miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells by Xuanran Feng, Xue Du, Xiaoyu Yang, Changqi Chen, Zhanping Liang, Xiaonan Xu, Yi Wang, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Jianhui Liu, Jianhui Liu

“…The effects of miR-185-5p on NPCs was confirmed in vivo through stereotactic injection of miR-185-5p antagonists to the brains of mice at postnatal day 1 (P1).ResultsThe expression levels of miR-185-5p kept increasing in the differentiation process of NPCs in vivo and in vitro. Perturbation of miR-185-5p’s function showed that miR-185-5p inhibited NPCs’ proliferation and promoted embryonic NPCs to differentiate more favorably to the glial lineage. …”
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Cancer chemoprevention: signaling pathways and strategic approaches by Junling Ren, Guangli Yan, Le Yang, Ling Kong, Yu Guan, Hui Sun, Chang Liu, Lei Liu, Ying Han, Xijun Wang

“…Considering the lengthy prevention process, an ideal chemopreventive agent should be nontoxic, inexpensive, and oral. …”
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Elementary Growth Modes provide a molecular description of cellular self-fabrication. by Daan H de Groot, Josephus Hulshof, Bas Teusink, Frank J Bruggeman, Robert Planqué

“…The phenotype of a cell is only extended with one more EGM whenever growth becomes limited by an additional biophysical constraint, such as a limited solvent capacity of a cellular compartment. …”
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PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling i... by Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Zetao Pan, Zetao Pan, Zetao Pan, Jiayan Sun, Jiayan Sun, Jiayan Sun, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Di Yin, Di Yin, Di Yin, Cunyang Huo, Cunyang Huo, Cunyang Huo, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo

“…BackgroundThe co-occurrence of pulmonary hypertension (PH) in patients with pulmonary fibrosis (PF) is linked to a more unfavorable prognosis and increased mortality compared to PF cases without PH. …”
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Development of a rapid on-site detection method for largemouth bass virus based on RPA-CRISPR/Cas12a system by Na Li, Chunmei Dai, Yuelin Mao, Yimeng Zhang, Huiyuan Yan, Huijiao Wang, Yinghui Qin, Baicheng Huang, Xinjie Wang, Lunguang Yao

“…The one-pot method and lyophilization strategy demonstrated consistent detection results with two-step RPA-CRISPR methods in clinical sample testing, offering more convenient and stable application characteristics for on-site detection.DiscussionThis study establishes an efficient process for detecting LMBV nucleic acids in fish clinical samples, culminating in a CRISPR-based fluorescent readout, offering significant advantages for viral diagnosis and monitoring.…”
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Improving the high stress abrasive wear resistance of medium carbon quenched and partitioned bainitic steel by controlling the phase transformation sequence by Qiangguo Li, Wandong Li, Mingwei Li, Minghua Su, Zhihua Hu, Hongbo Ma, Zhengyun Wang, Tong Li, Yanan Zhang

“…The results revealed that the transformation sequence of bainite followed by martensite (B-Q&P process) is more favorable for obtaining a finer multiphase microstructure comprising bainite-martensite-retained austenite than the reverse sequence of martensite followed by bainite transformation. …”
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Differences in volatility and organoleptic characteristics of mixed and sequential fermentation of mulberry fruit juices by Weissella confusa and Pichia kudriavzevii using metabolo... by Changqi Cai, Fuchao Yan, Junhong Li, Baochang Du, Qingshen Sun, Xiaoyun Han

“…Fermentation can improve the nutritional value of fruit juice processed from mulberries, making it easier to absorb, and can also improve the taste and aroma, thus promoting further development. …”
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Integrated transcriptomic and metabolomic analyses identify key factors in the vitellogenesis of juvenile Sichuan bream (Sinibrama taeniatus) by Zhe Zhao, Zhe Zhao, Qiang Zhao, Qiang Zhao, Haoyu Wang, Haoyu Wang, Lan Wei, Siya Wang, Siya Wang, Shilin Li, Shilin Li, Dengyue Yuan, Dengyue Yuan, Zhijian Wang, Zhijian Wang

“…The initiation of vitellogenesis was found to be associated with a surge in serum E2 levels, but the sustained increase in Vtg levels in the late stage may be due more to upregulation of the estrogen receptor. These results provide valuable information about the regulation of ovarian development in cultured fish.…”
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Designing electrolyte with multi-ether solvation structure enabling low-temperature sodium ion capacitor by Dongming Liu, Mengfan Pei, Xin Jin, Lin Wang, Wanyuan Jiang, Borui Li, Runyue Mao, Xigao Jian, Fangyuan Hu

