GRADE guidance 40: The GRADE evidence-to-decision framework for environmental and occupational health by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…Results: Consistent with existing GRADE EtD frameworks, the EtD framework for EOH includes a scoping and contextualization process and twelve assessment criteria. Modifications to the existing EtD frameworks include: consideration of the socio-political context when making judgments about the priority of the problem and feasibility of different alternatives; the addition of timing when making judgments about benefits and harms, the balance of effects, and feasibility; broadening of the equity criterion to include considerations beyond health equity; and more explicit accommodation of variable or conflicting stakeholder views when considering values and acceptability. …”
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A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children by Chengliang Zhong, Qingyuan Liu, Shengxuan Guo, Deyang Sun, Boyang Wang, Siyuan Hu, Xinmin Li, Weibo Zhao, Ying Ding, Bin Yuan, Jing Liu, Long Xiang, Nan Li, Zheng Xue, Yan Li, Yiqun Teng, Rongsong Yi, Shao Li, Rong Ma

“…The research program composed of computational prediction and clinical trials can significantly accelerate the research and development process and identify more effective treatment with good safety, which is worthy of clinical promotion. …”
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Performance assessment of a modified air-gap and water-gap membrane distillation systems by Dahiru U. Lawal, Suhaib Alawad, Jamilu Usman, Sani.I. Abba, S. Sekar, Ibrahim B. Mansir, Turki Baroud, Qusay F. Alsalhy, Mohamed A. Yassin, Syed Muzzamil Hussain Shah, Ahmad Hussaini Jagaba

“…Furthermore, modified MD systems recorded superior performance compared to conventional MD systems and the blade angle effect is more influential than the blade material. At 80 °C feed temperature and 3200 mg/L feed salinity, the M-WGMD reaches a maximum flux of 128.39 kg/m2h and a GOR of 0.7702. …”
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Clinical research report on Chinese patent medicines and classic traditional Chinese medicine prescriptions (2023) by Xiaolei Wu, Haiyin Hu, Yuetong Wang, Alice Josephine Fauci, Yazi Zhang, Wenting Song, Fengwen Yang, Boli Zhang, Junhua Zhang, Zhaochen Ji

“…However, quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.…”
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Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats by Danijel Matek, Irena Matek, Eva Staresinic, Mladen Japjec, Ivan Bojanic, Alenka Boban Blagaic, Lidija Beketic Oreskovic, Ivana Oreskovic, Tihomil Ziger, Tomislav Novinscak, Ivan Krezic, Sanja Strbe, Martin Drinkovic, Filip Brkic, Jelena Popic, Anita Skrtic, Sven Seiwerth, Mario Staresinic, Predrag Sikiric, Ivica Brizic

“…Consequently, at 3 months, the form was stable, and the balance between the muscle and bone was the following: well-organized bone, newly formed as more cortical bone providing a narrower bone marrow space, and the muscle and mature fibers were oriented parallel to the bone axis and were in close contact with bone. …”
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Controlling factors and exploration potential of shale gas enrichment and high yield in Permian Dalong Formation, northern Sichuan Basin, SW China by Rui YONG, Hongzhi YANG, Wei WU, Xue YANG, Yuran YANG, Haoyong HUANG

“…In addition to organic pores, a large number of inorganic pores are developed even in ultra-deep (deeper than 4 500 m) layers, contributing a total porosity of more than 5%, which significantly expands the storage space for shale gas. …”
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For health or for profit? Understanding how private financing and for-profit delivery operate within Canadian healthcare (4H|4P): protocol for a multimethod knowledge mobilisation... by Damien Contandriopoulos, Marie-Ève Poitras, Agnes Grudniewicz, Kimberlyn McGrail, Joel Lexchin, M Ruth Lavergne, David Rudoler, Lindsay Hedden, Maria Mathews, Madeleine McKay, Sheryl Spithoff, Meredith Vanstone, Sarah Spencer, Sara Allin, Frank Gavin, Rita K McCracken, Chad Leaver, Karen S Palmer

