Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation by Xinrui Zhang, Qian Cui, Li Yin, Jin Zhu, Yinghua Mao, Rong Yin, Hao Shao, Wenjing Wang, Xuewei Sun, Zhuohan Zhang, Chunyan Gu, Mingyan Zhang, Ruonan Zhang, Han Lu, Zhipeng Cai, Hong Li, Zhan Yang

“…Furthermore, elevated abundances of Akkermansia muciniphila (A. muciniphila), a bacterial strain of Akkermansia taxa responsive to GDN-Cur, especially their supernatants, were associated with post-radiation protection of intestinal function. …”
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The moderating and mediating role of resilience in the relationship between adverse childhood experiences and depression, PTSD, and suicidality in Kenyan youth by Victoria Mutiso, David Ndetei, Eric Jeremiah, Pascalyne Nyamai, Samuel Walusaka, Veronica Onyango, Christine Musyimi, Kamaldeep Bhui, Daniel Mamah

“…Adverse childhood experiences (ACEs) are widely associated with mental health disorders, such as depression, post-traumatic stress disorder (PTSD), and suicidality. …”
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Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome by Suzanne S. M. Miedema, Ana Rajicic, Merel O. Mol, Iryna Paliukhovich, Remco V. Klaassen, Renee van Buuren, Ka Wan Li, Frank T. W. Koopmans, Harro Seelaar, Jeroen G. J. van Rooij, August B. Smit, John C. van Swieten

“…In addition, we compared our dataset with other frontotemporal lobar degeneration subtypes and Alzheimer’s disease to separate SD disease-specific changes from common neurodegenerative processes. In the temporal cortex, involvement of the ribonucleoprotein complex and presynaptic regulation of cytosolic calcium levels by voltage-gated calcium channels appear unique facets of the SD disease process. …”
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Reduction in Acute Bee Paralysis Virus Infection and Mortality in Honey Bees (<i>Apis mellifera</i>) by RNA Interference Technology by Cecilia Ferrufino, Alejandra Scannapieco, Romina María Russo, Fernanda Noemí Gonzalez, Ricardo Salvador, María José Dus Santos

“…This is the first report demonstrating the reduction in ABPV infection in adult honey bees through post-transcriptional gene silencing achieved via oral administration of dsRNA.…”
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Transforming Hospital Housekeeping: The Kayakalp Journey by Jawahar S.K. Pillai, Biswajeevan Sahoo, Mukunda Chandra Sahoo, Bijayini Behera, Renju Sussan Baby, Mariamma V. George, Jyotirmayee Rath, Chandramani Sahoo, Ashoka Mohapatra, Gaurav Chhabra, Binod Kumar Behera, Arvind Kumar Singh, Binod Kumar Patro, Ashok Kumar Jena

“…The research objective was to study the implementation of the Kayakalp guidelines for quality improvement in housekeeping services at the institution. Methods A pre- and post-interventional study was conducted using the Plan-Do-Check-Act (PDCA) quality tool. …”
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PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance by Anoop S. Chauhan, Matthew J. W. Mackintosh, Joseph Cassar, Alexander J. Lanz, Mohammed Jamshad, Hannah L. Mackay, Alexander J. Garvin, Alexandra K. Walker, Satpal S. Jhujh, Teresa Carlomagno, Aneika C. Leney, Grant S. Stewart, Joanna R. Morris

“…Here, we reveal a cascade of post-translational modifications which act at three adjacent amino acids, threonine-208, proline-209 and lysine-210, to process RNF168 actively. …”
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The effect of heat-sensitive moxibustion in the elderly with nocturia: protocol for a randomized controlled trial by Jinhua Geng, Jinhua Geng, Xintong Ma, Yihui Lin, Qiaoli Lin, Qiaoli Lin, Kaitian Wen, Kaitian Wen, Chunyan Ruan, Chunyan Ruan, Zunjiang Li, Zunjiang Li, Zhaofan Mo, Shuang Li, Banghan Ding, Banghan Ding, Na Liu, Na Liu

