the system 8–10 for usabilityEquality impact: • The project had no adverse effects on any protected characteristic groups. …”
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Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants by D S Abdullah Al Maruf, Jiongyu Ren, Kai Cheng, Hai Xin, Will Lewin, Edmund Pickering, Hedi Verena Kruse, David Leinkram, Krishnan Parthasarathi, Innes Wise, Benjamin Filippi, Stephen Beirne, Cate Froggatt, James Wykes, Dale Howes, Natalka Suchowerska, Maria A. Woodruff, Jeremy M. Crook, David R. McKenzie, Jonathan R. Clark

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Informative Value of Combination of Molecular Genetic and Cytogenetic Diagnostic Methods in Myelofibrosis by Lozynskyy R., Voronyak M., Poluben L., Dmytrenko I., Lozynska M., Vygovska Ya., Maslyak Z.

“…Materials and research methods. 37 patients were recruited in the study (33 with primary myelofibrosis and 4 with secondary post-polycythemia vera myelofibrosis). Cytogenetic studies were performed for 34 patients. …”
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