“…Some cases of privatisation are widely recognised, while others are evolving and more hidden, and their extent differs across provinces and territories likely due in part to variability in policies governing private payment (out-of-pocket payments and private insurance) and delivery.Methods and analysis This pan-Canadian knowledge mobilisation project will collect, classify, analyse and interpret data about investor-owned privatisation of healthcare financing and delivery systems in Canada. …”
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Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial by Ambrose H Wong, James D Dziura, Mark Sevilla, Yue Hu, Megan Evans, Bidisha Nath, Rebekah Heckmann, Riddhi Desai, Anusha Kumar, Isaac V Faustino, Anthony J Pavlo, Joan M Cook, Kendra Davis-Plourde, Richard Youins, Kimberly Guy, Pastor Evelyn Smith, Pastor Dana Smith, Karen Kangas, Lou Hart, Seth Powsner, Chyrell Bellamy

“…Patients describe the restraint process as coercive and dehumanising. The use of peer support workers, who are individuals with lived experience of mental illness and behavioural conditions, has shown positive patient outcomes when assisting individuals experiencing behavioural crises. …”
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Community engagement for birth preparedness and complication readiness in the Community Level Interventions for Pre-eclampsia (CLIP) Trial in India: a mixed-method evaluation by Marianne Vidler, Peter von Dadelszen, Mai-Lei Woo Kinshella, Jeffrey N Bone, Shivaprasad S Goudar, Richard Derman, Umesh Charantimath, Avinash Kavi, Umesh Y Ramadurg, Geetanjali M Katageri, Chandrashekhar C Karadiguddi, Narayan V Honnungar, Shashidhar G Bannale, Geetanjali I Mungarwadi, Laura Magee, Ashalata Mallapur, Mrutyunjaya Bellad, The CLIP India Working Group

“…Objective To describe the process of community engagement (CE) in northern Karnataka, India and its impact on pre-eclampsia knowledge, birth preparedness and complication readiness, pregnancy-related care seeking and maternal morbidity.Design This study was a secondary analysis of a cluster randomised trial of Community Level Interventions for Pre-eclampsia (CLIP). …”
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Research priorities for children’s cancer: a James Lind Alliance Priority Setting Partnership in the UK by Nigel J Hall, David Weller, Bob Phillips, Faith Gibson, Susie Aldiss, Rachel Dommett, Jessica Elizabeth Morgan, Alex Brownsdon, Helen Morris, Julia Chisholm, Sonia Malik, Jonathan Gower, Andy Stewart, Dan Saunders, Ashley Ball-Gamble, Helen Hartley, Rachel Hollis, Scott Crowther, Jenni Hatton, Louise Henry, Loveday Langton, Kirsty Maddock, Keeley McEvoy, Simon Parke, Sue Picton, Rosa Reed-Berendt, Wendy Tarplee-Morris, Amy Walsh, Anna Watkins

“…The top priority was ‘can we find effective and kinder (less burdensome, more tolerable, with fewer short and long-term effects) treatments for children with cancer, including relapsed cancer?’…”
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CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis by Chunyu Hua, Guohui Zhang, Wendan Yu, Jie Zhou, Liyuan Ru, Guoqing Xue, Lina Zheng, Meiyi Wang, Yiwei Wang, Dianlin Yu, Qijing Wang, Jiaxin Liu, Ruonan Wang, Wuguo Deng, Ranran Tang, Wei Guo

“…Mechanistically, CROT is overactivated within peroxisomes in chemo-resistant NSCLC cells and drives chemoresistance relying on its involvement in lipid metabolism and oxidative stress processes. By mediating the production of Hydrogen Peroxide (H2O2) and reactive oxygen species (ROS), CROT stabilizes eryth-like-2 associated factor 2 (Nrf2) via preventing its ubiquitination and degradation, leading to more nuclear translocation of Nrf2, thereby inhibiting chemotherapy stress-induced ferroptosis. …”
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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

“…ResultsIntriguingly, RPE cells carrying high genetic risk proved more vulnerable to oxidative insult when exposed to HQ, as demonstrated by increased cytotoxicity and caspase activation, compared to the low-risk RPE cells. …”
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Specific features of current intraperitoneal therapy in patients with ovarian cancer by A. G. Kedrova, S. A. Levakov, S. E. Krasil’nikov, T. A. Maksimenko, V. I. Voznesenskiy, A. V. Gerasimov, D. A. Astakhov, V. V. Kosyy, O. E. Nechaeva

“…The obtained data were processed using standard statistical programs.Results. 55 of the 76 patients could complete more than 4 IP therapy cycles. …”
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Effects of different vegetation litter cover on hydrodynamic characteristics of soil runoff-sediment yield in Taiyi Mountain area of northern China by Yuan He, Zihao Fan, Wei Zhao, Zhihao Tian, Dingmeng Hu, Zixu Zhang, Yucun Lu, Peng Gao