“…To ensure objectivity, assessors and investigators will remain blinded to the randomization process. The primary outcome of this study is the reduction in the frequency of nocturia. …”
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Transcriptomic analysis reveals long non-coding RNA involved in the key metabolic pathway in response to Botrytis cinerea in kiwifruit by Yijia Ma, Tianjing Zeng, Zhexin Li, Dengwei Jue, Yuan Sui, Xu Wang, Hongpan Zhong, Jiaqi Yang

“…Results Our study aimed to identify lncRNAs induced by B. cinerea infection in ‘Hongyang’ kiwifruit at 0 to 3 days post-inoculation (dpi) through high-throughput sequencing. …”
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Hemolysis following Intravenous Immunoglobulin Therapy - Adverse effect to remember about by Sebastian Iwaniuk, Ignacy Maciejewski, Kinga Kowalik, Szymon Szypulski, Aleksandra Zielińska, Maria Michalska, Natalia Tylczyńska, Kinga Tylczyńska, Zuzanna Skiba, Jakub Skiba

“…Its pathophysiology involves both intravascular and extravascular mechanisms, influenced by factors such as blood group, IVIG dosage, and manufacturing processes.[11] While severe hemolysis is rare, mild cases are more common and may prolong hospitalizations.[12] Raising awareness of IVIG-related hemolysis can improve patient management and therapeutic decision-making, ultimately optimizing clinical outcomes. …”
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Analysis of the effectiveness and efficiency of the    Indonesian metastatic bone disease of unknown origin algorithm (INA-MBD): time to diagnosis and cost to diagnosis : Quasi-exp... by Moh Asri Abidin, Muhammad Phetrus Johan, Dibyo Pramono, Irianiwati Widodo, Teguh Aryandono, Yuni Artha Prabowo Putro, Rahadyan Magetsari, Paramita Ayu Saraswati, A Faiz Huwaidi, Ardanariswara Wikantyasa

“…Research method A quasi-experimental study with a pretest and post-test design was conducted with a total of 128 patients who met the inclusion and exclusion criteria. …”
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Clinical and Histopathological Determinants for Kidney Allograft Survival in the Eurotransplant Senior Program (ESP) at the Time of Allocation by Tom N. Langer, Tom N. Langer, Thorsten Wiech, Thorsten Wiech, Mercedes Noriega, Sergey Biniaminov, Tobias B. Huber, Tobias B. Huber, Lutz Fischer, Lutz Fischer, Florian Grahammer, Florian Grahammer, Florian Grahammer, Malte A. Kluger, Malte A. Kluger

“…This study aimed to evaluate post-transplant outcomes of deceased donor grafts and identify prognostic factors within the ESP population. …”
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Transcriptome Analysis of Pepper Leaves in Response to Tomato Brown Rugose Fruit Virus Infection by Boshen Zhang, Donghai Wang, Mangle Chen, Jiali Yang, Junmin Li, Jianping Chen, Fei Yan, Shaofei Rao

“…This research utilized RNA-Seq technology to analyze the transcriptional profiles of chili pepper leaves (‘Haonong 11’) 13 days post-infection with ToBRFV or mock treatment, identifying a total of 1468 differentially expressed genes (DEGs), of which 1366 were upregulated and 102 were downregulated. …”
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Characterization of Aspergillus oryzae mutant and its application in heterologous lipase expression by Qinghua Li, Chen Zhang, Jianghua Li, Guocheng Du, Zhaofeng Li, Jingwen Zhou, Guoqiang Zhang

“…The Aspergillus oryzae expression system has been developed into a chassis for the production of heterologous lipases, attributed to its strong capabilities in protein production and secretion, robust post-translational modifications, and favourable safety profile. …”
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Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches by Xiaoliang Fu, Azar Sheikholeslami, Ulanbek Zhanbyrbekuly, Faezeh Davoodi Asl, Nadiar M. Mussin, Hoda Fazaeli, Karim Daniyalov, Nader Tanideh, Nader Tanideh, Nader Tanideh, Mahdi Mahdipour, Mahdi Mahdipour, Madina A. Kurmanalina, Amin Tamadon, Amin Tamadon, Amin Tamadon

