Recombinant SAG2A Protein from <i>Toxoplasma gondii</i> Modulates Immune Profile and Induces Metabolic Changes Associated with Reduced Tachyzoite Infection in Peritoneal Exudate Ce... by Thaíse Anne Rocha dos Santos, Mário Cézar de Oliveira, Edson Mario de Andrade Silva, Uener Ribeiro dos Santos, Monaliza Macêdo Ferreira, Ana Luísa Corrêa Soares, Neide Maria Silva, Tiago Antônio de Oliveira Mendes, Jamilly Azevedo Leal-Sena, Jair Pereira da Cunha-Júnior, Tiago Wilson Patriarca Mineo, José Roberto Mineo, Érica Araújo Mendes, Jane Lima-Santos, Carlos Priminho Pirovani

“…Our results showed that rSAG2A-treated PECs presented a lower parasitism in C57BL/6 mice but not in the PECs from BALB/c mice, and induced a pro-inflammatory cytokine profile in C57BL/6 mice (<i>iNOS</i>, <i>TNF-α</i>, and <i>IL-6</i>). rSAG2A modulated different exclusive proteins in each mouse lineage, with PECs from the C57BL/6 mice being more sensitive to modulation by rSAG2A. Additionally, biological processes crucial to parasite survival and immune response were modulated by rSAG2A in the C57BL/6 PECs, including fatty acid beta-oxidation, reactive oxygen species metabolism, interferon production, and cytokine-mediated signaling pathways. …”
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Bringing a Systems Approach to Living Donor Kidney Transplantation by Anna Horton, Katya Loban, Peter Nugus, Marie-Chantal Fortin, Lakshman Gunaratnam, Greg Knoll, Istvan Mucsi, Prosanto Chaudhury, David Landsberg, Michel R. Pâquet, Marcelo Cantarovich, Shaifali Sandal

“…We aimed to identify and compare health system–level attributes and processes that are facilitators and barriers to LDKT. …”
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Axillary adipose tissue–derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer by Asumi Iesato, Jun Suzuka, Kazutaka Otsuji, Tomo Osako, Nami Yamashita, Yuka Inoue, Tetsuyo Maeda, Natsue Uehiro, Kazuyo Yoshida, Yoko Takahashi, Kohei Kumegawa, Sumito Saeki, Liying Yang, Ai Tsuchiya, Kana Sakiyama, Miwa Tanaka, Takehiko Sakai, Shinji Ohno, Tetsuo Noda, Takayuki Ueno, Reo Maruyama

“…This study emphasizes the importance of using patient-derived cells to accurately assess the tumor microenvironment, potentially leading to more personalized therapeutic approaches.…”
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A Relativistic Jet in the Radio-quiet Active Galactic Nucleus Mrk 110 by Ailing Wang, Tao An, Kenneth I. Kellermann, Hua Feng, Emmanuel K. Bempong-Manful, Roland Timmerman, Shaoguang Guo

“…Mrk 110 serves as a critical “missing link” between radio-loud and radio-quiet AGN, providing insight into jet formation mechanisms, environmental interactions, and physical processes that unify various AGN classifications.…”
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exoALMA. V. Gaseous Emission Surfaces and Temperature Structures by Maria Galloway-Sprietsma, Jaehan Bae, Andrés F. Izquierdo, Jochen Stadler, Cristiano Longarini, Richard Teague, Sean M. Andrews, Andrew J. Winter, Myriam Benisty, Stefano Facchini, Giovanni Rosotti, Brianna Zawadzki, Christophe Pinte, Daniele Fasano, Marcelo Barraza-Alfaro, Gianni Cataldi, Nicolás Cuello, Pietro Curone, Ian Czekala, Mario Flock, Misato Fukagawa, Charles H. Gardner, Himanshi Garg, Cassandra Hall, Jane Huang, John D. Ilee, Kazuhiro Kanagawa, Geoffroy Lesur, Giuseppe Lodato, Ryan A. Loomis, Francois Menard, Ryuta Orihara, Daniel J. Price, Gaylor Wafflard-Fernandez, David J. Wilner, Lisa Wölfer, Hsi-Wei Yen, Tomohiro C. Yoshida