“…The current research demonstrates that the characteristics of soil erosion and sediment yield under vegetation litter cover can be more accurately described by the stream power among the hydrodynamic parameters.…”
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Effect of remimazolam besylate versus midazolam on time to extubation in critically ill, mechanically ventilated patients: a randomized controlled trial by Renhuai Liu, Binxiao Su, Guifen Gan, Guangming Wang, Chengli Wang, Ning Xu, Guangcai Feng, Hao Guo, Qingxia Yuan, Aiguang Li, Wenping Zheng, Jiang Li, Yu Chen, Xijing Zhang

“…BackgroundPrevious studies have indicated that the administration of short-acting sedatives prior to weaning from mechanical ventilation is linked to a more rapid recovery and extubation process, in addition to lowering intensive care unit (ICU) treatment expenses. …”
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A novel therapeutic approach to hemangiomas: Combining photothermal therapy and ferroptosis in a microneedle delivery system by Yiming Geng, Cancan Meng, Hanzhi Zhang, Chuan Ma, Xiao Fu, Haiwei Wu

“…This approach can also become a more effective and safer treatment method for other diseases characterized by abnormal angiogenesis.…”
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A comprehensive integrated disease management program for phenylketonuria (IDMP-PKU) from Türkiye: rationale, design and patient characteristics by Mehmet Cihan Balci, Deniz Kor, Yilmaz Yildiz, Meryem Karaca, Fatma Derya Bulut, Ayca Burcu Kahraman, Alihan Yesil, Ezgi Burgac, Kismet Ciki, Arzu Selamioglu, Burcu Koseci, Asli Durmus, Irem Kaplan, Esra Kara, Halise Neslihan Mungan, Serap Sivri, Gulden Fatma Gokcay, Aysegul Tokatli, Mubeccel Demirkol, Turgay Coskun, Imran Ozalp

“…Homozygous mutations were more common in patients with parental consanguinity (76.8% vs 17.1%; p < 0.001). …”
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Nurturing transformative participation: A participatory realist review of mental health interventions in low resource settings by Rochelle A. Burgess, Hannah Maria Jennings, Kaaren Mathias, Farirai Gumbonzvanda, Nyaradzayi Gumbonzvanda, Garima Gupta, Cheyann Heap, Sumeet Jain, Pashupati Mahat, Rakchhya Maharjan, Sujen Man Maharjan, Pooja Pillai, Martin Webber, Jerome Wright, Bidya Maharjan

“…Long term engagement in a locality means that services are more responsive; 3. A trusting, supportive and collaborative therapeutic relationship is critical when responding to mental health needs; 4. it is important to integrate existing beliefs, metaphors and traditions into understandings about mental health; 5. …”
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Tracing priming effects in palsa peat carbon dynamics using a stable isotope-assisted metabolomics approach by Christian Ayala-Ortiz, Moira Hough, Elizabeth K. Eder, David W. Hoyt, Rosalie K. Chu, Jason Toyoda, Steven J. Blazewicz, Patrick M. Crill, Ruth Varner, Scott R. Saleska, Virginia I. Rich, Virginia I. Rich, Malak M. Tfaily, Malak M. Tfaily

“…Our findings demonstrate how technological advancements in analytical tools can provide a more detailed view of carbon cycling processes in complex soil systems.…”
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Comprehensive analysis of phagocytosis regulatory genes in bladder cancer: implications for prognosis and immunotherapy by Xueming Ma, Xueming Ma, Xueming Ma, Dongnuan Yao, Dongnuan Yao, Dongnuan Yao, Weitao Yu, Weitao Yu, Weitao Yu, Gongping Wu, Gongping Wu, Gongping Wu, Chengwei Fan, Chengwei Fan, Chengwei Fan, Junqiang Tian, Junqiang Tian, Junqiang Tian

“…Finally, the drug sensitivity analysis showed that high-risk patients benefited more from immunotherapy and chemotherapy drugs.ConclusionThis study has greatly deepened the understanding of the potential molecular mechanisms of bladder cancer, provided new insights and valuable potential therapeutic targets for the precision treatment of bladder cancer, and is expected to promote the innovation and optimization of bladder cancer treatment strategies.…”
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