LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria by A. Benitez-Amaro, E. Garcia, M.T. LaChica Lhoëst, A. Polishchuk, I. Zegri-Reiriz, D. Vilades, J.M. Guerra, L. Fernández-del-Rio, S. Mirabet, V. Samouillan, O. Shirihai, M. Liesa, C. Enrich, V. Llorente-Cortés

“…Additionally, anti-P3 Abs promoted more extensive interactions between mitochondria and lipid droplets (LDs), accompanied by an increase in LD diameter and electrodensity in cardiomyocytes. …”
Get full text

Study on the Movement Characteristics of Sediment Body in Mountain Rivers under Excessive Sediment Supply Conditions by ZHOU Qihang, ZHOU Yinjun, JIN Zhongwu, LI Zhijing, NIE Ruihua, LIU Xingnian

“…For the non-uniform sediment supply and bed material, the bed deposition in the upstream was stronger than that in the downstream, and the more the sediment supply, the greater the degree of bed aggradation. (2) For the constant sediment supply regime and stepped variable sediment supply regime, the sediment body presented a wedge shape, the longitudinal profile of sediment body shown a process of increasing and lengthening first, then decreasing and shortening, and finally stabilizing. …”
Get full text

Youth co-production for sustainable engagement and empowerment in health (YiPEE): protocol for a cluster-randomised controlled trial of an intervention for mental health promotion... by Josefien van Olmen, Pilvikki Absetz, Mark Tomlinson, Carina King, Edwin Wouters, Josefien van Olmen, G J Melendez-Torres, Jeroen De Man, Stefan Swartling Peterson, Suresh Kumar, Mariam Claeson, Monika Martens, Frances Mathews, Christina A Laurenzi, Yoona Kim, Yeukai Chideya, Maria Niemi, Vijaya Raghavan, Jill Åhs, Anu Linnansaari, Fredric Azariah, Moitreyee Sinha, Upasana Sharma, Orlaith O’Sullivan, Yoo Na Kim, Akshaya Rajesh, Samyukta Saravanan, Nivetha Vasanthan, N P Haritha, Lander Willem, Jeroen de Man, Christina Laurenzi, GJ Melendez Torres, Matt Hughsam, Maureen Gikonyo, Joyce Arita

“…Mental health is a complex phenomenon and may be best supported through multicomponent interventions that more holistically consider inner, social and environmental levels. …”
Get full text

Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. More effective therapeutic strategies are needed not only to improve the survival of cancer patients but also to relieve cancer-related pain. …”
Get full text

Deep learning-based multi-omics model to predict nasopharyngeal necrosis of re-irradiation for recurrent nasopharyngeal carcinoma by Xingwang Gao, Xingwang Gao, Xingwang Gao, Yinglin Peng, Shanfu Lu, Yuhan An, Meining Chen, Jun Zhang, Runda Huang, Yiran Wang, Zhenyu Qi, Yao Lu, Chong Zhao, Xiaowu Deng, Jingjing Miao, Yimei Liu

“…The models combining radiomics and dosiomics features were more accurate for the prediction of NN, especially the model of multi-sequence MRI radiomics plus dosiomics, which showed the best performance in the test set, with an AUC, ACC, and F1-Score of 0.81, 0.75, and 0.74, respectively.ConclusionThe deep learning model leveraging pre-treatment multi-sequence MRI radiomics and dosiomics of re-irradiation therapy can serve as a potential predictor of NN in patients with recurrent nasopharyngeal carcinoma, thereby improving clinical decision-making processes.…”
Get full text

Research on soil bacterial community assembly and function under different straw returning practices in arid and semi-arid agricultural ecosystems over multiple years by Rui-Zhi Liu, Rui-Zhi Liu, Rui-Zhi Liu, Xiao-Ya Zhao, Xiao-Ya Zhao, Xiao-Ya Zhao, Biao Feng, Biao Feng, Biao Feng, Wen-Shan Zhao, Wen-Shan Zhao, Wen-Shan Zhao, Ming-Yu Li, Ming-Yu Li, Ming-Yu Li, Xiao-Fang Yu, Xiao-Fang Yu, Xiao-Fang Yu, Shu-Ping Hu, Shu-Ping Hu, Shu-Ping Hu, Rui-Ping Li, Rui-Ping Li, Rui-Ping Li, Ju-Lin Gao, Ju-Lin Gao, Ju-Lin Gao, Qinggeer Borjigin, Qinggeer Borjigin, Qinggeer Borjigin

“…Predictions showed that DPR and NTR enhanced carbohydrate and amino acid metabolism and promoted more stable bacterial networks, with homogenous selection and drift effects. …”
Get full text