“…Ensuring the performance of SICs in low-temperature environments is crucial for applications in high-altitude cold regions, where the desolvation process of Na ^+ and the transport process in the solid electrolyte interphase (SEI) are determinant. …”
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Social norms and groups structure safe operating spaces in renewable resource use in a social–ecological multi-layer network model by M. Bechthold, M. Bechthold, M. Bechthold, W. Barfuss, W. Barfuss, A. Butz, J. Breier, J. Breier, S. M. Constantino, J. Heitzig, L. Schwarz, L. Schwarz, L. Schwarz, S. N. Vardag, J. F. Donges, J. F. Donges, J. F. Donges

“…Here we present a multi-level network framework with a complex contagion process for modelling the dynamics of descriptive and injunctive social norms. …”
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Targeting revascularization via tryptophan-indole-NETs axis: the synergistic power of acupuncture and rt-PA thrombolysis in ischemic stroke by Siqi Chang, Siqi Chang, Yi Zhao, Yi Zhao, Chengfeng Li, Chengfeng Li, Xinyu Liu, Xinyu Liu, Zixuan Fang, Zixuan Fang, Zihao Peng, Zihao Peng, Mingliang Gao, Mingliang Gao, Yawen Xia, Yawen Xia, Yawen Xia, Guangxia Ni, Guangxia Ni

“…Acupuncture and NETs inhibitors both offer similar vascular protection during ultra-time window rt-PA thrombolysis, with acupuncture being more effective in reducing cerebral infarction.ConclusionThe degradation of NETs via the tryptophan-indole pathway may facilitate the restoration of vascular structure and function following ischemic stroke. …”
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Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…Given its key role in cognitive control and emotion regulation — processes highly relevant for rumination — we focused on the frontoparietal network. …”
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Increasing access to psychological therapy on acute mental health wards: staff and patient experiences of a stepped psychological intervention by Isobel Johnston, Dawn Edge, Paul Wilson, Adele Beinaraviciute, Sandra Bucci, Richard Drake, Gill Gilworth, Gillian Haddock, Fritz Handerer, Sonalia Kaur, Karina Lovell, Helen Morley, Owen Price, Mica Samji, Katherine Berry

“…This understanding was associated with improved staff-patient relationships, more person focused practice and reduced conflict and burnout. …”
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Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects by Mufeng Wu, Xiao Liang, Ying Liu, Chunling Wu, Xingkui An, Zihua Zhao, Guifeng Hao, Ijiti Oluwole Gregory, Zhihong Li, Qing Chen

“…Linamarin-β-GLU (lima bean-derived) presented prompt HCN release, and molecular docking indicated higher binding energy and more robust binding sites compared with other two groups, i.e., lotaustralin-β-GLU (lima bean-derived) and amygdalin-β-GLU (almond-derived). …”
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Smart medical report: efficient detection of common and rare diseases on common blood tests by Ákos Németh, Ákos Németh, Gábor Tóth, Péter Fülöp, György Paragh, Bíborka Nádró, Zsolt Karányi, György Paragh, Zsolt Horváth, Zsolt Csernák, Zsolt Csernák, Erzsébet Pintér, Erzsébet Pintér, Dániel Sándor, Dániel Sándor, Gábor Bagyó, István Édes, János Kappelmayer, Mariann Harangi, Bálint Daróczy, Bálint Daróczy

“…IntroductionThe integration of AI into healthcare is widely anticipated to revolutionize medical diagnostics, enabling earlier, more accurate disease detection and personalized care.MethodsIn this study, we developed and validated an AI-assisted diagnostic support tool using only routinely ordered and broadly available blood tests to predict the presence of major chronic and acute diseases as well as rare disorders.ResultsOur model was tested on both retrospective and prospective datasets comprising over one million patients. …”
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The illusion of success: Test set disproportion causes inflated accuracy in remote sensing mapping research by Yuanjun Xiao, Zhen Zhao, Jingfeng Huang, Ran Huang, Wei Weng, Gerui Liang, Chang Zhou, Qi Shao, Qiyu Tian

“…A rigorous approach for accuracy assessment was suggested, and an example of tea plantations mapping is used to demonstrate the process and analyse potential issues in traditional approaches. …”
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Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states by Revathi Balasubramanian, Krishnakumar Kizhatil, Taibo Li, Nicholas Tolman, Aakriti Bhandari, Graham Clark, Violet Bupp-Chickering, Ruth A Kelly, Sally Zhou, John Peregrin, Marina Simón, Christa Montgomery, W Daniel Stamer, Jiang Qian, Simon WM John