“…Even though phosphodiesterase type 5 inhibitors (PDEi) and other conventional therapies have demonstrated efficacy, they frequently prove insufficient for patients with underlying medical disorders such as diabetes, Peyronie’s disease, or post-prostatectomy. This review delves into the therapeutic capacity of stem cells for ED, emphasizing the latest clinical and preclinical studies that showcase their efficacy across various models. …”
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High-vacuum laser treatments enhance strength, ductility and fatigue limit of additively manufactured stainless steel by Juan Guillermo Santos Macías, Kewei Chen, Alexandre Tanguy, Nathalie Isac, Maxime Vallet, Louis Cornet, Vincent Michel, Manas Vijay Upadhyay

“…Post-process laser scanning under high vacuum is proposed as a non-isothermal heat treatment to simultaneously refine the intragranular microstructure near the surface and reduce surface roughness, while preventing oxidation, to enhance the mechanical response of an alloy. …”
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ER membrane receptor FgGET2 plays critical roles in hyphal growth, asexual development, stress responses, and pathogenicity of Fusarium graminearum by Caihong Liu, Lu Lei, Jing Zhu, Mi Zhang, Ziyi Zhang, Shijing Peng, Jie Tang, Lirun Chen, Qing Chen, Li Kong, Yunfeng Jiang, Guoyue Chen, Qiantao Jiang, Yazhou Zhang, Qiang Xu, Youliang Zheng, Karl-Heinz Kogel, Yuming Wei, Pengfei Qi

“…GET2 is an endoplasmic reticulum (ER) membrane receptor protein in the guided entry of tail-anchored (TA) proteins (GET) pathway, which is the most widely studied post-translational pathway for targeting and inserting TA proteins into the ER. …”
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State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review by Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, Ilias Dumas, Żanna Fiodorenko-Dumas, Beata Wojtczak, Łukasz Kotyra, Irena Kustrzeba-Wójcicka, Łukasz Lewandowski, Beata Ponikowska, Aleksandra Kuzan, Joanna Kluz, Andrzej Gamian, Katarzyna Madziarska

“…Many factors can initiate the carcinogenesis process of various types of TC, which complicates diagnosis and treatment. …”
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Impact of in-hospital COVID-19 quarantine policy changes on quality of acute stroke care: a single center experience by Minkyung Kim, Keon-Joo Lee, Seong-Eun Kim, Hokyu Kim, Jung Hoon Han, Han Jun Kim, Kyungmi Oh, Sung-Jun Park, Chi Kyung Kim, Young-Duck Cho

“…IntroductionThe COVID-19 pandemic is known to impact in-hospital processes for acute stroke patients, potentially resulting in delays due to quarantine and screening measures. …”
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PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling by Alican Güran, Yanlong Ji, Pan Fang, Kuan-Ting Pan, Henning Urlaub, Metin Avkiran, Christof Lenz, Kate L. Weeks

“…In this study, mice deficient for B56α and wildtype controls received an intraperitoneal injection of isoproterenol (0.1 mg/kg) to activate β-AR signalling in vivo, and their hearts examined two minutes post-injection by quantitative phosphoproteomics to identify mechanisms of acute β-adrenergic signalling. …”
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Genetics of catatonia: a systematic review of case reports and a gene pathway analysis by Mylene Moyal, Anton Iftimovici, Wafa Ghoul, Marion Plaze, Boris Chaumette

“…Regarding the pathophysiology of catatonia, the gene ontology of biological processes reveals significant enrichment of variants in synaptic and post-synaptic regulatory genes, particularly within GABAergic neurons, reinforcing the implication of the excitatory/inhibitory imbalance. …”
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