Mechanism-based modular psychotherapy versus cognitive behavioural therapy for adolescents and young adults with childhood trauma experiences: study protocol for a feasibility tria... by Till Bärnighausen, Hanna Zimmermann, Christian Schmahl, Stephanie Bauer, Beate Ditzen, Hans-Christoph Friederich, Markus W Haun, Astrid Berner-Rodoreda, Elisabeth Schramm, Svenja Taubner, Corina Aguilar-Raab, Sabine C Herpertz, Manuel Feisst, Frank Enning, Katja I Seitz, Niklas Schouler, Jan Hundertmark, Maximilian Wilhelm, Svea Franz, Christoph W Korn, Ruben Vonderlin, Eva Vonderlin, Josef Bailer, Elias Bopp, Sophia von Stockert, Laura Tabea Kristalis, Claudia Calvano

“…They represent a patient group which requires more personalised interventions targeting the transdiagnostic mechanisms related to early trauma and its functional consequences. …”
Get full text

Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study by Karen J. Bosma, Claudio M. Martin, Karen E. A. Burns, Jordi Mancebo Cortes, Juan Carlos Suárez Montero, Yoanna Skrobik, Kevin E. Thorpe, Andre Carlos Kajdacsy-Balla Amaral, Yaseen Arabi, John Basmaji, Gaëtan Beduneau, Francois Beloncle, Guillaume Carteaux, Emmanuel Charbonney, Alexandre Demoule, Martin Dres, Vito Fanelli, Anna Geagea, Ewan Goligher, François Lellouche, Tommaso Maraffi, Alain Mercat, Pablo O. Rodriguez, Jason Shahin, Stephanie Sibley, Savino Spadaro, Katerina Vaporidi, M. Elizabeth Wilcox, Laurent Brochard, On behalf of the Canadian Critical Care Trials Group and, the REVA Network

“…Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better patient-ventilator synchrony and a more physiological response to changes in ventilatory demand. …”
Get full text

Barium Abundances of Common Stars in the Gaia-ESO Survey and the LAMOST Medium-resolution Survey by Tian-Yi Chen, Jian-Rong Shi, Hong-Liang Yan, Shuai Liu, Chun-Qian Li, Xiao-Jin Xie, Ze-Ming Zhou, Yao-Jia Tang, Ming-Yi Ding

“…Barium (Ba) abundance has been used as a crucial tracer of both slow and rapid neutron-capture processes to constrain the evolutionary models of the Galaxy. …”
Get full text

Metal-strong Inflows at the Outer-galactic-scale of a Quasar by Qiguo Tian, Lei Hao, Yipeng Zhou, Xiheng Shi, Tuo Ji, Peng Jiang, Lin Lin, Zhenya Zheng, Hongyan Zhou

“…Such a relatively rare system may hold important clues to understanding the baryonic cycling of galaxies, and more cases could be picked out using relatively strong Si iv and weak Lyman absorption lines.…”
Get full text

Genome-Wide Identification and Evolutionary Analysis of m6A-Related Gene Family in Poplar Nanlin895 by Zeyu Li, Rongxia Liu, Mingqiang Zhu, Jinye Zhang, Zhoujin Li, Kaixin Huang, Zehua Ren, Yan Zhao, Keming Luo, Qin Song

“…Phylogenetic analysis revealed that writers, erasers, and readers are categorized into six, four, and two groups, respectively, with these genes being more conserved among dicotyledonous plants. Gene structure, protein domains, and motifs exhibited greater conservation within the same group. …”
Get full text

Sustaining forest biodiversity: Exploring the effect of long-term natural disturbance dynamics on contemporary lichen communities in primary forest ecosystems by Rhiannon Gloor, Marek Svitok, Martin Mikoláš, Jeňýk Hofmeister, Josef Halda, Pavel Janda, Francesco Maria Sabatini, Lucie Zemanová, Arne Buechling, Daniel Kozák, Matej Ferenčík, Michal Frankovič, Martin Dušátko, Miroslav Svoboda

“…Therefore, while disturbance-mediated forest structures can promote overall richness, threatened species appear vulnerable to more severe disturbance events – a concern, as disturbances are predicted to intensify with climate change. …”
Get full text

Impact of seasonal changes on root-associated microbial communities among phreatophytes of three basins in desert ecosystem by Yulin Zhang, Yulin Zhang, Yulin Zhang, Yulin Zhang, Yi Du, Yi Du, Yi Du, Yi Du, Zhaobin Mu, Zhaobin Mu, Zhaobin Mu, Zhaobin Mu, Waqar Islam, Waqar Islam, Waqar Islam, Fanjiang Zeng, Fanjiang Zeng, Fanjiang Zeng, Fanjiang Zeng, Fanjiang Zeng, Norela C. T. Gonzalez, Zhihao Zhang, Zhihao Zhang, Zhihao Zhang

“…Environmental factors affect the BS bacterial community more than the fungal community across different seasons. …”
Get full text