“…Recent transcriptomic studies of the anterior segment added important knowledge, but were limited in power by SEC numbers or did not focus on SC. To gain a more comprehensive understanding of SC biology, we performed bulk RNA sequencing on C57BL/6 J SC, blood vessel, and lymphatic endothelial cells from limbal tissue (~4,500 SECs). …”
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Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways by Rui Teng, Yanmeng Wang, Nan Lv, Dan Zhang, Ramone A. Williamson, Lei Lei, Ping Chen, Li Lei, Baiyan Wang, Jiaqi Fu, Xuna Liu, Aili He, Michael O’Dwyer, Jinsong Hu

“…Consistent with this finding, we found that the reduction in NK cell cytotoxicity resulting from hypoxia correlated to the lower expression of granzyme B, IFN-γ, and degranulation marker CD107a, as well as activating receptors including NKp30, NKp46, and NKG2D expressed on the surface of NK cells. More importantly, we further demonstrated that a reduction in the phosphorylation levels of ERK and STAT3 secondary to hypoxia was strongly associated with the attenuated NK cell cytotoxicity. …”
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Weighted single-step genome-wide association study identified genomic regions and candidate genes for growth and reproductive traits in Wenchang chicken by Ranran Zhu, Yu Zhang, Yuxiang Jiang, Zihan Xu, Yurong Tai, Ziyi Lian, Zhandeng Li, Xiuping Wang, Na Luo, Guiping Zhao, Xuemei Deng

“…We performed weighted single-step genome-wide association study (wssGWAS) on six traits using a single-trait model, and searched for candidate genes within QTL regions explaining more than 1 % of the genetic variance. Based on the contribution to genetic variation from QTL regions, we identified 4, 8, 5, 6, 9, and 8 candidate regions for EP, 35w-EW, BW, FT, SL, and AFE, respectively. …”
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2024 Chinese guideline on the construction and application of medical blockchain# by Xiaoping Chen, Feng Cao, Qing Wang, Zhewei Ye, Xiaoping Chen, Zhewei Ye, Feng Cao, Weiqian Chen, Wei Cui, Donglei Feng, Guozhong Ji, Zhean Lin, Qinghu Meng, Min Luo, Yilong Luo, Weijia Lv, Yanguo Qin, Xihu Qin, Xueming Si, Bing Tan, Zhihong Tian, Qing Wang, Chenhui Wang, Weigang Wu, Lipeng Xiang, Guangjun Yu, Dawei Ye, Xiumei Zhang, He Zhao, Zibin Zheng, Ceng Zeng, Wei Zhang, Qiru Zhou, Peizhuo Zang, Xiaoping Chen, Feng Cao, Qing Wang, Zhewei Ye, Yi Xie, Zhewei Ye, Feng Cao, Geng Lu, He Zhao, Feng Cao, Weiqian Chen, Wurong Chen, Xiaoping Chen, Min Cai, Yang Deng, Donglei Feng, Liang Gao, Yong Gao, Wentao Gong, Zheng Guo, Bin He, Debiao He, Zhiwei Hao, Guoliang Hu, Yong Hu, Dongchen Huang, Jufang Huang, Biqiang Huang, Wei Huang, Guozhong Ji, Jie Ji, Yijie Kuang, Qing Lei, Huiwu Li, Jie Li, Jing Li, Kainan Li, Zhi Li, Zhean Lin, Yuehong Liu, Geng Lu, Tong Lu, Sheng Lu, Min Luo, Yilong Luo, Weijia Lv, Qinghu Meng, Qingjiang Pang, Shijie Peng, Xihu Qin, Yanguo Qin, Bing Qiu, Bing Qin, Hongxun Sang, Qing Shan, Xueming Si, Shan Tan, Zhihong Tian, Chenhui Wang, Kai Wang, Qing Wang, Yi Wang, Xiaoru Wen, Jiangxin Wu, Weigang Wu, Lipeng Xiang, Xuan Xiao, Yi Xie, Liming Xiong, Jinlin Xu, Dawei Ye, Zhewei Ye, Guangjun Yu, Huiwen Yang, Peizhuo Zang, Cheng Zeng, Wei Zhang, Xiumei Zhang, Yuanzhi Zhang, He Zhao, Meng Zhao, Zibin Zheng, Da Zhong, Feifei Zhou, Qiru Zhou, Qinmiao Zhu, Jun Zou, Yi Xie

“…Although blockchain technology has been applied in various industries, its application in the medical field needs more driving force, and its development needs to be standardized. …”
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