“…For most disks, we find that the physical and thermal structure is more complex than analytical models can account for, highlighting a need for more theoretical work and a better understanding of the role of projection effects on our observations.…”
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Vergence Eye Movements: From Basic Science to Clinical Application by Wolfgang Jaschinski, Rudolf Groner

“…What are the reasons why processes of vergence are underestimated in our scientific community? …”
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GRAVITY ANOMALIES OF THE CRUST AND UPPER MANTLE FOR CENTRAL AND SOUTH ASIA by V. N. Senachin, A. A. Baranov

“…The challenge of studying the global tectonic processes in the Earth’s tectonosphere can be addressed by gravity modeling in combination with seismic surveying.Data from previous studies. …”
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Uncertainties in the effects of organic aerosol coatings on polycyclic aromatic hydrocarbon concentrations and their estimated health effects by S. Lou, S. Lou, S. Lou, M. Shrivastava, A. Albinet, S. Tomaz, S. Tomaz, D. Srivastava, D. Srivastava, O. Favez, H. Shen, A. Ding, A. Ding, A. Ding

“…In contrast, the ROI-T approach forecasts lower concentrations in middle to low latitudes, as it assumes less effective OA coatings under warmer, more humid conditions. Evaluations against observed BaP concentrations show the shielded approach performs best, with a normalized mean bias (NMB) within <span class="inline-formula">±</span> 20 %. …”
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Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation by Hua Liu, Zhao Qi, Lan Tian, Zhe Chen, Haonan Li, Le Liu, Sicong Liu, Shuai Li, Jiumeng Sun, Ying Shao, Xiangjun Song, Jian Tu, Liangqiang Zhu, Kezong Qi, Zhenyu Wang

“…Abstract Getah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health. …”
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Bioplastic Production Using Natural Extracts with Cellulose Assisted by Experimental and Computational Screening by Lizbeth Zamora-Mendoza, Jhonny Caicho, José R. Mora, Daniela Negrete-Bolagay, Victor H. Guerrero, Noroska G. S. Mogollón, Melanie Ochoa-Ocampo, Jefferson Pastuña-Fasso, José F. Álvarez Barreto, Sebastián Ponce, Juan Paredes, Henry Erazo, Patricia I. Pontón, Marco León, Frank Alexis

“…The positive control (C4), containing NaOH and glycerol, degraded more slowly than the plant extract-based formulations. …”
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Early Forest Fire Detection With UAV Image Fusion: A Novel Deep Learning Method Using Visible and Infrared Sensors by Kunlong Niu, Chongyang Wang, Jianhui Xu, Jianrong Liang, Xia Zhou, Kaixiang Wen, Minjian Lu, Chuanxun Yang

“…This research contributes to multisource image fusion for forest fire detection, providing a more accurate and reliable early warning tool and laying the foundation for future work in this field.…”
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Capability Analysis of Earth Observation Data for Integrated Emergency Management by Kristina Wolf, Jon P. Mills, Luis Cormier, Ruth Dunn, Olivia Fairless, Adewale Falaye, Stuart Gordon, Oshadee Jayamanne, Carrow Morris-Wiltshire, Eleanor Myall, Francisco Salgado-Castillo, Yashvini Shukla, Luke Taylor, Ellen Robson, Daniel Donoghue, Richard J. Dawson, Elizabeth Lewis, Sim M. Reaney, Elaine Scott, Joel Freedman, Stuart Marshall, Patrick Walker, Helen Hinds

“…It is anticipated that the findings from the study will help stakeholders involved in IEMF management appreciate the added value of integrating satellite data into their current processes and analyses. By empowering key stakeholders to use satellite applications more effectively, it is predicted that better decisions will be achieved, thereby improving emergency risk management. …”
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Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach by Haiyang Yu, Haiyang Yu, Wang Yu, Wang Yu, Yuan Enwu, Yuan Enwu, Yuan Enwu, Jun Ma, Jun Ma, Xin Zhao, Xin Zhao, Linlin Zhang, Linlin Zhang, Linlin Zhang, Fang Yang, Fang Yang, Fang Yang