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections by Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen

“…And in vivo, the antiviral innate response is more dramatically enhanced in Nsun2+/− mice than in Nsun2+/+ mice. …”
Get full text

Local Outlier Detection Method Based on Improved K-means by Yu ZHOU, Hao XIA, Xuezhen YUE, Peichong WANG

“…This method highlights the degree of outlierness of outliers, incorporating more outlier information into the final anomaly score.Conclusions Experimental results on artificial and UCI real datasets demonstrated that the KLOD method can detect local outliers with moderate outliers. …”
Get full text

Study on Suture Tensile Properties of Polyimide Composites for Flexible Solar Wings by JIAO Yunlei, GUO Chenliang, FENG Shixu, WU Yuemin, ZUO Yangjie

“…In the tensile failure process, the failure modes of the specimens under different parameters were similar. …”
Get full text

Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation by Ilaria Gisone, Monica Boffito, Elisa Persiani, Roberta Pappalardo, Elisa Ceccherini, Andrea Alliaud, Manuela Cabiati, Rossella Laurano, Letizia Guiducci, Chiara Caselli, Rosetta Ragusa, Claudio Cassino, Chiara Ippolito, Silvia Del Ry, Susanna Sartori, Antonella Cecchettini, Antonella Cecchettini, Salvador Fernández-Arroyo, Gianluca Ciardelli, Federico Vozzi

“…A direct comparison with the classical 2D monoculture of hiPSC-CMs highlighted the improved maturation profile achieved by hiPSC-CMs in the 3D GelMA system, as demonstrated by the higher expression of cardiac maturation markers (TNNT2, ACTN2, Myl2, MYH 7, CX43 and PPAR-α), in association with proteomics and transcriptomics data, that showed the modulation of specific biological pathways related to cardiac differentiation and contraction processes in the 3D system. A more in-depth investigation of cell health and function also suggested a higher viability and less suffering condition for cells co-cultured in the 3D hydrogel.ConclusionOur results demonstrated that the 3D bioengineered model proposed here represents a good replica of the native cardiac tissue environment, improving the hiPSC-CMs maturation profile, thus opening the opportunity for its application in disease modeling and toxicological screening studies.…”
Get full text

Correction of TRMM 3B43 Monthly Precipitation Data Using Quantile Regression Model in the Urmia Lake Basin by Sima Kazempour Choursi, Mahdi Erfanian, Hirad Abghari, Mirhassan Miryaghoobzadeh, khadijeh Javan

“…Remote sensing, such as the TRMM 3B43, can provide a more accurate spatial distribution of rainfall, particularly in regions that lack rain gauge stations. …”
Get full text

Adolescents’ Digital activity and its Correlation with Cognitive-Emotional Features, School Performance, and Social and Age Factors: Cross-Sectional Study by George A. Karkashadze, Natalia E. Sergeeva, Leyla S. Namazova-Baranova, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva, Tinatin Yu. Gogberashvili, Dmitriy S. Kratko, Safarbegim Kh. Sadilloeva, Marina A. Kurakina, Anastasiya I. Rykunova, Tatiana A. Konstantinidi, Nadezhda A. Ulkina, Daria A. Bushueva, Inessa A. Povalyeva, Leonid M. Yatsyk, Tatiana A. Salimgareeva, Yuliya V. Nesterova, Pavel A. Prudnikov, Natalia S. Sergienko, Margarita A. Soloshenko, Nikita S. Shilko, Yuliya E. Kazantzeva

“…We have examined 438 teenagers. 53 (12%) respondents spend more than 5 hours a day with digital devices on weekdays, 133 (30%) — on weekends, 147 (34%) — during the holidays. …”
Get full text

Source apportionment of PM10 based on offline chemical speciation data at 24 European sites by Xiansheng Liu, Xun Zhang, Bowen Jin, Tao Wang, Siyuan Qian, Jin Zou, Vy Ngoc Thuy Dinh, Jean-Luc Jaffrezo, Gaëlle Uzu, Pamela Dominutti, Sophie Darfeuil, Olivier Favez, Sébastien Conil, Nicolas Marchand, Sonia Castillo, Jesús D. de la Rosa, Stuart Grange, Christoph Hueglin, Konstantinos Eleftheriadis, Evangelia Diapouli, Manousos-Ioannis Manousakas, Maria Gini, Silvia Nava, Giulia Calzolai, Célia Alves, Marta Monge, Cristina Reche, Roy M. Harrison, Philip K. Hopke, Andrés Alastuey, Xavier Querol

“…These secondary factors are primarily influenced by anthropogenic emissions, including the various combustion processes. Sea salt, predominantly found in coastal areas, contributed between 4% and 21%, reflecting the impact of the marine environments on air quality. …”
Get full text