“…Head and neck squamous cell carcinoma (HNSCC) represents the sixth most common cancer worldwide, with pathologists routinely analyzing histological slides to diagnose cancer by evaluating cellular heterogeneity, a process that remains time-consuming and labor-intensive. …”
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Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…To expand our knowledge of this process, we used RNA-seq and quantitative proteomics to examine matings in Phytophthora infestans. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…Here, to improve knowledge of the biological processes involved in trypanotolerance versus trypanosusceptibility, we identified bovine genes differentially expressed in five West African cattle breeds during an experimental infection by Trypanosoma congolense and their biological functions. …”
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Digital Storytelling and Students’ Academic Engagement in Civic Education: Implications for Sustainable Development by Celestine Nkanu, David Francis Ekpoto, Amina Peter Adams, Idorenyin Edet Johnson, Anthony Etta Bisong, Odim Otu Offem, Efut Etim Nkanu, Fredrick Awhen Opoh, Samuel Manyo Takon, Agnes Edet Asuquo Offiong, James Eburikure Olayi, Samuel Orim Orim, Flora Michael Monity, James Abua Ewa, Oyobo-Gladys Tom Abam, John Edogi Egbe, Akaninyene Billy Orok, Joseph Enyia Ekpang

“…Conclusion: From the outcome, the conclusion is that digital storytelling instructional strategy positively influences academic engagement of students more than the traditional storytelling strategy irrespective of their gender. …”
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Overexpression of vacuolar proton pump ATPase (V-H+-ATPase) subunits B, C and H confers tolerance to salt and saline-alkali stresses in transgenic alfalfa (Medicago sativa L.) by Fa-wei WANG, Chao WANG, Yao SUN, Nan WANG, Xiao-wei LI, Yuan-yuan DONG, Na YAO, Xiu-ming LIU, Huan CHEN, Xi-feng CHEN, Zhen-min WANG, Hai-yan LI

“…The vacuolar proton pump ATPase (V-H+-ATPase), which is a multi-subunit membrane protein complex, plays a major role in the activation of ion and nutrient transport and has been suggested to be involved in several physiological processes, such as cell expansion and salt tolerance. …”
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Post-traumatic stress disorder, trauma and parenting stress: an individual participant data meta-analysis by Laurien Meijer, Kathleen Thomaes, Matthijs Blankers, Maja Deković, Molly R. Franz, Rolf Kleber, Elise M. van de Putte, Elisa van Ee, Elena Camisasca, Steffany J. Fredman, Dominik Moser, Larry L. Mullins, Maria Muzik, Mathilde Overbeek, Abigail Palmer Molina, Jessica Riggs, Katherine Rosenblum, Kristin Samuelson, Daniel Schechter, Chiara Suttora, Catrin Finkenauer

“…In survivors of childhood interpersonal trauma, PTSD and parenting stress may be more strongly intertwined.Objective: This study examined whether the relation between parental PTSD and parenting stress is moderated by childhood interpersonal trauma. …”
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Fermi-LAT Discovery of a Gamma-Ray Outburst from the Peculiar Compact Steep Spectrum Radiogalaxy 3C 216 by Federica Giacchino, Giovanni La Mura, Stefano Ciprini, Dario Gasparrini, Marcello Giroletti, Marco Laurenti

“…Consequently, high-energy emission is more easily detected in blazars , where the jet is closely aligned with the line of sight of the observer. …”
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Aquaponics model can provide better productivity: Microorganisms affect the growth and health of tilapia by Dingyue Fan, Huimin Xu, Shunlong Meng, Limin Fan, Chao Song, Liping Qiu, Dandan Li, Longxiang Fang, Zhuping Liu, Xuwen Bing

“…Among these bacterial orders, we found that Pseudomonadales and Exiguobacterales were more abundant in aquaponics than control systems. …”
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